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The map label for this gene is pgsA [H]

Identifier: 78189382

GI number: 78189382

Start: 1888875

End: 1889495

Strand: Reverse

Name: pgsA [H]

Synonym: Cag_1419

Alternate gene names: 78189382

Gene position: 1889495-1888875 (Counterclockwise)

Preceding gene: 78189385

Following gene: 78189381

Centisome position: 73.46

GC content: 45.25

Gene sequence:

>621_bases
GTGAAAGAGCCGCACGAAACAATTCTTACCATTCCCAACCAATTAACCATGTTGCGGATTGTGCTGGTGCCAGTGTTTGT
GCTGCTGCTCCTTCAACCCGATGCGTGGTTGAAACTGCTTGGTGTGGTTGTCTTTACCGTTGCCTCGCTTACCGATTTGT
ATGATGGCTATCATGCACGTAAATATGGGGTTACTACTCGCCTCGGCGCTTTTCTCGATCCTCTTGCCGACAAGCTGCTC
ATTACGGCTGCCTTTTTACTCTATGTGTGGATGGGCTTTTTGCTTCTTTGGATGGTGCTTCTTGTGGTACTTCGTGATGT
ACTTATTACGGCGCTACGCATTTACGCCGAGTACAAAAATCGTCCTGTAATAACCAGCGTAGAGGCTAAGTACAAAACCC
TTGCACAAAACCTCTTTGTGTATCTCTTGATGGCAATGGTGCTTTTGCGTGAATCCTCTTTTTTTGGGCATGAACTTGCA
AGTAGCATCAATAGCTTTCTCACCTCCGATTATCTTGATGGCATTATGCTTGCCGTTACTCTTTTTACGGTTTACACGGG
TATTTCCTACTTAGTAAGCAATTGGGGCATCTATTTTCAAAAGCCCGCTGAAGGGAATTAA

Upstream 100 bases:

>100_bases
TGTGGTACGGTGGCATTGAAAAAGCTATGCTCAATGCGTATCTTGCCGCAACTCTTTTCAAGAGCCATACTATCCATACT
AATCTCAATTCCCATTAGGC

Downstream 100 bases:

>100_bases
ACCTTGAAACGCACCGTTGCACATCTTCTTGCCACTTGTTTTGGCATAGGTCATGCACCTGTAGCTCCGGGCACCGTTGC
CAGCTTTGCCGCCTTGCTTA

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MKEPHETILTIPNQLTMLRIVLVPVFVLLLLQPDAWLKLLGVVVFTVASLTDLYDGYHARKYGVTTRLGAFLDPLADKLL
ITAAFLLYVWMGFLLLWMVLLVVLRDVLITALRIYAEYKNRPVITSVEAKYKTLAQNLFVYLLMAMVLLRESSFFGHELA
SSINSFLTSDYLDGIMLAVTLFTVYTGISYLVSNWGIYFQKPAEGN

Sequences:

>Translated_206_residues
MKEPHETILTIPNQLTMLRIVLVPVFVLLLLQPDAWLKLLGVVVFTVASLTDLYDGYHARKYGVTTRLGAFLDPLADKLL
ITAAFLLYVWMGFLLLWMVLLVVLRDVLITALRIYAEYKNRPVITSVEAKYKTLAQNLFVYLLMAMVLLRESSFFGHELA
SSINSFLTSDYLDGIMLAVTLFTVYTGISYLVSNWGIYFQKPAEGN
>Mature_206_residues
MKEPHETILTIPNQLTMLRIVLVPVFVLLLLQPDAWLKLLGVVVFTVASLTDLYDGYHARKYGVTTRLGAFLDPLADKLL
ITAAFLLYVWMGFLLLWMVLLVVLRDVLITALRIYAEYKNRPVITSVEAKYKTLAQNLFVYLLMAMVLLRESSFFGHELA
SSINSFLTSDYLDGIMLAVTLFTVYTGISYLVSNWGIYFQKPAEGN

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=128, Percent_Identity=36.71875, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI10092647, Length=128, Percent_Identity=36.71875, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1788220, Length=132, Percent_Identity=39.3939393939394, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71984838, Length=197, Percent_Identity=29.9492385786802, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71984834, Length=197, Percent_Identity=29.9492385786802, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320059, Length=122, Percent_Identity=40.1639344262295, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650130, Length=201, Percent_Identity=28.8557213930348, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24650126, Length=201, Percent_Identity=28.8557213930348, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24650128, Length=201, Percent_Identity=28.8557213930348, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 23367; Mature: 23367

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEPHETILTIPNQLTMLRIVLVPVFVLLLLQPDAWLKLLGVVVFTVASLTDLYDGYHAR
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
KYGVTTRLGAFLDPLADKLLITAAFLLYVWMGFLLLWMVLLVVLRDVLITALRIYAEYKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPVITSVEAKYKTLAQNLFVYLLMAMVLLRESSFFGHELASSINSFLTSDYLDGIMLAVT
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFTVYTGISYLVSNWGIYFQKPAEGN
HHHHHHHHHHHHHCCCCEEECCCCCC
>Mature Secondary Structure
MKEPHETILTIPNQLTMLRIVLVPVFVLLLLQPDAWLKLLGVVVFTVASLTDLYDGYHAR
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
KYGVTTRLGAFLDPLADKLLITAAFLLYVWMGFLLLWMVLLVVLRDVLITALRIYAEYKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPVITSVEAKYKTLAQNLFVYLLMAMVLLRESSFFGHELASSINSFLTSDYLDGIMLAVT
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFTVYTGISYLVSNWGIYFQKPAEGN
HHHHHHHHHHHHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]