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The map label for this gene is hom [H]

Identifier: 78222838

GI number: 78222838

Start: 1825433

End: 1826743

Strand: Direct

Name: hom [H]

Synonym: Gmet_1629

Alternate gene names: 78222838

Gene position: 1825433-1826743 (Clockwise)

Preceding gene: 78222837

Following gene: 78222841

Centisome position: 45.67

GC content: 59.8

Gene sequence:

>1311_bases
ATGAACGAGATAAAGGTGGGCCTTCTCGGCCTGGGGACCATTGGTACGGGGGTCGCCAAGCTGCTCATGACCAATGCCGA
TCTGATCGCCGCCAAGGTGGGCGCCCGGATTACCCTGAAAAAGATCGCCGATCTGGATATAACCACCGACCGGGGGATTG
CGCTTCCGGCGGACATTCTCACCACCAACGCCGACGAGGTGCTCACCGATCCGGAGATCAGCGTGGTGATCGAGTTGATC
GGCGGCTATGAGCCGGCCAAGCGCTTCGTGCTCAAGGCCATCGAAAACGGCAAGCATGTGGTTACCGCCAACAAGGCGCT
TCTGGCTCTCCACGGTGAAGAGATCTACCCTGCCGCGGCCCGCAAGGGGGTAGAGGTTCTGTTTGAGGCCGCGGTCGGGG
GAGGCATCCCGGTCATTTCCGCCATACGCGGGAACATGGCAGCCAATAATTTTTCCACTGTTTTCGGCATACTGAACGGA
ACATGCAATTACATACTTACCCGAATGACCAAGGAGGGGGTGGACTTCGCCGACGTTCTCAAGAAGGCCCAGGAACTCGG
TTATGCTGAGGCTGACCCCACCTTCGACATCGAGGGGGTGGACACGGCCCACAAGCTGGCGCTCCTTGTTTCCCTCTGCT
TCGGGACCCGGGTCACCTTCAGCGACATCCATACGGAAGGAATCAGTTCCCTCTCCTCCGTTGACATCAAGTTTGCCCGG
GACTTCGGGTACAAGATCAAGCTCCTGGCCATCGGCAAGCGGGACGGCGACCGGGTGGAGGCCCGGGTTCACCCCACCAT
GATCCCGGTCAACAATCCGCTGGCCGATGTAGATGGCGCCTTTAACGCCATCCGCTTCACCGGCGACTTCATCGGTCCGG
TCATGTTCTATGGCCGCGGTGCCGGCATGGACCCTACCGCCAGCGCCGTGGTGGGTGATATCATCGAGGTCTCCCGCAAC
ATCGTGGCGGGCATCGGCCGTCGTTGTGCTCCTCTCGGCTACTGTGACGAGGCGGTCGCCACTCTTCCGCTCAAGCCCAT
GGGGGAAATCGAGAGCAAGTACTACATTCGCTTCAGCGCCGTGGACAGGCCCGGTGTTCTGGCGAGAATCTCCGGGATTC
TCGGAAAGTACGACATCAGCATCGAGTCCATGGTCCAGAGCGGCCGCATGGCCGGCGAGGAGGTCCCCATCGTCATCATG
ACCCATGAGGCCAGGGAAAGCGATGTACGGACGGCCCTCGACGAGATCGACACCTTTGATATCATTACCCAGAAGAGCCA
GGTCATCCGGATTGAGGACAATCTGGAATAG

Upstream 100 bases:

>100_bases
GCCTTCATCAACGGCATCCTCGACGAGGTCGCCTCGACCCTCCCCGACAAGGGGTAGCTCCAGCCATTGCATCGCGTCAT
TCCATACTGAGCGAGGACGT

Downstream 100 bases:

>100_bases
ACGGAGAGCTACAGCAGTGAAACGTGAAAGGCGGCCCGAACAGGCCGCCTTTTTTCATGGGTTGAGGCTTACCGATGAGG
TGTCGGGCGAGGGGATGAGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNEIKVGLLGLGTIGTGVAKLLMTNADLIAAKVGARITLKKIADLDITTDRGIALPADILTTNADEVLTDPEISVVIELI
GGYEPAKRFVLKAIENGKHVVTANKALLALHGEEIYPAAARKGVEVLFEAAVGGGIPVISAIRGNMAANNFSTVFGILNG
TCNYILTRMTKEGVDFADVLKKAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTRVTFSDIHTEGISSLSSVDIKFAR
DFGYKIKLLAIGKRDGDRVEARVHPTMIPVNNPLADVDGAFNAIRFTGDFIGPVMFYGRGAGMDPTASAVVGDIIEVSRN
IVAGIGRRCAPLGYCDEAVATLPLKPMGEIESKYYIRFSAVDRPGVLARISGILGKYDISIESMVQSGRMAGEEVPIVIM
THEARESDVRTALDEIDTFDIITQKSQVIRIEDNLE

Sequences:

>Translated_436_residues
MNEIKVGLLGLGTIGTGVAKLLMTNADLIAAKVGARITLKKIADLDITTDRGIALPADILTTNADEVLTDPEISVVIELI
GGYEPAKRFVLKAIENGKHVVTANKALLALHGEEIYPAAARKGVEVLFEAAVGGGIPVISAIRGNMAANNFSTVFGILNG
TCNYILTRMTKEGVDFADVLKKAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTRVTFSDIHTEGISSLSSVDIKFAR
DFGYKIKLLAIGKRDGDRVEARVHPTMIPVNNPLADVDGAFNAIRFTGDFIGPVMFYGRGAGMDPTASAVVGDIIEVSRN
IVAGIGRRCAPLGYCDEAVATLPLKPMGEIESKYYIRFSAVDRPGVLARISGILGKYDISIESMVQSGRMAGEEVPIVIM
THEARESDVRTALDEIDTFDIITQKSQVIRIEDNLE
>Mature_436_residues
MNEIKVGLLGLGTIGTGVAKLLMTNADLIAAKVGARITLKKIADLDITTDRGIALPADILTTNADEVLTDPEISVVIELI
GGYEPAKRFVLKAIENGKHVVTANKALLALHGEEIYPAAARKGVEVLFEAAVGGGIPVISAIRGNMAANNFSTVFGILNG
TCNYILTRMTKEGVDFADVLKKAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTRVTFSDIHTEGISSLSSVDIKFAR
DFGYKIKLLAIGKRDGDRVEARVHPTMIPVNNPLADVDGAFNAIRFTGDFIGPVMFYGRGAGMDPTASAVVGDIIEVSRN
IVAGIGRRCAPLGYCDEAVATLPLKPMGEIESKYYIRFSAVDRPGVLARISGILGKYDISIESMVQSGRMAGEEVPIVIM
THEARESDVRTALDEIDTFDIITQKSQVIRIEDNLE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=30.5220883534137, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790376, Length=354, Percent_Identity=23.728813559322, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=356, Percent_Identity=25.2808988764045, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46713; Mature: 46713

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIKVGLLGLGTIGTGVAKLLMTNADLIAAKVGARITLKKIADLDITTDRGIALPADIL
CCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHCCEEEEEHHCCCEEECCCCCCCCHHHH
TTNADEVLTDPEISVVIELIGGYEPAKRFVLKAIENGKHVVTANKALLALHGEEIYPAAA
CCCCHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCCHHH
RKGVEVLFEAAVGGGIPVISAIRGNMAANNFSTVFGILNGTCNYILTRMTKEGVDFADVL
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCHHHHH
KKAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTRVTFSDIHTEGISSLSSVDIKFAR
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCEEEEE
DFGYKIKLLAIGKRDGDRVEARVHPTMIPVNNPLADVDGAFNAIRFTGDFIGPVMFYGRG
CCCCEEEEEEEECCCCCEEEEEECCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHCCCC
AGMDPTASAVVGDIIEVSRNIVAGIGRRCAPLGYCDEAVATLPLKPMGEIESKYYIRFSA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEC
VDRPGVLARISGILGKYDISIESMVQSGRMAGEEVPIVIMTHEARESDVRTALDEIDTFD
CCCCCHHHHHHHHHHEECCCHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHH
IITQKSQVIRIEDNLE
EEECCCEEEEEECCCC
>Mature Secondary Structure
MNEIKVGLLGLGTIGTGVAKLLMTNADLIAAKVGARITLKKIADLDITTDRGIALPADIL
CCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHCCEEEEEHHCCCEEECCCCCCCCHHHH
TTNADEVLTDPEISVVIELIGGYEPAKRFVLKAIENGKHVVTANKALLALHGEEIYPAAA
CCCCHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCCHHH
RKGVEVLFEAAVGGGIPVISAIRGNMAANNFSTVFGILNGTCNYILTRMTKEGVDFADVL
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCHHHHH
KKAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTRVTFSDIHTEGISSLSSVDIKFAR
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCEEEEE
DFGYKIKLLAIGKRDGDRVEARVHPTMIPVNNPLADVDGAFNAIRFTGDFIGPVMFYGRG
CCCCEEEEEEEECCCCCEEEEEECCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHCCCC
AGMDPTASAVVGDIIEVSRNIVAGIGRRCAPLGYCDEAVATLPLKPMGEIESKYYIRFSA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEC
VDRPGVLARISGILGKYDISIESMVQSGRMAGEEVPIVIMTHEARESDVRTALDEIDTFD
CCCCCHHHHHHHHHHEECCCHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHH
IITQKSQVIRIEDNLE
EEECCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]