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The map label for this gene is cobB1 [H]

Identifier: 78221618

GI number: 78221618

Start: 439483

End: 440322

Strand: Direct

Name: cobB1 [H]

Synonym: Gmet_0397

Alternate gene names: 78221618

Gene position: 439483-440322 (Clockwise)

Preceding gene: 78221617

Following gene: 78221619

Centisome position: 10.99

GC content: 64.17

Gene sequence:

>840_bases
ATGGACCTTCAGGAGAAAGTTCGCGTTGCCGCCGAGGCGGTGAAGCACGCCGATGCCATCGTCATGACCGCCGGTGCCGG
CATGGGGGTTGATTCGGGGTTGCCTGATTTCCGTGGCGACACCGGGTTCTGGAAGGCGTATCCCCCTTACCAGAAGCTCG
GCATTACCTTTGTGGGGGCCGCGAATCCCGACCACTTCGAGCGGGATCCGTCCTTCGGCTGGGGATTCTACGGCCATCGG
ACCAACCTTTACCGGGCCACGGTCCCCCATGCCGGCTTCGACATCCTGCGGGAATGGGTCCAACGGTACGGCCTTGATTA
TTTCGTGGTCACCTCCAATGTGGACGGCCAGTTTCAGAAGGCCGGGTTTGCCGACGATCGTATCTTGGAAGTCCACGGCT
CCATCCACCATCTCCAGTGCACGACGCCCTGCACCATGGCCATCTGGGAGAACCGAGAGACCATTCCGGTGGACGAGGCG
ACCATGCGGGCTGGGCACGTCCCCCGCTGCATTCACTGCGGCGCCGTGGCTCGCCCCAATATCCTCATGTTCGGCGACTA
CGGCTGGGTGAGTGACCGCTCGGCCCGGCAGCAGCGGAACTTTGACGAGTTCCTCGCCGACACCCGGGGGGGCCGCCTGG
TGGTGGTCGAGATGGGGGCCGGCACCGCCATCCCGACTATTCGTTATCTGACCGAGGAACTTGGTTCCCGTTCCGAGGCG
CTGGCCGTGCGGATCAATCCGCGGGAGCCCCAGATTCGCGCGCCTCACCTCTCTCTCCCCTGCGGCGCCCGGGAGGGAGT
TGCCGCCATCAATGCCGTTCTTGCGGAGGAATCCCCTTGA

Upstream 100 bases:

>100_bases
AACGGCGGCAAGCGGGGATATCTCGTGGGGATTGATCCCCGTGACGTGGTGAAGCTTCTCAATCCGACCCTGGTTCGGGT
CGCCATCTGAGGGGGAACCC

Downstream 100 bases:

>100_bases
CGATCATCAGGAGAAAAGCAGCGGCCGGACCCTTCGTCGGCGAGCAGTCATTCTTTGCCACCACCGCCAAGGGGGTGGAG
GAGGTGCTTGCTCGGGAGAT

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MDLQEKVRVAAEAVKHADAIVMTAGAGMGVDSGLPDFRGDTGFWKAYPPYQKLGITFVGAANPDHFERDPSFGWGFYGHR
TNLYRATVPHAGFDILREWVQRYGLDYFVVTSNVDGQFQKAGFADDRILEVHGSIHHLQCTTPCTMAIWENRETIPVDEA
TMRAGHVPRCIHCGAVARPNILMFGDYGWVSDRSARQQRNFDEFLADTRGGRLVVVEMGAGTAIPTIRYLTEELGSRSEA
LAVRINPREPQIRAPHLSLPCGAREGVAAINAVLAEESP

Sequences:

>Translated_279_residues
MDLQEKVRVAAEAVKHADAIVMTAGAGMGVDSGLPDFRGDTGFWKAYPPYQKLGITFVGAANPDHFERDPSFGWGFYGHR
TNLYRATVPHAGFDILREWVQRYGLDYFVVTSNVDGQFQKAGFADDRILEVHGSIHHLQCTTPCTMAIWENRETIPVDEA
TMRAGHVPRCIHCGAVARPNILMFGDYGWVSDRSARQQRNFDEFLADTRGGRLVVVEMGAGTAIPTIRYLTEELGSRSEA
LAVRINPREPQIRAPHLSLPCGAREGVAAINAVLAEESP
>Mature_279_residues
MDLQEKVRVAAEAVKHADAIVMTAGAGMGVDSGLPDFRGDTGFWKAYPPYQKLGITFVGAANPDHFERDPSFGWGFYGHR
TNLYRATVPHAGFDILREWVQRYGLDYFVVTSNVDGQFQKAGFADDRILEVHGSIHHLQCTTPCTMAIWENRETIPVDEA
TMRAGHVPRCIHCGAVARPNILMFGDYGWVSDRSARQQRNFDEFLADTRGGRLVVVEMGAGTAIPTIRYLTEELGSRSEA
LAVRINPREPQIRAPHLSLPCGAREGVAAINAVLAEESP

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13787215, Length=186, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI6912664, Length=186, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI300795542, Length=175, Percent_Identity=33.1428571428571, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30798; Mature: 30798

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQEKVRVAAEAVKHADAIVMTAGAGMGVDSGLPDFRGDTGFWKAYPPYQKLGITFVGA
CCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCEEEEEC
ANPDHFERDPSFGWGFYGHRTNLYRATVPHAGFDILREWVQRYGLDYFVVTSNVDGQFQK
CCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCCHHH
AGFADDRILEVHGSIHHLQCTTPCTMAIWENRETIPVDEATMRAGHVPRCIHCGAVARPN
CCCCCCEEEEECCCEEEEEECCCEEEEEECCCCCCCCCHHHHHCCCCCCEEECCCCCCCC
ILMFGDYGWVSDRSARQQRNFDEFLADTRGGRLVVVEMGAGTAIPTIRYLTEELGSRSEA
EEEEECCCCCCCCHHHHHCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCE
LAVRINPREPQIRAPHLSLPCGAREGVAAINAVLAEESP
EEEEECCCCCCEECCEECCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MDLQEKVRVAAEAVKHADAIVMTAGAGMGVDSGLPDFRGDTGFWKAYPPYQKLGITFVGA
CCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCEEEEEC
ANPDHFERDPSFGWGFYGHRTNLYRATVPHAGFDILREWVQRYGLDYFVVTSNVDGQFQK
CCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCCHHH
AGFADDRILEVHGSIHHLQCTTPCTMAIWENRETIPVDEATMRAGHVPRCIHCGAVARPN
CCCCCCEEEEECCCEEEEEECCCEEEEEECCCCCCCCCHHHHHCCCCCCEEECCCCCCCC
ILMFGDYGWVSDRSARQQRNFDEFLADTRGGRLVVVEMGAGTAIPTIRYLTEELGSRSEA
EEEEECCCCCCCCHHHHHCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCE
LAVRINPREPQIRAPHLSLPCGAREGVAAINAVLAEESP
EEEEECCCCCCEECCEECCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]