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The map label for this gene is cysM [H]

Identifier: 78221487

GI number: 78221487

Start: 295860

End: 296786

Strand: Reverse

Name: cysM [H]

Synonym: Gmet_0264

Alternate gene names: 78221487

Gene position: 296786-295860 (Counterclockwise)

Preceding gene: 78221489

Following gene: 78221484

Centisome position: 7.42

GC content: 65.8

Gene sequence:

>927_bases
ATGGAACATACCCCCTTTTCCCTGTCAGGGAGCATCGGCTCCACCCCCCTCGTGGAGATCAGAAAGCTGAACCCCAACCC
GAAGGTGAGAATTCTCGCCAAGCTTGAGGGGAATAATGTGGGGGGCTCGGTCAAGGACCGCCCCGCCCTCTACATGCTTG
CCAAGGCCGAGGCTGCCGGGGAACTGTCCCCTGAGAGGACGATCCTGGAGCCCACCTCGGGAAACACCGGCATCGCCATC
GCCATGCTCGGCGCGGCCAAGGGGTACCGGGTGAAGCTCGTCATGCCTGCCTGCGTGAGCCTTGAGCGGCGGGCGGTGCT
GGAGGCCTACGGCGCCGAACTGGTTCTCTCTCCGGCAGAGGAGGCCACTGACGGCGCCATCCGCCTGGCGCACCGGATTC
TCGACGAAGAACCCGACCGCTACTACATGCCCAACCAGTATGCCAACCCCAACAACCCCCTCGCCCACTACGAGACCACC
GGTCCGGAGATTTACCGCGGCACCGACGGCACCGTCGACTTTTTCGTGGCCGGGATGGGGACCGGCGGAACCCTCATGGG
GGTAAGCCGCTACTTTCGGGAAACCAAGCCGTCCGTGCGCATCGTCGGCGTGGAGCCCCGGCTCGGCCACAAGGTCCAGG
GGCTCAAGAACATGCAGGAAGCCATCGTCCCAGCCATCTACAACCCCGCTGCCCTCGACCTGAAGCTCACCGTCCAGGAC
GAGCCCGCCTTCGATACGGCGCGGGATCTGGCCGTCCGCGAGGGGCTCTTCGTGGGGATGTCCAGCGGCGCGGCCATGGC
TGGCGCCATCCGGGTGGCCAAGGATGCCCCGGCCGGAAGCACCATCGTCGTCCTTCTCCCCGACAGAGGGGACCGTTACC
TCAGCACGGTGCTCTTCCGGTCCGTCTGCGGCAAATGCCCCCCCTAA

Upstream 100 bases:

>100_bases
CTTTCCCGCGGGCAATCCCCGCATTCGGGACGGTTGTAATTTCCCGTACATTCCTATAGCATAAGCGGTTATTAACCCAC
CAGAGCAGAGGACATCGTCC

Downstream 100 bases:

>100_bases
CAGGAATCACCACGCCCCCAGCCCCTTCAGGAACCCCACCAGGGCATCGTTGAAGGCCCCAGGGTGCTCCAGATTGGCCA
TGTGCCCCGCCTCGGTTACG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MEHTPFSLSGSIGSTPLVEIRKLNPNPKVRILAKLEGNNVGGSVKDRPALYMLAKAEAAGELSPERTILEPTSGNTGIAI
AMLGAAKGYRVKLVMPACVSLERRAVLEAYGAELVLSPAEEATDGAIRLAHRILDEEPDRYYMPNQYANPNNPLAHYETT
GPEIYRGTDGTVDFFVAGMGTGGTLMGVSRYFRETKPSVRIVGVEPRLGHKVQGLKNMQEAIVPAIYNPAALDLKLTVQD
EPAFDTARDLAVREGLFVGMSSGAAMAGAIRVAKDAPAGSTIVVLLPDRGDRYLSTVLFRSVCGKCPP

Sequences:

>Translated_308_residues
MEHTPFSLSGSIGSTPLVEIRKLNPNPKVRILAKLEGNNVGGSVKDRPALYMLAKAEAAGELSPERTILEPTSGNTGIAI
AMLGAAKGYRVKLVMPACVSLERRAVLEAYGAELVLSPAEEATDGAIRLAHRILDEEPDRYYMPNQYANPNNPLAHYETT
GPEIYRGTDGTVDFFVAGMGTGGTLMGVSRYFRETKPSVRIVGVEPRLGHKVQGLKNMQEAIVPAIYNPAALDLKLTVQD
EPAFDTARDLAVREGLFVGMSSGAAMAGAIRVAKDAPAGSTIVVLLPDRGDRYLSTVLFRSVCGKCPP
>Mature_308_residues
MEHTPFSLSGSIGSTPLVEIRKLNPNPKVRILAKLEGNNVGGSVKDRPALYMLAKAEAAGELSPERTILEPTSGNTGIAI
AMLGAAKGYRVKLVMPACVSLERRAVLEAYGAELVLSPAEEATDGAIRLAHRILDEEPDRYYMPNQYANPNNPLAHYETT
GPEIYRGTDGTVDFFVAGMGTGGTLMGVSRYFRETKPSVRIVGVEPRLGHKVQGLKNMQEAIVPAIYNPAALDLKLTVQD
EPAFDTARDLAVREGLFVGMSSGAAMAGAIRVAKDAPAGSTIVVLLPDRGDRYLSTVLFRSVCGKCPP

Specific function: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=39.0879478827362, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=39.0879478827362, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=39.0879478827362, Blast_Score=208, Evalue=6e-54,
Organism=Escherichia coli, GI2367138, Length=293, Percent_Identity=47.7815699658703, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=44.1269841269841, Blast_Score=210, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=42.3333333333333, Blast_Score=220, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17562970, Length=304, Percent_Identity=41.4473684210526, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI32566674, Length=296, Percent_Identity=41.8918918918919, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI115535073, Length=308, Percent_Identity=43.5064935064935, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=39.1447368421053, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25147552, Length=309, Percent_Identity=35.5987055016181, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=38.1165919282511, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=35.7366771159875, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=37.5796178343949, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6321449, Length=320, Percent_Identity=36.875, Blast_Score=143, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24643623, Length=307, Percent_Identity=37.4592833876222, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129101, Length=307, Percent_Identity=37.4592833876222, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32937; Mature: 32937

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHTPFSLSGSIGSTPLVEIRKLNPNPKVRILAKLEGNNVGGSVKDRPALYMLAKAEAAG
CCCCCCEECCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCC
ELSPERTILEPTSGNTGIAIAMLGAAKGYRVKLVMPACVSLERRAVLEAYGAELVLSPAE
CCCCCCEEECCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEECCCC
EATDGAIRLAHRILDEEPDRYYMPNQYANPNNPLAHYETTGPEIYRGTDGTVDFFVAGMG
HHCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEECCCCEEEECCCCCEEEEEEECC
TGGTLMGVSRYFRETKPSVRIVGVEPRLGHKVQGLKNMQEAIVPAIYNPAALDLKLTVQD
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
EPAFDTARDLAVREGLFVGMSSGAAMAGAIRVAKDAPAGSTIVVLLPDRGDRYLSTVLFR
CCCCHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHH
SVCGKCPP
HHHCCCCC
>Mature Secondary Structure
MEHTPFSLSGSIGSTPLVEIRKLNPNPKVRILAKLEGNNVGGSVKDRPALYMLAKAEAAG
CCCCCCEECCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCC
ELSPERTILEPTSGNTGIAIAMLGAAKGYRVKLVMPACVSLERRAVLEAYGAELVLSPAE
CCCCCCEEECCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEECCCC
EATDGAIRLAHRILDEEPDRYYMPNQYANPNNPLAHYETTGPEIYRGTDGTVDFFVAGMG
HHCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEECCCCEEEECCCCCEEEEEEECC
TGGTLMGVSRYFRETKPSVRIVGVEPRLGHKVQGLKNMQEAIVPAIYNPAALDLKLTVQD
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
EPAFDTARDLAVREGLFVGMSSGAAMAGAIRVAKDAPAGSTIVVLLPDRGDRYLSTVLFR
CCCCHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHH
SVCGKCPP
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188958; 9205837; 9278503 [H]