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The map label for this gene is guaD [H]

Identifier: 78221462

GI number: 78221462

Start: 269344

End: 269904

Strand: Direct

Name: guaD [H]

Synonym: Gmet_0239

Alternate gene names: 78221462

Gene position: 269344-269904 (Clockwise)

Preceding gene: 78221461

Following gene: 78221467

Centisome position: 6.74

GC content: 61.32

Gene sequence:

>561_bases
ATGCTGCATCTGTCGATGCCGTTGCCCGAATGGGCCCGGACGTCCGTGGGGAATTCGGGCATTTTTGCAGGGGATGCCGA
GAAAATGGCCTTTGCCATCAGTCTTGCTCGGAGCAATGTGGAAGAGGGGACCGGAGGCCCGTTCGGTGCGGCCATATTCA
ACCGGGAAAGCGGCGAGCTGGTGAGTGTGGGGGTGAACCTCGTGGTTGCAGGCATGAACTCCGTACTCCATGCCGAGATG
GTGGCCATCATGGCGGCCGAAGCGGTGTTGGGGACCTATACCCTGGCAGTCAGGGGACGTTTCGAGCTGTTCTCCTCCTG
TGAACCGTGCGCCATGTGCCTCGGGGGGATCCTCTGGAGTGGGGTGGAGAGACTGGTGTGTGCCGCTGCGGCCGACGACG
CCCGGGCAATCGGCTTCGATGAGGGGCCGGTGTATCCTGAGTCGTACTGCTACCTGAAGGAGCGTGGAATCGAGATTGAA
AGGGGTTTCATGCGTGAAGAAGGGAAGAGGGTGCTGGAACTCTACCGGGAGCGGGGGGGTATCCTCTACAACCGGCGGTA
G

Upstream 100 bases:

>100_bases
TATACTTAATTCAAAAAGGCGACCAATAGGTCGCCTTTTCTGTCTCTGTGCAGATCGTTGATATGGACCGAAAGCCCTTT
GGGGTGAAGGGGGTAACCTG

Downstream 100 bases:

>100_bases
CCATTGCCCGCGAGTTGCTTCGGATTGTCGGATCAGCTCGGATAGGATCCTGAAGAATCAGGAGGTATTCTCACTCCTGG
CCGTGCCCCTGTCGCTGGCG

Product: CMP/dCMP deaminase, zinc-binding protein

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MLHLSMPLPEWARTSVGNSGIFAGDAEKMAFAISLARSNVEEGTGGPFGAAIFNRESGELVSVGVNLVVAGMNSVLHAEM
VAIMAAEAVLGTYTLAVRGRFELFSSCEPCAMCLGGILWSGVERLVCAAAADDARAIGFDEGPVYPESYCYLKERGIEIE
RGFMREEGKRVLELYRERGGILYNRR

Sequences:

>Translated_186_residues
MLHLSMPLPEWARTSVGNSGIFAGDAEKMAFAISLARSNVEEGTGGPFGAAIFNRESGELVSVGVNLVVAGMNSVLHAEM
VAIMAAEAVLGTYTLAVRGRFELFSSCEPCAMCLGGILWSGVERLVCAAAADDARAIGFDEGPVYPESYCYLKERGIEIE
RGFMREEGKRVLELYRERGGILYNRR
>Mature_186_residues
MLHLSMPLPEWARTSVGNSGIFAGDAEKMAFAISLARSNVEEGTGGPFGAAIFNRESGELVSVGVNLVVAGMNSVLHAEM
VAIMAAEAVLGTYTLAVRGRFELFSSCEPCAMCLGGILWSGVERLVCAAAADDARAIGFDEGPVYPESYCYLKERGIEIE
RGFMREEGKRVLELYRERGGILYNRR

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17555996, Length=127, Percent_Identity=40.1574803149606, Blast_Score=90, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17554608, Length=113, Percent_Identity=37.1681415929204, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 20121; Mature: 20121

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHLSMPLPEWARTSVGNSGIFAGDAEKMAFAISLARSNVEEGTGGPFGAAIFNRESGEL
CEECCCCCCHHHHHCCCCCCEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHEEECCCCCE
VSVGVNLVVAGMNSVLHAEMVAIMAAEAVLGTYTLAVRGRFELFSSCEPCAMCLGGILWS
EEECHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHCCCCHHHHHHHHHHHH
GVERLVCAAAADDARAIGFDEGPVYPESYCYLKERGIEIERGFMREEGKRVLELYRERGG
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
ILYNRR
EEECCC
>Mature Secondary Structure
MLHLSMPLPEWARTSVGNSGIFAGDAEKMAFAISLARSNVEEGTGGPFGAAIFNRESGEL
CEECCCCCCHHHHHCCCCCCEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHEEECCCCCE
VSVGVNLVVAGMNSVLHAEMVAIMAAEAVLGTYTLAVRGRFELFSSCEPCAMCLGGILWS
EEECHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHCCCCHHHHHHHHHHHH
GVERLVCAAAADDARAIGFDEGPVYPESYCYLKERGIEIERGFMREEGKRVLELYRERGG
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
ILYNRR
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]