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The map label for this gene is iscS [H]

Identifier: 78222092

GI number: 78222092

Start: 960680

End: 961822

Strand: Direct

Name: iscS [H]

Synonym: Gmet_0872

Alternate gene names: 78222092

Gene position: 960680-961822 (Clockwise)

Preceding gene: 78222091

Following gene: 78222093

Centisome position: 24.03

GC content: 65.62

Gene sequence:

>1143_bases
ATGATGATCTATCTGGACCACAATGCGACAACGCCGGTCCACCCTGATGTGGTGGAGGCGTTGTTGCCGTTTCTGCAGGG
GAAGTTCGGCAACCCGTCCAGCATCCACTGGGCCGGTCGGGCCGTGAAGGGGGCGGTGGAGGAGGCCCGGGAACAGGTGT
CGGCGCTCGTGGGATGCGAGCCGGGTGAGGTGGTGTTCACCTCGTCGGGAACCGAGGCCGACAACATGGCCATCAAGGGG
GTCGCTGCGGCCCTTGGGGGGCGCGGCAACCACATCGTCACCACCCAGGTGGAGCACCCAGGAGTGGCAAACCCCTGCCT
CTACCTGGAGAGTCTCGGTTTCGAGGTGACCCGCGTGACCGTGGACCGGGACGGCCTTCTGGACCTGGAGCGGCTGGAGG
CGGCCATCACCGACCGGACCATTCTCATCTCGGCCATGGCCGCCAACAACGAGACCGGCGTCCTCTTCCCGGTACGCGAG
ATCGGTGAGATTGCAGCGTGCCGCCGTGTCTATTTCCACTGCGACGGGGTCCAGGCGGCCGGCAGGATTCCACTCTCGGT
CCGGGATGACAGCATCTCGTTTCTGGCCCTCTCGGGGCACAAGCTCTATGCCCCGAAGGGGATAGGAGCCTTGGTGGTGC
GGCGCGGGGTGAAGTGCCACCCGCTGATCCATGGTGGCTCCCAGGAGCGCAACCGCCGCGGAGGGACCGAGAACGTGGCC
GGCATCGTGGCCTTTGGCAGGGCGTGCGCCATTGCCCGCGAAACCATGAATGGCGAAATGGGGCGGATTAAAGGATTGCG
CGACCGGTTGGAAGAGGGGATACTGTCACGGGTTTCCGGCGCCTGCGTGAACGGCCACCGGGAGCAGCGGCTCCCCACCA
CTACCAATATCACGATTCCCGGTGTGGAGGCCGATTCGCTCCTCATGGCACTGGACCTGGAGGGGATAGCTGCGTCATCG
GGCTCCGCGTGCAGTTCCGGCACCCTCAAGCTCTCGCCGGTCCTGGCCGCCATGGGACGCACTCCCGAGGAGGCCAAGGG
TTCGGTGCGGTTCTCGCTGGGGAAGGGGAATACCGTCGAGGAGATAGACCGGGTGCTGGCGGTTCTGCCGGCCATCGTTG
CCCGGTTGCGGGGAGAATCATGA

Upstream 100 bases:

>100_bases
AGAACCTTTCTCGATTCCATTACCCTGGAGGACCTGGTAATCGAGGCACGGGGGCGCGGAGGCGAGGAGTGAGGGCGGTA
TTGCCCGCATTTGAGACTGC

Downstream 100 bases:

>100_bases
CGGAAAAAGCGAGAAAACGGATTGTCGTCGCCATGAGCGGCGGGGTCGATTCGTCGGTGACGGCGGCGCTCCTGAAGGAG
GAGGGGCACGAGGTCATCGG

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MMIYLDHNATTPVHPDVVEALLPFLQGKFGNPSSIHWAGRAVKGAVEEAREQVSALVGCEPGEVVFTSSGTEADNMAIKG
VAAALGGRGNHIVTTQVEHPGVANPCLYLESLGFEVTRVTVDRDGLLDLERLEAAITDRTILISAMAANNETGVLFPVRE
IGEIAACRRVYFHCDGVQAAGRIPLSVRDDSISFLALSGHKLYAPKGIGALVVRRGVKCHPLIHGGSQERNRRGGTENVA
GIVAFGRACAIARETMNGEMGRIKGLRDRLEEGILSRVSGACVNGHREQRLPTTTNITIPGVEADSLLMALDLEGIAASS
GSACSSGTLKLSPVLAAMGRTPEEAKGSVRFSLGKGNTVEEIDRVLAVLPAIVARLRGES

Sequences:

>Translated_380_residues
MMIYLDHNATTPVHPDVVEALLPFLQGKFGNPSSIHWAGRAVKGAVEEAREQVSALVGCEPGEVVFTSSGTEADNMAIKG
VAAALGGRGNHIVTTQVEHPGVANPCLYLESLGFEVTRVTVDRDGLLDLERLEAAITDRTILISAMAANNETGVLFPVRE
IGEIAACRRVYFHCDGVQAAGRIPLSVRDDSISFLALSGHKLYAPKGIGALVVRRGVKCHPLIHGGSQERNRRGGTENVA
GIVAFGRACAIARETMNGEMGRIKGLRDRLEEGILSRVSGACVNGHREQRLPTTTNITIPGVEADSLLMALDLEGIAASS
GSACSSGTLKLSPVLAAMGRTPEEAKGSVRFSLGKGNTVEEIDRVLAVLPAIVARLRGES
>Mature_380_residues
MMIYLDHNATTPVHPDVVEALLPFLQGKFGNPSSIHWAGRAVKGAVEEAREQVSALVGCEPGEVVFTSSGTEADNMAIKG
VAAALGGRGNHIVTTQVEHPGVANPCLYLESLGFEVTRVTVDRDGLLDLERLEAAITDRTILISAMAANNETGVLFPVRE
IGEIAACRRVYFHCDGVQAAGRIPLSVRDDSISFLALSGHKLYAPKGIGALVVRRGVKCHPLIHGGSQERNRRGGTENVA
GIVAFGRACAIARETMNGEMGRIKGLRDRLEEGILSRVSGACVNGHREQRLPTTTNITIPGVEADSLLMALDLEGIAASS
GSACSSGTLKLSPVLAAMGRTPEEAKGSVRFSLGKGNTVEEIDRVLAVLPAIVARLRGES

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=378, Percent_Identity=43.9153439153439, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI156713448, Length=415, Percent_Identity=32.289156626506, Blast_Score=203, Evalue=2e-52,
Organism=Escherichia coli, GI48994898, Length=380, Percent_Identity=45.2631578947368, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1789175, Length=386, Percent_Identity=26.4248704663212, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=24.0694789081886, Blast_Score=78, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI25143064, Length=379, Percent_Identity=41.9525065963061, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17533177, Length=313, Percent_Identity=33.8658146964856, Blast_Score=150, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319831, Length=378, Percent_Identity=42.5925925925926, Blast_Score=292, Evalue=7e-80,
Organism=Drosophila melanogaster, GI20129463, Length=378, Percent_Identity=43.6507936507937, Blast_Score=298, Evalue=4e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 40141; Mature: 40141

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIYLDHNATTPVHPDVVEALLPFLQGKFGNPSSIHWAGRAVKGAVEEAREQVSALVGCE
CEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
PGEVVFTSSGTEADNMAIKGVAAALGGRGNHIVTTQVEHPGVANPCLYLESLGFEVTRVT
CCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCEEEEEE
VDRDGLLDLERLEAAITDRTILISAMAANNETGVLFPVREIGEIAACRRVYFHCDGVQAA
ECCCCCCCHHHHHHHHCCCEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHEEEECCCCCC
GRIPLSVRDDSISFLALSGHKLYAPKGIGALVVRRGVKCHPLIHGGSQERNRRGGTENVA
CCCCEEEECCCEEEEEECCCEEECCCCCHHHHHHCCCCEEEEEECCCHHHHCCCCCCHHH
GIVAFGRACAIARETMNGEMGRIKGLRDRLEEGILSRVSGACVNGHREQRLPTTTNITIP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCCCCCEEEEC
GVEADSLLMALDLEGIAASSGSACSSGTLKLSPVLAAMGRTPEEAKGSVRFSLGKGNTVE
CCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHCCCCHHCCCCEEEEECCCCCHH
EIDRVLAVLPAIVARLRGES
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMIYLDHNATTPVHPDVVEALLPFLQGKFGNPSSIHWAGRAVKGAVEEAREQVSALVGCE
CEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
PGEVVFTSSGTEADNMAIKGVAAALGGRGNHIVTTQVEHPGVANPCLYLESLGFEVTRVT
CCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCEEEEEE
VDRDGLLDLERLEAAITDRTILISAMAANNETGVLFPVREIGEIAACRRVYFHCDGVQAA
ECCCCCCCHHHHHHHHCCCEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHEEEECCCCCC
GRIPLSVRDDSISFLALSGHKLYAPKGIGALVVRRGVKCHPLIHGGSQERNRRGGTENVA
CCCCEEEECCCEEEEEECCCEEECCCCCHHHHHHCCCCEEEEEECCCHHHHCCCCCCHHH
GIVAFGRACAIARETMNGEMGRIKGLRDRLEEGILSRVSGACVNGHREQRLPTTTNITIP
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCCCCCEEEEC
GVEADSLLMALDLEGIAASSGSACSSGTLKLSPVLAAMGRTPEEAKGSVRFSLGKGNTVE
CCCCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHCCCCHHCCCCEEEEECCCCCHH
EIDRVLAVLPAIVARLRGES
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA