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The map label for this gene is folK [H]

Identifier: 78221716

GI number: 78221716

Start: 540263

End: 540769

Strand: Direct

Name: folK [H]

Synonym: Gmet_0495

Alternate gene names: 78221716

Gene position: 540263-540769 (Clockwise)

Preceding gene: 78221715

Following gene: 78221717

Centisome position: 13.52

GC content: 64.89

Gene sequence:

>507_bases
TTGTGCTCTAATCTACCGGTGAAATCGAACGTTTTCATAGCCCTCGGCTCGAACCAGGGGGATCGGGAACTGAACCTGCT
ACGGGCCGTGGCCGAGATCGGCAGGCTGGAGCAGACCCGCATCACGGCCCTTTCCGGCTTCTACGACACCGACCCCGTCG
GGCCGGTGGACCAGCCCAACTTCCTCAACGCTGCCCTCAGGCTCGAAACGGCCCTCTCGCCCCGCCAGTTGCTCGCGGAA
CTCCAGCGGATCGAAACCGACGTGTTCCGGAGGGTGCGGGACGTCCCGTGGGGACCGCGCTCCATGGACCTGGACATCCT
CCTCTACGGCGATCTCATCCTTGACGAAGAGGGGCTCGTCATCCCCCATCCCCGGCTCCACGAGCGGCGCTTCGTGCTGG
TTCCCCTGGCGGAGATCGCCCCTGACGTTCATCATCCCCTGCTTGGGAAGCGGGTGGATGAACTGCTCCGCTCGCTCCCT
CCCGGCGAGCGGGTGACCAGGATTTAG

Upstream 100 bases:

>100_bases
ACGGCAAGCTCGTCATGACCACCACGGGGGAGGAACTGCACTGAAAGGCCGGGACCGGGGTCCGGGAAAAGCGGTCAGGG
GCGTTGAAAAATAGGGCGCG

Downstream 100 bases:

>100_bases
GAGTTTGCCGATGCGGCTGATTATCATGCTCATCCTGTTTTATGTGGGCTTCAGGATCGTGCAGGGTTTTTTGAAAAAGA
AGCAGGAAGAGAAGCCGACG

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MCSNLPVKSNVFIALGSNQGDRELNLLRAVAEIGRLEQTRITALSGFYDTDPVGPVDQPNFLNAALRLETALSPRQLLAE
LQRIETDVFRRVRDVPWGPRSMDLDILLYGDLILDEEGLVIPHPRLHERRFVLVPLAEIAPDVHHPLLGKRVDELLRSLP
PGERVTRI

Sequences:

>Translated_168_residues
MCSNLPVKSNVFIALGSNQGDRELNLLRAVAEIGRLEQTRITALSGFYDTDPVGPVDQPNFLNAALRLETALSPRQLLAE
LQRIETDVFRRVRDVPWGPRSMDLDILLYGDLILDEEGLVIPHPRLHERRFVLVPLAEIAPDVHHPLLGKRVDELLRSLP
PGERVTRI
>Mature_168_residues
MCSNLPVKSNVFIALGSNQGDRELNLLRAVAEIGRLEQTRITALSGFYDTDPVGPVDQPNFLNAALRLETALSPRQLLAE
LQRIETDVFRRVRDVPWGPRSMDLDILLYGDLILDEEGLVIPHPRLHERRFVLVPLAEIAPDVHHPLLGKRVDELLRSLP
PGERVTRI

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=136, Percent_Identity=42.6470588235294, Blast_Score=115, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=154, Percent_Identity=36.3636363636364, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18936; Mature: 18936

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSNLPVKSNVFIALGSNQGDRELNLLRAVAEIGRLEQTRITALSGFYDTDPVGPVDQPN
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCH
FLNAALRLETALSPRQLLAELQRIETDVFRRVRDVPWGPRSMDLDILLYGDLILDEEGLV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEECCCCEE
IPHPRLHERRFVLVPLAEIAPDVHHPLLGKRVDELLRSLPPGERVTRI
CCCCCCCCCCEEEEEHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MCSNLPVKSNVFIALGSNQGDRELNLLRAVAEIGRLEQTRITALSGFYDTDPVGPVDQPN
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCH
FLNAALRLETALSPRQLLAELQRIETDVFRRVRDVPWGPRSMDLDILLYGDLILDEEGLV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEECCCCEE
IPHPRLHERRFVLVPLAEIAPDVHHPLLGKRVDELLRSLPPGERVTRI
CCCCCCCCCCEEEEEHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]