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The map label for this gene is nuoL [H]

Identifier: 78221393

GI number: 78221393

Start: 195257

End: 197134

Strand: Direct

Name: nuoL [H]

Synonym: Gmet_0168

Alternate gene names: 78221393

Gene position: 195257-197134 (Clockwise)

Preceding gene: 78221392

Following gene: 78221394

Centisome position: 4.88

GC content: 66.61

Gene sequence:

>1878_bases
ATGAAACTCTACCTCACCACCATACTCCTGCTCCCCCTCCTCGGGGGAGCCATCAATGCCGTTATCGGGCGCAAACTCCC
CCGCCGCGCGTGCGAGGCCCTGGCCTGCACCGCGGTCTGGGGGGCTTTTGCCGGCGCGGTCCTGGCCTTCGCGGCCTACC
GGACCCCGGTCACGGTGGAGCTGGCCTCGTGGCTGGCTGACTTCGATTTTTCCGCTCCCGTTACCCTCTACCTGGACCCC
CTCTCCCTGGTGATGATGGTCATGGTCACCTTCGTCTGCGGGATCATCCACCTCTATTCCGTGGGATACATGGCGAAGGA
GGAAAGCCCGGCCCGGTTCTTCGCCCTCCTGAACCTCTTCGTTTTCGCCATGCTGGTCCTGGTCCTGGCGGAGAACCTGC
CGCTCCTCTATCTCGGCTGGGAGGGGGTCGGCTTCTGCTCCTACGCTCTCATCGGCTTCTGGTACGACGACCCGAAGAAC
GCCACCGCCGGCCGCAAGGCCTTCATCGTGACGCGGATCGGCGACACCGCCTTCGGCATCGGCATTGTCTGGTGCTTCCA
GCTCTTCCAGACCGTCTCCATTACTCAGATCAACCAGATGGGGTTCCTGATGCCCGTGGGGATCATCACCACCCTCGGGC
TCCTCTTTCTGGCCGGGGCCATGGGGAAATCGGCCCAGGTTCCGCTCATGGTCTGGCTCCCCGACGCCATGGCCGGCCCC
ACGCCGGTCTCGGCCCTGATCCACGCCGCCACCATGGTCACCGCCGGGGTCTACCTCATGGCGAGGATGTCGCCCCTCTT
CGGGGCGGCTCCCGTGGTCATGGCCGCCGTAGCCGTCACCGGGGCGGTCACCGCCTTCTACGGCGCCTCGTGTGCCTTGG
TGCAGCGGGACTTCAAGCGAGTGCTGGCCTACTCCACCATCAGCCAGATCGGCTACATGATGCTCGGCGTGGGGGCCGGC
GCCGTCACCGCCGCCACCTTTCACCTCCTGGAGCACGCTTTCTTCAAGGCCCTCCTCTTCCTGGGAGCCGGCTGCGTCAT
CACGGCTCTCCACCACGAGCAGGACATCTTCAGGATGGGGGGACTGCGCACGCGGATGCCCCTCACCTTCTGGGCCTTCC
TGGCCGGGGCCGCCTGTCTGGCCGGACTTCCCCCCACCGGCGGATTCTTCAGCAAGGACGCCATCCTGGCCGCGGTCTGG
GCCAAGGGGGGGCTCCTCTACGGCGGGCTCTTCACCCTGGGCCTTCTGGCGGCGCTCTTCACCTCCTTCTACACGTTTCG
AATGGTTTACCTGGTCTTTGGCGGCGAAGGGGTGACAGAGGTCCACCACGCTCCCCGGATCATGGAGACAATGCTGCTCC
CCCTGGCGCTCCTAGGGCTCCTGGGAGGCATCATTCACCTCCCCGACTTTCTGGCCGAAGGCTGGCTCGGCCGCTTCCTG
GCCACGGCCTTGACCGAACGCGCCCCTCACCTCGCCCACGGTGAGGAGATGGCCGTAGAGGGAGTCGCGGCCCTGGTGGC
CCTCGCCGGCCTCGCCGCGGCCCACCTCCGCTACGGAGGAGTGCGGCGCGCGGCCCGGATCGAGGGGGCCGCCGCGGAAC
CACGGGGAATCACCGCCTTCCTCCTGAACGGCTGGTACGCCGACAATTTCTACCGGTTCCTTCTCATCCGCCCCTACGAG
GCCCTGGCAGGCTTCCTCTGGCGCCGGGTGGACGAAGGGGTGATCGACGATTCCCTGGACCGTCTGGCCGGCAACTTGGG
CAAAACCGGCCAAGGGCTGGGGGGGTGGAGCTGCGGGAGGGTGTCAGTCTATCTCCTCAGTTTTGCCGCGGGGTTGGCGC
TGATTCTGGGGTGGCTGGCGTGGGAGATGGTGTGGTAG

Upstream 100 bases:

>100_bases
CCCTCACCTCAGCCGAGGTCTCCCTGGCCCTGGCCATGGTGGTCTACCTCCACCGGCGCAAGAGGACGGTGGATGCGGAT
GAGTTCAGCGAGCTGAAGGG

Downstream 100 bases:

>100_bases
ATGGAGAACCGCCGGAATGGATGCGCAGCATGAATGACCGGACTGAACACGGAAGGGACCGGGGATGAGCACGAAGAGCG
AAACTCACTATGCGGAGCGA

Product: NADH-plastoquinone oxidoreductase, chain 5

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L; NUO12 [H]

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MKLYLTTILLLPLLGGAINAVIGRKLPRRACEALACTAVWGAFAGAVLAFAAYRTPVTVELASWLADFDFSAPVTLYLDP
LSLVMMVMVTFVCGIIHLYSVGYMAKEESPARFFALLNLFVFAMLVLVLAENLPLLYLGWEGVGFCSYALIGFWYDDPKN
ATAGRKAFIVTRIGDTAFGIGIVWCFQLFQTVSITQINQMGFLMPVGIITTLGLLFLAGAMGKSAQVPLMVWLPDAMAGP
TPVSALIHAATMVTAGVYLMARMSPLFGAAPVVMAAVAVTGAVTAFYGASCALVQRDFKRVLAYSTISQIGYMMLGVGAG
AVTAATFHLLEHAFFKALLFLGAGCVITALHHEQDIFRMGGLRTRMPLTFWAFLAGAACLAGLPPTGGFFSKDAILAAVW
AKGGLLYGGLFTLGLLAALFTSFYTFRMVYLVFGGEGVTEVHHAPRIMETMLLPLALLGLLGGIIHLPDFLAEGWLGRFL
ATALTERAPHLAHGEEMAVEGVAALVALAGLAAAHLRYGGVRRAARIEGAAAEPRGITAFLLNGWYADNFYRFLLIRPYE
ALAGFLWRRVDEGVIDDSLDRLAGNLGKTGQGLGGWSCGRVSVYLLSFAAGLALILGWLAWEMVW

Sequences:

>Translated_625_residues
MKLYLTTILLLPLLGGAINAVIGRKLPRRACEALACTAVWGAFAGAVLAFAAYRTPVTVELASWLADFDFSAPVTLYLDP
LSLVMMVMVTFVCGIIHLYSVGYMAKEESPARFFALLNLFVFAMLVLVLAENLPLLYLGWEGVGFCSYALIGFWYDDPKN
ATAGRKAFIVTRIGDTAFGIGIVWCFQLFQTVSITQINQMGFLMPVGIITTLGLLFLAGAMGKSAQVPLMVWLPDAMAGP
TPVSALIHAATMVTAGVYLMARMSPLFGAAPVVMAAVAVTGAVTAFYGASCALVQRDFKRVLAYSTISQIGYMMLGVGAG
AVTAATFHLLEHAFFKALLFLGAGCVITALHHEQDIFRMGGLRTRMPLTFWAFLAGAACLAGLPPTGGFFSKDAILAAVW
AKGGLLYGGLFTLGLLAALFTSFYTFRMVYLVFGGEGVTEVHHAPRIMETMLLPLALLGLLGGIIHLPDFLAEGWLGRFL
ATALTERAPHLAHGEEMAVEGVAALVALAGLAAAHLRYGGVRRAARIEGAAAEPRGITAFLLNGWYADNFYRFLLIRPYE
ALAGFLWRRVDEGVIDDSLDRLAGNLGKTGQGLGGWSCGRVSVYLLSFAAGLALILGWLAWEMVW
>Mature_625_residues
MKLYLTTILLLPLLGGAINAVIGRKLPRRACEALACTAVWGAFAGAVLAFAAYRTPVTVELASWLADFDFSAPVTLYLDP
LSLVMMVMVTFVCGIIHLYSVGYMAKEESPARFFALLNLFVFAMLVLVLAENLPLLYLGWEGVGFCSYALIGFWYDDPKN
ATAGRKAFIVTRIGDTAFGIGIVWCFQLFQTVSITQINQMGFLMPVGIITTLGLLFLAGAMGKSAQVPLMVWLPDAMAGP
TPVSALIHAATMVTAGVYLMARMSPLFGAAPVVMAAVAVTGAVTAFYGASCALVQRDFKRVLAYSTISQIGYMMLGVGAG
AVTAATFHLLEHAFFKALLFLGAGCVITALHHEQDIFRMGGLRTRMPLTFWAFLAGAACLAGLPPTGGFFSKDAILAAVW
AKGGLLYGGLFTLGLLAALFTSFYTFRMVYLVFGGEGVTEVHHAPRIMETMLLPLALLGLLGGIIHLPDFLAEGWLGRFL
ATALTERAPHLAHGEEMAVEGVAALVALAGLAAAHLRYGGVRRAARIEGAAAEPRGITAFLLNGWYADNFYRFLLIRPYE
ALAGFLWRRVDEGVIDDSLDRLAGNLGKTGQGLGGWSCGRVSVYLLSFAAGLALILGWLAWEMVW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=425, Percent_Identity=36.9411764705882, Blast_Score=245, Evalue=1e-64,
Organism=Escherichia coli, GI1788614, Length=546, Percent_Identity=43.956043956044, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1788829, Length=415, Percent_Identity=33.0120481927711, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788827, Length=365, Percent_Identity=30.958904109589, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788831, Length=373, Percent_Identity=29.4906166219839, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI2367154, Length=418, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788613, Length=466, Percent_Identity=26.1802575107296, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI145693160, Length=304, Percent_Identity=23.6842105263158, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66982; Mature: 66982

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYLTTILLLPLLGGAINAVIGRKLPRRACEALACTAVWGAFAGAVLAFAAYRTPVTVE
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LASWLADFDFSAPVTLYLDPLSLVMMVMVTFVCGIIHLYSVGYMAKEESPARFFALLNLF
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VFAMLVLVLAENLPLLYLGWEGVGFCSYALIGFWYDDPKNATAGRKAFIVTRIGDTAFGI
HHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHEEECCCCCCCCCCEEEEEEECCCHHHHH
GIVWCFQLFQTVSITQINQMGFLMPVGIITTLGLLFLAGAMGKSAQVPLMVWLPDAMAGP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
TPVSALIHAATMVTAGVYLMARMSPLFGAAPVVMAAVAVTGAVTAFYGASCALVQRDFKR
CHHHHHHHHHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VLAYSTISQIGYMMLGVGAGAVTAATFHLLEHAFFKALLFLGAGCVITALHHEQDIFRMG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GLRTRMPLTFWAFLAGAACLAGLPPTGGFFSKDAILAAVWAKGGLLYGGLFTLGLLAALF
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TSFYTFRMVYLVFGGEGVTEVHHAPRIMETMLLPLALLGLLGGIIHLPDFLAEGWLGRFL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATALTERAPHLAHGEEMAVEGVAALVALAGLAAAHLRYGGVRRAARIEGAAAEPRGITAF
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEE
LLNGWYADNFYRFLLIRPYEALAGFLWRRVDEGVIDDSLDRLAGNLGKTGQGLGGWSCGR
EECCEECCCEEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHH
VSVYLLSFAAGLALILGWLAWEMVW
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLYLTTILLLPLLGGAINAVIGRKLPRRACEALACTAVWGAFAGAVLAFAAYRTPVTVE
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LASWLADFDFSAPVTLYLDPLSLVMMVMVTFVCGIIHLYSVGYMAKEESPARFFALLNLF
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VFAMLVLVLAENLPLLYLGWEGVGFCSYALIGFWYDDPKNATAGRKAFIVTRIGDTAFGI
HHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHEEECCCCCCCCCCEEEEEEECCCHHHHH
GIVWCFQLFQTVSITQINQMGFLMPVGIITTLGLLFLAGAMGKSAQVPLMVWLPDAMAGP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
TPVSALIHAATMVTAGVYLMARMSPLFGAAPVVMAAVAVTGAVTAFYGASCALVQRDFKR
CHHHHHHHHHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VLAYSTISQIGYMMLGVGAGAVTAATFHLLEHAFFKALLFLGAGCVITALHHEQDIFRMG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GLRTRMPLTFWAFLAGAACLAGLPPTGGFFSKDAILAAVWAKGGLLYGGLFTLGLLAALF
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TSFYTFRMVYLVFGGEGVTEVHHAPRIMETMLLPLALLGLLGGIIHLPDFLAEGWLGRFL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATALTERAPHLAHGEEMAVEGVAALVALAGLAAAHLRYGGVRRAARIEGAAAEPRGITAF
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEE
LLNGWYADNFYRFLLIRPYEALAGFLWRRVDEGVIDDSLDRLAGNLGKTGQGLGGWSCGR
EECCEECCCEEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHH
VSVYLLSFAAGLALILGWLAWEMVW
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7690854; 9205837; 9278503 [H]