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The map label for this gene is prsA [H]

Identifier: 78222152

GI number: 78222152

Start: 1028524

End: 1029516

Strand: Direct

Name: prsA [H]

Synonym: Gmet_0932

Alternate gene names: 78222152

Gene position: 1028524-1029516 (Clockwise)

Preceding gene: 78222151

Following gene: 78222153

Centisome position: 25.73

GC content: 51.26

Gene sequence:

>993_bases
ATGAGATTAAATCGTTCGCTAACATTTGGATTATTCCTTTTGGGAGTGATGTTCACTCTTCATCTGCTTCAGACGCCTGT
CTCCGCGGATGAGGTGAATAAAACCGGGAAAGTAGTAGCCCGGGTCAATGGGGTTCCGATCTACGAGAATGCTTTGCAGT
CGCACCTTGCCGCATTGGCTAATAAGGGAAGAGCTTCCGGATTCGCGCGTGATCCAGCAAAGATGAACGACTACCAAAAG
AAAAAAGCACTCTATTCCCTCATTGATGCAGAACTGCTTCGCCAGGCAAGCAACCAGCAGCAAGTTACCGACCTTGACGC
CAAGGTGAGCAAGCGGTTACAGGAAGTTAAAGGGAAGTTTCCCGACGAAGAGGCGTTTCTCAAAAATCTCCAGGCCAGAG
GGAAGACCCTCGACATCTTTGTGGCTGAACTTCGGGACGGGATTCGCTACGACGAATATCTTACGAGCAAGAAGGTCATT
GGCGTTCCGGTTCCCGATGAGGAGATCCAGAAGTTCTACCGCGACAATCCGACGAGCTTCAGTGTTCCGGAGCAGATCAA
GGTCAGACATATTCTGATCGAGCCCGATGGTAGCACCGCTGAGGCTGTTGCCAAGGCCGAAAAGAAGGCCGGTGAAATCC
GTAATCGGGTTGTCAGGGATAAGGACTTTGCCGCAGTTGCCAAGGAGGTATCGGCGTGCTCCACCGCTTCGTCCGGTGGG
GATCTGGGCTATGTTTCGCGAGGAACCATGCCCGCTGAGTTCGATAAGGTCGCCTTTTCACTCAAGCTCAATGAGGTGAG
CGAACCGGTCAGGACTAAATTTGGTTTCCACATTATGGAAGTTTTGGATAAAAAGCCGGTGACGGTACGGCCGTACTCGG
AAGTTCGAGAGTTCATTTCCCGCTACCTGCAACGTTTCGACGATGAAAAACGTTTGAATGCACACACGCTGGAGTTGCGG
AAGAAAGCAACCATCGAGGTTCTGCTCGATTGA

Upstream 100 bases:

>100_bases
TCAAACGACGCTTGTTTTTACCCCGTCCGGTGACATTGGTTCCTCAGCTGACATCACCATCACGAAACTCGCCCGGTAAC
GGGTGACGCATAGAGGAAAA

Downstream 100 bases:

>100_bases
AAGGGTGTGCGGAACGCAGTACGGCACTAAACAAAGTCAGTCGTCTATAGTCGTATTTTTGTTCAAGCTTTTATTAGGAA
TTGAAAGGGAGAAGGTACTC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRLNRSLTFGLFLLGVMFTLHLLQTPVSADEVNKTGKVVARVNGVPIYENALQSHLAALANKGRASGFARDPAKMNDYQK
KKALYSLIDAELLRQASNQQQVTDLDAKVSKRLQEVKGKFPDEEAFLKNLQARGKTLDIFVAELRDGIRYDEYLTSKKVI
GVPVPDEEIQKFYRDNPTSFSVPEQIKVRHILIEPDGSTAEAVAKAEKKAGEIRNRVVRDKDFAAVAKEVSACSTASSGG
DLGYVSRGTMPAEFDKVAFSLKLNEVSEPVRTKFGFHIMEVLDKKPVTVRPYSEVREFISRYLQRFDDEKRLNAHTLELR
KKATIEVLLD

Sequences:

>Translated_330_residues
MRLNRSLTFGLFLLGVMFTLHLLQTPVSADEVNKTGKVVARVNGVPIYENALQSHLAALANKGRASGFARDPAKMNDYQK
KKALYSLIDAELLRQASNQQQVTDLDAKVSKRLQEVKGKFPDEEAFLKNLQARGKTLDIFVAELRDGIRYDEYLTSKKVI
GVPVPDEEIQKFYRDNPTSFSVPEQIKVRHILIEPDGSTAEAVAKAEKKAGEIRNRVVRDKDFAAVAKEVSACSTASSGG
DLGYVSRGTMPAEFDKVAFSLKLNEVSEPVRTKFGFHIMEVLDKKPVTVRPYSEVREFISRYLQRFDDEKRLNAHTLELR
KKATIEVLLD
>Mature_330_residues
MRLNRSLTFGLFLLGVMFTLHLLQTPVSADEVNKTGKVVARVNGVPIYENALQSHLAALANKGRASGFARDPAKMNDYQK
KKALYSLIDAELLRQASNQQQVTDLDAKVSKRLQEVKGKFPDEEAFLKNLQARGKTLDIFVAELRDGIRYDEYLTSKKVI
GVPVPDEEIQKFYRDNPTSFSVPEQIKVRHILIEPDGSTAEAVAKAEKKAGEIRNRVVRDKDFAAVAKEVSACSTASSGG
DLGYVSRGTMPAEFDKVAFSLKLNEVSEPVRTKFGFHIMEVLDKKPVTVRPYSEVREFISRYLQRFDDEKRLNAHTLELR
KKATIEVLLD

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=154, Percent_Identity=29.8701298701299, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790211, Length=80, Percent_Identity=40, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322478, Length=127, Percent_Identity=32.2834645669291, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 37078; Mature: 37078

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNRSLTFGLFLLGVMFTLHLLQTPVSADEVNKTGKVVARVNGVPIYENALQSHLAALA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
NKGRASGFARDPAKMNDYQKKKALYSLIDAELLRQASNQQQVTDLDAKVSKRLQEVKGKF
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
PDEEAFLKNLQARGKTLDIFVAELRDGIRYDEYLTSKKVIGVPVPDEEIQKFYRDNPTSF
CCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHCCCCEEECCCCHHHHHHHHCCCCCCC
SVPEQIKVRHILIEPDGSTAEAVAKAEKKAGEIRNRVVRDKDFAAVAKEVSACSTASSGG
CCCHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
DLGYVSRGTMPAEFDKVAFSLKLNEVSEPVRTKFGFHIMEVLDKKPVTVRPYSEVREFIS
CCCCCCCCCCCHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHH
RYLQRFDDEKRLNAHTLELRKKATIEVLLD
HHHHHCCCHHHCCHHHHHHHHHCCEEEEEC
>Mature Secondary Structure
MRLNRSLTFGLFLLGVMFTLHLLQTPVSADEVNKTGKVVARVNGVPIYENALQSHLAALA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
NKGRASGFARDPAKMNDYQKKKALYSLIDAELLRQASNQQQVTDLDAKVSKRLQEVKGKF
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
PDEEAFLKNLQARGKTLDIFVAELRDGIRYDEYLTSKKVIGVPVPDEEIQKFYRDNPTSF
CCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHCCCCEEECCCCHHHHHHHHCCCCCCC
SVPEQIKVRHILIEPDGSTAEAVAKAEKKAGEIRNRVVRDKDFAAVAKEVSACSTASSGG
CCCHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
DLGYVSRGTMPAEFDKVAFSLKLNEVSEPVRTKFGFHIMEVLDKKPVTVRPYSEVREFIS
CCCCCCCCCCCHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHH
RYLQRFDDEKRLNAHTLELRKKATIEVLLD
HHHHHCCCHHHCCHHHHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]