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The map label for this gene is czcR [H]

Identifier: 78222245

GI number: 78222245

Start: 1141939

End: 1142613

Strand: Direct

Name: czcR [H]

Synonym: Gmet_1026

Alternate gene names: 78222245

Gene position: 1141939-1142613 (Clockwise)

Preceding gene: 78222244

Following gene: 78222246

Centisome position: 28.57

GC content: 56.44

Gene sequence:

>675_bases
ATGAAAATCCTCATTATCGAAGACGAAAAGAGAATGGCCGGGATTCTGAAAAAGGGGCTCGAGGAAAACGCCTTCATCGT
CGACCTGGCCGGCGACGGTGAAGAAGGGTTGTACATGGCCGAGAACTATCCCTACGACGCGGTACTGCTCGACATCATGC
TCCCGGTCATGGACGGCCTCTCGATCCTGAGCGCGTTGCGGTCGAAGAGAAGCGAGGTACCGGTCCTCCTGATCACCGCC
CGGGGGGAGATCGAGAGCAGAATAAAGGGGCTCAATTTCGGAGCGGATGACTATATCGTGAAGCCCTTTGACTTTCATGA
ACTCCTGGCGCGGCTGAAATCGGTGATCCGGAGGAGCAAGGGGAGACCTTCACCCCTTGTTGCAATCGACGACCTATCAC
TGGACACGAACTCCCGGAGCGTATGCCGCGGCGGGAGAGAGATCCGCCTGTCCGCTACCGAATACAATCTCCTTGAATAC
CTGGCGCTGAACAGCGGCAGGGTAATCAGCAGGACTGAACTTACGGAGCATATCTACGACACGGACTTCGACCGCGACAG
CAACGTCATCGACGTCTATGTGAACCACCTGCGAAACAAGCTGGATAAGGGCTTTGACCGACAGCTCATCCACACGGTGC
GGGGCGCGGGCTACATCCTGAAAGGCGATGCATGA

Upstream 100 bases:

>100_bases
GATAGGCACTGAGTCGGGGCGGGGTCTTCCCTGCCCCGGCAACGGTTCCCTCTGGTAGAATGAAAGGAAGTCATGACCTC
TGGCCTAACGGTGGCGCGAG

Downstream 100 bases:

>100_bases
GAGGGATGCCGAACTCCATACAAGGAAGGCTCTTCCTCTCGATTGTCACGTTTACGTCTCTGTTGTTCATCGCGGTCGGC
GTCTTCATCTACCGCGAGGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKILIIEDEKRMAGILKKGLEENAFIVDLAGDGEEGLYMAENYPYDAVLLDIMLPVMDGLSILSALRSKRSEVPVLLITA
RGEIESRIKGLNFGADDYIVKPFDFHELLARLKSVIRRSKGRPSPLVAIDDLSLDTNSRSVCRGGREIRLSATEYNLLEY
LALNSGRVISRTELTEHIYDTDFDRDSNVIDVYVNHLRNKLDKGFDRQLIHTVRGAGYILKGDA

Sequences:

>Translated_224_residues
MKILIIEDEKRMAGILKKGLEENAFIVDLAGDGEEGLYMAENYPYDAVLLDIMLPVMDGLSILSALRSKRSEVPVLLITA
RGEIESRIKGLNFGADDYIVKPFDFHELLARLKSVIRRSKGRPSPLVAIDDLSLDTNSRSVCRGGREIRLSATEYNLLEY
LALNSGRVISRTELTEHIYDTDFDRDSNVIDVYVNHLRNKLDKGFDRQLIHTVRGAGYILKGDA
>Mature_224_residues
MKILIIEDEKRMAGILKKGLEENAFIVDLAGDGEEGLYMAENYPYDAVLLDIMLPVMDGLSILSALRSKRSEVPVLLITA
RGEIESRIKGLNFGADDYIVKPFDFHELLARLKSVIRRSKGRPSPLVAIDDLSLDTNSRSVCRGGREIRLSATEYNLLEY
LALNSGRVISRTELTEHIYDTDFDRDSNVIDVYVNHLRNKLDKGFDRQLIHTVRGAGYILKGDA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=46.3963963963964, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=43.1192660550459, Blast_Score=182, Evalue=1e-47,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=41.3636363636364, Blast_Score=161, Evalue=3e-41,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=37.10407239819, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=33.0316742081448, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=38.3928571428571, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=35.9090909090909, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=34.051724137931, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=36.3636363636364, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=33.0434782608696, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=32.7354260089686, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=30.8695652173913, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=30.3030303030303, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=37.3831775700935, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=29.535864978903, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=31.6239316239316, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=26.0162601626016, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=31.6831683168317, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=112, Percent_Identity=32.1428571428571, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25200; Mature: 25200

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIIEDEKRMAGILKKGLEENAFIVDLAGDGEEGLYMAENYPYDAVLLDIMLPVMDGL
CEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
SILSALRSKRSEVPVLLITARGEIESRIKGLNFGADDYIVKPFDFHELLARLKSVIRRSK
HHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCC
GRPSPLVAIDDLSLDTNSRSVCRGGREIRLSATEYNLLEYLALNSGRVISRTELTEHIYD
CCCCCEEEEECCCCCCCCHHHHCCCCEEEEECHHHHHHHHHHCCCCCEEEHHHHHHHHHC
TDFDRDSNVIDVYVNHLRNKLDKGFDRQLIHTVRGAGYILKGDA
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCC
>Mature Secondary Structure
MKILIIEDEKRMAGILKKGLEENAFIVDLAGDGEEGLYMAENYPYDAVLLDIMLPVMDGL
CEEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
SILSALRSKRSEVPVLLITARGEIESRIKGLNFGADDYIVKPFDFHELLARLKSVIRRSK
HHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCC
GRPSPLVAIDDLSLDTNSRSVCRGGREIRLSATEYNLLEYLALNSGRVISRTELTEHIYD
CCCCCEEEEECCCCCCCCHHHHCCCCEEEEECHHHHHHHHHHCCCCCEEEHHHHHHHHHC
TDFDRDSNVIDVYVNHLRNKLDKGFDRQLIHTVRGAGYILKGDA
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]