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The map label for this gene is gmk

Identifier: 78189417

GI number: 78189417

Start: 1922567

End: 1923139

Strand: Reverse

Name: gmk

Synonym: Cag_1456

Alternate gene names: 78189417

Gene position: 1923139-1922567 (Counterclockwise)

Preceding gene: 78189418

Following gene: 78189416

Centisome position: 74.77

GC content: 43.63

Gene sequence:

>573_bases
ATGGCAGTTGAACCTTCAGGCAAACTTATTGTGTTTTCAGCTCCATCGGGGGCAGGCAAAACTACCATTGCAACTATGGT
ATTGCAACGCATTGCAAATCTTAGCTTTTCGGTGTCGGCAACAACACGCAAGCAACGAGAAGGGGAGCAAGATGGGGTGA
ATTATTATTTTCTTGATAAAGCCACCTTTGAAAAAAAAATTGAGCAAGGCGGTTTTATTGAACATGAATTTTTCTTTGGC
AACTACTACGGCACCTTGCTTGATGCCACCGAATCGGTGTTGGCATCGGGCAAAAATTTGCTGCTTGATGTAGATGTTAA
AGGAGCGTTAAACGTCCGTAAATTGTTTGGTGAACGCTCACTCCTTATTTTTATACAGCCACCAAGTATGGAAGTGCTTA
TTGAGCGCTTGCAAGGGCGTGGCAGCGAAGATGATGCTGCATTGCAAGAGCGCCTTGAACGTGCTCGCTTTGAAATGAGC
TTTGCCGATCAGTTCGATACAATTATAGTGAACAACAATTTAACAGCCGCTGTTGATGACGTTGAAGCGGCAATTGTCAA
CTTTATAGGATAG

Upstream 100 bases:

>100_bases
CATCAAAATCGCAAAATGCGGCTATTTCGCAACATGTTGTACACATTAAAGAAGAGCTTGAAAAAATTCGTGAACAACTC
CAAAACATAGAATAAGCGTT

Downstream 100 bases:

>100_bases
AAAATACTATGTCGGTTAAACCTGTTGATCTTAATGCTTTGCGTGCAACGCACGGTAATTTATATGAAACCGTTGTAGCT
ATGTCGCGTCGGGCACGAAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MAVEPSGKLIVFSAPSGAGKTTIATMVLQRIANLSFSVSATTRKQREGEQDGVNYYFLDKATFEKKIEQGGFIEHEFFFG
NYYGTLLDATESVLASGKNLLLDVDVKGALNVRKLFGERSLLIFIQPPSMEVLIERLQGRGSEDDAALQERLERARFEMS
FADQFDTIIVNNNLTAAVDDVEAAIVNFIG

Sequences:

>Translated_190_residues
MAVEPSGKLIVFSAPSGAGKTTIATMVLQRIANLSFSVSATTRKQREGEQDGVNYYFLDKATFEKKIEQGGFIEHEFFFG
NYYGTLLDATESVLASGKNLLLDVDVKGALNVRKLFGERSLLIFIQPPSMEVLIERLQGRGSEDDAALQERLERARFEMS
FADQFDTIIVNNNLTAAVDDVEAAIVNFIG
>Mature_189_residues
AVEPSGKLIVFSAPSGAGKTTIATMVLQRIANLSFSVSATTRKQREGEQDGVNYYFLDKATFEKKIEQGGFIEHEFFFGN
YYGTLLDATESVLASGKNLLLDVDVKGALNVRKLFGERSLLIFIQPPSMEVLIERLQGRGSEDDAALQERLERARFEMSF
ADQFDTIIVNNNLTAAVDDVEAAIVNFIG

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=182, Percent_Identity=39.010989010989, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI226874833, Length=182, Percent_Identity=39.010989010989, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4504221, Length=182, Percent_Identity=39.010989010989, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI111154074, Length=159, Percent_Identity=36.4779874213836, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI21361598, Length=189, Percent_Identity=29.6296296296296, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI38570142, Length=175, Percent_Identity=32, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI14780902, Length=194, Percent_Identity=30.9278350515464, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI52630447, Length=189, Percent_Identity=24.8677248677249, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21536464, Length=166, Percent_Identity=27.1084337349398, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=182, Percent_Identity=41.2087912087912, Blast_Score=135, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17508835, Length=194, Percent_Identity=36.5979381443299, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193203132, Length=194, Percent_Identity=36.5979381443299, Blast_Score=116, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71988041, Length=178, Percent_Identity=26.9662921348315, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=178, Percent_Identity=26.9662921348315, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71984092, Length=182, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=176, Percent_Identity=37.5, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356141, Length=186, Percent_Identity=35.4838709677419, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161077626, Length=178, Percent_Identity=29.7752808988764, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45554489, Length=178, Percent_Identity=29.7752808988764, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24640542, Length=178, Percent_Identity=29.7752808988764, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI116007136, Length=178, Percent_Identity=29.7752808988764, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI85724806, Length=178, Percent_Identity=29.7752808988764, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45554481, Length=178, Percent_Identity=29.7752808988764, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CHLCH (Q3AQL3)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379755.1
- HSSP:   P60546
- ProteinModelPortal:   Q3AQL3
- SMR:   Q3AQL3
- STRING:   Q3AQL3
- GeneID:   3746654
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1456
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   CCHL340177:CAG_1456-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 20968; Mature: 20837

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVEPSGKLIVFSAPSGAGKTTIATMVLQRIANLSFSVSATTRKQREGEQDGVNYYFLDK
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECHHHHHCCCCCCCCEEEECC
ATFEKKIEQGGFIEHEFFFGNYYGTLLDATESVLASGKNLLLDVDVKGALNVRKLFGERS
HHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCE
LLIFIQPPSMEVLIERLQGRGSEDDAALQERLERARFEMSFADQFDTIIVNNNLTAAVDD
EEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHH
VEAAIVNFIG
HHHHHHHHCC
>Mature Secondary Structure 
AVEPSGKLIVFSAPSGAGKTTIATMVLQRIANLSFSVSATTRKQREGEQDGVNYYFLDK
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECHHHHHCCCCCCCCEEEECC
ATFEKKIEQGGFIEHEFFFGNYYGTLLDATESVLASGKNLLLDVDVKGALNVRKLFGERS
HHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCE
LLIFIQPPSMEVLIERLQGRGSEDDAALQERLERARFEMSFADQFDTIIVNNNLTAAVDD
EEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHH
VEAAIVNFIG
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA