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The map label for this gene is aroK

Identifier: 78189187

GI number: 78189187

Start: 1618311

End: 1618883

Strand: Reverse

Name: aroK

Synonym: Cag_1220

Alternate gene names: 78189187

Gene position: 1618883-1618311 (Counterclockwise)

Preceding gene: 78189188

Following gene: 78189186

Centisome position: 62.94

GC content: 48.34

Gene sequence:

>573_bases
GTGCAAAAAGAACCCTCTCTTATTTTTCTTACCGGCTTTAGCGGTTCGGGTAAATCAACCATTGGTCCGTTGCTTGCTAA
TTCGTTGGGTTATGAGTTTGTTGATCTTGATGCTTTAATTGAGCGTGAATGCGGTAAGAGCATTAATCAGATTTTTGCTG
AAGCGGGTGAGGCGGCTTTTCGTCAGCATGAAGAGCAAACCTTAGAAACCCTCTTAATGCGCCGCAAAACGGTGGTTTCG
CTTGGTGGTGGGGTGCTTGAACAGCCGCGCGCCTTTGAGTTGGTGCGTCAAGCGGGTACTGTTGTCTATTTAAAGTCGCC
TGTAAAAACGTTGGCTCGGCGGCTGAGCAATAAAACGGATCGCCCGCTTTTAAAGGGTGAGCAGGGTGAAAAGTTGTCGC
AGGAGGAAATTGAGCAAAAAATTGCGGAGTTGCTTGCTCGGCGTGAGCCTCGTTATGAGTGCGCTGATATTACGGTGGAG
ACGGATGCCAAGCGTATTGGTAGTACGGTTGAGGAGCTTACTCGTAAAATTGAGCGTTATATGCGCACTCTTGCTTTATC
GTCGGAGGAGTGA

Upstream 100 bases:

>100_bases
TGCCTTTACGGTAGTTGGGCTATTATGGCGAGCGTGATGCTTTGTTGGGAAAAAAGGCGCTCCGCCTCTTATTTCGATAT
ATTATTTCTGCTGAAAATTC

Downstream 100 bases:

>100_bases
AGCGCACGTTTCTTCACCCGTTCATGTCAAGTGCTTTTTGTTATGCCCATTTCCTCATTAATTCTTTCTCTTGATATAAA
AAAAAGATGAGCACCATTAT

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MQKEPSLIFLTGFSGSGKSTIGPLLANSLGYEFVDLDALIERECGKSINQIFAEAGEAAFRQHEEQTLETLLMRRKTVVS
LGGGVLEQPRAFELVRQAGTVVYLKSPVKTLARRLSNKTDRPLLKGEQGEKLSQEEIEQKIAELLARREPRYECADITVE
TDAKRIGSTVEELTRKIERYMRTLALSSEE

Sequences:

>Translated_190_residues
MQKEPSLIFLTGFSGSGKSTIGPLLANSLGYEFVDLDALIERECGKSINQIFAEAGEAAFRQHEEQTLETLLMRRKTVVS
LGGGVLEQPRAFELVRQAGTVVYLKSPVKTLARRLSNKTDRPLLKGEQGEKLSQEEIEQKIAELLARREPRYECADITVE
TDAKRIGSTVEELTRKIERYMRTLALSSEE
>Mature_190_residues
MQKEPSLIFLTGFSGSGKSTIGPLLANSLGYEFVDLDALIERECGKSINQIFAEAGEAAFRQHEEQTLETLLMRRKTVVS
LGGGVLEQPRAFELVRQAGTVVYLKSPVKTLARRLSNKTDRPLLKGEQGEKLSQEEIEQKIAELLARREPRYECADITVE
TDAKRIGSTVEELTRKIERYMRTLALSSEE

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=158, Percent_Identity=37.9746835443038, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1786587, Length=154, Percent_Identity=32.4675324675325, Blast_Score=74, Evalue=9e-15,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_CHLCH (Q3AR93)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379525.1
- ProteinModelPortal:   Q3AR93
- SMR:   Q3AR93
- STRING:   Q3AR93
- GeneID:   3748254
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1220
- eggNOG:   COG0703
- HOGENOM:   HBG335815
- OMA:   VIYLRAN
- ProtClustDB:   PRK00131
- BioCyc:   CCHL340177:CAG_1220-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 21289; Mature: 21289

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 37-37 BINDING 61-61 BINDING 83-83 BINDING 121-121 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKEPSLIFLTGFSGSGKSTIGPLLANSLGYEFVDLDALIERECGKSINQIFAEAGEAAF
CCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQHEEQTLETLLMRRKTVVSLGGGVLEQPRAFELVRQAGTVVYLKSPVKTLARRLSNKTD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC
RPLLKGEQGEKLSQEEIEQKIAELLARREPRYECADITVETDAKRIGSTVEELTRKIERY
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHCEEECHHHHHHHHHHHHHHHHHHHH
MRTLALSSEE
HHHHHCCCCC
>Mature Secondary Structure
MQKEPSLIFLTGFSGSGKSTIGPLLANSLGYEFVDLDALIERECGKSINQIFAEAGEAAF
CCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQHEEQTLETLLMRRKTVVSLGGGVLEQPRAFELVRQAGTVVYLKSPVKTLARRLSNKTD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC
RPLLKGEQGEKLSQEEIEQKIAELLARREPRYECADITVETDAKRIGSTVEELTRKIERY
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHCEEECHHHHHHHHHHHHHHHHHHHH
MRTLALSSEE
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA