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The map label for this gene is ydgK [H]

Identifier: 78222891

GI number: 78222891

Start: 1889034

End: 1890278

Strand: Reverse

Name: ydgK [H]

Synonym: Gmet_1682

Alternate gene names: 78222891

Gene position: 1890278-1889034 (Counterclockwise)

Preceding gene: 78222911

Following gene: 78222890

Centisome position: 47.29

GC content: 64.82

Gene sequence:

>1245_bases
ATGGAAATGACCGCTGCGCCGGCTATCCAACCAGCAGACATGACCCGACGCCAACTGGCACGGCTGGTCCTGATCCTCGG
GGCGCTGACTGCCTTCAGTTCCATGTCCATCGACATGTACCTCCCCGCCTTCCCGCAGATCGCCCGGGATCTCGCCGCGC
CGCTCGGTATGGTGCAGCTCTCCATCTCCGCCTTCCTCTTCGGTTCGGCCGCCGGGCAGCTGTTTTACGGCCCGATGGCC
GACCGGTGGGGAAGGCGAACGCCCCTCCTCCTGGGACTGACGCTCTACGTCGCGGCAGCGTTCGGATGTGCCTTCGTCCA
CACGGGTGAGGGTCTCCTCTTCTGGCGCGTGGTAATGGCGGTCGGAGGGGGAGCCGGCATGGTGATCTCGCGCGCTGTGG
TACGCGACCTCTACGATACCGCCGAAGCGGCGAGGATGTTTTCGCTCCTCATGCTGGTCATGGGCGCGGCGCCAATACTG
GCTCCTATCGTGGGAGGACAGCTCCTGCTGATCACCGGATGGCGCGGCATTTTCGGCTTTCTGGCAATCTTCGGTCTCCT
TTCCCTCGCCGCGGCGGCAATGTTCCTTCCCGAATCCCTGCCGGCGGAGCGTCGCAGCCGGCGCGGCGTTGTCGAGATGG
GTACCATTTATGCTCACCTTCTCCGCAACAACCGTTATCTCCGCTACGCCATCGCCCTTGGCTGCGTCGCCGGGGTCAAT
TTTTCCTACATCTCGGGTGCACCATTCGTCTTCATCGAATTGCACGGCGTCACCCCCCAGCACTTCGGCCTTTTCTTCGG
CGCCAACGCCTGCGGACTGATCGGCGCCTCCCAGGTCAACCGCCGCCTTCTTCGCCGCTTCAGCGCCCAACGTATCCTGG
GCACCGCAGCCACCGTCAATGCGGTGGGAGCCCTTCTTCTCGCGGTTGCAGGGTTCACGGGGATCGGTGGTTTTCCTGTC
CAGGTCGCACTCCTGTTCGTTTGCCTCTGTACGTCCGGGTTCCTCTATCCCAACGTGACCGCCCTCGCCATGGCCCCCTT
CGACAAGGCGGCAGGGAGCGCGTCGGCGCTTCTGGGGACGATCCAGTACACCCTCGGGGCAACCGCGGGTGCGCTCGTGG
GGATGTTCCACAACGGGACGGCGGTACCGATGACCGCTACCATGGCTCTCTGCGGGGTGCTGGGCTGGTGTGCCATTGTC
GGGGTTGCCCGAGCATCGTCGGCCCGGCGTGCGCCGGCGCCATAA

Upstream 100 bases:

>100_bases
TTCATCTAATGAATAAAGCTACCAACGCATCGAAACACCCCTTCATACTCACGCCATGATCAACTAGGAAACTGTTTTGA
GCTTGGAGAAAGGATTTATA

Downstream 100 bases:

>100_bases
AGCATCGAGTGCCTTCAGTTGCCACCCGAATCGTATCGTGCCTCACTGCATGCGGGAAAAGAGGTGCGAAAACCATTCCC
TGGCTCTGGAGGAACTGCGG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MEMTAAPAIQPADMTRRQLARLVLILGALTAFSSMSIDMYLPAFPQIARDLAAPLGMVQLSISAFLFGSAAGQLFYGPMA
DRWGRRTPLLLGLTLYVAAAFGCAFVHTGEGLLFWRVVMAVGGGAGMVISRAVVRDLYDTAEAARMFSLLMLVMGAAPIL
APIVGGQLLLITGWRGIFGFLAIFGLLSLAAAAMFLPESLPAERRSRRGVVEMGTIYAHLLRNNRYLRYAIALGCVAGVN
FSYISGAPFVFIELHGVTPQHFGLFFGANACGLIGASQVNRRLLRRFSAQRILGTAATVNAVGALLLAVAGFTGIGGFPV
QVALLFVCLCTSGFLYPNVTALAMAPFDKAAGSASALLGTIQYTLGATAGALVGMFHNGTAVPMTATMALCGVLGWCAIV
GVARASSARRAPAP

Sequences:

>Translated_414_residues
MEMTAAPAIQPADMTRRQLARLVLILGALTAFSSMSIDMYLPAFPQIARDLAAPLGMVQLSISAFLFGSAAGQLFYGPMA
DRWGRRTPLLLGLTLYVAAAFGCAFVHTGEGLLFWRVVMAVGGGAGMVISRAVVRDLYDTAEAARMFSLLMLVMGAAPIL
APIVGGQLLLITGWRGIFGFLAIFGLLSLAAAAMFLPESLPAERRSRRGVVEMGTIYAHLLRNNRYLRYAIALGCVAGVN
FSYISGAPFVFIELHGVTPQHFGLFFGANACGLIGASQVNRRLLRRFSAQRILGTAATVNAVGALLLAVAGFTGIGGFPV
QVALLFVCLCTSGFLYPNVTALAMAPFDKAAGSASALLGTIQYTLGATAGALVGMFHNGTAVPMTATMALCGVLGWCAIV
GVARASSARRAPAP
>Mature_414_residues
MEMTAAPAIQPADMTRRQLARLVLILGALTAFSSMSIDMYLPAFPQIARDLAAPLGMVQLSISAFLFGSAAGQLFYGPMA
DRWGRRTPLLLGLTLYVAAAFGCAFVHTGEGLLFWRVVMAVGGGAGMVISRAVVRDLYDTAEAARMFSLLMLVMGAAPIL
APIVGGQLLLITGWRGIFGFLAIFGLLSLAAAAMFLPESLPAERRSRRGVVEMGTIYAHLLRNNRYLRYAIALGCVAGVN
FSYISGAPFVFIELHGVTPQHFGLFFGANACGLIGASQVNRRLLRRFSAQRILGTAATVNAVGALLLAVAGFTGIGGFPV
QVALLFVCLCTSGFLYPNVTALAMAPFDKAAGSASALLGTIQYTLGATAGALVGMFHNGTAVPMTATMALCGVLGWCAIV
GVARASSARRAPAP

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=380, Percent_Identity=35.5263157894737, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI48994889, Length=346, Percent_Identity=31.5028901734104, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1790146, Length=347, Percent_Identity=26.5129682997118, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87082312, Length=339, Percent_Identity=28.6135693215339, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1787065, Length=254, Percent_Identity=25.5905511811024, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790794, Length=286, Percent_Identity=22.3776223776224, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319657, Length=169, Percent_Identity=28.9940828402367, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43337; Mature: 43337

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMTAAPAIQPADMTRRQLARLVLILGALTAFSSMSIDMYLPAFPQIARDLAAPLGMVQL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCHHHHHH
SISAFLFGSAAGQLFYGPMADRWGRRTPLLLGLTLYVAAAFGCAFVHTGEGLLFWRVVMA
HHHHHHHHCCCCCEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
VGGGAGMVISRAVVRDLYDTAEAARMFSLLMLVMGAAPILAPIVGGQLLLITGWRGIFGF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEEECHHHHHHH
LAIFGLLSLAAAAMFLPESLPAERRSRRGVVEMGTIYAHLLRNNRYLRYAIALGCVAGVN
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCC
FSYISGAPFVFIELHGVTPQHFGLFFGANACGLIGASQVNRRLLRRFSAQRILGTAATVN
EEEECCCCEEEEEEECCCHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVGALLLAVAGFTGIGGFPVQVALLFVCLCTSGFLYPNVTALAMAPFDKAAGSASALLGT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHEEECCCHHCCCCHHHHHHH
IQYTLGATAGALVGMFHNGTAVPMTATMALCGVLGWCAIVGVARASSARRAPAP
HHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEMTAAPAIQPADMTRRQLARLVLILGALTAFSSMSIDMYLPAFPQIARDLAAPLGMVQL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCHHHHHH
SISAFLFGSAAGQLFYGPMADRWGRRTPLLLGLTLYVAAAFGCAFVHTGEGLLFWRVVMA
HHHHHHHHCCCCCEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
VGGGAGMVISRAVVRDLYDTAEAARMFSLLMLVMGAAPILAPIVGGQLLLITGWRGIFGF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEEECHHHHHHH
LAIFGLLSLAAAAMFLPESLPAERRSRRGVVEMGTIYAHLLRNNRYLRYAIALGCVAGVN
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCC
FSYISGAPFVFIELHGVTPQHFGLFFGANACGLIGASQVNRRLLRRFSAQRILGTAATVN
EEEECCCCEEEEEEECCCHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVGALLLAVAGFTGIGGFPVQVALLFVCLCTSGFLYPNVTALAMAPFDKAAGSASALLGT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHEEECCCHHCCCCHHHHHHH
IQYTLGATAGALVGMFHNGTAVPMTATMALCGVLGWCAIVGVARASSARRAPAP
HHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]