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The map label for this gene is gcvT

Identifier: 78189613

GI number: 78189613

Start: 2153251

End: 2154351

Strand: Reverse

Name: gcvT

Synonym: Cag_1656

Alternate gene names: 78189613

Gene position: 2154351-2153251 (Counterclockwise)

Preceding gene: 78189614

Following gene: 78189612

Centisome position: 83.76

GC content: 46.96

Gene sequence:

>1101_bases
ATGAAAAAAACAGCGTTGTACCCTTGCCACGAGCAGTCTGGGGCAAAAATTATTGATTTTGGTGGCTATTTAATGCCCGT
GCAGTATGCTGGTATTATTGCTGAGCATAAGGCGGTACGGAGTGCGGCTGGATTGTTTGATGTTTCGCATATGGGCAACT
TTTTTGTAAAGGGGAGCCGTGCGTTGGAGTTTTTGCAGTTTGTAACAACAAACGACCTTGCTAAAGTGGTTGATGGGCAG
GCGCAGTACAATCTTATGCTTTACCCAAGCGGTGGTATTGTGGATGACCTTATTATTTACCGCATGAGCGCTGATACCTT
TTTCTTGATTGTTAATGCGAGCAATGCCGACAAAGATTTTGCATGGTTGCAGCAACATATTGATCAATTTGAGGGCGTTA
CGCTTGAAGATCACACCGAGCGTTTGTCGCTTATTGCATTGCAAGGTCCGCTTGCGCTTTCAATTCTTAACCGTCTCTTC
CCATCAATAGATGGTGAGGCACTTGGTTCTTTCCATTTTTGTTCAGCCTCGTTTAATGGCTTTGATGTTATTATTGCACG
CACGGGTTACACGGGTGAAAAGGGCGTTGAAATGTGTGTGCCAAACGAAGCAGCAATTGCTTTGTGGGAAGCATTAATGG
CAGCAGGAGCCGCAGATGGCATTCAGCCAATTGGGCTTGGCGCTCGCGATACCTTGCGGCTTGAAATGGGCTATTCTCTC
TATGGGCATGAAATCAATCAAGATACCAATCCGCTTGAAGCGCGGTTAAAGTGGGTGGTAAAAATGGATAAAGGGCACTT
TATTGGTAAAGAGGCATGTGAACAAGCAATGCAACATCCTCAACGCACTGTTATAGGCTTTAGCCTTGAAGGGCGCGCTT
TGCCTCGTCAAGGGTTTACGCTTTACAATAGCGATCGTCAAGCAATTGGTGTGGTTTGCAGTGGCACGCTTTCGCCAACC
TTGCAAGAGCCTGTTGGCACCTGCTCGGTGTTGCGTGAATACGGTAAGCCAGGTACGCCAATTTTGGTAGAGGTGCGTGG
AGCGTTTCACGCGGGCATTATTCGTTCGCTGCCTTTTGTAACCAATACATCGTTGGCGTAA

Upstream 100 bases:

>100_bases
CGATGCCAAAATGCTCTCCTTATTTTGGGTTGGGTTGCGGCAGTACGTTTAGCATGTTATCAAGTTGTTCTCAAACAATT
CTTTCATTCCATTTTTTGTT

Downstream 100 bases:

>100_bases
CGCATCATTATATAGAAGAGGAATAGGAAGAGAGAGTTAAACGTATGGCAACCACTATAAAGCAACGGCTAAAAAACCTT
TTCGTGCGGGCGCTTGATCG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKKTALYPCHEQSGAKIIDFGGYLMPVQYAGIIAEHKAVRSAAGLFDVSHMGNFFVKGSRALEFLQFVTTNDLAKVVDGQ
AQYNLMLYPSGGIVDDLIIYRMSADTFFLIVNASNADKDFAWLQQHIDQFEGVTLEDHTERLSLIALQGPLALSILNRLF
PSIDGEALGSFHFCSASFNGFDVIIARTGYTGEKGVEMCVPNEAAIALWEALMAAGAADGIQPIGLGARDTLRLEMGYSL
YGHEINQDTNPLEARLKWVVKMDKGHFIGKEACEQAMQHPQRTVIGFSLEGRALPRQGFTLYNSDRQAIGVVCSGTLSPT
LQEPVGTCSVLREYGKPGTPILVEVRGAFHAGIIRSLPFVTNTSLA

Sequences:

>Translated_366_residues
MKKTALYPCHEQSGAKIIDFGGYLMPVQYAGIIAEHKAVRSAAGLFDVSHMGNFFVKGSRALEFLQFVTTNDLAKVVDGQ
AQYNLMLYPSGGIVDDLIIYRMSADTFFLIVNASNADKDFAWLQQHIDQFEGVTLEDHTERLSLIALQGPLALSILNRLF
PSIDGEALGSFHFCSASFNGFDVIIARTGYTGEKGVEMCVPNEAAIALWEALMAAGAADGIQPIGLGARDTLRLEMGYSL
YGHEINQDTNPLEARLKWVVKMDKGHFIGKEACEQAMQHPQRTVIGFSLEGRALPRQGFTLYNSDRQAIGVVCSGTLSPT
LQEPVGTCSVLREYGKPGTPILVEVRGAFHAGIIRSLPFVTNTSLA
>Mature_366_residues
MKKTALYPCHEQSGAKIIDFGGYLMPVQYAGIIAEHKAVRSAAGLFDVSHMGNFFVKGSRALEFLQFVTTNDLAKVVDGQ
AQYNLMLYPSGGIVDDLIIYRMSADTFFLIVNASNADKDFAWLQQHIDQFEGVTLEDHTERLSLIALQGPLALSILNRLF
PSIDGEALGSFHFCSASFNGFDVIIARTGYTGEKGVEMCVPNEAAIALWEALMAAGAADGIQPIGLGARDTLRLEMGYSL
YGHEINQDTNPLEARLKWVVKMDKGHFIGKEACEQAMQHPQRTVIGFSLEGRALPRQGFTLYNSDRQAIGVVCSGTLSPT
LQEPVGTCSVLREYGKPGTPILVEVRGAFHAGIIRSLPFVTNTSLA

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=374, Percent_Identity=31.8181818181818, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI257796258, Length=359, Percent_Identity=32.3119777158774, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI257796256, Length=316, Percent_Identity=31.0126582278481, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI257796254, Length=372, Percent_Identity=29.8387096774194, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI24797151, Length=331, Percent_Identity=28.0966767371601, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI194306651, Length=271, Percent_Identity=29.8892988929889, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI197927446, Length=310, Percent_Identity=27.741935483871, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI21361378, Length=310, Percent_Identity=27.741935483871, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789272, Length=352, Percent_Identity=39.2045454545455, Blast_Score=241, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17560118, Length=373, Percent_Identity=34.0482573726542, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71994052, Length=320, Percent_Identity=26.5625, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71994045, Length=320, Percent_Identity=26.5625, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI32563613, Length=309, Percent_Identity=25.8899676375405, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320222, Length=383, Percent_Identity=35.7702349869452, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI20129441, Length=377, Percent_Identity=33.6870026525199, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI28571104, Length=258, Percent_Identity=27.5193798449612, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20130091, Length=324, Percent_Identity=24.6913580246914, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_CHLCH (Q3AQ17)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379951.1
- HSSP:   P27248
- ProteinModelPortal:   Q3AQ17
- SMR:   Q3AQ17
- STRING:   Q3AQ17
- GeneID:   3747674
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1656
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- BioCyc:   CCHL340177:CAG_1656-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39885; Mature: 39885

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTALYPCHEQSGAKIIDFGGYLMPVQYAGIIAEHKAVRSAAGLFDVSHMGNFFVKGSR
CCCCCCCCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHH
ALEFLQFVTTNDLAKVVDGQAQYNLMLYPSGGIVDDLIIYRMSADTFFLIVNASNADKDF
HHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHEEEEEECCCEEEEEEECCCCCHHH
AWLQQHIDQFEGVTLEDHTERLSLIALQGPLALSILNRLFPSIDGEALGSFHFCSASFNG
HHHHHHHHHHCCCEECCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
FDVIIARTGYTGEKGVEMCVPNEAAIALWEALMAAGAADGIQPIGLGARDTLRLEMGYSL
EEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEE
YGHEINQDTNPLEARLKWVVKMDKGHFIGKEACEQAMQHPQRTVIGFSLEGRALPRQGFT
ECCCCCCCCCHHHHHEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCE
LYNSDRQAIGVVCSGTLSPTLQEPVGTCSVLREYGKPGTPILVEVRGAFHAGIIRSLPFV
EECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCC
TNTSLA
CCCCCC
>Mature Secondary Structure
MKKTALYPCHEQSGAKIIDFGGYLMPVQYAGIIAEHKAVRSAAGLFDVSHMGNFFVKGSR
CCCCCCCCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHH
ALEFLQFVTTNDLAKVVDGQAQYNLMLYPSGGIVDDLIIYRMSADTFFLIVNASNADKDF
HHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHEEEEEECCCEEEEEEECCCCCHHH
AWLQQHIDQFEGVTLEDHTERLSLIALQGPLALSILNRLFPSIDGEALGSFHFCSASFNG
HHHHHHHHHHCCCEECCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
FDVIIARTGYTGEKGVEMCVPNEAAIALWEALMAAGAADGIQPIGLGARDTLRLEMGYSL
EEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEE
YGHEINQDTNPLEARLKWVVKMDKGHFIGKEACEQAMQHPQRTVIGFSLEGRALPRQGFT
ECCCCCCCCCHHHHHEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCE
LYNSDRQAIGVVCSGTLSPTLQEPVGTCSVLREYGKPGTPILVEVRGAFHAGIIRSLPFV
EECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCC
TNTSLA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA