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The map label for this gene is sdhA

Identifier: 78189887

GI number: 78189887

Start: 2465683

End: 2467623

Strand: Reverse

Name: sdhA

Synonym: Cag_1934

Alternate gene names: 78189887

Gene position: 2467623-2465683 (Counterclockwise)

Preceding gene: 78189888

Following gene: 78189886

Centisome position: 95.94

GC content: 49.82

Gene sequence:

>1941_bases
ATGACTATGTTCGATGCCAAAATTCCTGAAGGAGCGTTGGCGCAAAAGTGGAGCCGCTATCAAGCGTCGTGCAAATTAGT
GAGCCCTGCAAACAAGCGGAAGCTCGATATTATTGTGGTGGGAACAGGCTTAGCAGGCGCTTCAGCGGCAGCATCGCTGG
GGGAGCTTGGCTATAACGTTAAGGTCTTTTGCTATCAAGATTCACCTCGTCGCGCCCATAGCATTGCAGCGCAAGGTGGC
ATTAATGCGGCAAAGAATTACCAAAATGATGGCGATAGTGTTTCGCGCTTGTTTTACGATACCATTAAAGGTGGTGATTA
TCGGGCGCGTGAGGCAAATGTGTATCGCTTAGCGGAGGTGAGCAGTCGCATTATTGACGTGTGCGTGGCGCAAGGGGTGC
CGTTTGCGCGTGAGTATGGTGGGTTACTTGCAAACCGTTCGTTTGGCGGTGCGCAGGTGTCGCGCACTTTTTATGCGCGT
GGGCAAACAGGGCAGCAGTTGTTGCTTGGCGCGTATAGTGCTATGAGCCGTCAAATTGCGTTGGGGCATGTAACGCTTTA
CAATCGCCGTGATGTGCTTGATATGGTTTTGGTTGATGGCAAGGCGCGTGGCATTATTGCTCGGAACCTTGTTACGGGCG
AAATTGAGCGCCATGCGGCTCATGCGGTGGTGCTTGCAAGTGGCGGTTATGGGAACGTCTTTTTTCTCTCCACCAACGCT
ATGGGTTCCAACGTTACGCCTGTATGGAGCGCTTATAAAAAAGGGGCGATGTTTGCCAATCCCTCATTTACACAAATTCA
CCCTACCTGCTTGCCGCAACATGCAGAGTTTCAATCGAAGCTTACTTTGATGAGCGAAAGCTTGCGGAATGATGGACGTA
TTTGGGTGCCCAAACGCCTTCAGGATGCTGAAAAGCTGCGTAAGCGTGAAATAATGCCTTCGTCAATTCCAGATGCTGAG
CGCGATTATTATCTCGAACGGCGTTATCCCGCCTTTGGCAATTTGGTGCCGCGCGATGTGGCTTCGCGAGCCGCAAAAGA
GCGCTGTGACGCAGGTTTTGGTGTTGGGCGCACGGGTTTAGCGGTTTTTCTCGATTTTGCGGATGCTATTAAACGCAAAG
GGCGCGATAAAATTGATTCGCTCTACGGCAATTTGTTCCACATGTACGAGCAAATTGTAGCAGAAAATCCTATGGAAACG
CCTATGATGATTTACCCTGCTGTGCATTACACTATGGGTGGCTTATGGGTTGATTATGAACTAATGACCACCATTCCCGG
TTTGTACGCAATTGGAGAGGCTAATTTTTCGGATCACGGAGCAAATCGGCTTGGAGCTTCCGCCTTAATGCAAGGGTTAG
CCGATGGCTATTTTATTCTGCCGAGTACCATTGGCAACTATCTTTCGCATGAAATTCATACGCCACGTTTTAACCCCGAT
AGCGCTGAATTTACCCTTGCGGCTGAAGCAGTACGCGATCGTCTCCAGCGATTTTTGAAGCAGGGCGGTAATGAAAGTGT
AGATTCTTTTCACCGTCGGCTTGGACGCATTATGTGGGATTATTGCGGTATGGCGCGTCGTGAAAGTGGACTTTTGCAGG
CACAAGAGCTGCTTGCTGCCTTGCGCCACGAGTATGAGCACGGGGTGAAAGTGCTTGGTGGTTTAAACGAGTACAACCCT
GAACTTGAAAAAGCGTGCCGTGTGGCTGATTTTATTGAGCTTGGTGAACTGATGGTGCGCGATGCTCAAGCGCGCAATGA
ATCATGCGGTGGGCACTTTCGCGAAGAGTTCCAAACAAGTGAAGGCGAAGCCCTTCGCAACGATGAAGCCTTTTCGTTTG
TTGCGGCATGGGAATACAAAGGCAAACATGCTGAAGCCACCATGCACCGCGAAGCGTTGAATTTTCAAGAAATTACTCCA
ACTCAGCGTTGTTATAAGTAA

Upstream 100 bases:

>100_bases
ATTGCTACGGGTTTTTCAATTGTGCCTATCGTGCTATGCTTTTTCCGTCCGTAATGCCTCTTAGCCCATCTTTTTTTCCA
ACCCTCAGTTTTTTTCTTGT

Downstream 100 bases:

>100_bases
ACCTATACCTATGAACTTTACGCTTCATATTTGGCGACAGAAAAATGCTACAGCGCAAGGGCGCATGGTAACTTATACGG
TCAGCAATATTTCGCCCGAT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 646; Mature: 645

Protein sequence:

>646_residues
MTMFDAKIPEGALAQKWSRYQASCKLVSPANKRKLDIIVVGTGLAGASAAASLGELGYNVKVFCYQDSPRRAHSIAAQGG
INAAKNYQNDGDSVSRLFYDTIKGGDYRAREANVYRLAEVSSRIIDVCVAQGVPFAREYGGLLANRSFGGAQVSRTFYAR
GQTGQQLLLGAYSAMSRQIALGHVTLYNRRDVLDMVLVDGKARGIIARNLVTGEIERHAAHAVVLASGGYGNVFFLSTNA
MGSNVTPVWSAYKKGAMFANPSFTQIHPTCLPQHAEFQSKLTLMSESLRNDGRIWVPKRLQDAEKLRKREIMPSSIPDAE
RDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGRTGLAVFLDFADAIKRKGRDKIDSLYGNLFHMYEQIVAENPMET
PMMIYPAVHYTMGGLWVDYELMTTIPGLYAIGEANFSDHGANRLGASALMQGLADGYFILPSTIGNYLSHEIHTPRFNPD
SAEFTLAAEAVRDRLQRFLKQGGNESVDSFHRRLGRIMWDYCGMARRESGLLQAQELLAALRHEYEHGVKVLGGLNEYNP
ELEKACRVADFIELGELMVRDAQARNESCGGHFREEFQTSEGEALRNDEAFSFVAAWEYKGKHAEATMHREALNFQEITP
TQRCYK

Sequences:

>Translated_646_residues
MTMFDAKIPEGALAQKWSRYQASCKLVSPANKRKLDIIVVGTGLAGASAAASLGELGYNVKVFCYQDSPRRAHSIAAQGG
INAAKNYQNDGDSVSRLFYDTIKGGDYRAREANVYRLAEVSSRIIDVCVAQGVPFAREYGGLLANRSFGGAQVSRTFYAR
GQTGQQLLLGAYSAMSRQIALGHVTLYNRRDVLDMVLVDGKARGIIARNLVTGEIERHAAHAVVLASGGYGNVFFLSTNA
MGSNVTPVWSAYKKGAMFANPSFTQIHPTCLPQHAEFQSKLTLMSESLRNDGRIWVPKRLQDAEKLRKREIMPSSIPDAE
RDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGRTGLAVFLDFADAIKRKGRDKIDSLYGNLFHMYEQIVAENPMET
PMMIYPAVHYTMGGLWVDYELMTTIPGLYAIGEANFSDHGANRLGASALMQGLADGYFILPSTIGNYLSHEIHTPRFNPD
SAEFTLAAEAVRDRLQRFLKQGGNESVDSFHRRLGRIMWDYCGMARRESGLLQAQELLAALRHEYEHGVKVLGGLNEYNP
ELEKACRVADFIELGELMVRDAQARNESCGGHFREEFQTSEGEALRNDEAFSFVAAWEYKGKHAEATMHREALNFQEITP
TQRCYK
>Mature_645_residues
TMFDAKIPEGALAQKWSRYQASCKLVSPANKRKLDIIVVGTGLAGASAAASLGELGYNVKVFCYQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVSRLFYDTIKGGDYRAREANVYRLAEVSSRIIDVCVAQGVPFAREYGGLLANRSFGGAQVSRTFYARG
QTGQQLLLGAYSAMSRQIALGHVTLYNRRDVLDMVLVDGKARGIIARNLVTGEIERHAAHAVVLASGGYGNVFFLSTNAM
GSNVTPVWSAYKKGAMFANPSFTQIHPTCLPQHAEFQSKLTLMSESLRNDGRIWVPKRLQDAEKLRKREIMPSSIPDAER
DYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGRTGLAVFLDFADAIKRKGRDKIDSLYGNLFHMYEQIVAENPMETP
MMIYPAVHYTMGGLWVDYELMTTIPGLYAIGEANFSDHGANRLGASALMQGLADGYFILPSTIGNYLSHEIHTPRFNPDS
AEFTLAAEAVRDRLQRFLKQGGNESVDSFHRRLGRIMWDYCGMARRESGLLQAQELLAALRHEYEHGVKVLGGLNEYNPE
LEKACRVADFIELGELMVRDAQARNESCGGHFREEFQTSEGEALRNDEAFSFVAAWEYKGKHAEATMHREALNFQEITPT
QRCYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=575, Percent_Identity=25.7391304347826, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1790597, Length=579, Percent_Identity=26.2521588946459, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI1788928, Length=590, Percent_Identity=25.7627118644068, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1786942, Length=595, Percent_Identity=26.5546218487395, Blast_Score=123, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17505833, Length=550, Percent_Identity=27.4545454545455, Blast_Score=161, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17550100, Length=567, Percent_Identity=27.1604938271605, Blast_Score=152, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6322701, Length=605, Percent_Identity=27.1074380165289, Blast_Score=157, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6322416, Length=583, Percent_Identity=25.9005145797599, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI17137288, Length=594, Percent_Identity=25.9259259259259, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24655642, Length=594, Percent_Identity=25.9259259259259, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24655647, Length=594, Percent_Identity=25.9259259259259, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24663005, Length=622, Percent_Identity=25.8842443729904, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 71800; Mature: 71669

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMFDAKIPEGALAQKWSRYQASCKLVSPANKRKLDIIVVGTGLAGASAAASLGELGYNV
CCCCCCCCCCCHHHHHHHHHHHCEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCE
KVFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVSRLFYDTIKGGDYRAREANVYRLAEV
EEEEEECCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
SSRIIDVCVAQGVPFAREYGGLLANRSFGGAQVSRTFYARGQTGQQLLLGAYSAMSRQIA
HHHHHHHHHHCCCCHHHHHCCHHCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHEE
LGHVTLYNRRDVLDMVLVDGKARGIIARNLVTGEIERHAAHAVVLASGGYGNVFFLSTNA
EEEEEEECCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECC
MGSNVTPVWSAYKKGAMFANPSFTQIHPTCLPQHAEFQSKLTLMSESLRNDGRIWVPKRL
CCCCCCHHHHHHHCCCEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHH
QDAEKLRKREIMPSSIPDAERDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGRTGL
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
AVFLDFADAIKRKGRDKIDSLYGNLFHMYEQIVAENPMETPMMIYPAVHYTMGGLWVDYE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHCCEEEEEE
LMTTIPGLYAIGEANFSDHGANRLGASALMQGLADGYFILPSTIGNYLSHEIHTPRFNPD
HHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCC
SAEFTLAAEAVRDRLQRFLKQGGNESVDSFHRRLGRIMWDYCGMARRESGLLQAQELLAA
CCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHH
LRHEYEHGVKVLGGLNEYNPELEKACRVADFIELGELMVRDAQARNESCGGHFREEFQTS
HHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
EGEALRNDEAFSFVAAWEYKGKHAEATMHREALNFQEITPTQRCYK
CCCHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCHHHCCCHHHHCC
>Mature Secondary Structure 
TMFDAKIPEGALAQKWSRYQASCKLVSPANKRKLDIIVVGTGLAGASAAASLGELGYNV
CCCCCCCCCCHHHHHHHHHHHCEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCE
KVFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVSRLFYDTIKGGDYRAREANVYRLAEV
EEEEEECCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
SSRIIDVCVAQGVPFAREYGGLLANRSFGGAQVSRTFYARGQTGQQLLLGAYSAMSRQIA
HHHHHHHHHHCCCCHHHHHCCHHCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHEE
LGHVTLYNRRDVLDMVLVDGKARGIIARNLVTGEIERHAAHAVVLASGGYGNVFFLSTNA
EEEEEEECCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECC
MGSNVTPVWSAYKKGAMFANPSFTQIHPTCLPQHAEFQSKLTLMSESLRNDGRIWVPKRL
CCCCCCHHHHHHHCCCEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHH
QDAEKLRKREIMPSSIPDAERDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGRTGL
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
AVFLDFADAIKRKGRDKIDSLYGNLFHMYEQIVAENPMETPMMIYPAVHYTMGGLWVDYE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHCCEEEEEE
LMTTIPGLYAIGEANFSDHGANRLGASALMQGLADGYFILPSTIGNYLSHEIHTPRFNPD
HHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCC
SAEFTLAAEAVRDRLQRFLKQGGNESVDSFHRRLGRIMWDYCGMARRESGLLQAQELLAA
CCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHH
LRHEYEHGVKVLGGLNEYNPELEKACRVADFIELGELMVRDAQARNESCGGHFREEFQTS
HHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
EGEALRNDEAFSFVAAWEYKGKHAEATMHREALNFQEITPTQRCYK
CCCHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]