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The map label for this gene is atoC [H]

Identifier: 78222300

GI number: 78222300

Start: 1204135

End: 1205553

Strand: Reverse

Name: atoC [H]

Synonym: Gmet_1082

Alternate gene names: 78222300

Gene position: 1205553-1204135 (Counterclockwise)

Preceding gene: 78222301

Following gene: 78222299

Centisome position: 30.16

GC content: 62.16

Gene sequence:

>1419_bases
ATGCCTGATCAACAGACTTTTCCCATCCTGGTGGTGGACGATGAGGAGGAAATCCTCTTCACCACCAGCATCACGTTGCG
GAGCGCCGGCTTTCCCCCGGTGCTGACGGAAAGCGACAGCCGCAACGTCATGGGAATCCTTGCCCGACAGGAGGTGGCCC
TCGTTCTCCTGGACCTCTACATGCCGCACCTGCCGGGATACGAGCTCCTGAAGGAGATCACCGCGAACCATCCTGAGATC
CCGGTCATCGTGGTCACGGCCGCAAACGAGGTGGGAATGGCCGTGGAGTGCATGAAAGCAGGTGCGTTCGACTATTTCGT
CAAGCCGATGGAACCGCCGCGGCTCCTGGCAACAGTCAGGAGAGCGCTGGAGATGCACTCGCTCCGCTCCCAGGTGAATT
CCCTGAGCAGCCACATCCTCACCGGCGGGCTCGACAACGAAGAAGCTTTCGCCCCGATCATCACCCGCAGTCGAAAGATG
CACTCCATCTTCCAGTATCTGGAGGCGATTGCCCCCAGTAACCAGCCCCTTCTGATTACCGGCGAGACGGGGGTCGGCAA
GGAGCTTATCGCCCGTACCGTTCACAACATCAGCGGCTGTAGGGGTCCCTTCGTGGCGGTCAACATCGCCGGCCTTGACG
ACATGGTCTTCTCCGACACCCTGTTCGGCCACCTCAAGGGGGCATTCACCGGTGCCGACCGGCAGCGGGAGGGTCTCATA
GCCAAGGCAGCGGGCGGCACCCTCTTCCTCGACGAGATCGGCGACCTGCAGCCGTCATCCCAGGTGAAGCTGCTCAGACT
CCTCCAGGAGCAGGAATACTACCCCCTGGGTGCGGACACGCCGGTCCACGCCGCCGCCCGGGTTGTCGTCGCCACGAACC
GGGACCTGAAAGCGATAATGGCGGACGGAAGCTTCCGGAAAGACCTCTACTACCGCCTGAGCGCCCATCAGGTTCTGATC
CCCCCCCTGCGCGACCGGCGGGAGGATATCCCACTCCTGGTGGATCACTTCTTCGATGAGGCCGCGGCCTCCCTCTCCCG
GCAGAAACCGACGATCCCTCCGGAACTCGCCTGTTACCTCGGCACCTACGCGTTTCCGGGCAACATTCGAGAGTTGCGGG
CCATGGTTTTCGACGCCATGGCCCGCCATGAAAAAGGGGTGCTTTCCCTGGCCGGCTTCAGAGAGGTGATCGGCAATCCT
CGCTCCCCGGCTGAAACATCTCCCCTTCCCTTCATTGAAGGACTGAGGGAAGAGTCCGGCAATGCCGGCCGCATGCCGAC
CCTGAAGGAGGCGGAGGATGCCCTTATCGCCCATGCCCTGAGCATCGCCAACGGCAACCAGGGGATAGCCTCGGCCCATC
TGGGGATAACCCGCCAGGCCCTCAACAAGCGCCTCAACAGAAAAACCGCCGACGAATAA

Upstream 100 bases:

>100_bases
AGAGAACACGACGGCACGCTGACATTCGAATCGACTCCCGGCAAGGGAACCACCGCCACGGTAACCCTGCCGCTCGCCTA
TCCCGCCGGAGAACGAAACC

Downstream 100 bases:

>100_bases
CCCCTGCGCCATTTGTTGCACCGGCAACCAATGGCGCATATCCCCCGGAAACCCGCGCCAACCGCCTATTTCCCCAACAA
TCACCCCGCCAGCTGCAACT

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MPDQQTFPILVVDDEEEILFTTSITLRSAGFPPVLTESDSRNVMGILARQEVALVLLDLYMPHLPGYELLKEITANHPEI
PVIVVTAANEVGMAVECMKAGAFDYFVKPMEPPRLLATVRRALEMHSLRSQVNSLSSHILTGGLDNEEAFAPIITRSRKM
HSIFQYLEAIAPSNQPLLITGETGVGKELIARTVHNISGCRGPFVAVNIAGLDDMVFSDTLFGHLKGAFTGADRQREGLI
AKAAGGTLFLDEIGDLQPSSQVKLLRLLQEQEYYPLGADTPVHAAARVVVATNRDLKAIMADGSFRKDLYYRLSAHQVLI
PPLRDRREDIPLLVDHFFDEAAASLSRQKPTIPPELACYLGTYAFPGNIRELRAMVFDAMARHEKGVLSLAGFREVIGNP
RSPAETSPLPFIEGLREESGNAGRMPTLKEAEDALIAHALSIANGNQGIASAHLGITRQALNKRLNRKTADE

Sequences:

