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The map label for this gene is mutY [H]

Identifier: 78222863

GI number: 78222863

Start: 1859653

End: 1860510

Strand: Reverse

Name: mutY [H]

Synonym: Gmet_1654

Alternate gene names: 78222863

Gene position: 1860510-1859653 (Counterclockwise)

Preceding gene: 78222864

Following gene: 78222858

Centisome position: 46.54

GC content: 56.41

Gene sequence:

>858_bases
TTGAGCCTGGAAAGCCACATCAGGGAAATGTATACCTCCGGGGGACTCACCCCGGAGGCTGCCACCCTCTTCCGACAGAT
TGTTTATGGCCACTACCGGCGCCACGGGCGCACCCTTCCGTGGCGTGAAACCAGTGACCCCTACGCCATCCTCGTTTCCG
AGATAATGCTTCAGCAAACCCAGGTCGACAGGGTGACAGGTAAGTATATGTCATTCCTTTCGGCGTTCCCCGATTTCAGG
GCCCTTGCCGCAGCCCCACTTGACGCGGTTCTTGCCGCCTGGCAAGGGCTCGGCTACAACCGGCGCGCCCTCAATCTGAA
GCGGTGCTCCGAAGCAGTCGTAACAGAATATGGCGGCACCCTTCCCTCCACCATCGCGGAACTGGAAAAGCTCCCCGGCA
TAGGACACTACACAGCACGAGCCGTGGCTGCCTTTGCCTTCTCCGTGCCTTCCGCATTCATCGAAACCAACATCAGAACC
GTTTTCATCCATCACTTCTTCAATGATTCCGAAAAGGTCCATGACCGCGAGATCGCACCCCTGGTCGAAGGGGCTCTCGA
TTATGGCAATCCCCGGGAATGGTATTATGCCCTCATGGACTACGGTGCCCACCTCAAGAGGCTCCACGGCAATCCTTCAC
GGCGCAGTGCCCATCACGCAACCCAGAGCCCCTTCAAGGGATCCAATCGGGAACTACGGAGCCTGATACTTAAGGCAATA
CTGGACAGACCAGGCATAACGCTTGAAGAAATTACGTCTTTTCTGAACAAGCCCCAGGATGCGGTGCTGAGCAACCTGAA
GCAGATGGAAGCAGAAGGGTTTATCGCGAAGAGGAAGGGACGACTCTTTATCGCTTGA

Upstream 100 bases:

>100_bases
GCGCTGAAAGCGATGCCGCCGTGGAGGCATGCCGCAGACACGGAATCAGCGTCATTGCCGACGGGACCTGCATCCTGGTC
GTTCTCGGCTATCACGACCA

Downstream 100 bases:

>100_bases
CGCCGGCGCCAGGAGTTCAGAGCGATACTTACTTCTTTATCTGATCCGCCACCATCCTGCTTGCCCTGGCCACGTCATCC
GGATCACCGAGATAGTAGCT

Product: HhH-GPD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSLESHIREMYTSGGLTPEAATLFRQIVYGHYRRHGRTLPWRETSDPYAILVSEIMLQQTQVDRVTGKYMSFLSAFPDFR
ALAAAPLDAVLAAWQGLGYNRRALNLKRCSEAVVTEYGGTLPSTIAELEKLPGIGHYTARAVAAFAFSVPSAFIETNIRT
VFIHHFFNDSEKVHDREIAPLVEGALDYGNPREWYYALMDYGAHLKRLHGNPSRRSAHHATQSPFKGSNRELRSLILKAI
LDRPGITLEEITSFLNKPQDAVLSNLKQMEAEGFIAKRKGRLFIA

Sequences:

>Translated_285_residues
MSLESHIREMYTSGGLTPEAATLFRQIVYGHYRRHGRTLPWRETSDPYAILVSEIMLQQTQVDRVTGKYMSFLSAFPDFR
ALAAAPLDAVLAAWQGLGYNRRALNLKRCSEAVVTEYGGTLPSTIAELEKLPGIGHYTARAVAAFAFSVPSAFIETNIRT
VFIHHFFNDSEKVHDREIAPLVEGALDYGNPREWYYALMDYGAHLKRLHGNPSRRSAHHATQSPFKGSNRELRSLILKAI
LDRPGITLEEITSFLNKPQDAVLSNLKQMEAEGFIAKRKGRLFIA
>Mature_284_residues
SLESHIREMYTSGGLTPEAATLFRQIVYGHYRRHGRTLPWRETSDPYAILVSEIMLQQTQVDRVTGKYMSFLSAFPDFRA
LAAAPLDAVLAAWQGLGYNRRALNLKRCSEAVVTEYGGTLPSTIAELEKLPGIGHYTARAVAAFAFSVPSAFIETNIRTV
FIHHFFNDSEKVHDREIAPLVEGALDYGNPREWYYALMDYGAHLKRLHGNPSRRSAHHATQSPFKGSNRELRSLILKAIL
DRPGITLEEITSFLNKPQDAVLSNLKQMEAEGFIAKRKGRLFIA

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=194, Percent_Identity=33.5051546391753, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI115298648, Length=194, Percent_Identity=33.5051546391753, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI115298654, Length=194, Percent_Identity=33.5051546391753, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI115298652, Length=194, Percent_Identity=33.5051546391753, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI115298650, Length=194, Percent_Identity=33.5051546391753, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI190358497, Length=194, Percent_Identity=33.5051546391753, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1789331, Length=143, Percent_Identity=40.5594405594406, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 32066; Mature: 31935

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLESHIREMYTSGGLTPEAATLFRQIVYGHYRRHGRTLPWRETSDPYAILVSEIMLQQT
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
QVDRVTGKYMSFLSAFPDFRALAAAPLDAVLAAWQGLGYNRRALNLKRCSEAVVTEYGGT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCC
LPSTIAELEKLPGIGHYTARAVAAFAFSVPSAFIETNIRTVFIHHFFNDSEKVHDREIAP
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHEEHHHHHCCCHHHHHHHHHH
LVEGALDYGNPREWYYALMDYGAHLKRLHGNPSRRSAHHATQSPFKGSNRELRSLILKAI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHH
LDRPGITLEEITSFLNKPQDAVLSNLKQMEAEGFIAKRKGRLFIA
HCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHCCCCEECC
>Mature Secondary Structure 
SLESHIREMYTSGGLTPEAATLFRQIVYGHYRRHGRTLPWRETSDPYAILVSEIMLQQT
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
QVDRVTGKYMSFLSAFPDFRALAAAPLDAVLAAWQGLGYNRRALNLKRCSEAVVTEYGGT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCC
LPSTIAELEKLPGIGHYTARAVAAFAFSVPSAFIETNIRTVFIHHFFNDSEKVHDREIAP
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHEEHHHHHCCCHHHHHHHHHH
LVEGALDYGNPREWYYALMDYGAHLKRLHGNPSRRSAHHATQSPFKGSNRELRSLILKAI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHH
LDRPGITLEEITSFLNKPQDAVLSNLKQMEAEGFIAKRKGRLFIA
HCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]