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The map label for this gene is ubiB [C]

Identifier: 78222731

GI number: 78222731

Start: 1720455

End: 1721906

Strand: Reverse

Name: ubiB [C]

Synonym: Gmet_1519

Alternate gene names: 78222731

Gene position: 1721906-1720455 (Counterclockwise)

Preceding gene: 78222732

Following gene: 78222730

Centisome position: 43.08

GC content: 63.5

Gene sequence:

>1452_bases
ATGAAGCCTGAGAAGCGTCACGCAACGGAGTCGATGACCATGGAGGCGCTGCTCGACCTTCTCCCCAAGGATGCTGCAAC
TGATCCGACCGGCCGGCGGTTGGCGGAGCTGGTGACCCGTATCGCCACGAAAAGGGTGCCGGTCAGCTCGTTTTCCCGTA
TCTGGAACCTCGGCTCCCTCCAGGCCAGGGTGACCATTGGCTATGTTGCCTACTGGCTGCGCAGCCGCTTTGCCGATAGT
GACGAGAAGCAAAGGCTCCGGAACGAAGCCCATCTTGCCGCGGCCCTGAGGCTGTTCGGCACCATGGGGTACCTGCGGGG
TGCGGTGATGAAGATCGGCCAGCTCCTGGCCAATCTCCCCGAGGTGGTGCCGGAGGAGTTTGCCGAGGTGCTGTCGGCCC
TGCACTTCGAGGCGCCTCCTATGCACTTCTCCCTGGTGCGGGAGCTGTTTCTCGACGAGTTCGGCCGTGAACCGGAGGAG
CTGTTCGCCTCCTTCGACCGCCAAGCCTTTGCCGCCGCCTCCCTGGGGCAGGTGCACCGCGCCCGGCTTAAAAGCGGCGA
GGAGGTGGCGGTGAAGATCCAGTACCCAGGCATTGCCAGGACCATCAAAGCCGACCTGCGCAACCTCCGGCTCCTGCTCC
AGCCCCTCTGTCTGACCAACGACTGGCAGAACACCCTCGACAAGCTGGCCGACATCGAGCAGATGCTGCTCATGGAGACC
GATTACGAGCAGGAGGCCCGCTTCTGCCGGGAGGCGCGGCTCCTCTTTACGACCGAAGACCGGGTGGTGGTGCCGCGGGT
CTTTGACGACTATTCCACCAAACGGGTCCTGACCACCGAGTTCCTCACCGGCTGTCATCTGGATCAGTTCTTGGCGGGCA
ATCCGAGCCAGGCGGAGCGGGATCACTTCACCACCCTCCTCACCGTGGCCACCATGCGGATCTATTACCGGCTCCACTGG
TTCTGCGCCGACCCCCATCCGGGGAACTTCATCTTCATGCTGGATGGTCGGCTCGGCCTGATCGACTTCGGCTGCACCAG
GGCCATGAATGGGGAGGAGTGGCGTCTGATCTGCGAATTGGAGCAGGCGCATCAGGAGGAGGATGCGGAGCAGTTCGACC
GGGTGATTGCCCGGGCGACGCTGTACGACTCGCCCGAGGCGATGGGGAAGGAGCAGCTGGCGGTGGTCCGGCGCAATGTC
TTATGGAACATGGAACCGTGGCTCAAGGAGGGGCTCTTCGATTTCGGGGACCGGGAGTTCTTTATGCGCGGCATCGACGG
GCTCATGGAGCTGACCCGCAAGCGGTACACCCGGGGCTCCCCTCTGTACCTCTGGTCCACTCGTTTCGTCCTGGGAGGCC
GGGCCGTCTGCTACCAGATGCGGGGGCGATGCGAATTCCAGGAGATCTTCCGGCAGGAGTCGGCATGGGTCTGCCCGGAA
CCACCCATTTGA

Upstream 100 bases:

>100_bases
GAGTCGCCCAACCAAGAAGCATCCCGGGCCTTGATAGACTATTCGATCCGGATGTTCGTACAGGTGATCTCCGGCAGCGG
TCCGGATGGAGGAGGCGCGC

Downstream 100 bases:

>100_bases
ACCAAGGAGGCGGTACGCAATGCTGAAACTCCACAACGTATGCAAGAGCTACGAGGGGAAGTCACAGGTAACGGCCCTGG
CCGGGATCGACCTGGCCATC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKPEKRHATESMTMEALLDLLPKDAATDPTGRRLAELVTRIATKRVPVSSFSRIWNLGSLQARVTIGYVAYWLRSRFADS
DEKQRLRNEAHLAAALRLFGTMGYLRGAVMKIGQLLANLPEVVPEEFAEVLSALHFEAPPMHFSLVRELFLDEFGREPEE
LFASFDRQAFAAASLGQVHRARLKSGEEVAVKIQYPGIARTIKADLRNLRLLLQPLCLTNDWQNTLDKLADIEQMLLMET
DYEQEARFCREARLLFTTEDRVVVPRVFDDYSTKRVLTTEFLTGCHLDQFLAGNPSQAERDHFTTLLTVATMRIYYRLHW
FCADPHPGNFIFMLDGRLGLIDFGCTRAMNGEEWRLICELEQAHQEEDAEQFDRVIARATLYDSPEAMGKEQLAVVRRNV
LWNMEPWLKEGLFDFGDREFFMRGIDGLMELTRKRYTRGSPLYLWSTRFVLGGRAVCYQMRGRCEFQEIFRQESAWVCPE
PPI

Sequences:

>Translated_483_residues
MKPEKRHATESMTMEALLDLLPKDAATDPTGRRLAELVTRIATKRVPVSSFSRIWNLGSLQARVTIGYVAYWLRSRFADS
DEKQRLRNEAHLAAALRLFGTMGYLRGAVMKIGQLLANLPEVVPEEFAEVLSALHFEAPPMHFSLVRELFLDEFGREPEE
LFASFDRQAFAAASLGQVHRARLKSGEEVAVKIQYPGIARTIKADLRNLRLLLQPLCLTNDWQNTLDKLADIEQMLLMET
DYEQEARFCREARLLFTTEDRVVVPRVFDDYSTKRVLTTEFLTGCHLDQFLAGNPSQAERDHFTTLLTVATMRIYYRLHW
FCADPHPGNFIFMLDGRLGLIDFGCTRAMNGEEWRLICELEQAHQEEDAEQFDRVIARATLYDSPEAMGKEQLAVVRRNV
LWNMEPWLKEGLFDFGDREFFMRGIDGLMELTRKRYTRGSPLYLWSTRFVLGGRAVCYQMRGRCEFQEIFRQESAWVCPE
PPI
>Mature_483_residues
MKPEKRHATESMTMEALLDLLPKDAATDPTGRRLAELVTRIATKRVPVSSFSRIWNLGSLQARVTIGYVAYWLRSRFADS
DEKQRLRNEAHLAAALRLFGTMGYLRGAVMKIGQLLANLPEVVPEEFAEVLSALHFEAPPMHFSLVRELFLDEFGREPEE
LFASFDRQAFAAASLGQVHRARLKSGEEVAVKIQYPGIARTIKADLRNLRLLLQPLCLTNDWQNTLDKLADIEQMLLMET
DYEQEARFCREARLLFTTEDRVVVPRVFDDYSTKRVLTTEFLTGCHLDQFLAGNPSQAERDHFTTLLTVATMRIYYRLHW
FCADPHPGNFIFMLDGRLGLIDFGCTRAMNGEEWRLICELEQAHQEEDAEQFDRVIARATLYDSPEAMGKEQLAVVRRNV
LWNMEPWLKEGLFDFGDREFFMRGIDGLMELTRKRYTRGSPLYLWSTRFVLGGRAVCYQMRGRCEFQEIFRQESAWVCPE
PPI

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=471, Percent_Identity=27.1762208067941, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI27363457, Length=384, Percent_Identity=28.125, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI41393593, Length=262, Percent_Identity=35.1145038167939, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI40254938, Length=297, Percent_Identity=29.2929292929293, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI217416386, Length=324, Percent_Identity=29.320987654321, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI217035081, Length=211, Percent_Identity=27.4881516587678, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI2367309, Length=301, Percent_Identity=25.9136212624585, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI32565180, Length=445, Percent_Identity=27.6404494382022, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17559152, Length=311, Percent_Identity=27.3311897106109, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=314, Percent_Identity=29.9363057324841, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323282, Length=268, Percent_Identity=25.3731343283582, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18859849, Length=259, Percent_Identity=33.976833976834, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI22024280, Length=245, Percent_Identity=27.7551020408163, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24662575, Length=282, Percent_Identity=31.5602836879433, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 55800; Mature: 55800

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPEKRHATESMTMEALLDLLPKDAATDPTGRRLAELVTRIATKRVPVSSFSRIWNLGSL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
QARVTIGYVAYWLRSRFADSDEKQRLRNEAHLAAALRLFGTMGYLRGAVMKIGQLLANLP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVPEEFAEVLSALHFEAPPMHFSLVRELFLDEFGREPEELFASFDRQAFAAASLGQVHR
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ARLKSGEEVAVKIQYPGIARTIKADLRNLRLLLQPLCLTNDWQNTLDKLADIEQMLLMET
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
DYEQEARFCREARLLFTTEDRVVVPRVFDDYSTKRVLTTEFLTGCHLDQFLAGNPSQAER
CHHHHHHHHHHHHEEEECCCCEEECHHHCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCHH
DHFTTLLTVATMRIYYRLHWFCADPHPGNFIFMLDGRLGLIDFGCTRAMNGEEWRLICEL
HHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCCCEEEEEEH
EQAHQEEDAEQFDRVIARATLYDSPEAMGKEQLAVVRRNVLWNMEPWLKEGLFDFGDREF
HHHHCCCHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHH
FMRGIDGLMELTRKRYTRGSPLYLWSTRFVLGGRAVCYQMRGRCEFQEIFRQESAWVCPE
HHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCCC
PPI
CCC
>Mature Secondary Structure
MKPEKRHATESMTMEALLDLLPKDAATDPTGRRLAELVTRIATKRVPVSSFSRIWNLGSL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
QARVTIGYVAYWLRSRFADSDEKQRLRNEAHLAAALRLFGTMGYLRGAVMKIGQLLANLP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVPEEFAEVLSALHFEAPPMHFSLVRELFLDEFGREPEELFASFDRQAFAAASLGQVHR
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ARLKSGEEVAVKIQYPGIARTIKADLRNLRLLLQPLCLTNDWQNTLDKLADIEQMLLMET
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
DYEQEARFCREARLLFTTEDRVVVPRVFDDYSTKRVLTTEFLTGCHLDQFLAGNPSQAER
CHHHHHHHHHHHHEEEECCCCEEECHHHCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCHH
DHFTTLLTVATMRIYYRLHWFCADPHPGNFIFMLDGRLGLIDFGCTRAMNGEEWRLICEL
HHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCCCEEEEEEH
EQAHQEEDAEQFDRVIARATLYDSPEAMGKEQLAVVRRNVLWNMEPWLKEGLFDFGDREF
HHHHCCCHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHH
FMRGIDGLMELTRKRYTRGSPLYLWSTRFVLGGRAVCYQMRGRCEFQEIFRQESAWVCPE
HHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCCC
PPI
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]