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The map label for this gene is ubiB [H]

Identifier: 78221980

GI number: 78221980

Start: 832155

End: 833840

Strand: Direct

Name: ubiB [H]

Synonym: Gmet_0760

Alternate gene names: 78221980

Gene position: 832155-833840 (Clockwise)

Preceding gene: 78221979

Following gene: 78221982

Centisome position: 20.82

GC content: 64.06

Gene sequence:

>1686_bases
ATGCTGACGTTCATCCAGCTCAACCGCAATATTCGGAGCCTGCGGCGCTACCGGCAGATTGTCCGCGTCCTCTTCAAGTT
CGGCTTCGACCATGCGCTGGAGCTCATGGGGCTCTCCCAGTTCGTGGCCCGGGGGCGCAAGCTCTTCCGCAGGCCGGCGT
CGGAGCTTGCTCTCCTCTCGCCTGCCGAGCGGATGCGCCTCTCTCTGGAGGAGTTGGGACCCACCTTTGTGAAGCTGGGG
CAGATCCTCTCCACCCGACCCGACGTCATTCCCCGCAGCTTCATCCTGGAATTCGCCAAGCTCCAGGATCAGGTGCCGTC
GTTCCCCTTCGAGGCGGTGGAGGACCAGATCCGCAAGCACCTGGGACGGGAGCCGTCCGAGTGCTATTCCTTTATCGACT
CCGAGCCCCTGGCCGCCGCCTCCATTGCCCAGGTCCACCGGGCCCGGCTCGTCTCCGGCGAGGATGTGGTCATCAAGGTC
CGCCGTCCCGGCGTCGTGGGGCTCGTGGAGACCGATGTGGACGCCATGATGGGGCTCGCGATGCTGGCCGAGCGGCACCT
CCCCGGCAGCGACCTCTACGATCCCGTGGGGCTCGTGAAGGAGTTTGCCCGCACCATCCGGCGAGAGATGGATTTCTCCC
GGGAGGCCCATACCATCGAGAAGTTCGCCGAGAACTTCGCCGGCGACCCCACCCTCCATTTCCCCACGGTCTACTGGGGC
CAGACCGCCGGCGGGGTCCTGACCATGGAGCACGTGGACGGGATCAAGGTCTCGGACACGGCGGCCCTGGATGCGGCGGG
GCTCGACCGCAAGCTCCTCGCCCGGCGGGGGGCCGATGCCTTCCTCAAGATGGTCCTCATCCACGGCTTCTTCCACGGCG
ACCCCCATCCGGGCAACGTCCTGATCCTCCCCAACAACGTCATCTGCCTCCTGGACTACGGCATGGTGGGGCGCCTCGAC
ACCCAGCTCAAGGGGTACCTGACCGACATCCTCCTGGCCATCGTGCAGCGTGATGTGGACGAGGTGATCTCGCTGCTGCT
CTACTCCGGGGACATTACCGACACCCTCGACACCCGGGCCCTGCGGCGGGACCTGTCGGGGCTCATCGACAGCTACTACG
AGGTGCCGCTCCAGCAGATCGAGGTGGGGCGGATGCTCCTTGAATTCCTGGAGGTGATCACCACCTACCACATCCGGTTC
CAGCCCGACCTGATGCTCCTGGCCAAGGCCCTGGTGGCCATCGAGGGGATGGGGCGGGAGCTGGACCCCGACTTCGACAT
GGTGGAGCACCTGCGTCCCTTCATGAAAAAGGCCCTGCGGGACCGGTTCTCGCCGGAACACCTCGTGCGCGAAATGGGCT
CGCACATCACCTCCTACGTGACCCTGTTCCGCAATCTTCCCAAGGATTTGAAGGAGTTCCTCAACCGGATCAATCGCAAC
AAATTCAAGATCGATCTGGAGCACCGGGGGCTCGACCGGGCCCTCAGGGACTTCGACAAGTCCATCAACCGCCTCTCCTC
CAGCCTCATCATCGCCGCCCTTATCGTCGGTTCATCCATCATCATGCAGACCGACAAGGGGCCGAAGATCTTCGAATTTC
CCATCTTCGCCTTCATGGGATACACCATCGCCGGCTTCATCGGCCTCTGGTGGGTCTTCGCCATCATCCGCTCCGGCAGG
CTGTAG

Upstream 100 bases:

>100_bases
AGCGGCTCGGCCTCGTCCCACGCGAAGAGTACGACCGTCTCGTGAAGCGGGTGGATGTCCTGGAGGCGAAGCTCTCCACC
TGCACCGAACCCGGCACTGA

Downstream 100 bases:

>100_bases
CTACATCCTTGCTGTTGCATTAATGCAACACTGGTCGTGGCGCCAGCACCACACCCGCAGCGCCGACGCCCCACTTTGAA
TGGTAACCTCTGTCCGCAAC

Product: 2-octaprenylphenol hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MLTFIQLNRNIRSLRRYRQIVRVLFKFGFDHALELMGLSQFVARGRKLFRRPASELALLSPAERMRLSLEELGPTFVKLG
QILSTRPDVIPRSFILEFAKLQDQVPSFPFEAVEDQIRKHLGREPSECYSFIDSEPLAAASIAQVHRARLVSGEDVVIKV
RRPGVVGLVETDVDAMMGLAMLAERHLPGSDLYDPVGLVKEFARTIRREMDFSREAHTIEKFAENFAGDPTLHFPTVYWG
QTAGGVLTMEHVDGIKVSDTAALDAAGLDRKLLARRGADAFLKMVLIHGFFHGDPHPGNVLILPNNVICLLDYGMVGRLD
TQLKGYLTDILLAIVQRDVDEVISLLLYSGDITDTLDTRALRRDLSGLIDSYYEVPLQQIEVGRMLLEFLEVITTYHIRF
QPDLMLLAKALVAIEGMGRELDPDFDMVEHLRPFMKKALRDRFSPEHLVREMGSHITSYVTLFRNLPKDLKEFLNRINRN
KFKIDLEHRGLDRALRDFDKSINRLSSSLIIAALIVGSSIIMQTDKGPKIFEFPIFAFMGYTIAGFIGLWWVFAIIRSGR
L

Sequences:

>Translated_561_residues
MLTFIQLNRNIRSLRRYRQIVRVLFKFGFDHALELMGLSQFVARGRKLFRRPASELALLSPAERMRLSLEELGPTFVKLG
QILSTRPDVIPRSFILEFAKLQDQVPSFPFEAVEDQIRKHLGREPSECYSFIDSEPLAAASIAQVHRARLVSGEDVVIKV
RRPGVVGLVETDVDAMMGLAMLAERHLPGSDLYDPVGLVKEFARTIRREMDFSREAHTIEKFAENFAGDPTLHFPTVYWG
QTAGGVLTMEHVDGIKVSDTAALDAAGLDRKLLARRGADAFLKMVLIHGFFHGDPHPGNVLILPNNVICLLDYGMVGRLD
TQLKGYLTDILLAIVQRDVDEVISLLLYSGDITDTLDTRALRRDLSGLIDSYYEVPLQQIEVGRMLLEFLEVITTYHIRF
QPDLMLLAKALVAIEGMGRELDPDFDMVEHLRPFMKKALRDRFSPEHLVREMGSHITSYVTLFRNLPKDLKEFLNRINRN
KFKIDLEHRGLDRALRDFDKSINRLSSSLIIAALIVGSSIIMQTDKGPKIFEFPIFAFMGYTIAGFIGLWWVFAIIRSGR
L
>Mature_561_residues
MLTFIQLNRNIRSLRRYRQIVRVLFKFGFDHALELMGLSQFVARGRKLFRRPASELALLSPAERMRLSLEELGPTFVKLG
QILSTRPDVIPRSFILEFAKLQDQVPSFPFEAVEDQIRKHLGREPSECYSFIDSEPLAAASIAQVHRARLVSGEDVVIKV
RRPGVVGLVETDVDAMMGLAMLAERHLPGSDLYDPVGLVKEFARTIRREMDFSREAHTIEKFAENFAGDPTLHFPTVYWG
QTAGGVLTMEHVDGIKVSDTAALDAAGLDRKLLARRGADAFLKMVLIHGFFHGDPHPGNVLILPNNVICLLDYGMVGRLD
TQLKGYLTDILLAIVQRDVDEVISLLLYSGDITDTLDTRALRRDLSGLIDSYYEVPLQQIEVGRMLLEFLEVITTYHIRF
QPDLMLLAKALVAIEGMGRELDPDFDMVEHLRPFMKKALRDRFSPEHLVREMGSHITSYVTLFRNLPKDLKEFLNRINRN
KFKIDLEHRGLDRALRDFDKSINRLSSSLIIAALIVGSSIIMQTDKGPKIFEFPIFAFMGYTIAGFIGLWWVFAIIRSGR
L

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=323, Percent_Identity=28.1733746130031, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=30.7407407407407, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI32261307, Length=335, Percent_Identity=24.7761194029851, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI217035081, Length=231, Percent_Identity=29.4372294372294, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI34147522, Length=289, Percent_Identity=26.9896193771626, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI27363457, Length=293, Percent_Identity=24.2320819112628, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI217416386, Length=233, Percent_Identity=24.4635193133047, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI2367309, Length=547, Percent_Identity=32.9067641681901, Blast_Score=259, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17559152, Length=338, Percent_Identity=29.8816568047337, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17555620, Length=475, Percent_Identity=23.7894736842105, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=242, Percent_Identity=28.099173553719, Blast_Score=92, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6325148, Length=437, Percent_Identity=22.6544622425629, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321319, Length=240, Percent_Identity=27.5, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323282, Length=243, Percent_Identity=25.9259259259259, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI22024280, Length=267, Percent_Identity=31.8352059925094, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24662575, Length=281, Percent_Identity=30.2491103202847, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI18859849, Length=266, Percent_Identity=31.9548872180451, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63696; Mature: 63696

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTFIQLNRNIRSLRRYRQIVRVLFKFGFDHALELMGLSQFVARGRKLFRRPASELALLS
CCEEEEECHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
PAERMRLSLEELGPTFVKLGQILSTRPDVIPRSFILEFAKLQDQVPSFPFEAVEDQIRKH
CHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LGREPSECYSFIDSEPLAAASIAQVHRARLVSGEDVVIKVRRPGVVGLVETDVDAMMGLA
HCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHH
MLAERHLPGSDLYDPVGLVKEFARTIRREMDFSREAHTIEKFAENFAGDPTLHFPTVYWG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEECCEEEEC
QTAGGVLTMEHVDGIKVSDTAALDAAGLDRKLLARRGADAFLKMVLIHGFFHGDPHPGNV
CCCCCEEEEECCCCCCCCCCHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEE
LILPNNVICLLDYGMVGRLDTQLKGYLTDILLAIVQRDVDEVISLLLYSGDITDTLDTRA
EEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRRDLSGLIDSYYEVPLQQIEVGRMLLEFLEVITTYHIRFQPDLMLLAKALVAIEGMGRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCC
LDPDFDMVEHLRPFMKKALRDRFSPEHLVREMGSHITSYVTLFRNLPKDLKEFLNRINRN
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
KFKIDLEHRGLDRALRDFDKSINRLSSSLIIAALIVGSSIIMQTDKGPKIFEFPIFAFMG
CEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCEEHHHHHHHHH
YTIAGFIGLWWVFAIIRSGRL
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTFIQLNRNIRSLRRYRQIVRVLFKFGFDHALELMGLSQFVARGRKLFRRPASELALLS
CCEEEEECHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
PAERMRLSLEELGPTFVKLGQILSTRPDVIPRSFILEFAKLQDQVPSFPFEAVEDQIRKH
CHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LGREPSECYSFIDSEPLAAASIAQVHRARLVSGEDVVIKVRRPGVVGLVETDVDAMMGLA
HCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHH
MLAERHLPGSDLYDPVGLVKEFARTIRREMDFSREAHTIEKFAENFAGDPTLHFPTVYWG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEECCEEEEC
QTAGGVLTMEHVDGIKVSDTAALDAAGLDRKLLARRGADAFLKMVLIHGFFHGDPHPGNV
CCCCCEEEEECCCCCCCCCCHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEE
LILPNNVICLLDYGMVGRLDTQLKGYLTDILLAIVQRDVDEVISLLLYSGDITDTLDTRA
EEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRRDLSGLIDSYYEVPLQQIEVGRMLLEFLEVITTYHIRFQPDLMLLAKALVAIEGMGRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCC
LDPDFDMVEHLRPFMKKALRDRFSPEHLVREMGSHITSYVTLFRNLPKDLKEFLNRINRN
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
KFKIDLEHRGLDRALRDFDKSINRLSSSLIIAALIVGSSIIMQTDKGPKIFEFPIFAFMG
CEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCEEHHHHHHHHH
YTIAGFIGLWWVFAIIRSGRL
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]