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The map label for this gene is nuoH1

Identifier: 78221386

GI number: 78221386

Start: 191547

End: 192536

Strand: Direct

Name: nuoH1

Synonym: Gmet_0161

Alternate gene names: 78221386

Gene position: 191547-192536 (Clockwise)

Preceding gene: 78221385

Following gene: 78221387

Centisome position: 4.79

GC content: 64.34

Gene sequence:

>990_bases
ATGACCCCTGTAGCCCTCGACATAGCCATCCACCTGGCCAAGATCGCCCTGATCTTCTTCGTGGTGCTGACTCTGGCGGC
CTACCTGGTCTTCGCCGAGCGGCGGATTCTGGCCTGGATCCAGGACCGGAAGGGACCGAACCGGGTGGGGCCCTTTGGCC
TCTTGCAGCCCCTGGCGGATCTCATCAAGCTCCTGACCAAGGAGGACTTCCGACCCGCCGGGGCCGACAAGTGGCTCTTC
TACCTGGCCCCTGCCATGGCGGCGATCCCGGCCATTCTCACCTTCGCGGTGATCCCCTTCGGGGCCCCTCTGACGCTCTT
CGGCAGGGAGGTGCCGCTCCAGGTGGCGGACCTGAACGTGGGGCTCCTTTTCTTTCTGGCACTCTCCTCAATAGCGGTGT
ATGGTGTGGCCCTGGGGGGGTGGGCGTCCAACTCCAAGTACGCGCTTTTGGGCTCCATCCGGGGGCTGGCGCAACTCATC
TCCTACGAGCTGTCCATGGGGTTGTCGCTGGTGCCGACGGTGATGCTGGCCGGGTCGCTCCGGCTCTCGGACATCGTGGC
GGCCCAGGAGGGGATCTGGTTCATCGTCTATCAGCCCCTGGCATTCGTGATCTTCCTCATCAGCATCGCGGCGGAGTGCA
AGCGGATTCCCTTCGACATCCCCGAGGCGGAGGGGGAGCTGGTGGCCGGGTTCCACACCGAGTACTCGGGGATGCGCTTC
GGCCTTTTCTTCGTGGGGGAGTACATCAACATCATCGTCCTCGGCGGGCTGGCAACCACCTTCTTCCTGGGGGGTTGGCA
CGGGCCGTGGCTCCCCCCCTTCGTCTGGTTCTCGGCGAAGACCCTCGCCTTCGCCTTCTTCTTCATCTGGATGCGGGGGA
CGCTGCCGCGGCTTCGCTACGACCAGCTCATGCACCTGGGCTGGAAGGTGCTGACGCCGCTGGCGCTGGTCAACATTCTT
GTCACCGGCTGGATACTGATGCTCCGCTAA

Upstream 100 bases:

>100_bases
AGCCTTGCATGATATCCAATCACAAACCTTGCCAAGCGGCTGGGGGTGACCAAGCGGCGTGACAGGCTGAGACGACAGGC
AGCGAAACAGAGATGATGGA

Downstream 100 bases:

>100_bases
CGGAGCATCGGACATTTTAACGGAAAGGAGGGGAACGGGTAGTCCGCACGCATCAAGGTATCACTCACGCATTGGTCATT
GTCCCGGAGAAGTGAACTCA

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 1; NDH-1 subunit H 1

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTPVALDIAIHLAKIALIFFVVLTLAAYLVFAERRILAWIQDRKGPNRVGPFGLLQPLADLIKLLTKEDFRPAGADKWLF
YLAPAMAAIPAILTFAVIPFGAPLTLFGREVPLQVADLNVGLLFFLALSSIAVYGVALGGWASNSKYALLGSIRGLAQLI
SYELSMGLSLVPTVMLAGSLRLSDIVAAQEGIWFIVYQPLAFVIFLISIAAECKRIPFDIPEAEGELVAGFHTEYSGMRF
GLFFVGEYINIIVLGGLATTFFLGGWHGPWLPPFVWFSAKTLAFAFFFIWMRGTLPRLRYDQLMHLGWKVLTPLALVNIL
VTGWILMLR

Sequences:

>Translated_329_residues
MTPVALDIAIHLAKIALIFFVVLTLAAYLVFAERRILAWIQDRKGPNRVGPFGLLQPLADLIKLLTKEDFRPAGADKWLF
YLAPAMAAIPAILTFAVIPFGAPLTLFGREVPLQVADLNVGLLFFLALSSIAVYGVALGGWASNSKYALLGSIRGLAQLI
SYELSMGLSLVPTVMLAGSLRLSDIVAAQEGIWFIVYQPLAFVIFLISIAAECKRIPFDIPEAEGELVAGFHTEYSGMRF
GLFFVGEYINIIVLGGLATTFFLGGWHGPWLPPFVWFSAKTLAFAFFFIWMRGTLPRLRYDQLMHLGWKVLTPLALVNIL
VTGWILMLR
>Mature_328_residues
TPVALDIAIHLAKIALIFFVVLTLAAYLVFAERRILAWIQDRKGPNRVGPFGLLQPLADLIKLLTKEDFRPAGADKWLFY
LAPAMAAIPAILTFAVIPFGAPLTLFGREVPLQVADLNVGLLFFLALSSIAVYGVALGGWASNSKYALLGSIRGLAQLIS
YELSMGLSLVPTVMLAGSLRLSDIVAAQEGIWFIVYQPLAFVIFLISIAAECKRIPFDIPEAEGELVAGFHTEYSGMRFG
LFFVGEYINIIVLGGLATTFFLGGWHGPWLPPFVWFSAKTLAFAFFFIWMRGTLPRLRYDQLMHLGWKVLTPLALVNILV
TGWILMLR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=292, Percent_Identity=45.2054794520548, Blast_Score=244, Evalue=6e-65,
Organism=Escherichia coli, GI1788618, Length=327, Percent_Identity=47.7064220183486, Blast_Score=310, Evalue=8e-86,
Organism=Escherichia coli, GI1789077, Length=313, Percent_Identity=28.4345047923323, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH1_GEOMG (Q39ZB6)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383133.1
- STRING:   Q39ZB6
- GeneID:   3739642
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0161
- NMPDR:   fig|269799.3.peg.59
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   MSWLTPE
- PhylomeDB:   Q39ZB6
- ProtClustDB:   CLSK829280
- BioCyc:   GMET269799:GMET_0161-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 36324; Mature: 36193

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd2e7f2c)-; HASH(0xefdb4ac)-; HASH(0xd674e4c)-; HASH(0xf2f9b18)-; HASH(0xfd2e728)-; HASH(0xfa0e164)-; HASH(0xdb05c6c)-; HASH(0xf346cb0)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPVALDIAIHLAKIALIFFVVLTLAAYLVFAERRILAWIQDRKGPNRVGPFGLLQPLAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LIKLLTKEDFRPAGADKWLFYLAPAMAAIPAILTFAVIPFGAPLTLFGREVPLQVADLNV
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCH
GLLFFLALSSIAVYGVALGGWASNSKYALLGSIRGLAQLISYELSMGLSLVPTVMLAGSL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
RLSDIVAAQEGIWFIVYQPLAFVIFLISIAAECKRIPFDIPEAEGELVAGFHTEYSGMRF
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEE
GLFFVGEYINIIVLGGLATTFFLGGWHGPWLPPFVWFSAKTLAFAFFFIWMRGTLPRLRY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
DQLMHLGWKVLTPLALVNILVTGWILMLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
TPVALDIAIHLAKIALIFFVVLTLAAYLVFAERRILAWIQDRKGPNRVGPFGLLQPLAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LIKLLTKEDFRPAGADKWLFYLAPAMAAIPAILTFAVIPFGAPLTLFGREVPLQVADLNV
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCH
GLLFFLALSSIAVYGVALGGWASNSKYALLGSIRGLAQLISYELSMGLSLVPTVMLAGSL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
RLSDIVAAQEGIWFIVYQPLAFVIFLISIAAECKRIPFDIPEAEGELVAGFHTEYSGMRF
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEE
GLFFVGEYINIIVLGGLATTFFLGGWHGPWLPPFVWFSAKTLAFAFFFIWMRGTLPRLRY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
DQLMHLGWKVLTPLALVNILVTGWILMLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA