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The map label for this gene is hemH

Identifier: 78221247

GI number: 78221247

Start: 26344

End: 27297

Strand: Direct

Name: hemH

Synonym: Gmet_0019

Alternate gene names: 78221247

Gene position: 26344-27297 (Clockwise)

Preceding gene: 78221245

Following gene: 78221248

Centisome position: 0.66

GC content: 64.26

Gene sequence:

>954_bases
ATGTCAGAAAAAACCGCTGTCCTCCTCCTTCAGATGGGGGGGCCCGACTCCCTGGACGCCGTGGAGCCCTTCCTCGTCAA
CCTCTTTTCCGACCGGGACATCATCCGGATTGGCCCCGCCTTCCTGCAGCCCTTTATCGCCCGGCTCATCGCCAAGAAGC
GGGCCACGCCGGTGGAGCGGAAGTATGAGGAGATCGGCGGCAAGTCCCCCATCCGGGAGCTGACCGAGGCCCAGGCGAAG
GCCCTGGAGGAGGTTCTGGGGGACGGGTACTGCTGCTTCACGGCCATGCGCTACTGGAAGCCCACCACGGTGGAGGCCCT
GGCGGCCATCCGGCGGGAGGGAATCACGCGGATCATCGCCCTCTCCCTCTATCCCCACTACTCCCGGGCCACCACCGGCT
CCAGCGTGAACGAGCTGAAGCGGGTCCTGGCCCAATCGGGCGCCACCTTTGACGTCACCTACGTGGATCGCTTCTTTGAC
CATCCCCGCTACATCGAGGCCCTGGCCGAGAAAATAAAGGAAGGGCTCGACGACTTCCACCCCCTGGCCGAGGTGCAGAT
CCTCTTTTCGGCCCATTCCCTTCCCCAGTCCTTTATCGACGAAGGTGACCCCTACCTCTCCCATATCGAGGAGACGGTGC
GGCTCGTTATGGAGCGGTTCGAGGGGGTCACCTACCACCTGGCCTTCCAGTCCCGGGCCGGGCCGGTCAAGTGGCTGGAG
CCCTCCACCGAGGAGATACTGGAGTACCTGGCGGCCCACCAGGTGAAGAACCTCCTCATGGTTCCCCTCTCCTTCGTGTC
GGACCACATCGAGACCCTCCACGAGATCGACATCGAGTACGCCATGCTGGCCCACCGGCTGGGGTACGCCAAATTCCGCC
GCTCCCCCTCCCTGAACACCTCTCCCCTCTTCATCGACTGCCTGGCGGACCTGGTGCGGAAGGCGGGGATGTGA

Upstream 100 bases:

>100_bases
GCGACGAATTCCCTCTTCTTCCTCCTTGACCGGTCCGGGGTAATGGGGTATCTGGAAGGGGTGCCGAAAGGCCCAACCTT
CGACCGTTCGCGAGGCGACC

Downstream 100 bases:

>100_bases
GCCGGATGGAAAAGGAAACGAAAGCCTGCGCCATCTGCGGAAATGAATTCACCCCCGGAGAGGAGCGCACCCCCTACGAG
GAGGCGGGGGAGTGGCTGGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSEKTAVLLLQMGGPDSLDAVEPFLVNLFSDRDIIRIGPAFLQPFIARLIAKKRATPVERKYEEIGGKSPIRELTEAQAK
ALEEVLGDGYCCFTAMRYWKPTTVEALAAIRREGITRIIALSLYPHYSRATTGSSVNELKRVLAQSGATFDVTYVDRFFD
HPRYIEALAEKIKEGLDDFHPLAEVQILFSAHSLPQSFIDEGDPYLSHIEETVRLVMERFEGVTYHLAFQSRAGPVKWLE
PSTEEILEYLAAHQVKNLLMVPLSFVSDHIETLHEIDIEYAMLAHRLGYAKFRRSPSLNTSPLFIDCLADLVRKAGM

Sequences:

>Translated_317_residues
MSEKTAVLLLQMGGPDSLDAVEPFLVNLFSDRDIIRIGPAFLQPFIARLIAKKRATPVERKYEEIGGKSPIRELTEAQAK
ALEEVLGDGYCCFTAMRYWKPTTVEALAAIRREGITRIIALSLYPHYSRATTGSSVNELKRVLAQSGATFDVTYVDRFFD
HPRYIEALAEKIKEGLDDFHPLAEVQILFSAHSLPQSFIDEGDPYLSHIEETVRLVMERFEGVTYHLAFQSRAGPVKWLE
PSTEEILEYLAAHQVKNLLMVPLSFVSDHIETLHEIDIEYAMLAHRLGYAKFRRSPSLNTSPLFIDCLADLVRKAGM
>Mature_316_residues
SEKTAVLLLQMGGPDSLDAVEPFLVNLFSDRDIIRIGPAFLQPFIARLIAKKRATPVERKYEEIGGKSPIRELTEAQAKA
LEEVLGDGYCCFTAMRYWKPTTVEALAAIRREGITRIIALSLYPHYSRATTGSSVNELKRVLAQSGATFDVTYVDRFFDH
PRYIEALAEKIKEGLDDFHPLAEVQILFSAHSLPQSFIDEGDPYLSHIEETVRLVMERFEGVTYHLAFQSRAGPVKWLEP
STEEILEYLAAHQVKNLLMVPLSFVSDHIETLHEIDIEYAMLAHRLGYAKFRRSPSLNTSPLFIDCLADLVRKAGM

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=322, Percent_Identity=42.8571428571429, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI60499025, Length=322, Percent_Identity=42.8571428571429, Blast_Score=222, Evalue=4e-58,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=29.375, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324750, Length=321, Percent_Identity=38.9408099688474, Blast_Score=216, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17864156, Length=321, Percent_Identity=38.006230529595, Blast_Score=217, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=35.9375, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45552018, Length=164, Percent_Identity=40.8536585365854, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_GEOMG (Q39ZQ5)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_382994.1
- ProteinModelPortal:   Q39ZQ5
- SMR:   Q39ZQ5
- STRING:   Q39ZQ5
- GeneID:   3739921
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0019
- NMPDR:   fig|269799.3.peg.83
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- PhylomeDB:   Q39ZQ5
- ProtClustDB:   CLSK790160
- BioCyc:   GMET269799:GMET_0019-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35818; Mature: 35686

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKTAVLLLQMGGPDSLDAVEPFLVNLFSDRDIIRIGPAFLQPFIARLIAKKRATPVER
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCHHH
KYEEIGGKSPIRELTEAQAKALEEVLGDGYCCFTAMRYWKPTTVEALAAIRREGITRIIA
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LSLYPHYSRATTGSSVNELKRVLAQSGATFDVTYVDRFFDHPRYIEALAEKIKEGLDDFH
HHHCCCHHHCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
PLAEVQILFSAHSLPQSFIDEGDPYLSHIEETVRLVMERFEGVTYHLAFQSRAGPVKWLE
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
PSTEEILEYLAAHQVKNLLMVPLSFVSDHIETLHEIDIEYAMLAHRLGYAKFRRSPSLNT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SPLFIDCLADLVRKAGM
CCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEKTAVLLLQMGGPDSLDAVEPFLVNLFSDRDIIRIGPAFLQPFIARLIAKKRATPVER
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCHHH
KYEEIGGKSPIRELTEAQAKALEEVLGDGYCCFTAMRYWKPTTVEALAAIRREGITRIIA
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LSLYPHYSRATTGSSVNELKRVLAQSGATFDVTYVDRFFDHPRYIEALAEKIKEGLDDFH
HHHCCCHHHCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
PLAEVQILFSAHSLPQSFIDEGDPYLSHIEETVRLVMERFEGVTYHLAFQSRAGPVKWLE
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
PSTEEILEYLAAHQVKNLLMVPLSFVSDHIETLHEIDIEYAMLAHRLGYAKFRRSPSLNT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SPLFIDCLADLVRKAGM
CCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA