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The map label for this gene is mutM

Identifier: 78222421

GI number: 78222421

Start: 1352332

End: 1353135

Strand: Reverse

Name: mutM

Synonym: Gmet_1206

Alternate gene names: 78222421

Gene position: 1353135-1352332 (Counterclockwise)

Preceding gene: 78222422

Following gene: 78222420

Centisome position: 33.85

GC content: 66.92

Gene sequence:

>804_bases
GTGCCTGAACTCCCCGAGGTAGAACTGACCCGCCGCAGGCTGGAGCGGGAACTGACCGGCAAGAGGATCGACCGAGTGGT
GGTGCGGACGCCGAAGCTCCGTTTTCCGATCCCCCAGGAGCTGCACGTTTCCCTGCCGGGGCGGACGGTGCGATCCGTGG
GACGACGGGGCAAGTACCTGCTGTTTGACTGTGAAACGGGGTGGCTCATCGTCCATCTGGGGATGACCGGCTTTCTCCGT
CTGGTTGCCGGGACGGCGCCCCCGGGCAAACACGACCACCTGGACATCGTCTTTGCCGATGGCACGGTGCTCCGTTTCCA
CGACCCGCGAAAGTTCGGCACCGTGGCCTGGACCACGGATGCCCCCGCAACGCATCCGCTCCTGGCCGCAATCGGCCCGG
AACCGCTGACCGCCACCTTTGACGGCGCCTATCTCTTCGCGGTGACCCGGACGCGCCGGGTCGCGGTGAAACAGCTCCTC
ATGAACGCGGCCATTGTTGCCGGAGTCGGCAACATCTACGCCAACGAGGCCCTGTTCCGCGCCGGCATCCGTCCCGACCG
GCCCGCTTCCTCCCTCGGCCGCCCTGAATGCGAGCGGCTGGCCCGCACCGTCCGGGAGGTGCTGCAGGAGTCCATTGATC
AGGGGAGCACCTACCGGGTGGAGGAAGAGACGGTCGCCTACCATCCGCTGAATTTCGATGTTTATGGGCGGGGCACTGAC
GCCTGCACCCGCTGCGGCGGGGCGCTGGAGGAGATCCGGCTCGGCAACCGGAGCACGGTCTTCTGCCCCCGCTGTCAAAC
GTGA

Upstream 100 bases:

>100_bases
GATATGTTTTGACAAGATCCAACTTGCGGCGGCAGCAGGCAGGCTGCTGCGCCTTTTGACGTTGGCAAACCATGAGCAAT
CACCCCACTGGAGAATTACC

Downstream 100 bases:

>100_bases
CCGGGCCTATGATTTCGGAGACTTCATGCTTATGAAGAAAAAAGGAGTTTTATGCTTGGCTCTCTAACCCTCATTCTCAT
CTGCCAGCTGATCGGAGAGA

Product: DNA-(apurinic or apyrimidinic site) lyase/formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MPELPEVELTRRRLERELTGKRIDRVVVRTPKLRFPIPQELHVSLPGRTVRSVGRRGKYLLFDCETGWLIVHLGMTGFLR
LVAGTAPPGKHDHLDIVFADGTVLRFHDPRKFGTVAWTTDAPATHPLLAAIGPEPLTATFDGAYLFAVTRTRRVAVKQLL
MNAAIVAGVGNIYANEALFRAGIRPDRPASSLGRPECERLARTVREVLQESIDQGSTYRVEEETVAYHPLNFDVYGRGTD
ACTRCGGALEEIRLGNRSTVFCPRCQT

Sequences:

>Translated_267_residues
MPELPEVELTRRRLERELTGKRIDRVVVRTPKLRFPIPQELHVSLPGRTVRSVGRRGKYLLFDCETGWLIVHLGMTGFLR
LVAGTAPPGKHDHLDIVFADGTVLRFHDPRKFGTVAWTTDAPATHPLLAAIGPEPLTATFDGAYLFAVTRTRRVAVKQLL
MNAAIVAGVGNIYANEALFRAGIRPDRPASSLGRPECERLARTVREVLQESIDQGSTYRVEEETVAYHPLNFDVYGRGTD
ACTRCGGALEEIRLGNRSTVFCPRCQT
>Mature_266_residues
PELPEVELTRRRLERELTGKRIDRVVVRTPKLRFPIPQELHVSLPGRTVRSVGRRGKYLLFDCETGWLIVHLGMTGFLRL
VAGTAPPGKHDHLDIVFADGTVLRFHDPRKFGTVAWTTDAPATHPLLAAIGPEPLTATFDGAYLFAVTRTRRVAVKQLLM
NAAIVAGVGNIYANEALFRAGIRPDRPASSLGRPECERLARTVREVLQESIDQGSTYRVEEETVAYHPLNFDVYGRGTDA
CTRCGGALEEIRLGNRSTVFCPRCQT

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=270, Percent_Identity=45.1851851851852, Blast_Score=237, Evalue=7e-64,
Organism=Escherichia coli, GI1786932, Length=272, Percent_Identity=27.2058823529412, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_GEOMG (Q39WD1)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384168.1
- ProteinModelPortal:   Q39WD1
- SMR:   Q39WD1
- STRING:   Q39WD1
- GeneID:   3738746
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1206
- NMPDR:   fig|269799.3.peg.1773
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RYAKMIG
- PhylomeDB:   Q39WD1
- ProtClustDB:   CLSK770481
- BioCyc:   GMET269799:GMET_1206-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 29699; Mature: 29567

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 257-257 BINDING 91-91 BINDING 110-110 BINDING 152-152

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVELTRRRLERELTGKRIDRVVVRTPKLRFPIPQELHVSLPGRTVRSVGRRGKYL
CCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHEEEECCCHHHHHHCCCCCEE
LFDCETGWLIVHLGMTGFLRLVAGTAPPGKHDHLDIVFADGTVLRFHDPRKFGTVAWTTD
EEECCCCEEEEEECHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEEECCCCCCCEEEECC
APATHPLLAAIGPEPLTATFDGAYLFAVTRTRRVAVKQLLMNAAIVAGVGNIYANEALFR
CCCCCCEEEECCCCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AGIRPDRPASSLGRPECERLARTVREVLQESIDQGSTYRVEEETVAYHPLNFDVYGRGTD
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCEEEEECCCH
ACTRCGGALEEIRLGNRSTVFCPRCQT
HHHHHCCCHHHHHCCCCCEEECCCCCC
>Mature Secondary Structure 
PELPEVELTRRRLERELTGKRIDRVVVRTPKLRFPIPQELHVSLPGRTVRSVGRRGKYL
CCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHEEEECCCHHHHHHCCCCCEE
LFDCETGWLIVHLGMTGFLRLVAGTAPPGKHDHLDIVFADGTVLRFHDPRKFGTVAWTTD
EEECCCCEEEEEECHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEEECCCCCCCEEEECC
APATHPLLAAIGPEPLTATFDGAYLFAVTRTRRVAVKQLLMNAAIVAGVGNIYANEALFR
CCCCCCEEEECCCCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AGIRPDRPASSLGRPECERLARTVREVLQESIDQGSTYRVEEETVAYHPLNFDVYGRGTD
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCEEEEECCCH
ACTRCGGALEEIRLGNRSTVFCPRCQT
HHHHHCCCHHHHHCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA