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The map label for this gene is mco [H]

Identifier: 78223361

GI number: 78223361

Start: 2424766

End: 2426313

Strand: Reverse

Name: mco [H]

Synonym: Gmet_2154

Alternate gene names: 78223361

Gene position: 2426313-2424766 (Counterclockwise)

Preceding gene: 78223362

Following gene: 78223360

Centisome position: 60.7

GC content: 62.21

Gene sequence:

>1548_bases
ATGAAAAAAAGAGGAATGAACCGCAGGAAATTCATCACTGCGGCATCGGTGGGCGTTGCGGGCGTTTACGCCACTCTCCA
CGCCGGCGTGGTCAGGGCCATGATGGGGAGTGGCGGCATGGGCGGCGGTGGCATGGGGGGCGGCGGCATGGGGGGGACGA
CTACGACGATTGTCGATCCGCCGCCGGGAGCGTCGTTCTTCGATATTCCCAATGCCACGAAGAATAGCGCCGGGGCCTAC
GAGCTTCTGGTGAAGGAGGCACGGCTGCGGCTGAACGGCACCGCGGTGACCCTTCTTACTTACAACGGCATGTATCCTGG
CCCGGTCATTCGGGCTGCCCGGGGCGATATGCTCAAGGTGCGAATGGTCAATATGCTGCCGAAAACGACCGCCAGCAACA
TCCTCGGTCATGTGCGCAACATCACCAACATCCATACCCATGGTCTTCACGTCACCCCCTCGGGGATGGGCGACAACATG
ATGATGACGGCGGCGCCGGGCACGGAGCTCAATTACGAATACGATCTCGCCCTGGAAGAGCCAGGGCACCTCAATTTCTA
CCATCCCCACGTGCACGGCTCCGTTGCCGAGCAGTACTGGGGCGGGCTTGCCGGCCCTCTGGTGATTGACGATGCTGCGG
GAAGCCCGCTTTCCGGCTACGAGACCCATGTGATGTTCATCAAGGACCTCACCATTGCCAACGGCCTTCCCGAGCCGTAC
ACCTCCAACTCCGACTTCATGCGGGGGAAGGAGGGGAACCTGGTCATGGTTAACGGGCAGGTGAACCCGGTCCTGTCGAT
CCGGCCGGGGCAGGTGCAGCGGTGGCAGATCGTCAACGCCTGCAATGCCCGCTTCCTGAAGCTTTCCCTCGACAGGCACT
CCCTCTGGCTCGTGGGGACCGACGGTGGGCTCCTCGACAAGCCCTATAAGCTTTCCACCATCCTCCTGGCGCCGGGAGAG
CGGGTCGATGTCCTGGTCAAGGCGGACCAGGGGGGCGGGAACTTCAAGCTGCTGTCGCTCCCCTACGCCCGGGGGGGCGG
CTCCCTGCAGCAGGTGACGCTCCTGACCCTCGCCTATGGCGGGATATCCGCGGGCGACACCCTCCCCACGGCGGTGAATC
CGGCGGCGGCACGGCTGAACATGAACCTTTCCCTCCTGCCGCGGCGGCAGATCTCTCTCAGCATGATGATGGGGAGAGGG
TACATCAACGGCATTTCGTACACCGACATGGACCACGCCTATACGATTTCGTCCGGCCTCGGCACCTACGAGGTCTGGGA
GATCGTCAACCAGAGCGGCATGGATCACCCGTTCCACCAGCATGTCAATTCGTGCCAGGTTCTTTCCGTCACCGGCGGCG
ATCCCGACTATGCCTCGCTCTACACCACCATACCGGCCTGGAAGGACGTGGTCATCATCCCGAAGATGGGGAGCGCCACC
ATCCTCGTCCCGGTCAAGGACTACGACGGCATGACCATGTTCCACTGCCACATCGTCGAGCATGAGGATATCGGGATGAT
GGGGGTGTGGGACATCGGCATGATGTAA

Upstream 100 bases:

>100_bases
CTGTGTCGCGATGCACGAAACCCGCCCTTCGGGGCGGGTTTTCGTTACCTCGACGGTGTTCGCGAAAACAACGGAAATTC
CAGGGAAAGGAGATTTCATC

Downstream 100 bases:

>100_bases
AAATCATTCGTTTGCCATCGCATGGCGACGGAAGGGGCGAAACTCTCGCTCCGAAGCGATCCAGCGTCACTGGTCGGTCT
TCGTGGCACGTGAGCCGCTA

Product: twin-arginine translocation pathway signal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MKKRGMNRRKFITAASVGVAGVYATLHAGVVRAMMGSGGMGGGGMGGGGMGGTTTTIVDPPPGASFFDIPNATKNSAGAY
ELLVKEARLRLNGTAVTLLTYNGMYPGPVIRAARGDMLKVRMVNMLPKTTASNILGHVRNITNIHTHGLHVTPSGMGDNM
MMTAAPGTELNYEYDLALEEPGHLNFYHPHVHGSVAEQYWGGLAGPLVIDDAAGSPLSGYETHVMFIKDLTIANGLPEPY
TSNSDFMRGKEGNLVMVNGQVNPVLSIRPGQVQRWQIVNACNARFLKLSLDRHSLWLVGTDGGLLDKPYKLSTILLAPGE
RVDVLVKADQGGGNFKLLSLPYARGGGSLQQVTLLTLAYGGISAGDTLPTAVNPAAARLNMNLSLLPRRQISLSMMMGRG
YINGISYTDMDHAYTISSGLGTYEVWEIVNQSGMDHPFHQHVNSCQVLSVTGGDPDYASLYTTIPAWKDVVIIPKMGSAT
ILVPVKDYDGMTMFHCHIVEHEDIGMMGVWDIGMM

Sequences:

>Translated_515_residues
MKKRGMNRRKFITAASVGVAGVYATLHAGVVRAMMGSGGMGGGGMGGGGMGGTTTTIVDPPPGASFFDIPNATKNSAGAY
ELLVKEARLRLNGTAVTLLTYNGMYPGPVIRAARGDMLKVRMVNMLPKTTASNILGHVRNITNIHTHGLHVTPSGMGDNM
MMTAAPGTELNYEYDLALEEPGHLNFYHPHVHGSVAEQYWGGLAGPLVIDDAAGSPLSGYETHVMFIKDLTIANGLPEPY
TSNSDFMRGKEGNLVMVNGQVNPVLSIRPGQVQRWQIVNACNARFLKLSLDRHSLWLVGTDGGLLDKPYKLSTILLAPGE
RVDVLVKADQGGGNFKLLSLPYARGGGSLQQVTLLTLAYGGISAGDTLPTAVNPAAARLNMNLSLLPRRQISLSMMMGRG
YINGISYTDMDHAYTISSGLGTYEVWEIVNQSGMDHPFHQHVNSCQVLSVTGGDPDYASLYTTIPAWKDVVIIPKMGSAT
ILVPVKDYDGMTMFHCHIVEHEDIGMMGVWDIGMM
>Mature_515_residues
MKKRGMNRRKFITAASVGVAGVYATLHAGVVRAMMGSGGMGGGGMGGGGMGGTTTTIVDPPPGASFFDIPNATKNSAGAY
ELLVKEARLRLNGTAVTLLTYNGMYPGPVIRAARGDMLKVRMVNMLPKTTASNILGHVRNITNIHTHGLHVTPSGMGDNM
MMTAAPGTELNYEYDLALEEPGHLNFYHPHVHGSVAEQYWGGLAGPLVIDDAAGSPLSGYETHVMFIKDLTIANGLPEPY
TSNSDFMRGKEGNLVMVNGQVNPVLSIRPGQVQRWQIVNACNARFLKLSLDRHSLWLVGTDGGLLDKPYKLSTILLAPGE
RVDVLVKADQGGGNFKLLSLPYARGGGSLQQVTLLTLAYGGISAGDTLPTAVNPAAARLNMNLSLLPRRQISLSMMMGRG
YINGISYTDMDHAYTISSGLGTYEVWEIVNQSGMDHPFHQHVNSCQVLSVTGGDPDYASLYTTIPAWKDVVIIPKMGSAT
ILVPVKDYDGMTMFHCHIVEHEDIGMMGVWDIGMM

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=493, Percent_Identity=25.5578093306288, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789394, Length=443, Percent_Identity=26.1851015801354, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 55208; Mature: 55208

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRGMNRRKFITAASVGVAGVYATLHAGVVRAMMGSGGMGGGGMGGGGMGGTTTTIVDP
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECC
PPGASFFDIPNATKNSAGAYELLVKEARLRLNGTAVTLLTYNGMYPGPVIRAARGDMLKV
CCCCCEEECCCCCCCCCCHHHHHHHHHHEEECCEEEEEEEECCCCCCCEEECCCCCEEEE
RMVNMLPKTTASNILGHVRNITNIHTHGLHVTPSGMGDNMMMTAAPGTELNYEYDLALEE
EEEHHCCCHHHHHHHHHHHHHCEEEECCEEEECCCCCCCEEEEECCCCCCCEEEEEEECC
PGHLNFYHPHVHGSVAEQYWGGLAGPLVIDDAAGSPLSGYETHVMFIKDLTIANGLPEPY
CCCEEEECCCCCCHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEEEEEEHHHCCCCCCC
TSNSDFMRGKEGNLVMVNGQVNPVLSIRPGQVQRWQIVNACNARFLKLSLDRHSLWLVGT
CCCCCCCCCCCCCEEEECCCCCEEEEECCCCCEEEEEEHHCCCEEEEEEECCCEEEEEEC
DGGLLDKPYKLSTILLAPGERVDVLVKADQGGGNFKLLSLPYARGGGSLQQVTLLTLAYG
CCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHEEEEEEEEEC
GISAGDTLPTAVNPAAARLNMNLSLLPRRQISLSMMMGRGYINGISYTDMDHAYTISSGL
CCCCCCCCCCCCCCCCEEEECCEEECCCCCEEEEEEECCCEECCCCCCCCCCEEEECCCC
GTYEVWEIVNQSGMDHPFHQHVNSCQVLSVTGGDPDYASLYTTIPAWKDVVIIPKMGSAT
CHHHHHHHHHHCCCCCHHHHCCCCEEEEEEECCCCCHHEEEEECCCCCCEEEEECCCCEE
ILVPVKDYDGMTMFHCHIVEHEDIGMMGVWDIGMM
EEEEECCCCCEEEEEEEEEECCCCCEEEEECCCCC
>Mature Secondary Structure
MKKRGMNRRKFITAASVGVAGVYATLHAGVVRAMMGSGGMGGGGMGGGGMGGTTTTIVDP
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECC
PPGASFFDIPNATKNSAGAYELLVKEARLRLNGTAVTLLTYNGMYPGPVIRAARGDMLKV
CCCCCEEECCCCCCCCCCHHHHHHHHHHEEECCEEEEEEEECCCCCCCEEECCCCCEEEE
RMVNMLPKTTASNILGHVRNITNIHTHGLHVTPSGMGDNMMMTAAPGTELNYEYDLALEE
EEEHHCCCHHHHHHHHHHHHHCEEEECCEEEECCCCCCCEEEEECCCCCCCEEEEEEECC
PGHLNFYHPHVHGSVAEQYWGGLAGPLVIDDAAGSPLSGYETHVMFIKDLTIANGLPEPY
CCCEEEECCCCCCHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEEEEEEHHHCCCCCCC
TSNSDFMRGKEGNLVMVNGQVNPVLSIRPGQVQRWQIVNACNARFLKLSLDRHSLWLVGT
CCCCCCCCCCCCCEEEECCCCCEEEEECCCCCEEEEEEHHCCCEEEEEEECCCEEEEEEC
DGGLLDKPYKLSTILLAPGERVDVLVKADQGGGNFKLLSLPYARGGGSLQQVTLLTLAYG
CCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHEEEEEEEEEC
GISAGDTLPTAVNPAAARLNMNLSLLPRRQISLSMMMGRGYINGISYTDMDHAYTISSGL
CCCCCCCCCCCCCCCCEEEECCEEECCCCCEEEEEEECCCEECCCCCCCCCCEEEECCCC
GTYEVWEIVNQSGMDHPFHQHVNSCQVLSVTGGDPDYASLYTTIPAWKDVVIIPKMGSAT
CHHHHHHHHHHCCCCCHHHHCCCCEEEEEEECCCCCHHEEEEECCCCCCEEEEECCCCEE
ILVPVKDYDGMTMFHCHIVEHEDIGMMGVWDIGMM
EEEEECCCCCEEEEEEEEEECCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA