Click here to switch to the map view.

The map label for this gene is pheS

Identifier: 78189667

GI number: 78189667

Start: 2224770

End: 2225804

Strand: Reverse

Name: pheS

Synonym: Cag_1711

Alternate gene names: 78189667

Gene position: 2225804-2224770 (Counterclockwise)

Preceding gene: 78189668

Following gene: 78189666

Centisome position: 86.54

GC content: 49.47

Gene sequence:

>1035_bases
ATGGAAGAGCGCATTCTTCAGGCAAAACAGGAAATTCTTGAGGCTCCACTTACCACGTTGGCAGAGCTTGAAAGCTTTCG
CCTTCACTTTACCGTTCGCAAAGGGCTTGTTGCAGCTCTTTTTGGTGAACTAAAAAATGTGGCATCGGCTGATAAGCCAC
GCATTGGGCAATTGCTTAATGAGCTAAAGCAAACAGCAGAAAGCCGCGTTAGCGATGCTGAAGCGCACCTTGCAGCAGCT
CAAAATAGCAAACAGCAGCCCAGCCTCCTCGACCTGACCTTGCCGGGAAGGCGCTCCTTCTGCGGAAGCGAACATCCCGT
ACAAAAAGTACTTGGCGACATGAAATCCATTTTCAACGCCATGGGCTTTACCATTGCTACGGGACCTGAGCTTGAAGTTG
GCAACTACAACTTCGACATGCTCAACTTTGCGCCCGACCATCCCGCACGCGATATGCAGGATACCTTTTTTGTGCGCACC
GGCAGTGGCAACACACCCGATGTGCTTCTTCGTACACACACCTCACCCGTACAAATTCGGGTAATGCTCGATGAAAAACC
ACCCATTCGAGTAATATGCCCCGGTAAAGTATATCGCAACGAAGCCATTAGCGCCCGAAGCTATTGTGTTTTCCACCAGC
TTGAAGGGCTGTATATTGATAAAAATGTGTCGTTTGCTGACCTTAAAGCCACCATCTACTCATTTGCACAACAAATGTTT
GGCAGCGATGTAAAACTTCGCTTTCGCCCAAGCTTTTTCCCCTTCACCGAACCCTCAGCCGAAGTTGATGTAACCTGCTA
CCTCTGCGGTGGTAAAGGGTGCCGCGTCTGCAAAAAATCGGGTTGGTTGGAAATTCTTGGTTGCGGCATGGTGCATCCTA
ATGTGCTTCGCAATTGCGGCATAGATCCCGAAGAGTGGTCAGGCTATGCGTTTGGCATGGGCGTTGATCGCACGGTGCTT
CTCCGCTACAAAATTGACGACATCCGCTTGCTCTTTGAAAATGATGTACGAATGTTGCAGCAGTTTAAGGCATAG

Upstream 100 bases:

>100_bases
ATATTCAAATTGACCGCAAAGCCCTTGCTGAAATTGCAGTAAAAGATGCAGCCGCATTCAGCGCAATTGTGCAAGCCGCT
AACAAATAAGCAGGACAATA

Downstream 100 bases:

>100_bases
AGTTGGGGGGATTCAATAACAGTAATGAACCCTCTCCTCTCAAATAACAAGGCATAGTCTGCTCTTAAAAAGCCTATCGC
ATCTTATTCTGCTAATAACA

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MEERILQAKQEILEAPLTTLAELESFRLHFTVRKGLVAALFGELKNVASADKPRIGQLLNELKQTAESRVSDAEAHLAAA
QNSKQQPSLLDLTLPGRRSFCGSEHPVQKVLGDMKSIFNAMGFTIATGPELEVGNYNFDMLNFAPDHPARDMQDTFFVRT
GSGNTPDVLLRTHTSPVQIRVMLDEKPPIRVICPGKVYRNEAISARSYCVFHQLEGLYIDKNVSFADLKATIYSFAQQMF
GSDVKLRFRPSFFPFTEPSAEVDVTCYLCGGKGCRVCKKSGWLEILGCGMVHPNVLRNCGIDPEEWSGYAFGMGVDRTVL
LRYKIDDIRLLFENDVRMLQQFKA

Sequences:

>Translated_344_residues
MEERILQAKQEILEAPLTTLAELESFRLHFTVRKGLVAALFGELKNVASADKPRIGQLLNELKQTAESRVSDAEAHLAAA
QNSKQQPSLLDLTLPGRRSFCGSEHPVQKVLGDMKSIFNAMGFTIATGPELEVGNYNFDMLNFAPDHPARDMQDTFFVRT
GSGNTPDVLLRTHTSPVQIRVMLDEKPPIRVICPGKVYRNEAISARSYCVFHQLEGLYIDKNVSFADLKATIYSFAQQMF
GSDVKLRFRPSFFPFTEPSAEVDVTCYLCGGKGCRVCKKSGWLEILGCGMVHPNVLRNCGIDPEEWSGYAFGMGVDRTVL
LRYKIDDIRLLFENDVRMLQQFKA
>Mature_344_residues
MEERILQAKQEILEAPLTTLAELESFRLHFTVRKGLVAALFGELKNVASADKPRIGQLLNELKQTAESRVSDAEAHLAAA
QNSKQQPSLLDLTLPGRRSFCGSEHPVQKVLGDMKSIFNAMGFTIATGPELEVGNYNFDMLNFAPDHPARDMQDTFFVRT
GSGNTPDVLLRTHTSPVQIRVMLDEKPPIRVICPGKVYRNEAISARSYCVFHQLEGLYIDKNVSFADLKATIYSFAQQMF
GSDVKLRFRPSFFPFTEPSAEVDVTCYLCGGKGCRVCKKSGWLEILGCGMVHPNVLRNCGIDPEEWSGYAFGMGVDRTVL
LRYKIDDIRLLFENDVRMLQQFKA

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI4758340, Length=277, Percent_Identity=30.3249097472924, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI5729820, Length=241, Percent_Identity=28.6307053941909, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1788007, Length=344, Percent_Identity=44.7674418604651, Blast_Score=304, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17508957, Length=276, Percent_Identity=29.7101449275362, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32563657, Length=276, Percent_Identity=29.7101449275362, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32566635, Length=262, Percent_Identity=29.7709923664122, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321087, Length=276, Percent_Identity=29.3478260869565, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6325304, Length=100, Percent_Identity=38, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI18858079, Length=282, Percent_Identity=29.4326241134752, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17137424, Length=254, Percent_Identity=26.7716535433071, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_CHLCH (Q3APW3)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_380005.1
- ProteinModelPortal:   Q3APW3
- SMR:   Q3APW3
- STRING:   Q3APW3
- GeneID:   3746977
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1711
- eggNOG:   COG0016
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- ProtClustDB:   PRK00488
- BioCyc:   CCHL340177:CAG_1711-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 38567; Mature: 38567

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEERILQAKQEILEAPLTTLAELESFRLHFTVRKGLVAALFGELKNVASADKPRIGQLLN
CCHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ELKQTAESRVSDAEAHLAAAQNSKQQPSLLDLTLPGRRSFCGSEHPVQKVLGDMKSIFNA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
MGFTIATGPELEVGNYNFDMLNFAPDHPARDMQDTFFVRTGSGNTPDVLLRTHTSPVQIR
HCCEEECCCCEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEE
VMLDEKPPIRVICPGKVYRNEAISARSYCVFHQLEGLYIDKNVSFADLKATIYSFAQQMF
EEECCCCCEEEECCCHHHHHHHHCHHHEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHC
GSDVKLRFRPSFFPFTEPSAEVDVTCYLCGGKGCRVCKKSGWLEILGCGMVHPNVLRNCG
CCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCHHHHCCCEEEEECCCCCHHHHHHCC
IDPEEWSGYAFGMGVDRTVLLRYKIDDIRLLFENDVRMLQQFKA
CCHHHCCCEEEECCCCEEEEEEEEECCEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MEERILQAKQEILEAPLTTLAELESFRLHFTVRKGLVAALFGELKNVASADKPRIGQLLN
CCHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ELKQTAESRVSDAEAHLAAAQNSKQQPSLLDLTLPGRRSFCGSEHPVQKVLGDMKSIFNA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
MGFTIATGPELEVGNYNFDMLNFAPDHPARDMQDTFFVRTGSGNTPDVLLRTHTSPVQIR
HCCEEECCCCEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEE
VMLDEKPPIRVICPGKVYRNEAISARSYCVFHQLEGLYIDKNVSFADLKATIYSFAQQMF
EEECCCCCEEEECCCHHHHHHHHCHHHEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHC
GSDVKLRFRPSFFPFTEPSAEVDVTCYLCGGKGCRVCKKSGWLEILGCGMVHPNVLRNCG
CCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCHHHHCCCEEEEECCCCCHHHHHHCC
IDPEEWSGYAFGMGVDRTVLLRYKIDDIRLLFENDVRMLQQFKA
CCHHHCCCEEEECCCCEEEEEEEEECCEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA