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The map label for this gene is cirA [H]

Identifier: 78222878

GI number: 78222878

Start: 1874607

End: 1876637

Strand: Reverse

Name: cirA [H]

Synonym: Gmet_1669

Alternate gene names: 78222878

Gene position: 1876637-1874607 (Counterclockwise)

Preceding gene: 78222879

Following gene: 78222877

Centisome position: 46.95

GC content: 54.41

Gene sequence:

>2031_bases
ATGCTCCTGCTTTCCAAGTTGGCACCTGCCCTGATGATTTGCACGATCCCCTTCATAGGCTTGATCGACCCGTCGTGGGG
ATCGGAACACGAAGACCTGAACCTCAGTGAACTCGGTCTCGAAGACTTGATGAATATTCAGGTGACATCGGTATCGAAAA
AGCAGCAGAAGCTATCCGATGCCGGTGCGGCTGTCTTCGTCGTCACCAGGGAAGATATCCGACGCTCCGGGGCTACCAGC
ATACCCGAAGTGCTCCGCATGGTGCCGGGCATTCAGGTGGCGCGTCTCGATGCGAACAAGTGGGCTGTCTCTGCACGGGG
TTTCAATGATCGCTTCGCGGACAAGCTGCTGGTCCTGATGGATGGCCGGACCGTCTTTACCCCCCTCTTTTCCGGTGTGT
ACTGGGATGTCCAGGACACGATGCTCGAAGACATAGACCGCATCGAGGTGATTCGGGGGCCGGGAGCTGCCCTCTGGGGA
GCCAATGCCTTCAATGGCGTCATCAACATCATTACCAAGCACGCCCAGGAAACCCAGGGAGGGCTTCTGAGCGCCGGTGC
TGGAACGGAAGAAAGAGGGTTCGGCGGGGTGCGCTATGGCGGCCGTGTTGGTGACGATACCTATTACCGGTTGTACACGA
AATATTTCAACAGGGATGGTGGCGTCGATGTCGCCGGCAACGAGGGGAATGACGACTGGAGTGTCCTGCGGGGAGGATTC
CGTGTGGATTCGGACCTGACTGCACACGATTCGTTGACCGTCCAAGGTGACATGTACCATGGGAAAGAAGAAGAAACGTT
CTCCGTACCTCTCGTGGTACCGCCCTATTCCCGAACCTTCAACTCGGATACCGATATCGCCGGGGGGAATGTCCTGTCCC
GCTGGACGCGCAAGTTTTCCGATACTGCCGACATGGCGCTGCAGCTTTACTATGACCGGACTGAACGTGACATGGCAATC
CTTGGTGAAACCCGGGACACCATTGATGTCGACTTCCAGAACCGGTTCAGGTGGGGCTCCCGGCAAGAAATCATGTGGGG
ATTAGGCTACCGTTTCAGCCATGAAAGCATCACCAACCGAATCCCGATCTCCTTTGTCCCCGACAAGCGTAGTGACAATC
TTTACAGCCTTTTCGTACAGGACGACATAGCGCTCATTGAAGAGAAACTCCGGCTGGTTCTGGGATCACGGTTTGAGCAT
AACGACTTTACCGGTCTTGAGATCCAGCCCAATGCCCGTCTTATCTGGACGCCTGACTATCGCCAGACTGTCTGGGCTGC
TGTTTCACGCGCCGTGAGGACACCTTCCAGCGCCGAGGAACATTTTCGAAATGATATTTCCGTTTATCCTCCTGGAACTG
TCAACCAGACACTCCCCGTACTCTTTTCCGGCTTCGGTTCCAGGGACTTCAAGAGTGAAGACGTGATTGCCTACGAGCTC
GGTTATCGCGTTGCCCCAGCTGAACACTTTTCAGTTGATATCGCTACATTTTACGACAATTTCTCGCGTCTTCGCACGCT
TGAGTTCGGTACACCCTATCTTGAAGTCTCCCCGTCACCACATCTCGTTCTGCCTGGGATAACCGCAAATAAGATGCATG
GTGAATCCTATGGAATTGAAGTGGCCGCAGACTGGTTGGCGCTTGAATGGTGGCGTTTGCAAGCCGCATACAGTTTCCTG
GAGATGCAGATGCGCCTTGATCCTGACAGCAACTCACTGTTTTATCTTGGTTTTACCCAAGGGACGAGCCCGCGGCATCA
GGGTTCACTTCGCTCTTCCATGGAGTTAGGCAGAAGCGTCGAACTGGATGTCTGGGTACGGTATGTGGATAAACTGCCAG
AATTCGATATTAACCGCTATGTAACGCTTGATGCCCGTCTGGCATGGAAACCAACGAGAAACCTGGAGTTTTCACTCGTT
GGCAGGAACCTTGCCGACAGTCACCATCCCGAATTCAATTCGGCGATCATTGCCACCGCCCCCACCGAGGTGGAGCGCAG
CTATTACGGGAAAATCACCTGGCGCTATTAG

Upstream 100 bases:

>100_bases
TAGGTTCGCTCCGTCAACGTTATCGTAATGCCGGTCCTGATTATCGTTTGCGGCAATGGCGCATCCAAGGGCGCAAAAGA
GAATTCCCGCGAGGTACTAT

Downstream 100 bases:

>100_bases
TCGGCAGCAACGCTGCCACATCGAAGTCAACCAAGACAACGGATATCTAGAAAAGACCCTGTGATCAAGAGAGCTGTCAC
AATACTCATCATACTGGCGT

Product: TonB-dependent receptor, plug

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MLLLSKLAPALMICTIPFIGLIDPSWGSEHEDLNLSELGLEDLMNIQVTSVSKKQQKLSDAGAAVFVVTREDIRRSGATS
IPEVLRMVPGIQVARLDANKWAVSARGFNDRFADKLLVLMDGRTVFTPLFSGVYWDVQDTMLEDIDRIEVIRGPGAALWG
ANAFNGVINIITKHAQETQGGLLSAGAGTEERGFGGVRYGGRVGDDTYYRLYTKYFNRDGGVDVAGNEGNDDWSVLRGGF
RVDSDLTAHDSLTVQGDMYHGKEEETFSVPLVVPPYSRTFNSDTDIAGGNVLSRWTRKFSDTADMALQLYYDRTERDMAI
LGETRDTIDVDFQNRFRWGSRQEIMWGLGYRFSHESITNRIPISFVPDKRSDNLYSLFVQDDIALIEEKLRLVLGSRFEH
NDFTGLEIQPNARLIWTPDYRQTVWAAVSRAVRTPSSAEEHFRNDISVYPPGTVNQTLPVLFSGFGSRDFKSEDVIAYEL
GYRVAPAEHFSVDIATFYDNFSRLRTLEFGTPYLEVSPSPHLVLPGITANKMHGESYGIEVAADWLALEWWRLQAAYSFL
EMQMRLDPDSNSLFYLGFTQGTSPRHQGSLRSSMELGRSVELDVWVRYVDKLPEFDINRYVTLDARLAWKPTRNLEFSLV
GRNLADSHHPEFNSAIIATAPTEVERSYYGKITWRY

Sequences:

>Translated_676_residues
MLLLSKLAPALMICTIPFIGLIDPSWGSEHEDLNLSELGLEDLMNIQVTSVSKKQQKLSDAGAAVFVVTREDIRRSGATS
IPEVLRMVPGIQVARLDANKWAVSARGFNDRFADKLLVLMDGRTVFTPLFSGVYWDVQDTMLEDIDRIEVIRGPGAALWG
ANAFNGVINIITKHAQETQGGLLSAGAGTEERGFGGVRYGGRVGDDTYYRLYTKYFNRDGGVDVAGNEGNDDWSVLRGGF
RVDSDLTAHDSLTVQGDMYHGKEEETFSVPLVVPPYSRTFNSDTDIAGGNVLSRWTRKFSDTADMALQLYYDRTERDMAI
LGETRDTIDVDFQNRFRWGSRQEIMWGLGYRFSHESITNRIPISFVPDKRSDNLYSLFVQDDIALIEEKLRLVLGSRFEH
NDFTGLEIQPNARLIWTPDYRQTVWAAVSRAVRTPSSAEEHFRNDISVYPPGTVNQTLPVLFSGFGSRDFKSEDVIAYEL
GYRVAPAEHFSVDIATFYDNFSRLRTLEFGTPYLEVSPSPHLVLPGITANKMHGESYGIEVAADWLALEWWRLQAAYSFL
EMQMRLDPDSNSLFYLGFTQGTSPRHQGSLRSSMELGRSVELDVWVRYVDKLPEFDINRYVTLDARLAWKPTRNLEFSLV
GRNLADSHHPEFNSAIIATAPTEVERSYYGKITWRY
>Mature_676_residues
MLLLSKLAPALMICTIPFIGLIDPSWGSEHEDLNLSELGLEDLMNIQVTSVSKKQQKLSDAGAAVFVVTREDIRRSGATS
IPEVLRMVPGIQVARLDANKWAVSARGFNDRFADKLLVLMDGRTVFTPLFSGVYWDVQDTMLEDIDRIEVIRGPGAALWG
ANAFNGVINIITKHAQETQGGLLSAGAGTEERGFGGVRYGGRVGDDTYYRLYTKYFNRDGGVDVAGNEGNDDWSVLRGGF
RVDSDLTAHDSLTVQGDMYHGKEEETFSVPLVVPPYSRTFNSDTDIAGGNVLSRWTRKFSDTADMALQLYYDRTERDMAI
LGETRDTIDVDFQNRFRWGSRQEIMWGLGYRFSHESITNRIPISFVPDKRSDNLYSLFVQDDIALIEEKLRLVLGSRFEH
NDFTGLEIQPNARLIWTPDYRQTVWAAVSRAVRTPSSAEEHFRNDISVYPPGTVNQTLPVLFSGFGSRDFKSEDVIAYEL
GYRVAPAEHFSVDIATFYDNFSRLRTLEFGTPYLEVSPSPHLVLPGITANKMHGESYGIEVAADWLALEWWRLQAAYSFL
EMQMRLDPDSNSLFYLGFTQGTSPRHQGSLRSSMELGRSVELDVWVRYVDKLPEFDINRYVTLDARLAWKPTRNLEFSLV
GRNLADSHHPEFNSAIIATAPTEVERSYYGKITWRY

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=167, Percent_Identity=32.9341317365269, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1790405, Length=185, Percent_Identity=33.5135135135135, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790743, Length=112, Percent_Identity=32.1428571428571, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 76375; Mature: 76375

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLSKLAPALMICTIPFIGLIDPSWGSEHEDLNLSELGLEDLMNIQVTSVSKKQQKLSD
CCCHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCHHHHCHHHHCEEEEEECHHHHHHHHC
AGAAVFVVTREDIRRSGATSIPEVLRMVPGIQVARLDANKWAVSARGFNDRFADKLLVLM
CCCEEEEEEHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHCEEEEEE
DGRTVFTPLFSGVYWDVQDTMLEDIDRIEVIRGPGAALWGANAFNGVINIITKHAQETQG
CCCCHHHHHHCCEEECHHHHHHHCCCCEEEEECCCCEEECCHHHHHHHHHHHHHHHHHCC
GLLSAGAGTEERGFGGVRYGGRVGDDTYYRLYTKYFNRDGGVDVAGNEGNDDWSVLRGGF
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHCCCE
RVDSDLTAHDSLTVQGDMYHGKEEETFSVPLVVPPYSRTFNSDTDIAGGNVLSRWTRKFS
EECCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHC
DTADMALQLYYDRTERDMAILGETRDTIDVDFQNRFRWGSRQEIMWGLGYRFSHESITNR
CHHHEEEEEEECCCCCCEEEECCCCCEEEECHHHHCCCCCCCCEEEECCEEECCHHHHCC
IPISFVPDKRSDNLYSLFVQDDIALIEEKLRLVLGSRFEHNDFTGLEIQPNARLIWTPDY
CCEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEECCCH
RQTVWAAVSRAVRTPSSAEEHFRNDISVYPPGTVNQTLPVLFSGFGSRDFKSEDVIAYEL
HHHHHHHHHHHHCCCCCHHHHHCCCCEECCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEC
GYRVAPAEHFSVDIATFYDNFSRLRTLEFGTPYLEVSPSPHLVLPGITANKMHGESYGIE
CCEECCCHHCEEEHHHHHCCHHHEEEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCEE
VAADWLALEWWRLQAAYSFLEMQMRLDPDSNSLFYLGFTQGTSPRHQGSLRSSMELGRSV
EEEHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCC
ELDVWVRYVDKLPEFDINRYVTLDARLAWKPTRNLEFSLVGRNLADSHHPEFNSAIIATA
CHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCEEEEEC
PTEVERSYYGKITWRY
CCHHHHHHCCEEEEEC
>Mature Secondary Structure
MLLLSKLAPALMICTIPFIGLIDPSWGSEHEDLNLSELGLEDLMNIQVTSVSKKQQKLSD
CCCHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCHHHHCHHHHCEEEEEECHHHHHHHHC
AGAAVFVVTREDIRRSGATSIPEVLRMVPGIQVARLDANKWAVSARGFNDRFADKLLVLM
CCCEEEEEEHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHCEEEEEE
DGRTVFTPLFSGVYWDVQDTMLEDIDRIEVIRGPGAALWGANAFNGVINIITKHAQETQG
CCCCHHHHHHCCEEECHHHHHHHCCCCEEEEECCCCEEECCHHHHHHHHHHHHHHHHHCC
GLLSAGAGTEERGFGGVRYGGRVGDDTYYRLYTKYFNRDGGVDVAGNEGNDDWSVLRGGF
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHCCCE
RVDSDLTAHDSLTVQGDMYHGKEEETFSVPLVVPPYSRTFNSDTDIAGGNVLSRWTRKFS
EECCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHC
DTADMALQLYYDRTERDMAILGETRDTIDVDFQNRFRWGSRQEIMWGLGYRFSHESITNR
CHHHEEEEEEECCCCCCEEEECCCCCEEEECHHHHCCCCCCCCEEEECCEEECCHHHHCC
IPISFVPDKRSDNLYSLFVQDDIALIEEKLRLVLGSRFEHNDFTGLEIQPNARLIWTPDY
CCEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEECCCH
RQTVWAAVSRAVRTPSSAEEHFRNDISVYPPGTVNQTLPVLFSGFGSRDFKSEDVIAYEL
HHHHHHHHHHHHCCCCCHHHHHCCCCEECCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEC
GYRVAPAEHFSVDIATFYDNFSRLRTLEFGTPYLEVSPSPHLVLPGITANKMHGESYGIE
CCEECCCHHCEEEHHHHHCCHHHEEEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCEE
VAADWLALEWWRLQAAYSFLEMQMRLDPDSNSLFYLGFTQGTSPRHQGSLRSSMELGRSV
EEEHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCC
ELDVWVRYVDKLPEFDINRYVTLDARLAWKPTRNLEFSLVGRNLADSHHPEFNSAIIATA
CHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCEEEEEC
PTEVERSYYGKITWRY
CCHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]