Click here to switch to the map view.

The map label for this gene is argH

Identifier: 78221433

GI number: 78221433

Start: 242364

End: 243740

Strand: Direct

Name: argH

Synonym: Gmet_0209

Alternate gene names: 78221433

Gene position: 242364-243740 (Clockwise)

Preceding gene: 78221432

Following gene: 78221434

Centisome position: 6.06

GC content: 60.71

Gene sequence:

>1377_bases
ATGACACACGAAAAACTCTGGGGCGGCCGCTTTTCCGAACCCACCGACAAATTCGTCGAGGAGTTCACCGCTTCCATCGA
TTTCGACAAGCGGCTCTACCACCAGGATATCCGCGGCTCCATCGCCCACGCCCGCATGCTCGGCAAGCAGGGTATTATCC
CCATGGAGGATGTGGAGAAGATCACGGCCGGCCTCCAGGAGATTCTGCGCCAGATCCAGGGGGGGCAGTTCAAGTTCTCG
GTGGCCCTGGAAGACATCCACATGAACATCGAGGCCCGTCTCTCCGAGAAAATCGGCGAGGCCGGCAAGCGCCTCCACAC
CGGCCGTTCCCGCAACGACCAGGTGGCCCTCGACATCCGCCTCTATCTGCGGGACGAGATCGTGGAGGTTTCGGCCTACC
TCGACCTGCTGGTGGATTCCCTCATTTCCCAGGCCGAAAAGAACTTGGGGGTCATCATGCCTGGGTATACCCACCTCCAG
ACCGCCCAGCCGATTCTCTTCTCCCACCACATGATGGCCTATGTGGAGATGTTCAGCCGGGACAAGGGGCGGATGGAGGA
CTGCCTGCGGCGTATGAACGTCCTTCCCCTGGGGGCCGGAGCCCTGGCGGGAACCACTTTCCCCATCGACCGGGAGCATG
TGGCCGAGATTCTGGACTTCCCCGAAGTGACCCGCAATTCCCTCGACTCGGTTTCGGACCGGGACTTCGCCCTGGAGTTT
ATGGCTGCCTCGTCGATACTGATGATGCACCTCTCCCGCTTCTCCGAGGAGTTGATTCTCTGGTCCACCAGCGAGTTTAA
GTTCGTGGACCTTTCCGACTCCTTCTGCACCGGCTCCTCCATCATGCCCCAGAAGAAGAACCCGGACGTGCCGGAGCTGG
TCCGCGGCAAGACCGGCCGGGTCTACGGCAACCTCATGGCGCTCCTCACGGTCATGAAGGCCCTTCCCCTTGCCTACAAC
AAGGATATGCAAGAGGACAAGGAGCCCCTCTTCGACACCATCGACACCGTGAAGGGGAGCCTGAAGATATTTGCCGACAT
GGTTGGCGAGATGCGGATCAACACCGGGAATATGCGCGCCGCAGCGGCCAAGGGGTTTTCCACCGCCACTGATGTGGCCG
ATTACCTTGTCCGCAAGGGGATGCCGTTCCGCGATGCCCATGAGGTGGTGGGCAAGACCGTGGCTTACTGCCTCTCCAAC
GGCAAGGACCTGCCGGACCTGACTCTTGGGGAATGGCAAGGATTCTCCGATAAAATCGGGGAAGATATCTTCGGCTGCAT
CACCCTCGAGGCATCGGTAAATGCCCGGTCCGCCACCGGCGGTACTGCGTTGGAGCGGGTGAAGGCCGAGATCGCGCGGG
TCAAGGCGGGCAGATAA

Upstream 100 bases:

>100_bases
GATGGTGGCCGAGTTCGAGATCGGGCAGGAAGGATGAGGGAATTAAAAACCTCGTTCCTGAAAATATCAGCAAAAACGCT
CTGAATTGAAGGAGATAACC

Downstream 100 bases:

>100_bases
TCCCTTGGGATAACCATCAACGAGCGGGCGGGGCATCCCCCGCCCCCACGGACGGACAGATGATAGCCAGATATCTTGTG
ATAGTAGGGTTGCTCCTCCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTHEKLWGGRFSEPTDKFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGIIPMEDVEKITAGLQEILRQIQGGQFKFS
VALEDIHMNIEARLSEKIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEVSAYLDLLVDSLISQAEKNLGVIMPGYTHLQ
TAQPILFSHHMMAYVEMFSRDKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAEILDFPEVTRNSLDSVSDRDFALEF
MAASSILMMHLSRFSEELILWSTSEFKFVDLSDSFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKALPLAYN
KDMQEDKEPLFDTIDTVKGSLKIFADMVGEMRINTGNMRAAAAKGFSTATDVADYLVRKGMPFRDAHEVVGKTVAYCLSN
GKDLPDLTLGEWQGFSDKIGEDIFGCITLEASVNARSATGGTALERVKAEIARVKAGR

Sequences:

>Translated_458_residues
MTHEKLWGGRFSEPTDKFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGIIPMEDVEKITAGLQEILRQIQGGQFKFS
VALEDIHMNIEARLSEKIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEVSAYLDLLVDSLISQAEKNLGVIMPGYTHLQ
TAQPILFSHHMMAYVEMFSRDKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAEILDFPEVTRNSLDSVSDRDFALEF
MAASSILMMHLSRFSEELILWSTSEFKFVDLSDSFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKALPLAYN
KDMQEDKEPLFDTIDTVKGSLKIFADMVGEMRINTGNMRAAAAKGFSTATDVADYLVRKGMPFRDAHEVVGKTVAYCLSN
GKDLPDLTLGEWQGFSDKIGEDIFGCITLEASVNARSATGGTALERVKAEIARVKAGR
>Mature_457_residues
THEKLWGGRFSEPTDKFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGIIPMEDVEKITAGLQEILRQIQGGQFKFSV
ALEDIHMNIEARLSEKIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEVSAYLDLLVDSLISQAEKNLGVIMPGYTHLQT
AQPILFSHHMMAYVEMFSRDKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAEILDFPEVTRNSLDSVSDRDFALEFM
AASSILMMHLSRFSEELILWSTSEFKFVDLSDSFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKALPLAYNK
DMQEDKEPLFDTIDTVKGSLKIFADMVGEMRINTGNMRAAAAKGFSTATDVADYLVRKGMPFRDAHEVVGKTVAYCLSNG
KDLPDLTLGEWQGFSDKIGEDIFGCITLEASVNARSATGGTALERVKAEIARVKAGR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=452, Percent_Identity=44.4690265486726, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303542, Length=452, Percent_Identity=44.4690265486726, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI68303547, Length=452, Percent_Identity=42.2566371681416, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI68303549, Length=452, Percent_Identity=42.2566371681416, Blast_Score=354, Evalue=9e-98,
Organism=Escherichia coli, GI1790398, Length=452, Percent_Identity=47.1238938053097, Blast_Score=435, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=46.0698689956332, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI221473854, Length=451, Percent_Identity=40.7982261640798, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI78706858, Length=451, Percent_Identity=40.7982261640798, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_GEOMG (Q39Z69)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383180.1
- ProteinModelPortal:   Q39Z69
- SMR:   Q39Z69
- STRING:   Q39Z69
- GeneID:   3739671
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0209
- NMPDR:   fig|269799.3.peg.240
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- PhylomeDB:   Q39Z69
- ProtClustDB:   PRK00855
- BioCyc:   GMET269799:GMET_0209-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51048; Mature: 50917

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHEKLWGGRFSEPTDKFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGIIPMEDVEK
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ITAGLQEILRQIQGGQFKFSVALEDIHMNIEARLSEKIGEAGKRLHTGRSRNDQVALDIR
HHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
LYLRDEIVEVSAYLDLLVDSLISQAEKNLGVIMPGYTHLQTAQPILFSHHMMAYVEMFSR
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCHHHHHHHHHHHHHHHHC
DKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAEILDFPEVTRNSLDSVSDRDFALEF
CCCHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHH
MAASSILMMHLSRFSEELILWSTSEFKFVDLSDSFCTGSSIMPQKKNPDVPELVRGKTGR
HHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCH
VYGNLMALLTVMKALPLAYNKDMQEDKEPLFDTIDTVKGSLKIFADMVGEMRINTGNMRA
HHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH
AAAKGFSTATDVADYLVRKGMPFRDAHEVVGKTVAYCLSNGKDLPDLTLGEWQGFSDKIG
HHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHH
EDIFGCITLEASVNARSATGGTALERVKAEIARVKAGR
HHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
THEKLWGGRFSEPTDKFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGIIPMEDVEK
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ITAGLQEILRQIQGGQFKFSVALEDIHMNIEARLSEKIGEAGKRLHTGRSRNDQVALDIR
HHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
LYLRDEIVEVSAYLDLLVDSLISQAEKNLGVIMPGYTHLQTAQPILFSHHMMAYVEMFSR
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCHHHHHHHHHHHHHHHHC
DKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAEILDFPEVTRNSLDSVSDRDFALEF
CCCHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHH
MAASSILMMHLSRFSEELILWSTSEFKFVDLSDSFCTGSSIMPQKKNPDVPELVRGKTGR
HHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCH
VYGNLMALLTVMKALPLAYNKDMQEDKEPLFDTIDTVKGSLKIFADMVGEMRINTGNMRA
HHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH
AAAKGFSTATDVADYLVRKGMPFRDAHEVVGKTVAYCLSNGKDLPDLTLGEWQGFSDKIG
HHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHH
EDIFGCITLEASVNARSATGGTALERVKAEIARVKAGR
HHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA