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The map label for this gene is lysC [H]

Identifier: 78223087

GI number: 78223087

Start: 2095712

End: 2096929

Strand: Reverse

Name: lysC [H]

Synonym: Gmet_1880

Alternate gene names: 78223087

Gene position: 2096929-2095712 (Counterclockwise)

Preceding gene: 78223088

Following gene: 78223086

Centisome position: 52.46

GC content: 54.27

Gene sequence:

>1218_bases
ATGGCTCTGGTGGTCCAAAAATACGGCGGCACCTCAATGGGATCGATTGAACGGATCCGCAATGTTGCCAAGAGGGTCGC
CAAGACCTACGACGCGGGCAACGATATGGTGGTCGTCGTTTCGGCCATGTCCGGCGAAACCAACAAGCTCGTGGCCCTGG
CCAATGAGGTGTGCGAGTTTCCCGATAACCGCGAGTATGACGTTCTGGTTGCCTCGGGCGAACAGGTATCCATCGCCCTT
CTCGCCATGTGTCTCAAATCCATGGGATACAAAGCAAAATCCTACCATGGCTGGCAGGTGCCGATCATTACCGACAGCGT
CTTCAGCAAGGCCCGCATTGAAGAGATTCCCGACGCAAAGGTGAGGGCTGACCTCAAGGACGGGACTATCGTTGTCGTGG
CCGGTTTCCAGGGGATAGACAAGGACGGCAACGTTACCACGTTGGGGCGCGGCGGTTCCGATACCTCGGCCGTGGCCATG
GCTGCCGCCATGAAGGCCGATGTCTGCGAGATCTACACCGACGTTGACGGTGTCTACACCACCGACCCCAACATCTGTGA
GGACGCCCGTAAGATCGATAAGATTTCCTACGACGAGATGCTGGAACTGGCGAGCCTTGGAGCGAAAGTGCTCCAGATTC
GTTCAGTCGAATTTGCCAAGAAATACAATGTGGACATACATGTCCGCTCAAGTTTCAATGACAATCAAGGGACTATGGTC
ACCAAGGAGGATAAGGACATGGAAGCTGTACTCGTTTCGGGTATCGCCTACGACAAGAATGAAGCTAAGATTGCCGTACT
GGGCGTGCCGGACAAACCGGGGATTGCCGCCAAGATTTTGTCGTCCCTTTCCGATGCCAATATCTCGGTCGATATGATCG
TCCAGAACGTGAGTGGTGGCGATCTTACCGATTTCACTTTTACTGTCACCAAGGCCGACTTCAAAAAGGCACTTGCCATC
ACCAAGGAAATTGCCACTGAGATCAAGGCAACGGGCGTGTCGGCCGATGAAAGCATTTCCAAGGTCTCCATCGTCGGCGT
CGGCATGCGGAGCCATGCCGGTGTCGCCACCAAGATGTTCCAAACCCTTGCAAATGAAGGAATCAATATTCAGATGATTT
CCACCTCCGAGATCAAGGTGTCTGTCGTTATTGACGCCAAGTACACGGAACTCGCCGTGAGGGTGCTCCACGAGGCATTC
GGCCTTTCCGGCAAATAG

Upstream 100 bases:

>100_bases
ATTAAAAAAATGTTTTGACCGTCGTTTGGATTCCTGCTATTAAGGGACGACGCGAAGCGGCGTATTCATTAGGACTCGAT
ACGTAAAGGAGGAACGGTAG

Downstream 100 bases:

>100_bases
CTTCAGATTAACTTCAGCGTATTCGTGTATAGCGTCTAGTGTCCGGCAACGCCGGCATGCTAAACGCTATACGCGTATCT
AACACTTCATTTCAAAGGTG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEVCEFPDNREYDVLVASGEQVSIAL
LAMCLKSMGYKAKSYHGWQVPIITDSVFSKARIEEIPDAKVRADLKDGTIVVVAGFQGIDKDGNVTTLGRGGSDTSAVAM
AAAMKADVCEIYTDVDGVYTTDPNICEDARKIDKISYDEMLELASLGAKVLQIRSVEFAKKYNVDIHVRSSFNDNQGTMV
TKEDKDMEAVLVSGIAYDKNEAKIAVLGVPDKPGIAAKILSSLSDANISVDMIVQNVSGGDLTDFTFTVTKADFKKALAI
TKEIATEIKATGVSADESISKVSIVGVGMRSHAGVATKMFQTLANEGINIQMISTSEIKVSVVIDAKYTELAVRVLHEAF
GLSGK

Sequences:

>Translated_405_residues
MALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEVCEFPDNREYDVLVASGEQVSIAL
LAMCLKSMGYKAKSYHGWQVPIITDSVFSKARIEEIPDAKVRADLKDGTIVVVAGFQGIDKDGNVTTLGRGGSDTSAVAM
AAAMKADVCEIYTDVDGVYTTDPNICEDARKIDKISYDEMLELASLGAKVLQIRSVEFAKKYNVDIHVRSSFNDNQGTMV
TKEDKDMEAVLVSGIAYDKNEAKIAVLGVPDKPGIAAKILSSLSDANISVDMIVQNVSGGDLTDFTFTVTKADFKKALAI
TKEIATEIKATGVSADESISKVSIVGVGMRSHAGVATKMFQTLANEGINIQMISTSEIKVSVVIDAKYTELAVRVLHEAF
GLSGK
>Mature_404_residues
ALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEVCEFPDNREYDVLVASGEQVSIALL
AMCLKSMGYKAKSYHGWQVPIITDSVFSKARIEEIPDAKVRADLKDGTIVVVAGFQGIDKDGNVTTLGRGGSDTSAVAMA
AAMKADVCEIYTDVDGVYTTDPNICEDARKIDKISYDEMLELASLGAKVLQIRSVEFAKKYNVDIHVRSSFNDNQGTMVT
KEDKDMEAVLVSGIAYDKNEAKIAVLGVPDKPGIAAKILSSLSDANISVDMIVQNVSGGDLTDFTFTVTKADFKKALAIT
KEIATEIKATGVSADESISKVSIVGVGMRSHAGVATKMFQTLANEGINIQMISTSEIKVSVVIDAKYTELAVRVLHEAFG
LSGK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=346, Percent_Identity=32.9479768786127, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1790455, Length=458, Percent_Identity=28.6026200873362, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790376, Length=288, Percent_Identity=25.6944444444444, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320893, Length=496, Percent_Identity=24.5967741935484, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43311; Mature: 43180

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEVCEF
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCC
PDNREYDVLVASGEQVSIALLAMCLKSMGYKAKSYHGWQVPIITDSVFSKARIEEIPDAK
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCC
VRADLKDGTIVVVAGFQGIDKDGNVTTLGRGGSDTSAVAMAAAMKADVCEIYTDVDGVYT
EEEECCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
TDPNICEDARKIDKISYDEMLELASLGAKVLQIRSVEFAKKYNVDIHVRSSFNDNQGTMV
CCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEE
TKEDKDMEAVLVSGIAYDKNEAKIAVLGVPDKPGIAAKILSSLSDANISVDMIVQNVSGG
EECCCCCEEHEEECEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEECCCC
DLTDFTFTVTKADFKKALAITKEIATEIKATGVSADESISKVSIVGVGMRSHAGVATKMF
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHH
QTLANEGINIQMISTSEIKVSVVIDAKYTELAVRVLHEAFGLSGK
HHHHCCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEVCEF
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCC
PDNREYDVLVASGEQVSIALLAMCLKSMGYKAKSYHGWQVPIITDSVFSKARIEEIPDAK
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCC
VRADLKDGTIVVVAGFQGIDKDGNVTTLGRGGSDTSAVAMAAAMKADVCEIYTDVDGVYT
EEEECCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
TDPNICEDARKIDKISYDEMLELASLGAKVLQIRSVEFAKKYNVDIHVRSSFNDNQGTMV
CCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEE
TKEDKDMEAVLVSGIAYDKNEAKIAVLGVPDKPGIAAKILSSLSDANISVDMIVQNVSGG
EECCCCCEEHEEECEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEECCCC
DLTDFTFTVTKADFKKALAITKEIATEIKATGVSADESISKVSIVGVGMRSHAGVATKMF
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHH
QTLANEGINIQMISTSEIKVSVVIDAKYTELAVRVLHEAFGLSGK
HHHHCCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]