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The map label for this gene is xseA

Identifier: 78223055

GI number: 78223055

Start: 2059258

End: 2060619

Strand: Reverse

Name: xseA

Synonym: Gmet_1848

Alternate gene names: 78223055

Gene position: 2060619-2059258 (Counterclockwise)

Preceding gene: 78223057

Following gene: 78223054

Centisome position: 51.55

GC content: 55.8

Gene sequence:

>1362_bases
GTGGAACTCTTTCCTGAAAAACGGATTTTAACCGTATCCCAACTCACCTCCCTCATCAGGGGAGTACTTGAAGAGAATTT
CGAGCACGTTTGGGTGGAGGGTGAGGTTTCAAACCTTGCAATGCCTGCTTCCGGGCACCTGTATTTTACGCTCAAGGATG
CCGGCGCCCAGATTCGCTGCGTTATGTTCCGTGCGTCAGCTCGAGCCCTTAAATTCCGCCCCAGGGATGGTATGGGATTG
ATCGTCAGGGGGCGGATTACGGTTTACGAACAGCGGGGTGACTATCAGTTTCTCGTTGAATATCTGGAGCCGCGGGGAGT
CGGAGCACTCCAGCTTGCGTTCATTCAGCTAAAGGAAAAATTGGCCAAGGAGGGGCTTTTCGCCGAGGAACATAAGAGGC
CGATCCCATCCCTGCCGCAGCGGATCGGAGTGGTGACCTCGGCAACCGGGGCAGCTATTCACGATATTCTCAACGTCCTG
AACCGACGCTTTGCCAACGTGGAAGTTCTCATCAGACCCGTCAAAGTCCAGGGTGAAGGGGCGGCTGACGAGATTGCCGA
AGCGATCATCGACTTCAACCGTTACGGTGCTGTTGATGTCATGATCGTGGGGAGGGGAGGGGGATCGCTGGAGGATCTGT
GGGCCTTTAACGAGGAGAAGGTCGCTCGTGCGGTCCACCGCTCCAGAATACCAATCATATCTGCCGTGGGTCACGAAATC
GATTTTACCATTGCAGACTTTGTTGCTGACCTTAGGGCACCGACTCCATCGGCAGCGGCAGAACTGGTCGTCAAGAGCAA
AGAGGAGTTGGCGTCGAAAGTCGAGTTCCTCCGTCACCGGCTCATACAGACACTGCGGCGCATTCTGGCCGATGCTGGTG
GTGAGTTGGAGAGCTTGAGCCGTGCCCTCCGCGACCCTACCGTGCTTTTAGGACACCTCTCCCAGCGCTTGGATGACATC
TTCGTACGACTTGAACGCGCTATTGCGGGAGACCTTAAAGACCGTGGGAGGATGCTAGAAGCACTCAAGAATCATCTGAG
GCTCAGAAATCCGGCCCTTAAGGTGGAGCGTGCACGGGAACGGGTTATTGCTTTGAGCGACAAAAGTGAAATAGCCCTGC
TTCGTCACGTCGACCGCTACCGTGAGGCTGCGGCCGTGCATTCGGCACGGCTGGAAACGCTTTCTCCACTCGGCACCTTG
GCGAGGGGGTACAGCGTAGCCCTTAAACTGCCTGAACGGGTTCCTGTCAAGACGTTCAGGCAACTCGCCCTGAAAGATAG
GCTTGAACTTCTTTTTCATCACGGACGAGCCTGGTGCCGGGTGGAGTCCCTTGACGAGGATGCGTCCTGCAGCCATGAAT
GA

Upstream 100 bases:

>100_bases
ACCATACTACACTGAGGGGACAGCGACGGTCAACCGGTTTGACACGCCGCGAACCCTATGCTAGAACCGCTGCAACTAGC
AGTATTTACGAGGAGATTTT

Downstream 100 bases:

>100_bases
AATCGTGCGCGCGCCGTCAGGGCAATTTGGGGAAACTGGTGCAAATCTGCTATACTTTCTTCTAGAAAAGCTGCTCAGAT
TCGGGAGGTGCTTGTTATGA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MELFPEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLAMPASGHLYFTLKDAGAQIRCVMFRASARALKFRPRDGMGL
IVRGRITVYEQRGDYQFLVEYLEPRGVGALQLAFIQLKEKLAKEGLFAEEHKRPIPSLPQRIGVVTSATGAAIHDILNVL
NRRFANVEVLIRPVKVQGEGAADEIAEAIIDFNRYGAVDVMIVGRGGGSLEDLWAFNEEKVARAVHRSRIPIISAVGHEI
DFTIADFVADLRAPTPSAAAELVVKSKEELASKVEFLRHRLIQTLRRILADAGGELESLSRALRDPTVLLGHLSQRLDDI
FVRLERAIAGDLKDRGRMLEALKNHLRLRNPALKVERARERVIALSDKSEIALLRHVDRYREAAAVHSARLETLSPLGTL
ARGYSVALKLPERVPVKTFRQLALKDRLELLFHHGRAWCRVESLDEDASCSHE

Sequences:

>Translated_453_residues
MELFPEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLAMPASGHLYFTLKDAGAQIRCVMFRASARALKFRPRDGMGL
IVRGRITVYEQRGDYQFLVEYLEPRGVGALQLAFIQLKEKLAKEGLFAEEHKRPIPSLPQRIGVVTSATGAAIHDILNVL
NRRFANVEVLIRPVKVQGEGAADEIAEAIIDFNRYGAVDVMIVGRGGGSLEDLWAFNEEKVARAVHRSRIPIISAVGHEI
DFTIADFVADLRAPTPSAAAELVVKSKEELASKVEFLRHRLIQTLRRILADAGGELESLSRALRDPTVLLGHLSQRLDDI
FVRLERAIAGDLKDRGRMLEALKNHLRLRNPALKVERARERVIALSDKSEIALLRHVDRYREAAAVHSARLETLSPLGTL
ARGYSVALKLPERVPVKTFRQLALKDRLELLFHHGRAWCRVESLDEDASCSHE
>Mature_453_residues
MELFPEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLAMPASGHLYFTLKDAGAQIRCVMFRASARALKFRPRDGMGL
IVRGRITVYEQRGDYQFLVEYLEPRGVGALQLAFIQLKEKLAKEGLFAEEHKRPIPSLPQRIGVVTSATGAAIHDILNVL
NRRFANVEVLIRPVKVQGEGAADEIAEAIIDFNRYGAVDVMIVGRGGGSLEDLWAFNEEKVARAVHRSRIPIISAVGHEI
DFTIADFVADLRAPTPSAAAELVVKSKEELASKVEFLRHRLIQTLRRILADAGGELESLSRALRDPTVLLGHLSQRLDDI
FVRLERAIAGDLKDRGRMLEALKNHLRLRNPALKVERARERVIALSDKSEIALLRHVDRYREAAAVHSARLETLSPLGTL
ARGYSVALKLPERVPVKTFRQLALKDRLELLFHHGRAWCRVESLDEDASCSHE

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=401, Percent_Identity=47.6309226932668, Blast_Score=356, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_GEOMG (Q39UJ7)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384802.1
- STRING:   Q39UJ7
- GeneID:   3741525
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1848
- NMPDR:   fig|269799.3.peg.2111
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   SAVGHER
- PhylomeDB:   Q39UJ7
- ProtClustDB:   PRK00286
- BioCyc:   GMET269799:GMET_1848-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50756; Mature: 50756

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFPEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLAMPASGHLYFTLKDAGAQIRC
CCCCCCCHHEEHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCEEEEEEECCCCEEEE
VMFRASARALKFRPRDGMGLIVRGRITVYEQRGDYQFLVEYLEPRGVGALQLAFIQLKEK
EEEECCCHHEEECCCCCCEEEEEEEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHH
LAKEGLFAEEHKRPIPSLPQRIGVVTSATGAAIHDILNVLNRRFANVEVLIRPVKVQGEG
HHHCCCCHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCC
AADEIAEAIIDFNRYGAVDVMIVGRGGGSLEDLWAFNEEKVARAVHRSRIPIISAVGHEI
CHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCEEECCCCCC
DFTIADFVADLRAPTPSAAAELVVKSKEELASKVEFLRHRLIQTLRRILADAGGELESLS
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RALRDPTVLLGHLSQRLDDIFVRLERAIAGDLKDRGRMLEALKNHLRLRNPALKVERARE
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RVIALSDKSEIALLRHVDRYREAAAVHSARLETLSPLGTLARGYSVALKLPERVPVKTFR
HEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHH
QLALKDRLELLFHHGRAWCRVESLDEDASCSHE
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MELFPEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLAMPASGHLYFTLKDAGAQIRC
CCCCCCCHHEEHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCEEEEEEECCCCEEEE
VMFRASARALKFRPRDGMGLIVRGRITVYEQRGDYQFLVEYLEPRGVGALQLAFIQLKEK
EEEECCCHHEEECCCCCCEEEEEEEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHH
LAKEGLFAEEHKRPIPSLPQRIGVVTSATGAAIHDILNVLNRRFANVEVLIRPVKVQGEG
HHHCCCCHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCC
AADEIAEAIIDFNRYGAVDVMIVGRGGGSLEDLWAFNEEKVARAVHRSRIPIISAVGHEI
CHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCEEECCCCCC
DFTIADFVADLRAPTPSAAAELVVKSKEELASKVEFLRHRLIQTLRRILADAGGELESLS
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RALRDPTVLLGHLSQRLDDIFVRLERAIAGDLKDRGRMLEALKNHLRLRNPALKVERARE
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RVIALSDKSEIALLRHVDRYREAAAVHSARLETLSPLGTLARGYSVALKLPERVPVKTFR
HEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHH
QLALKDRLELLFHHGRAWCRVESLDEDASCSHE
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA