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The map label for this gene is penA [H]

Identifier: 78221627

GI number: 78221627

Start: 447082

End: 449055

Strand: Direct

Name: penA [H]

Synonym: Gmet_0406

Alternate gene names: 78221627

Gene position: 447082-449055 (Clockwise)

Preceding gene: 78221626

Following gene: 78221628

Centisome position: 11.18

GC content: 60.33

Gene sequence:

>1974_bases
ATGAGGTACGACGCGGAGAAATGGATAACTCTCCGTATCCGCTTCATCGGGGGGTTCTTCGTTCTCCTCTTTGCGTTGAC
GTTCTGCCGAGCTTTTTACCTTCAGGTGATCAAGCGCGACTACCTTCTCAAGCTCGCCGATCGGCAGCACCAGAAGATTA
TTCCCCTTACGCCGGTTCGCGGGACGATCTACGATGCGAATGGCGCCGCCTTGGCCGTTTCGGTTGAGATGGATTCCTGT
TATGCCGAGCCAAAGTCCATGGAGGACTTGGGCGAGGCTTCGGCGCAGTTGGCGCCAGTCCTTGGCATGCCAAAGGAGTC
GATCCTGAAGAAGCTCCAGGGGAACAAGAACTTCGTCTGGCTCCAACGGCGGCTTACCCCCGATGTGGTGAAGCGAATCC
GGGACCTGGATCTCGAGGGGATCGGTTTCGTCAAGGAGACAAAGCGCTTTTATCCCAACTCAGAGGTGGCTGCCCACGTG
ATCGGGTTCACCGGCCTGGACCCCGAGGGACTGGAGGGAGTAGAGCGACGCTATGACTCTACGATCCTTGGTGGAACCGG
CTATCTGGTGACCGAGCGGGACGCCCTGGGACGCAACGTGGCCCTCAAGGGGACGGTGATCCAGAATGGGGCCATGGGGC
ACGACGTCACCCTTACCCTGGACAAGAACATCCAGTATATCGCCGAGAAGGAACTGGCCCAGGCGGTGGAAAAAAGCGGA
GCCCGCGCCGGTACCGCGCTCGTGATGGATCCCCACACCGGCAAGGTGCTGGCCATGGCAAATTATCCGACCTTCAATCT
GAACTCCCATGCCTCCTACTCTCCGCAGGTATGGCGTAACCGCGCCGTTGCCGACAGCTATGAGCCCGGTTCCACCTTCA
AGACCTTCCTGGTCGCCGCCGCGTTGGAGGAAAAGGTGATCCGGCCCGGCGACGGCATAAATTGCGAGGGAGGAAGCTAC
GCGATCGGCGGAAGGACGATCCACGACACGCACAAGTACGGCCGGCTCAGTATCGCCGAGGTCCTCAAGTATTCCAGCAA
TATCGGCGCCGCCAAAATCGGGAGCCGCCTGGGACCGTCACGCTTGTACACCTATCTGAAGAATTTTGGAATCGGCGACA
GGAGTGGGGTTGATCTGCCCGGTGAAGTGGGGGGAAGTCTACGGCCATGGAGCCAGTGGTACGGCATCGATCTCGCCACT
ATTTCGTTTGGTCAGGGTGTGACGACATCGTCGCTGCAACTGGCCTCCGCCGTATCGGCCATTGCCAACGGCGGTGTTCT
CATGAAACCCTATCTGGTCGAGAAGATCACCGACAGCGAAGGGAATGTAGTCACGTCTTTCGAGCCACAGGTGCGCCGAC
GGGTCATTTCCCCTGAAACGGCCAAAACGGTTTCCCGGATGATGGAAGGGGTTGCCGCCGAGGGGGGGACCGGAACCAAT
GCCTCGGTTGAAGGCTACCGGGTTGCCGGCAAGACCGGCACTGCGCAGAAGGTGGACCCGGTCACCCACGGGTACTCCGC
CACGAAACGGACCGCGTCCTTCATCGGATTTGTCCCCGCAGACCGTCCCCGAATCACCATTCTTGTGGTGATTGATGAGC
CGAAGACAAGCCCCTATGGCGGTGTGGTGGCCGCTCCAGCTTTCAGCAGCATCGCGTTGCAGACCCTCTGCTACCTTAAA
GTTCCGCCCGACACCGTCGTCAGGAGCAAGCCGAAGACAGTGGAAGCCAAGGCAATTCCGGAGGCCGCGGAGGCCACCGA
GGCCGCCGAAGGGGCGATCGTCGAGGAGGGGGAGGGGATTGTGATGCCCAACTTCCGGGGGATGAGCATGCGCCAGACGC
TCAAGGTTATGGAAGAGAAGGGGCTCAACGTACGTCTTCACGGAAGCGGGCGGGCCATGGAGCAGAGCCCCCTTCCCGGG
CACCGGATCAAGCCCAGCGACCAGGTTTGGGTCAAGTTCACGCCGACGGCGTAA

Upstream 100 bases:

>100_bases
TCGAGGTTGCATCCCTGAAAACTCCGGCCCGGATCGAGGCCCTTGCCAAGGGGGACCTCGGCATGGCGCTCCCCACTGAC
CAGCAGGTGGTGGTAGTGAA

Downstream 100 bases:

>100_bases
CAAGGCTGGCTGAAGAAAGATGAAAATGAGCACAAGTAAATTCTATGGCGAGGGAACATGAGACTGGAAGATCTGGCACG
GGTCATTAATCCCTCTGAAG

Product: penicillin-binding protein, transpeptidase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MRYDAEKWITLRIRFIGGFFVLLFALTFCRAFYLQVIKRDYLLKLADRQHQKIIPLTPVRGTIYDANGAALAVSVEMDSC
YAEPKSMEDLGEASAQLAPVLGMPKESILKKLQGNKNFVWLQRRLTPDVVKRIRDLDLEGIGFVKETKRFYPNSEVAAHV
IGFTGLDPEGLEGVERRYDSTILGGTGYLVTERDALGRNVALKGTVIQNGAMGHDVTLTLDKNIQYIAEKELAQAVEKSG
ARAGTALVMDPHTGKVLAMANYPTFNLNSHASYSPQVWRNRAVADSYEPGSTFKTFLVAAALEEKVIRPGDGINCEGGSY
AIGGRTIHDTHKYGRLSIAEVLKYSSNIGAAKIGSRLGPSRLYTYLKNFGIGDRSGVDLPGEVGGSLRPWSQWYGIDLAT
ISFGQGVTTSSLQLASAVSAIANGGVLMKPYLVEKITDSEGNVVTSFEPQVRRRVISPETAKTVSRMMEGVAAEGGTGTN
ASVEGYRVAGKTGTAQKVDPVTHGYSATKRTASFIGFVPADRPRITILVVIDEPKTSPYGGVVAAPAFSSIALQTLCYLK
VPPDTVVRSKPKTVEAKAIPEAAEATEAAEGAIVEEGEGIVMPNFRGMSMRQTLKVMEEKGLNVRLHGSGRAMEQSPLPG
HRIKPSDQVWVKFTPTA

Sequences:

>Translated_657_residues
MRYDAEKWITLRIRFIGGFFVLLFALTFCRAFYLQVIKRDYLLKLADRQHQKIIPLTPVRGTIYDANGAALAVSVEMDSC
YAEPKSMEDLGEASAQLAPVLGMPKESILKKLQGNKNFVWLQRRLTPDVVKRIRDLDLEGIGFVKETKRFYPNSEVAAHV
IGFTGLDPEGLEGVERRYDSTILGGTGYLVTERDALGRNVALKGTVIQNGAMGHDVTLTLDKNIQYIAEKELAQAVEKSG
ARAGTALVMDPHTGKVLAMANYPTFNLNSHASYSPQVWRNRAVADSYEPGSTFKTFLVAAALEEKVIRPGDGINCEGGSY
AIGGRTIHDTHKYGRLSIAEVLKYSSNIGAAKIGSRLGPSRLYTYLKNFGIGDRSGVDLPGEVGGSLRPWSQWYGIDLAT
ISFGQGVTTSSLQLASAVSAIANGGVLMKPYLVEKITDSEGNVVTSFEPQVRRRVISPETAKTVSRMMEGVAAEGGTGTN
ASVEGYRVAGKTGTAQKVDPVTHGYSATKRTASFIGFVPADRPRITILVVIDEPKTSPYGGVVAAPAFSSIALQTLCYLK
VPPDTVVRSKPKTVEAKAIPEAAEATEAAEGAIVEEGEGIVMPNFRGMSMRQTLKVMEEKGLNVRLHGSGRAMEQSPLPG
HRIKPSDQVWVKFTPTA
>Mature_657_residues
MRYDAEKWITLRIRFIGGFFVLLFALTFCRAFYLQVIKRDYLLKLADRQHQKIIPLTPVRGTIYDANGAALAVSVEMDSC
YAEPKSMEDLGEASAQLAPVLGMPKESILKKLQGNKNFVWLQRRLTPDVVKRIRDLDLEGIGFVKETKRFYPNSEVAAHV
IGFTGLDPEGLEGVERRYDSTILGGTGYLVTERDALGRNVALKGTVIQNGAMGHDVTLTLDKNIQYIAEKELAQAVEKSG
ARAGTALVMDPHTGKVLAMANYPTFNLNSHASYSPQVWRNRAVADSYEPGSTFKTFLVAAALEEKVIRPGDGINCEGGSY
AIGGRTIHDTHKYGRLSIAEVLKYSSNIGAAKIGSRLGPSRLYTYLKNFGIGDRSGVDLPGEVGGSLRPWSQWYGIDLAT
ISFGQGVTTSSLQLASAVSAIANGGVLMKPYLVEKITDSEGNVVTSFEPQVRRRVISPETAKTVSRMMEGVAAEGGTGTN
ASVEGYRVAGKTGTAQKVDPVTHGYSATKRTASFIGFVPADRPRITILVVIDEPKTSPYGGVVAAPAFSSIALQTLCYLK
VPPDTVVRSKPKTVEAKAIPEAAEATEAAEGAIVEEGEGIVMPNFRGMSMRQTLKVMEEKGLNVRLHGSGRAMEQSPLPG
HRIKPSDQVWVKFTPTA

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=569, Percent_Identity=34.622144112478, Blast_Score=328, Evalue=1e-90,
Organism=Escherichia coli, GI1786854, Length=628, Percent_Identity=26.5923566878981, Blast_Score=147, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71183; Mature: 71183

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDAEKWITLRIRFIGGFFVLLFALTFCRAFYLQVIKRDYLLKLADRQHQKIIPLTPVR
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCC
GTIYDANGAALAVSVEMDSCYAEPKSMEDLGEASAQLAPVLGMPKESILKKLQGNKNFVW
CEEEECCCCEEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEE
LQRRLTPDVVKRIRDLDLEGIGFVKETKRFYPNSEVAAHVIGFTGLDPEGLEGVERRYDS
EEECCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHEEEEEEECCCCCHHHHHHHHHHCC
TILGGTGYLVTERDALGRNVALKGTVIQNGAMGHDVTLTLDKNIQYIAEKELAQAVEKSG
EEECCCCEEEECHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCC
ARAGTALVMDPHTGKVLAMANYPTFNLNSHASYSPQVWRNRAVADSYEPGSTFKTFLVAA
CCCCEEEEECCCCCCEEEEECCCEECCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHH
ALEEKVIRPGDGINCEGGSYAIGGRTIHDTHKYGRLSIAEVLKYSSNIGAAKIGSRLGPS
HHHHHHCCCCCCCCCCCCCEEECCEEEECCCCCCCEEHHHHHHHCCCCCHHHHHCCCCHH
RLYTYLKNFGIGDRSGVDLPGEVGGSLRPWSQWYGIDLATISFGQGVTTSSLQLASAVSA
HHHHHHHHCCCCCCCCCCCCHHCCCCCCCCHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
IANGGVLMKPYLVEKITDSEGNVVTSFEPQVRRRVISPETAKTVSRMMEGVAAEGGTGTN
HHCCCEEECCHHHHHEECCCCCEEECCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCC
ASVEGYRVAGKTGTAQKVDPVTHGYSATKRTASFIGFVPADRPRITILVVIDEPKTSPYG
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCEEEEEEEECCCCCCCC
GVVAAPAFSSIALQTLCYLKVPPDTVVRSKPKTVEAKAIPEAAEATEAAEGAIVEEGEGI
CEEECCCHHHHHHHHEEEEECCCHHHHCCCCCCEEHHCCCCHHHHHHHHCCCEEECCCEE
VMPNFRGMSMRQTLKVMEEKGLNVRLHGSGRAMEQSPLPGHRIKPSDQVWVKFTPTA
ECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MRYDAEKWITLRIRFIGGFFVLLFALTFCRAFYLQVIKRDYLLKLADRQHQKIIPLTPVR
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCC
GTIYDANGAALAVSVEMDSCYAEPKSMEDLGEASAQLAPVLGMPKESILKKLQGNKNFVW
CEEEECCCCEEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEE
LQRRLTPDVVKRIRDLDLEGIGFVKETKRFYPNSEVAAHVIGFTGLDPEGLEGVERRYDS
EEECCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHEEEEEEECCCCCHHHHHHHHHHCC
TILGGTGYLVTERDALGRNVALKGTVIQNGAMGHDVTLTLDKNIQYIAEKELAQAVEKSG
EEECCCCEEEECHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCC
ARAGTALVMDPHTGKVLAMANYPTFNLNSHASYSPQVWRNRAVADSYEPGSTFKTFLVAA
CCCCEEEEECCCCCCEEEEECCCEECCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHH
ALEEKVIRPGDGINCEGGSYAIGGRTIHDTHKYGRLSIAEVLKYSSNIGAAKIGSRLGPS
HHHHHHCCCCCCCCCCCCCEEECCEEEECCCCCCCEEHHHHHHHCCCCCHHHHHCCCCHH
RLYTYLKNFGIGDRSGVDLPGEVGGSLRPWSQWYGIDLATISFGQGVTTSSLQLASAVSA
HHHHHHHHCCCCCCCCCCCCHHCCCCCCCCHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
IANGGVLMKPYLVEKITDSEGNVVTSFEPQVRRRVISPETAKTVSRMMEGVAAEGGTGTN
HHCCCEEECCHHHHHEECCCCCEEECCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCC
ASVEGYRVAGKTGTAQKVDPVTHGYSATKRTASFIGFVPADRPRITILVVIDEPKTSPYG
CCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCEEEEEEEECCCCCCCC
GVVAAPAFSSIALQTLCYLKVPPDTVVRSKPKTVEAKAIPEAAEATEAAEGAIVEEGEGI
CEEECCCHHHHHHHHEEEEECCCHHHHCCCCCCEEHHCCCCHHHHHHHHCCCEEECCCEE
VMPNFRGMSMRQTLKVMEEKGLNVRLHGSGRAMEQSPLPGHRIKPSDQVWVKFTPTA
ECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]