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The map label for this gene is wecB [H]

Identifier: 78222701

GI number: 78222701

Start: 1683769

End: 1684935

Strand: Direct

Name: wecB [H]

Synonym: Gmet_1489

Alternate gene names: 78222701

Gene position: 1683769-1684935 (Clockwise)

Preceding gene: 78222700

Following gene: 78222702

Centisome position: 42.12

GC content: 53.04

Gene sequence:

>1167_bases
ATGGATAAATTGAATGTAATGTTTGTGTTCGGAACTCGCCCCGAGGCCATAAAAATGGCGCCGTTGGTGAAGGAACTGCA
GAAGCAAGCCGGACAGTTCAAGACCATAGTCTGTGTATCCGCGCAACATCGGCAGATGCTCGATCAGGTGCTCCAACTCT
TTGACATCAGGCCCGAGTATGATCTCGACATCATGAAGCCGGGGCAGGACCTCTTCGATATCACCAGCAACGTGCTCCTG
GGACTGAAGCCTGTCTTGACGAAAGAACAGCCCGATATCCTGCTTGTCCACGGTGACACCACTACGACAATGTCGGCGGC
CCTTGCCGCCTACTATTGCCGGATTCCTGTCGGTCATGTTGAAGCAGGGCTGCGAACCTATAATAAATTTTCGCCTTTTC
CCGAGGAAATGAATCGCAGAACGGCCGGAGCATTGACGGATCTTCACTTCGCACCCACCGAAACTGCCCGTCGAAACCTT
CTGAGCGAAGGGGTGGCGGACACTTCTATCTTCGTGACAGGCAATACCGTAATTGATGCGCTTTTTTCGGTCATTGGCGA
AATCAACGCCAATAGGGAGCTTAAAGAAAGCCTGTCCACCCAATTCCAGTTTCTCGATCCCCATAAGAGGCTGATACTGG
TAACCGGCCATAGAAGAGAAAATTTCGGTGCTGGTTTTGAAAGTATATGCAGGGCTATTGCGCGAATAGCCGAGAGATAT
CCGGACGTGGAGATTCTCTATCCAGTGCATCTGAATCCGAATGTACGTGAACCGGTCAGGCGTCTCCTGGGTAATGGAAA
GCTATCCAACGTCCATCTTATCGAACCTGTTGATTATCTGCCCTTTGTTTACCTGATGGCTCAATCGTATCTCATCATTA
CCGATTCCGGTGGCGTGCAGGAAGAGGCCCCATCCCTGGGAAAGCCGGTGCTCGTGATGCGCGATACCACCGAACGCCCG
GAGGCAATTGGTGCCGGAACGGTCAAGCTGGTTGGAACCCGTGAGGAGTCCATTTACCGCGAGGCAGCCCGCCTACTTGA
TGCCGCGGACGCGTATCAAGTCATGTCGCAGGCTCTCAATCCGTATGGTGACGGCCGGGCGGCAGAACGAATCGCGAAAT
GTCTTGCTGATTTCCCCAACACCTGCATGGGCGGACAGCTGGCATGA

Upstream 100 bases:

>100_bases
AAGCGGGTGCTCGGCTGGCAACAGCAGACCAGCTTTGACCAGTTGGTCGCCATGATGACCGATGCCGATCTGGCGCTGGC
AGAGCGGGAAATGCGCGCCA

Downstream 100 bases:

>100_bases
ACATGAATGCGATTATCCTCTCCTGGTGCCCGAATATACTTTCGTCAACCCTGGAGCGTATCAGAAGCTCCAAGGTTGGC
TACCGATTTGCGAAGGGAAT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MDKLNVMFVFGTRPEAIKMAPLVKELQKQAGQFKTIVCVSAQHRQMLDQVLQLFDIRPEYDLDIMKPGQDLFDITSNVLL
GLKPVLTKEQPDILLVHGDTTTTMSAALAAYYCRIPVGHVEAGLRTYNKFSPFPEEMNRRTAGALTDLHFAPTETARRNL
LSEGVADTSIFVTGNTVIDALFSVIGEINANRELKESLSTQFQFLDPHKRLILVTGHRRENFGAGFESICRAIARIAERY
PDVEILYPVHLNPNVREPVRRLLGNGKLSNVHLIEPVDYLPFVYLMAQSYLIITDSGGVQEEAPSLGKPVLVMRDTTERP
EAIGAGTVKLVGTREESIYREAARLLDAADAYQVMSQALNPYGDGRAAERIAKCLADFPNTCMGGQLA

Sequences:

>Translated_388_residues
MDKLNVMFVFGTRPEAIKMAPLVKELQKQAGQFKTIVCVSAQHRQMLDQVLQLFDIRPEYDLDIMKPGQDLFDITSNVLL
GLKPVLTKEQPDILLVHGDTTTTMSAALAAYYCRIPVGHVEAGLRTYNKFSPFPEEMNRRTAGALTDLHFAPTETARRNL
LSEGVADTSIFVTGNTVIDALFSVIGEINANRELKESLSTQFQFLDPHKRLILVTGHRRENFGAGFESICRAIARIAERY
PDVEILYPVHLNPNVREPVRRLLGNGKLSNVHLIEPVDYLPFVYLMAQSYLIITDSGGVQEEAPSLGKPVLVMRDTTERP
EAIGAGTVKLVGTREESIYREAARLLDAADAYQVMSQALNPYGDGRAAERIAKCLADFPNTCMGGQLA
>Mature_388_residues
MDKLNVMFVFGTRPEAIKMAPLVKELQKQAGQFKTIVCVSAQHRQMLDQVLQLFDIRPEYDLDIMKPGQDLFDITSNVLL
GLKPVLTKEQPDILLVHGDTTTTMSAALAAYYCRIPVGHVEAGLRTYNKFSPFPEEMNRRTAGALTDLHFAPTETARRNL
LSEGVADTSIFVTGNTVIDALFSVIGEINANRELKESLSTQFQFLDPHKRLILVTGHRRENFGAGFESICRAIARIAERY
PDVEILYPVHLNPNVREPVRRLLGNGKLSNVHLIEPVDYLPFVYLMAQSYLIITDSGGVQEEAPSLGKPVLVMRDTTERP
EAIGAGTVKLVGTREESIYREAARLLDAADAYQVMSQALNPYGDGRAAERIAKCLADFPNTCMGGQLA

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=374, Percent_Identity=61.7647058823529, Blast_Score=461, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 43064; Mature: 43064

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLNVMFVFGTRPEAIKMAPLVKELQKQAGQFKTIVCVSAQHRQMLDQVLQLFDIRPEY
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHCCCCCC
DLDIMKPGQDLFDITSNVLLGLKPVLTKEQPDILLVHGDTTTTMSAALAAYYCRIPVGHV
CCEEECCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHH
EAGLRTYNKFSPFPEEMNRRTAGALTDLHFAPTETARRNLLSEGVADTSIFVTGNTVIDA
HHHHHHHHCCCCCHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECHHHHHH
LFSVIGEINANRELKESLSTQFQFLDPHKRLILVTGHRRENFGAGFESICRAIARIAERY
HHHHHHCCCCCHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHC
PDVEILYPVHLNPNVREPVRRLLGNGKLSNVHLIEPVDYLPFVYLMAQSYLIITDSGGVQ
CCEEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCEEEEECCCCCC
EEAPSLGKPVLVMRDTTERPEAIGAGTVKLVGTREESIYREAARLLDAADAYQVMSQALN
CCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
PYGDGRAAERIAKCLADFPNTCMGGQLA
CCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDKLNVMFVFGTRPEAIKMAPLVKELQKQAGQFKTIVCVSAQHRQMLDQVLQLFDIRPEY
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHCCCCCC
DLDIMKPGQDLFDITSNVLLGLKPVLTKEQPDILLVHGDTTTTMSAALAAYYCRIPVGHV
CCEEECCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHH
EAGLRTYNKFSPFPEEMNRRTAGALTDLHFAPTETARRNLLSEGVADTSIFVTGNTVIDA
HHHHHHHHCCCCCHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECHHHHHH
LFSVIGEINANRELKESLSTQFQFLDPHKRLILVTGHRRENFGAGFESICRAIARIAERY
HHHHHHCCCCCHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHC
PDVEILYPVHLNPNVREPVRRLLGNGKLSNVHLIEPVDYLPFVYLMAQSYLIITDSGGVQ
CCEEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCEEEEECCCCCC
EEAPSLGKPVLVMRDTTERPEAIGAGTVKLVGTREESIYREAARLLDAADAYQVMSQALN
CCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
PYGDGRAAERIAKCLADFPNTCMGGQLA
CCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]