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The map label for this gene is glmS [H]

Identifier: 78222699

GI number: 78222699

Start: 1680833

End: 1682662

Strand: Direct

Name: glmS [H]

Synonym: Gmet_1487

Alternate gene names: 78222699

Gene position: 1680833-1682662 (Clockwise)

Preceding gene: 78222698

Following gene: 78222700

Centisome position: 42.05

GC content: 65.52

Gene sequence:

>1830_bases
ATGTGCGGCATAGTTGGCTACACGGGGCGTCAGCCGGCGGTCCCCGTCATCCTCGAAGGTCTGCGGCGCCTGGAGTACCG
GGGGTATGACTCGGCAGGCATCTGCACCATGAATGGCCACGGCGCCGAAATGCTTCGCTGCGAAGGGAAGCTGGCGAACT
TGGAACGGCTTCTGACGGAAACGCCCCTGGGGGGAACCATCGGCATCGGCCACACCCGCTGGGCCACCCACGGCCGGCCG
TCGGAGAAGAACGCCCACCCCCACCGGGCAGGCGAGGTCTTCGTGGTCCACAACGGGATCATCGAGAACCACCGGGAGTT
GAAGGAGAAACTGGAACGGCTGGGGCACTCGTTCCGCAGCGACACCGATACCGAGGTCATCTCCCACCTCATCGAGCACA
ACATGAAGCTCGGGTCCGATTTCGAAACCGCTGTCCGCGAGAGCCTGCGGGAACTCCGGGGAGCCTACGCCCTCTGCATC
CTCTGCGAGGGGATGCCCGGCACCCTGATCGCCGCCCGTAATGGCTCCCCACTGGTGGTGGGGCTCGGCGAACGGGAGTT
TCTGGTCGCCTCCGACATCCCGGCGCTCCTCTCCCACACCCGCCGGGTAGTCTTCCTGGATGACGGTGAGGTGGCCCTCT
TCTGCGACGGCGAGGCATCGTTGACCCGCATCGACGGCCGTCCCGTGGCCAAGGAGCCCACCACCATCGACTGGACCCCG
GTCATGGCCGAGAAGGGGGGCTTTCGCCATTTCATGCTCAAGGAGATCTTCGAGCAGCCCCGGGCCATTGCCGACACCAT
CGCCGGTCAGGTCTTCGAGGAAGAGGGGGCCGTATTCCTGGATGAACTGAAGATGACCGACGACGAACTGGCGCAGGTTT
CCCGGGTGGTCATCGTTGCCTGCGGCACCTCGTGGCACGCGGGTCTCGTGGGAAAGTTTCTCCTTGAAGACCTCTGCCGG
CTGCCGGTGGAGGTGGAGATCGCCTCCGAGTACCGCTACCGCAATCCGGTGGTGGGGGAGGAGAGTCTGGTGCTGGCCAT
CTCCCAGTCGGGAGAAACCGCCGACACCCTGGCAGCCCTCAGGGAAGCGAAGCTGCGGGGCGCCCGCACCGCCACCATCT
GCAACGTGGTCGGCTCATCCATCGCCCGTGAGGCCCATGGCGTCATTTACACCCACGCCGGCCCCGAGATTGGCGTCGCC
TCCACCAAGGCCTTCGTTACCCAACTGGCGGCGCTCCATCTTCTGGCCATCCGGCTCGGCCGGACCGTGGGGACCATCTC
CCGGGAGAAGGGGAGGGAGCTGATCGGTTCCCTGGTGAAGCTTCCCGGCCTCGTGGAAGAAACCCTCCGGATAGCGCCCG
TTGTGGAGGCGGTCGCCCGCGGATGCCATCATGCCCGCGATTTCCTCTACCTGGGGCGTGGCTCCTGCTACCCCGTGGCC
CTGGAAGGTGCCCTCAAGCTCAAGGAGATCTCCTACATCCACGCCGAGGGGTACCCGGCGGGCGAGATGAAGCACGGCCC
CATCGCCCTCATCGACGAGCAGATGCCGGTAGTGGTCCTGGCGCCGCGAAACGCCCACTACGAAAAGACCATCTCCAACA
TGGAGGAAGTCATCGCCCGGGGGGGCCGGGTCATCGCCGTCGCCACCGAGGGGGACGACACCCTGGTCGCCAAGGCGGAA
ATCATGCTGGAGATTCCCGAGGCGCCTCCGGAACTTCTTCCCATCCTCGCCACCGTGCCGTTGCAGCTTCTGGCCTACCA
CGTGGCGGTGCTGCGGGGGAACGACGTTGATCAGCCGCGGAACCTGGCAAAGAGTGTGACGGTTGAATGA

Upstream 100 bases:

>100_bases
AACTCCGATCCCTCATGAAGTGGGAGCCCCAATACGACAATCTCGACTTCATCATCAGGACTGCCTGGGAATGGGAGCTG
GCTCTCAAGCGGAGGGAGTC

Downstream 100 bases:

>100_bases
AGGGCATGAATTTGTCAGGTGGCTCTGCTTCAGAACCAGCAATGTATTGAAAAGAGGTAGGAACGTGAAAAAAGCACTGA
TTACCGGCATCACCGGTCAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGYTGRQPAVPVILEGLRRLEYRGYDSAGICTMNGHGAEMLRCEGKLANLERLLTETPLGGTIGIGHTRWATHGRP
SEKNAHPHRAGEVFVVHNGIIENHRELKEKLERLGHSFRSDTDTEVISHLIEHNMKLGSDFETAVRESLRELRGAYALCI
LCEGMPGTLIAARNGSPLVVGLGEREFLVASDIPALLSHTRRVVFLDDGEVALFCDGEASLTRIDGRPVAKEPTTIDWTP
VMAEKGGFRHFMLKEIFEQPRAIADTIAGQVFEEEGAVFLDELKMTDDELAQVSRVVIVACGTSWHAGLVGKFLLEDLCR
LPVEVEIASEYRYRNPVVGEESLVLAISQSGETADTLAALREAKLRGARTATICNVVGSSIAREAHGVIYTHAGPEIGVA
STKAFVTQLAALHLLAIRLGRTVGTISREKGRELIGSLVKLPGLVEETLRIAPVVEAVARGCHHARDFLYLGRGSCYPVA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEQMPVVVLAPRNAHYEKTISNMEEVIARGGRVIAVATEGDDTLVAKAE
IMLEIPEAPPELLPILATVPLQLLAYHVAVLRGNDVDQPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGYTGRQPAVPVILEGLRRLEYRGYDSAGICTMNGHGAEMLRCEGKLANLERLLTETPLGGTIGIGHTRWATHGRP
SEKNAHPHRAGEVFVVHNGIIENHRELKEKLERLGHSFRSDTDTEVISHLIEHNMKLGSDFETAVRESLRELRGAYALCI
LCEGMPGTLIAARNGSPLVVGLGEREFLVASDIPALLSHTRRVVFLDDGEVALFCDGEASLTRIDGRPVAKEPTTIDWTP
VMAEKGGFRHFMLKEIFEQPRAIADTIAGQVFEEEGAVFLDELKMTDDELAQVSRVVIVACGTSWHAGLVGKFLLEDLCR
LPVEVEIASEYRYRNPVVGEESLVLAISQSGETADTLAALREAKLRGARTATICNVVGSSIAREAHGVIYTHAGPEIGVA
STKAFVTQLAALHLLAIRLGRTVGTISREKGRELIGSLVKLPGLVEETLRIAPVVEAVARGCHHARDFLYLGRGSCYPVA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEQMPVVVLAPRNAHYEKTISNMEEVIARGGRVIAVATEGDDTLVAKAE
IMLEIPEAPPELLPILATVPLQLLAYHVAVLRGNDVDQPRNLAKSVTVE
>Mature_609_residues
MCGIVGYTGRQPAVPVILEGLRRLEYRGYDSAGICTMNGHGAEMLRCEGKLANLERLLTETPLGGTIGIGHTRWATHGRP
SEKNAHPHRAGEVFVVHNGIIENHRELKEKLERLGHSFRSDTDTEVISHLIEHNMKLGSDFETAVRESLRELRGAYALCI
LCEGMPGTLIAARNGSPLVVGLGEREFLVASDIPALLSHTRRVVFLDDGEVALFCDGEASLTRIDGRPVAKEPTTIDWTP
VMAEKGGFRHFMLKEIFEQPRAIADTIAGQVFEEEGAVFLDELKMTDDELAQVSRVVIVACGTSWHAGLVGKFLLEDLCR
LPVEVEIASEYRYRNPVVGEESLVLAISQSGETADTLAALREAKLRGARTATICNVVGSSIAREAHGVIYTHAGPEIGVA
STKAFVTQLAALHLLAIRLGRTVGTISREKGRELIGSLVKLPGLVEETLRIAPVVEAVARGCHHARDFLYLGRGSCYPVA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEQMPVVVLAPRNAHYEKTISNMEEVIARGGRVIAVATEGDDTLVAKAE
IMLEIPEAPPELLPILATVPLQLLAYHVAVLRGNDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=683, Percent_Identity=38.2137628111274, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=38.8321167883212, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI29570798, Length=198, Percent_Identity=29.2929292929293, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=49.1830065359477, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1788651, Length=214, Percent_Identity=30.3738317757009, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532899, Length=434, Percent_Identity=41.2442396313364, Blast_Score=322, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=41.2442396313364, Blast_Score=321, Evalue=7e-88,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=41.4351851851852, Blast_Score=317, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6322745, Length=447, Percent_Identity=40.0447427293065, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=31.7016317016317, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=39.3203883495146, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323958, Length=222, Percent_Identity=24.7747747747748, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357745, Length=684, Percent_Identity=39.1812865497076, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66165; Mature: 66165

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYTGRQPAVPVILEGLRRLEYRGYDSAGICTMNGHGAEMLRCEGKLANLERLLTE
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHC
TPLGGTIGIGHTRWATHGRPSEKNAHPHRAGEVFVVHNGIIENHRELKEKLERLGHSFRS
CCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
DTDTEVISHLIEHNMKLGSDFETAVRESLRELRGAYALCILCEGMPGTLIAARNGSPLVV
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEECCCCEEEE
GLGEREFLVASDIPALLSHTRRVVFLDDGEVALFCDGEASLTRIDGRPVAKEPTTIDWTP
ECCCCCEEEECCCHHHHHCCCEEEEEECCCEEEEECCCCCEEEECCCCCCCCCCEECCCC
VMAEKGGFRHFMLKEIFEQPRAIADTIAGQVFEEEGAVFLDELKMTDDELAQVSRVVIVA
HHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHHCEEEEEE
CGTSWHAGLVGKFLLEDLCRLPVEVEIASEYRYRNPVVGEESLVLAISQSGETADTLAAL
ECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHH
REAKLRGARTATICNVVGSSIAREAHGVIYTHAGPEIGVASTKAFVTQLAALHLLAIRLG
HHHHHCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
RTVGTISREKGRELIGSLVKLPGLVEETLRIAPVVEAVARGCHHARDFLYLGRGSCYPVA
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEE
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEQMPVVVLAPRNAHYEKTISNMEEVIAR
ECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHC
GGRVIAVATEGDDTLVAKAEIMLEIPEAPPELLPILATVPLQLLAYHVAVLRGNDVDQPR
CCEEEEEEECCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGYTGRQPAVPVILEGLRRLEYRGYDSAGICTMNGHGAEMLRCEGKLANLERLLTE
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHC
TPLGGTIGIGHTRWATHGRPSEKNAHPHRAGEVFVVHNGIIENHRELKEKLERLGHSFRS
CCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
DTDTEVISHLIEHNMKLGSDFETAVRESLRELRGAYALCILCEGMPGTLIAARNGSPLVV
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEECCCCEEEE
GLGEREFLVASDIPALLSHTRRVVFLDDGEVALFCDGEASLTRIDGRPVAKEPTTIDWTP
ECCCCCEEEECCCHHHHHCCCEEEEEECCCEEEEECCCCCEEEECCCCCCCCCCEECCCC
VMAEKGGFRHFMLKEIFEQPRAIADTIAGQVFEEEGAVFLDELKMTDDELAQVSRVVIVA
HHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHHCEEEEEE
CGTSWHAGLVGKFLLEDLCRLPVEVEIASEYRYRNPVVGEESLVLAISQSGETADTLAAL
ECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHH
REAKLRGARTATICNVVGSSIAREAHGVIYTHAGPEIGVASTKAFVTQLAALHLLAIRLG
HHHHHCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
RTVGTISREKGRELIGSLVKLPGLVEETLRIAPVVEAVARGCHHARDFLYLGRGSCYPVA
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEE
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEQMPVVVLAPRNAHYEKTISNMEEVIAR
ECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHC
GGRVIAVATEGDDTLVAKAEIMLEIPEAPPELLPILATVPLQLLAYHVAVLRGNDVDQPR
CCEEEEEEECCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA