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The map label for this gene is proC [H]

Identifier: 78189637

GI number: 78189637

Start: 2180632

End: 2181501

Strand: Reverse

Name: proC [H]

Synonym: Cag_1680

Alternate gene names: 78189637

Gene position: 2181501-2180632 (Counterclockwise)

Preceding gene: 78189638

Following gene: 78189636

Centisome position: 84.81

GC content: 49.08

Gene sequence:

>870_bases
ATGTTACTTCGACATAAAATATTGTCATTGAATGGAACATTATCCTCATTTGAAAACAAACGACCCATGCAACAAAAACT
TCGTATTGGCTTTATAGGTACCGGGCGTATTGCCCAAGCTCTTATTGGCGGCATGAGCAATAGCCCCAAATTCACCCTTT
TTGGTTACGATAAAGAGGCTACGGCACTTGCAACCGTTGCTGCTAACTATCCACTTCAGCCTTGTTCTTCAATTGCAGAA
GTTGGAAGCTCGGCTGATGTGATTATTCTTGCTGTAAAACCATATCAAATTGCCGATGTACTTGCCGAACTGAAATCTAC
GTTACAGCCTTCGCATCTACTGATTAGCGTGGCAGCAGGCATTTCAACCACTTTTATGGCAGAGTGGACATCGCCCGAAA
CGCGCATTGTTCGCGCCATGCCCAATACGCCAATGTTGGTTGGTTTGGGCATGACGGCGCTTTGCTGTGGTACGCAAGCT
ACAAGTGAGGATATGGCGTGCGCTGTTGAGCTTTTTAGTGCGGCTGGACGCACGGTGGTGCTTGATGAAGTGCAAATGGA
TGGTGCAACTGCGGTATCGGGCAGTGGACCAGCCTATATGTTTTACCTGCTTGAAGCGTTGGCTAAAGGGGGTGAAGCGT
GTGGACTTGTGTATGCCGATGCGCTGTTGCTTGCCTCGCAAACCATGCTGGGAGCGGCTACCATGGTAATGCAAAGCAGC
AAAAGCCCTGCCGAATTGCAGCACGATGTTACTACTCCGGGTGGTACCACCGAAGCGGGCTTGCGTGTTATGGATGTGAA
GCAAGTAAGTGATGCTATGCAGCAATGTGTTGCTGCCGCTGCGGCTCGATCGCGTGAATTAATGAAGTAG

Upstream 100 bases:

>100_bases
CTTCGGCTCAAAATAGTGTTCACACTTATTCGCAAAGCTAATGTTCGATGTAACCTCTTTTCGTTTCTGTCTCTACTCTG
CATAAGGGAGAATAGAACTC

Downstream 100 bases:

>100_bases
GCGTATGAGGCATATTTCATCAGCACTATATCGCTACGCATTCCATAGTGCAGCGCTTTGCACCATGCTTTACGTAGCCG
CGCCGCTTCACGTTGTGGCG

Product: Delta 1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MLLRHKILSLNGTLSSFENKRPMQQKLRIGFIGTGRIAQALIGGMSNSPKFTLFGYDKEATALATVAANYPLQPCSSIAE
VGSSADVIILAVKPYQIADVLAELKSTLQPSHLLISVAAGISTTFMAEWTSPETRIVRAMPNTPMLVGLGMTALCCGTQA
TSEDMACAVELFSAAGRTVVLDEVQMDGATAVSGSGPAYMFYLLEALAKGGEACGLVYADALLLASQTMLGAATMVMQSS
KSPAELQHDVTTPGGTTEAGLRVMDVKQVSDAMQQCVAAAAARSRELMK

Sequences:

>Translated_289_residues
MLLRHKILSLNGTLSSFENKRPMQQKLRIGFIGTGRIAQALIGGMSNSPKFTLFGYDKEATALATVAANYPLQPCSSIAE
VGSSADVIILAVKPYQIADVLAELKSTLQPSHLLISVAAGISTTFMAEWTSPETRIVRAMPNTPMLVGLGMTALCCGTQA
TSEDMACAVELFSAAGRTVVLDEVQMDGATAVSGSGPAYMFYLLEALAKGGEACGLVYADALLLASQTMLGAATMVMQSS
KSPAELQHDVTTPGGTTEAGLRVMDVKQVSDAMQQCVAAAAARSRELMK
>Mature_289_residues
MLLRHKILSLNGTLSSFENKRPMQQKLRIGFIGTGRIAQALIGGMSNSPKFTLFGYDKEATALATVAANYPLQPCSSIAE
VGSSADVIILAVKPYQIADVLAELKSTLQPSHLLISVAAGISTTFMAEWTSPETRIVRAMPNTPMLVGLGMTALCCGTQA
TSEDMACAVELFSAAGRTVVLDEVQMDGATAVSGSGPAYMFYLLEALAKGGEACGLVYADALLLASQTMLGAATMVMQSS
KSPAELQHDVTTPGGTTEAGLRVMDVKQVSDAMQQCVAAAAARSRELMK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=276, Percent_Identity=34.7826086956522, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI24797097, Length=276, Percent_Identity=34.7826086956522, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI21361454, Length=276, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI198041662, Length=270, Percent_Identity=33.7037037037037, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=33.9622641509434, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=36.1216730038023, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17540664, Length=278, Percent_Identity=30.5755395683453, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320861, Length=203, Percent_Identity=36.4532019704434, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21358587, Length=270, Percent_Identity=36.6666666666667, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=31.1827956989247, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=38.6904761904762, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 30306; Mature: 30306

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRHKILSLNGTLSSFENKRPMQQKLRIGFIGTGRIAQALIGGMSNSPKFTLFGYDKEA
CCCHHEEEECCCCHHHHHCCCCHHHHHEEEEEECHHHHHHHHCCCCCCCCEEEEECCCCH
TALATVAANYPLQPCSSIAEVGSSADVIILAVKPYQIADVLAELKSTLQPSHLLISVAAG
HHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHEEEEHHCC
ISTTFMAEWTSPETRIVRAMPNTPMLVGLGMTALCCGTQATSEDMACAVELFSAAGRTVV
CCEEEEEECCCCCCEEEEECCCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEE
LDEVQMDGATAVSGSGPAYMFYLLEALAKGGEACGLVYADALLLASQTMLGAATMVMQSS
EEEEECCCCEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KSPAELQHDVTTPGGTTEAGLRVMDVKQVSDAMQQCVAAAAARSRELMK
CCHHHHHCCCCCCCCCHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLRHKILSLNGTLSSFENKRPMQQKLRIGFIGTGRIAQALIGGMSNSPKFTLFGYDKEA
CCCHHEEEECCCCHHHHHCCCCHHHHHEEEEEECHHHHHHHHCCCCCCCCEEEEECCCCH
TALATVAANYPLQPCSSIAEVGSSADVIILAVKPYQIADVLAELKSTLQPSHLLISVAAG
HHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHEEEEHHCC
ISTTFMAEWTSPETRIVRAMPNTPMLVGLGMTALCCGTQATSEDMACAVELFSAAGRTVV
CCEEEEEECCCCCCEEEEECCCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEE
LDEVQMDGATAVSGSGPAYMFYLLEALAKGGEACGLVYADALLLASQTMLGAATMVMQSS
EEEEECCCCEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KSPAELQHDVTTPGGTTEAGLRVMDVKQVSDAMQQCVAAAAARSRELMK
CCHHHHHCCCCCCCCCHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]