>Translated_472_residues
MPDQQTFPILVVDDEEEILFTTSITLRSAGFPPVLTESDSRNVMGILARQEVALVLLDLYMPHLPGYELLKEITANHPEI
PVIVVTAANEVGMAVECMKAGAFDYFVKPMEPPRLLATVRRALEMHSLRSQVNSLSSHILTGGLDNEEAFAPIITRSRKM
HSIFQYLEAIAPSNQPLLITGETGVGKELIARTVHNISGCRGPFVAVNIAGLDDMVFSDTLFGHLKGAFTGADRQREGLI
AKAAGGTLFLDEIGDLQPSSQVKLLRLLQEQEYYPLGADTPVHAAARVVVATNRDLKAIMADGSFRKDLYYRLSAHQVLI
PPLRDRREDIPLLVDHFFDEAAASLSRQKPTIPPELACYLGTYAFPGNIRELRAMVFDAMARHEKGVLSLAGFREVIGNP
RSPAETSPLPFIEGLREESGNAGRMPTLKEAEDALIAHALSIANGNQGIASAHLGITRQALNKRLNRKTADE
>Mature_471_residues
PDQQTFPILVVDDEEEILFTTSITLRSAGFPPVLTESDSRNVMGILARQEVALVLLDLYMPHLPGYELLKEITANHPEIP
VIVVTAANEVGMAVECMKAGAFDYFVKPMEPPRLLATVRRALEMHSLRSQVNSLSSHILTGGLDNEEAFAPIITRSRKMH
SIFQYLEAIAPSNQPLLITGETGVGKELIARTVHNISGCRGPFVAVNIAGLDDMVFSDTLFGHLKGAFTGADRQREGLIA
KAAGGTLFLDEIGDLQPSSQVKLLRLLQEQEYYPLGADTPVHAAARVVVATNRDLKAIMADGSFRKDLYYRLSAHQVLIP
PLRDRREDIPLLVDHFFDEAAASLSRQKPTIPPELACYLGTYAFPGNIRELRAMVFDAMARHEKGVLSLAGFREVIGNPR
SPAETSPLPFIEGLREESGNAGRMPTLKEAEDALIAHALSIANGNQGIASAHLGITRQALNKRLNRKTADE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=479, Percent_Identity=36.3256784968685, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1790437, Length=463, Percent_Identity=37.7969762419007, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=34.2553191489362, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1788905, Length=468, Percent_Identity=34.8290598290598, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789087, Length=351, Percent_Identity=38.7464387464387, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI87082117, Length=241, Percent_Identity=44.3983402489627, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1789233, Length=233, Percent_Identity=40.7725321888412, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI87082152, Length=229, Percent_Identity=40.6113537117904, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI87081872, Length=311, Percent_Identity=35.6913183279743, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1786524, Length=420, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1787583, Length=235, Percent_Identity=36.5957446808511, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789828, Length=235, Percent_Identity=39.1489361702128, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI87081858, Length=302, Percent_Identity=28.1456953642384, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51670; Mature: 51539

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDQQTFPILVVDDEEEILFTTSITLRSAGFPPVLTESDSRNVMGILARQEVALVLLDLY
CCCCCCCCEEEECCCCCEEEEEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHH
MPHLPGYELLKEITANHPEIPVIVVTAANEVGMAVECMKAGAFDYFVKPMEPPRLLATVR
HCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHH
RALEMHSLRSQVNSLSSHILTGGLDNEEAFAPIITRSRKMHSIFQYLEAIAPSNQPLLIT
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GETGVGKELIARTVHNISGCRGPFVAVNIAGLDDMVFSDTLFGHLKGAFTGADRQREGLI
CCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHCCCE
AKAAGGTLFLDEIGDLQPSSQVKLLRLLQEQEYYPLGADTPVHAAARVVVATNRDLKAIM
EEECCCEEEECHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEEEECCCCEEEE
ADGSFRKDLYYRLSAHQVLIPPLRDRREDIPLLVDHFFDEAAASLSRQKPTIPPELACYL
CCCCHHHHHHEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
GTYAFPGNIRELRAMVFDAMARHEKGVLSLAGFREVIGNPRSPAETSPLPFIEGLREESG
HCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCC
NAGRMPTLKEAEDALIAHALSIANGNQGIASAHLGITRQALNKRLNRKTADE
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PDQQTFPILVVDDEEEILFTTSITLRSAGFPPVLTESDSRNVMGILARQEVALVLLDLY
CCCCCCCEEEECCCCCEEEEEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHH
MPHLPGYELLKEITANHPEIPVIVVTAANEVGMAVECMKAGAFDYFVKPMEPPRLLATVR
HCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHH
RALEMHSLRSQVNSLSSHILTGGLDNEEAFAPIITRSRKMHSIFQYLEAIAPSNQPLLIT
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GETGVGKELIARTVHNISGCRGPFVAVNIAGLDDMVFSDTLFGHLKGAFTGADRQREGLI
CCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHCCCE
AKAAGGTLFLDEIGDLQPSSQVKLLRLLQEQEYYPLGADTPVHAAARVVVATNRDLKAIM
EEECCCEEEECHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEEEECCCCEEEE
ADGSFRKDLYYRLSAHQVLIPPLRDRREDIPLLVDHFFDEAAASLSRQKPTIPPELACYL
CCCCHHHHHHEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
GTYAFPGNIRELRAMVFDAMARHEKGVLSLAGFREVIGNPRSPAETSPLPFIEGLREESG
HCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCC
NAGRMPTLKEAEDALIAHALSIANGNQGIASAHLGITRQALNKRLNRKTADE
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]