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The map label for this gene is czcR [H]

Identifier: 78221749

GI number: 78221749

Start: 567005

End: 567676

Strand: Reverse

Name: czcR [H]

Synonym: Gmet_0528

Alternate gene names: 78221749

Gene position: 567676-567005 (Counterclockwise)

Preceding gene: 78221750

Following gene: 78221748

Centisome position: 14.2

GC content: 65.48

Gene sequence:

>672_bases
ATGCGCATCCTGATCATAGAAGACGAGAAAAAGGCCGCCGCGTATCTTCAGAAAGGATTCACTGAGAACGGCTTTTCGGC
GGACACGGCCCAAAACGGCGAGGATGGTCTCCACCTGGCCCGTACCGAGGCCTACGACCTCGTCATCCTCGACATCATGC
TCCCCGGCCGGGATGGCTGGTCGGTGCTGGAAGAGCTGCGGCGCGGGGGGAGCGAGGTGCCGGTCATCTACCTGTCGGCC
CGGGACGCGGTCCAGGACCGGGTGCGAGGGCTGGAGCTGGGGGCCGACGACTACCTGGTGAAACCCTTCGCCTTTTCGGA
ACTGCTGGCCCGGGCCCGCAACATCCTCCGCCGGGGACCGGCACGGCAGCCGGAACGCCTGCGGGTCGACGATCTGGAAA
TGGACCTGGTGGGCCACAAGGCCTGGCGGGGAGGGACCCCCCTCGACCTCACCACCAAGGAGTTTCTCCTCCTGTCGCTC
CTGCTCCGCCGCAAGGGGGAGGTCCTCTCCCGAGCCCTCATCGCCGACCAGGTCTGGGGCATAAACTTCGACAGCGACAC
CAATATCGTCGACGTGGCAATCCGCCGCCTGCGGCGCAAGGTCGACGACCCCTTCGAGCGAAAGCTGATAAGTACCGTCC
GCGGAGCAGGCTATGTCCTCGACGGAGCGTGA

Upstream 100 bases:

>100_bases
TCGGGCGGCCTTTTTCATTTTCTCCCCAAGGGAAAGGGTTGCAGTCCCGAGGGGGGCCGCGCTACAATTCTCAGCGTTAC
CCTTGGGCTCCGGAGTTTCC

Downstream 100 bases:

>100_bases
AGTGACCCACCCGGGGGCTCTCTCCCTCACCGCACGGCTCACCATCCTCTCCACCCTGGCCACCACGTGTGTTCTCCTCT
TTGTCATCGTCTTCCAGTTT

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRILIIEDEKKAAAYLQKGFTENGFSADTAQNGEDGLHLARTEAYDLVILDIMLPGRDGWSVLEELRRGGSEVPVIYLSA
RDAVQDRVRGLELGADDYLVKPFAFSELLARARNILRRGPARQPERLRVDDLEMDLVGHKAWRGGTPLDLTTKEFLLLSL
LLRRKGEVLSRALIADQVWGINFDSDTNIVDVAIRRLRRKVDDPFERKLISTVRGAGYVLDGA

Sequences:

>Translated_223_residues
MRILIIEDEKKAAAYLQKGFTENGFSADTAQNGEDGLHLARTEAYDLVILDIMLPGRDGWSVLEELRRGGSEVPVIYLSA
RDAVQDRVRGLELGADDYLVKPFAFSELLARARNILRRGPARQPERLRVDDLEMDLVGHKAWRGGTPLDLTTKEFLLLSL
LLRRKGEVLSRALIADQVWGINFDSDTNIVDVAIRRLRRKVDDPFERKLISTVRGAGYVLDGA
>Mature_223_residues
MRILIIEDEKKAAAYLQKGFTENGFSADTAQNGEDGLHLARTEAYDLVILDIMLPGRDGWSVLEELRRGGSEVPVIYLSA
RDAVQDRVRGLELGADDYLVKPFAFSELLARARNILRRGPARQPERLRVDDLEMDLVGHKAWRGGTPLDLTTKEFLLLSL
LLRRKGEVLSRALIADQVWGINFDSDTNIVDVAIRRLRRKVDDPFERKLISTVRGAGYVLDGA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=58.1081081081081, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=55.5045871559633, Blast_Score=237, Evalue=4e-64,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=42.7272727272727, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=36.3636363636364, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=36.2068965517241, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=38.1165919282511, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=38.3561643835616, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=36.1607142857143, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=36.1607142857143, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=28.5067873303167, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=36.7965367965368, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=33.4801762114537, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=32.3275862068966, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=39.2523364485981, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1790437, Length=136, Percent_Identity=28.6764705882353, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=36.6336633663366, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=26.2773722627737, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25057; Mature: 25057

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIIEDEKKAAAYLQKGFTENGFSADTAQNGEDGLHLARTEAYDLVILDIMLPGRDGW
CEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCH
SVLEELRRGGSEVPVIYLSARDAVQDRVRGLELGADDYLVKPFAFSELLARARNILRRGP
HHHHHHHHCCCCCCEEEEECHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
ARQPERLRVDDLEMDLVGHKAWRGGTPLDLTTKEFLLLSLLLRRKGEVLSRALIADQVWG
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
INFDSDTNIVDVAIRRLRRKVDDPFERKLISTVRGAGYVLDGA
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MRILIIEDEKKAAAYLQKGFTENGFSADTAQNGEDGLHLARTEAYDLVILDIMLPGRDGW
CEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCH
SVLEELRRGGSEVPVIYLSARDAVQDRVRGLELGADDYLVKPFAFSELLARARNILRRGP
HHHHHHHHCCCCCCEEEEECHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
ARQPERLRVDDLEMDLVGHKAWRGGTPLDLTTKEFLLLSLLLRRKGEVLSRALIADQVWG
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
INFDSDTNIVDVAIRRLRRKVDDPFERKLISTVRGAGYVLDGA
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]