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The map label for this gene is comEC [H]

Identifier: 78223122

GI number: 78223122

Start: 2137982

End: 2140378

Strand: Reverse

Name: comEC [H]

Synonym: Gmet_1915

Alternate gene names: 78223122

Gene position: 2140378-2137982 (Counterclockwise)

Preceding gene: 78223123

Following gene: 78223121

Centisome position: 53.54

GC content: 58.91

Gene sequence:

>2397_bases
GTGACCGGAAGGCCCCTTCTTGTTCCACTCCTCGGCATGGTGGGCGGCCTTGCCTCTGCCCACCATCTTGGTATCGTACT
CCCGTACCAGTTCCTTCCGGGACTCCTTGTGGCCGCTCTGGCGGCTGTCTTCCTCAAAAGCCGCATCCCGTTCACGATAA
TCCTCATCGCTCTGTTTTTCGTCTGGGGGAGTGCTGCACTCCACCCGTTTCTCGCCCCTGTACACCCACCACACCATCTT
GTGCATAGTACCGATTCGAAACCGGTCATAGTTGAGGGGATCGTCGGCGTCCGACCCGAAGCCTCGGAAGGGGGGATGAG
AATCATTCTCAATGTCGACCGGATTATTCGGGACGAAAAATGCACTGCGGCCATCGGTCGTCTCTTGGTTTACGTTCGTG
AGGGGAGGGGGACCATTCTGACCGGCGACCGGGTAAGGCTCGAAGCCCGGATCCGTGAACCGGCAAATTTCGGGCTTCCG
GGAGAATTCGACTACCGTCGCTACCTTGCCTACCGTAACATCTGCGCCACGGCGTCAATCAAGAGTGCCGACGACATACT
CCTGATCCGCGAAGCGACAGCACATCCGGTCCAGCGTTGGTTTGACCGGCTGGCCGCGGAGCTAGGCGGTTTCATTGGCA
GCAGTGCGCCGGCCGAGGGGGGCTTGCTCAGGGCGATCCTCGTGGGAGAACGTGGTTTCGTTACGGAAGACACCGAGGAT
ATCTACGCCCGCGCCGGGGTTAACCACATCCTCTCCATCTCCGGCTTCCATATCGGGGTAATCGCCCTCACCATCCACTA
TCTCCTTTTTCACCTCCTCGTTCGGTGTGAATTTCTCACCCTGCACCTGAACCTTCGGCGCACCGTCCTTCTGGCCACGC
TCCCCCCTGTCGTCTTCTACCTCTTTATTGCCGGACTGGCTCCGGCCACGGTCCGCTCGGTAGTGATGATCGCCCTTGTA
ACCCTGGCGCTTTTCCTTGAGCGGGAGACCGATTCCCTCAACACATTGACGGCAGCCGCCTTCGGCATTCTGATGTTCAA
CCCCCAAGCCCTTTTCGATATCTCGTTCCAGCTCTCGTTTCTTGCCATCTGGGGGATACTGGTTCTGACGCCCCTCTGCA
TGGAACCTTTTGGCGATTTACGGGAAGGCACACTGAAGAAGGTACTGCTGTTTGCAGCCGTATCGGTCGCCGCCACCATA
GTCACGCTTCTTCCGGTGGTTCACACCTTTCACCGGGCATCGGTCGCCGGGCTCGTCGGAAATTTCGTGGCGGTTCCTCT
GTTGGGGTACGGAGCAGTAGTGGCAGGGTTTTCCGCTCTGCCGCTTATTTACCTTTTCCCTGCGGCGGCTAAATTCCTCC
TTGGAATCGCCGCGTGGCTGGTGAGAATTTCCGACGGAATCATGGCGACCGTGGCCCAAATTCCGCCTCTCCCTGTGCGA
AACGCGACCCTCGCGGACCTCTTCATTCTCTACCTTGCCCTCCTGGCGCTCTCACTCGTCAAGGGAAAGCGAATCCATTA
TCTCCTCTGCGCACTGGCTGCGGGGCTTGTGCTGGCGCTTCATCTGCCGGCGGTGGCTGATTCATCGAAAACACTCAGGA
TCACCTTTTTCAGTGTGGGGCAGGGGGAGTCGACCCTTGTCACGTTCCCTGACGGCAGACGAATGCTCGTGGATGGCGGC
GGCTCTCCCCACGAAGGCGGAATGGATGTAGGGAGGCAGCTTCTGGCCCCGGCACTCTGGAGCATGGGGATTGGCCGACT
CGACGTGGTTGTTCTGACTCACCCCCATCCCGATCATATCAAAGGGCTTATTTCTCTTGCCGCCCTGTTCCCCATCGGTG
AGTTCTGGGAAAGTGGCATCACAACACCAGTCGGCGACCATGCAAAGCTCCGGGAGATTCTTGCCGCTCACCGGGTTCCG
GTTCGATACATTACTTCTTCCTCTCCCCCATTTTCTGTCGGCAACGTTCGGATTGAACCCCTGGCTCCGGCACACCGCCC
CCTTGCAGAGCCGGATAGCGACCAAAACGATGATTCCCTCGTATTCAGGCTCACGCATGGAACGTTCAGCATGCTCTTAA
CCGGTGACATTGGCAGTTATGCCGAGGAGCGGCTTCTGTACGAGCCGGAAAGACTCGCCTGCACGGTCCTCAAGGTGCCC
CATCACGGCAGCCGTCACTCTTCGTCGCCCCGCTTTCTCGATGCAGCCTCCCCCCGTCTGGCGCTCATTTCAGCCGGAGC
CCGCAACAGCTTCGGCCTTCCGTCGCCGGAAACCATTTCACGTCTGAGGAAGCGCGGCGTTTCGGTCTGTCGCACCGACC
TGAACGGGACGATCCAGGTGGCAAGCGACGGGAACGGATATTCGGTCAAAACCTTCTCGGACGGGCATTTTCATTGA

Upstream 100 bases:

>100_bases
TCGGGAACAAAAAGCCGACGGCAACTGTTCCGCGGGTAGAGCTTGAAACTCAACTCCGGAAAGATTTGAGCCGTATTCGT
CCGACACGTTAGGGGCCTGA

Downstream 100 bases:

>100_bases
CAAGCATCCCGTTTTATCTGATAGTTTTAAGGGTTAAAGCGCGGACACTGCACAAATTCGCACCCTCAGGAGCTACCCTC
CATGGATAAAATCCTCGTCG

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 798; Mature: 797

Protein sequence:

>798_residues
MTGRPLLVPLLGMVGGLASAHHLGIVLPYQFLPGLLVAALAAVFLKSRIPFTIILIALFFVWGSAALHPFLAPVHPPHHL
VHSTDSKPVIVEGIVGVRPEASEGGMRIILNVDRIIRDEKCTAAIGRLLVYVREGRGTILTGDRVRLEARIREPANFGLP
GEFDYRRYLAYRNICATASIKSADDILLIREATAHPVQRWFDRLAAELGGFIGSSAPAEGGLLRAILVGERGFVTEDTED
IYARAGVNHILSISGFHIGVIALTIHYLLFHLLVRCEFLTLHLNLRRTVLLATLPPVVFYLFIAGLAPATVRSVVMIALV
TLALFLERETDSLNTLTAAAFGILMFNPQALFDISFQLSFLAIWGILVLTPLCMEPFGDLREGTLKKVLLFAAVSVAATI
VTLLPVVHTFHRASVAGLVGNFVAVPLLGYGAVVAGFSALPLIYLFPAAAKFLLGIAAWLVRISDGIMATVAQIPPLPVR
NATLADLFILYLALLALSLVKGKRIHYLLCALAAGLVLALHLPAVADSSKTLRITFFSVGQGESTLVTFPDGRRMLVDGG
GSPHEGGMDVGRQLLAPALWSMGIGRLDVVVLTHPHPDHIKGLISLAALFPIGEFWESGITTPVGDHAKLREILAAHRVP
VRYITSSSPPFSVGNVRIEPLAPAHRPLAEPDSDQNDDSLVFRLTHGTFSMLLTGDIGSYAEERLLYEPERLACTVLKVP
HHGSRHSSSPRFLDAASPRLALISAGARNSFGLPSPETISRLRKRGVSVCRTDLNGTIQVASDGNGYSVKTFSDGHFH

Sequences:

>Translated_798_residues
MTGRPLLVPLLGMVGGLASAHHLGIVLPYQFLPGLLVAALAAVFLKSRIPFTIILIALFFVWGSAALHPFLAPVHPPHHL
VHSTDSKPVIVEGIVGVRPEASEGGMRIILNVDRIIRDEKCTAAIGRLLVYVREGRGTILTGDRVRLEARIREPANFGLP
GEFDYRRYLAYRNICATASIKSADDILLIREATAHPVQRWFDRLAAELGGFIGSSAPAEGGLLRAILVGERGFVTEDTED
IYARAGVNHILSISGFHIGVIALTIHYLLFHLLVRCEFLTLHLNLRRTVLLATLPPVVFYLFIAGLAPATVRSVVMIALV
TLALFLERETDSLNTLTAAAFGILMFNPQALFDISFQLSFLAIWGILVLTPLCMEPFGDLREGTLKKVLLFAAVSVAATI
VTLLPVVHTFHRASVAGLVGNFVAVPLLGYGAVVAGFSALPLIYLFPAAAKFLLGIAAWLVRISDGIMATVAQIPPLPVR
NATLADLFILYLALLALSLVKGKRIHYLLCALAAGLVLALHLPAVADSSKTLRITFFSVGQGESTLVTFPDGRRMLVDGG
GSPHEGGMDVGRQLLAPALWSMGIGRLDVVVLTHPHPDHIKGLISLAALFPIGEFWESGITTPVGDHAKLREILAAHRVP
VRYITSSSPPFSVGNVRIEPLAPAHRPLAEPDSDQNDDSLVFRLTHGTFSMLLTGDIGSYAEERLLYEPERLACTVLKVP
HHGSRHSSSPRFLDAASPRLALISAGARNSFGLPSPETISRLRKRGVSVCRTDLNGTIQVASDGNGYSVKTFSDGHFH
>Mature_797_residues
TGRPLLVPLLGMVGGLASAHHLGIVLPYQFLPGLLVAALAAVFLKSRIPFTIILIALFFVWGSAALHPFLAPVHPPHHLV
HSTDSKPVIVEGIVGVRPEASEGGMRIILNVDRIIRDEKCTAAIGRLLVYVREGRGTILTGDRVRLEARIREPANFGLPG
EFDYRRYLAYRNICATASIKSADDILLIREATAHPVQRWFDRLAAELGGFIGSSAPAEGGLLRAILVGERGFVTEDTEDI
YARAGVNHILSISGFHIGVIALTIHYLLFHLLVRCEFLTLHLNLRRTVLLATLPPVVFYLFIAGLAPATVRSVVMIALVT
LALFLERETDSLNTLTAAAFGILMFNPQALFDISFQLSFLAIWGILVLTPLCMEPFGDLREGTLKKVLLFAAVSVAATIV
TLLPVVHTFHRASVAGLVGNFVAVPLLGYGAVVAGFSALPLIYLFPAAAKFLLGIAAWLVRISDGIMATVAQIPPLPVRN
ATLADLFILYLALLALSLVKGKRIHYLLCALAAGLVLALHLPAVADSSKTLRITFFSVGQGESTLVTFPDGRRMLVDGGG
SPHEGGMDVGRQLLAPALWSMGIGRLDVVVLTHPHPDHIKGLISLAALFPIGEFWESGITTPVGDHAKLREILAAHRVPV
RYITSSSPPFSVGNVRIEPLAPAHRPLAEPDSDQNDDSLVFRLTHGTFSMLLTGDIGSYAEERLLYEPERLACTVLKVPH
HGSRHSSSPRFLDAASPRLALISAGARNSFGLPSPETISRLRKRGVSVCRTDLNGTIQVASDGNGYSVKTFSDGHFH

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=576, Percent_Identity=25.3472222222222, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 86115; Mature: 85984

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRPLLVPLLGMVGGLASAHHLGIVLPYQFLPGLLVAALAAVFLKSRIPFTIILIALFF
CCCCCHHHHHHHHHHHHCCHHHCEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VWGSAALHPFLAPVHPPHHLVHSTDSKPVIVEGIVGVRPEASEGGMRIILNVDRIIRDEK
HHHHHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEEEHHHHHCCHH
CTAAIGRLLVYVREGRGTILTGDRVRLEARIREPANFGLPGEFDYRRYLAYRNICATASI
HHHHHHHHHEEEECCCCEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC
KSADDILLIREATAHPVQRWFDRLAAELGGFIGSSAPAEGGLLRAILVGERGFVTEDTED
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCHHH
IYARAGVNHILSISGFHIGVIALTIHYLLFHLLVRCEFLTLHLNLRRTVLLATLPPVVFY
HHHHHCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHH
LFIAGLAPATVRSVVMIALVTLALFLERETDSLNTLTAAAFGILMFNPQALFDISFQLSF
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCHHEEEEHHHHHH
LAIWGILVLTPLCMEPFGDLREGTLKKVLLFAAVSVAATIVTLLPVVHTFHRASVAGLVG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NFVAVPLLGYGAVVAGFSALPLIYLFPAAAKFLLGIAAWLVRISDGIMATVAQIPPLPVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
NATLADLFILYLALLALSLVKGKRIHYLLCALAAGLVLALHLPAVADSSKTLRITFFSVG
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEC
QGESTLVTFPDGRRMLVDGGGSPHEGGMDVGRQLLAPALWSMGIGRLDVVVLTHPHPDHI
CCCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHH
KGLISLAALFPIGEFWESGITTPVGDHAKLREILAAHRVPVRYITSSSPPFSVGNVRIEP
HHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEC
LAPAHRPLAEPDSDQNDDSLVFRLTHGTFSMLLTGDIGSYAEERLLYEPERLACTVLKVP
CCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHCCCCHHHEEEEEECC
HHGSRHSSSPRFLDAASPRLALISAGARNSFGLPSPETISRLRKRGVSVCRTDLNGTIQV
CCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCHHHEEECCCCEEEE
ASDGNGYSVKTFSDGHFH
EECCCCEEEEEECCCCCC
>Mature Secondary Structure 
TGRPLLVPLLGMVGGLASAHHLGIVLPYQFLPGLLVAALAAVFLKSRIPFTIILIALFF
CCCCHHHHHHHHHHHHCCHHHCEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VWGSAALHPFLAPVHPPHHLVHSTDSKPVIVEGIVGVRPEASEGGMRIILNVDRIIRDEK
HHHHHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEEEHHHHHCCHH
CTAAIGRLLVYVREGRGTILTGDRVRLEARIREPANFGLPGEFDYRRYLAYRNICATASI
HHHHHHHHHEEEECCCCEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC
KSADDILLIREATAHPVQRWFDRLAAELGGFIGSSAPAEGGLLRAILVGERGFVTEDTED
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCHHH
IYARAGVNHILSISGFHIGVIALTIHYLLFHLLVRCEFLTLHLNLRRTVLLATLPPVVFY
HHHHHCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHH
LFIAGLAPATVRSVVMIALVTLALFLERETDSLNTLTAAAFGILMFNPQALFDISFQLSF
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCHHEEEEHHHHHH
LAIWGILVLTPLCMEPFGDLREGTLKKVLLFAAVSVAATIVTLLPVVHTFHRASVAGLVG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NFVAVPLLGYGAVVAGFSALPLIYLFPAAAKFLLGIAAWLVRISDGIMATVAQIPPLPVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
NATLADLFILYLALLALSLVKGKRIHYLLCALAAGLVLALHLPAVADSSKTLRITFFSVG
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEC
QGESTLVTFPDGRRMLVDGGGSPHEGGMDVGRQLLAPALWSMGIGRLDVVVLTHPHPDHI
CCCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHH
KGLISLAALFPIGEFWESGITTPVGDHAKLREILAAHRVPVRYITSSSPPFSVGNVRIEP
HHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEC
LAPAHRPLAEPDSDQNDDSLVFRLTHGTFSMLLTGDIGSYAEERLLYEPERLACTVLKVP
CCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHCCCCHHHEEEEEECC
HHGSRHSSSPRFLDAASPRLALISAGARNSFGLPSPETISRLRKRGVSVCRTDLNGTIQV
CCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCHHHEEECCCCEEEE
ASDGNGYSVKTFSDGHFH
EECCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]