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The map label for this gene is cobT

Identifier: 78221688

GI number: 78221688

Start: 514370

End: 515431

Strand: Direct

Name: cobT

Synonym: Gmet_0467

Alternate gene names: 78221688

Gene position: 514370-515431 (Clockwise)

Preceding gene: 78221687

Following gene: 78221689

Centisome position: 12.87

GC content: 65.82

Gene sequence:

>1062_bases
ATGACCCTGTTGACCGAAACCCTGTCAAATATCCGTCCCGTGGACGCCGGCCTCATGGCCCAGGCCCAGGCGCGGCTCGA
CAACAAGACCAAGCCCATCGGCTCCCTCGGCCGCCTGGAGGAGTTCGCCCGGCGCACCGTGGCCATTAGCGGGAGCCTGG
ACCCTTCTACGGCGAAGAAAGCGATCTTCACCTTCGCCGCCGACCACGGGGTGGTGGAGGAGGGGGTTTCCGCCTTCCCG
AAGGAAGTGACGGTCCAGATGGTCTTCAATTTCCTCAAGGGGGGAGCCGGGATCAACGTCCTTGCCAACCACGTGGGTGC
CGATGTCCTCGTGGTGGACATGGGGATCGACCATGATTTCGGCGACACCCCTGGCCTCATCGACCGCAAGGTGGCCCGCG
GTACCCGCAACATGGCGAAGGGGCCGGCCATGACCCGGGAGGAGGCCGTGACGGCCCTGGAAGCGGGGATCGAACTGGCC
TGCGGCTGCAAGGCCGACGGAGTTGCCATGGCGGGTACCGGGGAGATGGGAATCGGCAACACGACGGCGGCATCGGCCAT
CATCGCCGCCTTCTCCGGGAAAACCGTCGCCGACGTGACCCACCGGGGAACCGGCATCAATGACGCCGCACTGGCGAAGA
AGGTCACGATCATCGAGCAGGCCCTTGCCGTGAACCGCCCCGACCCGAAGGACCCCATCGACGTCCTTGCCAAGGTGGGG
GGGCTGGAGATCGCCGGCATCGCCGGCCTTGTCCTCGGCTGCGCCGCCAATCGGATTCCGGTGGTGGTGGACGGCTTCAT
CTCCACGGCCGGCGCCCTCATTGCCTGTGAGCTTTGCCCCACGGTGAAGGAGTACATTTTCGCGGCCCACGAGTCGGTGG
AGATCGGCCACCGGTTCATGCTGGAGCGGATCGGCGCGGAACCGATCCTCGATCTGCACCTGCGCCTCGGCGAGGGGACC
GGAGCGGCTCTGGCCATGGGGCTCATCGAAGCGGGAGTCAAGATTCTGAAAGAAATGGCCACCTTCGCGGAGGCCGGCGT
GGAAAAAGGCCGGGACCAGTAA

Upstream 100 bases:

>100_bases
AAGTGAATGTGTAGGGGCGCTGCTTGCCGCACCCTTTGTGCAGTTGAAGAAGGGCGCGGCAAGCGGCGCCCCTACGAATA
ATCTTGAAAAGAGGTACTCT

Downstream 100 bases:

>100_bases
CCGGGGACCAGGGACTGGGAAAACCTTTATCCAACCGATGAACGGGATCAGGAACATGAATATGCTGAAGTCGCATGAGC
AGAAGAGGTTTTTTACCGGT

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTLLTETLSNIRPVDAGLMAQAQARLDNKTKPIGSLGRLEEFARRTVAISGSLDPSTAKKAIFTFAADHGVVEEGVSAFP
KEVTVQMVFNFLKGGAGINVLANHVGADVLVVDMGIDHDFGDTPGLIDRKVARGTRNMAKGPAMTREEAVTALEAGIELA
CGCKADGVAMAGTGEMGIGNTTAASAIIAAFSGKTVADVTHRGTGINDAALAKKVTIIEQALAVNRPDPKDPIDVLAKVG
GLEIAGIAGLVLGCAANRIPVVVDGFISTAGALIACELCPTVKEYIFAAHESVEIGHRFMLERIGAEPILDLHLRLGEGT
GAALAMGLIEAGVKILKEMATFAEAGVEKGRDQ

Sequences:

>Translated_353_residues
MTLLTETLSNIRPVDAGLMAQAQARLDNKTKPIGSLGRLEEFARRTVAISGSLDPSTAKKAIFTFAADHGVVEEGVSAFP
KEVTVQMVFNFLKGGAGINVLANHVGADVLVVDMGIDHDFGDTPGLIDRKVARGTRNMAKGPAMTREEAVTALEAGIELA
CGCKADGVAMAGTGEMGIGNTTAASAIIAAFSGKTVADVTHRGTGINDAALAKKVTIIEQALAVNRPDPKDPIDVLAKVG
GLEIAGIAGLVLGCAANRIPVVVDGFISTAGALIACELCPTVKEYIFAAHESVEIGHRFMLERIGAEPILDLHLRLGEGT
GAALAMGLIEAGVKILKEMATFAEAGVEKGRDQ
>Mature_352_residues
TLLTETLSNIRPVDAGLMAQAQARLDNKTKPIGSLGRLEEFARRTVAISGSLDPSTAKKAIFTFAADHGVVEEGVSAFPK
EVTVQMVFNFLKGGAGINVLANHVGADVLVVDMGIDHDFGDTPGLIDRKVARGTRNMAKGPAMTREEAVTALEAGIELAC
GCKADGVAMAGTGEMGIGNTTAASAIIAAFSGKTVADVTHRGTGINDAALAKKVTIIEQALAVNRPDPKDPIDVLAKVGG
LEIAGIAGLVLGCAANRIPVVVDGFISTAGALIACELCPTVKEYIFAAHESVEIGHRFMLERIGAEPILDLHLRLGEGTG
AALAMGLIEAGVKILKEMATFAEAGVEKGRDQ

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=349, Percent_Identity=42.4068767908309, Blast_Score=273, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_GEOMG (Q39YG4)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383435.1
- ProteinModelPortal:   Q39YG4
- SMR:   Q39YG4
- STRING:   Q39YG4
- GeneID:   3739834
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0467
- NMPDR:   fig|269799.3.peg.495
- eggNOG:   COG2038
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- PhylomeDB:   Q39YG4
- ProtClustDB:   PRK00105
- BioCyc:   GMET269799:GMET_0467-MONOMER
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 36519; Mature: 36387

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: ACT_SITE 318-318

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLTETLSNIRPVDAGLMAQAQARLDNKTKPIGSLGRLEEFARRTVAISGSLDPSTAKK
CCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEEECCCCCHHHHH
AIFTFAADHGVVEEGVSAFPKEVTVQMVFNFLKGGAGINVLANHVGADVLVVDMGIDHDF
HHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCCC
GDTPGLIDRKVARGTRNMAKGPAMTREEAVTALEAGIELACGCKADGVAMAGTGEMGIGN
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCCC
TTAASAIIAAFSGKTVADVTHRGTGINDAALAKKVTIIEQALAVNRPDPKDPIDVLAKVG
HHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
GLEIAGIAGLVLGCAANRIPVVVDGFISTAGALIACELCPTVKEYIFAAHESVEIGHRFM
CCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHEEHHHHHHHHHHHHHHCCHHHHHHHHH
LERIGAEPILDLHLRLGEGTGAALAMGLIEAGVKILKEMATFAEAGVEKGRDQ
HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLLTETLSNIRPVDAGLMAQAQARLDNKTKPIGSLGRLEEFARRTVAISGSLDPSTAKK
CCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEEECCCCCHHHHH
AIFTFAADHGVVEEGVSAFPKEVTVQMVFNFLKGGAGINVLANHVGADVLVVDMGIDHDF
HHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCCC
GDTPGLIDRKVARGTRNMAKGPAMTREEAVTALEAGIELACGCKADGVAMAGTGEMGIGN
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCCC
TTAASAIIAAFSGKTVADVTHRGTGINDAALAKKVTIIEQALAVNRPDPKDPIDVLAKVG
HHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
GLEIAGIAGLVLGCAANRIPVVVDGFISTAGALIACELCPTVKEYIFAAHESVEIGHRFM
CCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHEEHHHHHHHHHHHHHHCCHHHHHHHHH
LERIGAEPILDLHLRLGEGTGAALAMGLIEAGVKILKEMATFAEAGVEKGRDQ
HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA