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The map label for this gene is tyrS

Identifier: 78189128

GI number: 78189128

Start: 1555089

End: 1556297

Strand: Reverse

Name: tyrS

Synonym: Cag_1161

Alternate gene names: 78189128

Gene position: 1556297-1555089 (Counterclockwise)

Preceding gene: 78189129

Following gene: 78189127

Centisome position: 60.51

GC content: 45.57

Gene sequence:

>1209_bases
ATGAATTTTCCTTCCATACAGGAACAGTTAGACCTTATTACCCGTAACACGGTTGAAATTATTAGCGTTGACGAGCTTGA
GCAAAAGCTTGTGAGCAGCCAAAAAAGCGGTAAACCTCTCAATATTAAACTTGGTGCCGATCCTTCGCGCCCCGACTTAC
ACCTTGGGCACTCGGTTGTATTACGCAAACTCCGTGACTTTCAAGACCTTGGGCACCACGCAATTCTCATTATTGGCAAC
TTTACTGCCATGATTGGCGATCCATCGGGCAAAAGCAAAACACGCCCACAGCTCTCGGCTGAAGAGGCGGCTGAAAATGG
ACGCAGTTATTTTGAGCAAGCCATTAAAATTCTTGATGCTGCAAACACAACATTGTGCTCCAATGCCGATTGGCTTGGTG
CAATGACTTTTGCTGATGTGATTCGCCTTTCAAGCCACTACACCGTTGCCCGCATGTTGGAGCGCAACGACTTTGAGCAA
CGTTACCGAGCGCAAGAGCCAATTTCAATCCACGAATTTCTTTACCCTTTAGCGCAAGGCATGGATTCCGTGCACCTTAA
AAACGATGTTGAGCTTGGTGGCACCGATCAAAAATTCAACCTGCTTGTTGGGCGCGATTTACAGCGGGAATATGGCATTG
CGCCGCAAGTGTGCATTACCATGCCTCTTTTGGTGGGAACTGATGGTAAGGATAAAATGTCGAAGTCGCTTGATAACGCC
ATTAGCTTTACCGATACACCGAATGATATGTATGGTAGAGCACTTTCAATTCCCGATACGCTTATTGAAACCTACAGCCG
TTTATTGCTCTCCCAATTTGGCGCAGCGCTGAACGAAATTTTAAGCCAAATCGAAACCAATCCTCGTTTGGCAAAGCGTG
CTATGGCTCGCCATATTGTTGCCGATTATTATTCACCTGAAGCAGCCTCAGCGGCTGAAGAGCATTTCGATAAGCTTTTT
GTGCATAAGCAAGCCCCCGACAATCTTGAATTGCTTGAACTTGAAGCCACCTCAATGCCCATTATTGATTTGCTTACGTT
GCTTGGTGCTGCTCCCTCAAAAAGTGAAGCTCGCCGCATGATTCAAGCTAAATCTGTATCCATTGACGATGAAAAGATTG
AGGATTTTAATGCGGTAATTGCTTTAGAGGGTGAAGCAAAAATTGTTCGTGCGGGCAAGCGGAAGTTCTTTAAAATAAGG
TCAAAATAG

Upstream 100 bases:

>100_bases
AGCTTGCCATAGCACGCGGCAAAAAATTGTACGATAAACGTGAAACCCTTAAAAATCGCGAAAACCAACGTCATCTCGAT
CAACTCAGAAAACAGTACTC

Downstream 100 bases:

>100_bases
AGCCCAATACCGTGTGAAGTGGCGAGCTATTCATCGCAAAGATTTTTTTGCTGATAGCTTTTTAATTAAAACGGCTTTTT
TCTATAATTCACGCTTTCAT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MNFPSIQEQLDLITRNTVEIISVDELEQKLVSSQKSGKPLNIKLGADPSRPDLHLGHSVVLRKLRDFQDLGHHAILIIGN
FTAMIGDPSGKSKTRPQLSAEEAAENGRSYFEQAIKILDAANTTLCSNADWLGAMTFADVIRLSSHYTVARMLERNDFEQ
RYRAQEPISIHEFLYPLAQGMDSVHLKNDVELGGTDQKFNLLVGRDLQREYGIAPQVCITMPLLVGTDGKDKMSKSLDNA
ISFTDTPNDMYGRALSIPDTLIETYSRLLLSQFGAALNEILSQIETNPRLAKRAMARHIVADYYSPEAASAAEEHFDKLF
VHKQAPDNLELLELEATSMPIIDLLTLLGAAPSKSEARRMIQAKSVSIDDEKIEDFNAVIALEGEAKIVRAGKRKFFKIR
SK

Sequences:

>Translated_402_residues
MNFPSIQEQLDLITRNTVEIISVDELEQKLVSSQKSGKPLNIKLGADPSRPDLHLGHSVVLRKLRDFQDLGHHAILIIGN
FTAMIGDPSGKSKTRPQLSAEEAAENGRSYFEQAIKILDAANTTLCSNADWLGAMTFADVIRLSSHYTVARMLERNDFEQ
RYRAQEPISIHEFLYPLAQGMDSVHLKNDVELGGTDQKFNLLVGRDLQREYGIAPQVCITMPLLVGTDGKDKMSKSLDNA
ISFTDTPNDMYGRALSIPDTLIETYSRLLLSQFGAALNEILSQIETNPRLAKRAMARHIVADYYSPEAASAAEEHFDKLF
VHKQAPDNLELLELEATSMPIIDLLTLLGAAPSKSEARRMIQAKSVSIDDEKIEDFNAVIALEGEAKIVRAGKRKFFKIR
SK
>Mature_402_residues
MNFPSIQEQLDLITRNTVEIISVDELEQKLVSSQKSGKPLNIKLGADPSRPDLHLGHSVVLRKLRDFQDLGHHAILIIGN
FTAMIGDPSGKSKTRPQLSAEEAAENGRSYFEQAIKILDAANTTLCSNADWLGAMTFADVIRLSSHYTVARMLERNDFEQ
RYRAQEPISIHEFLYPLAQGMDSVHLKNDVELGGTDQKFNLLVGRDLQREYGIAPQVCITMPLLVGTDGKDKMSKSLDNA
ISFTDTPNDMYGRALSIPDTLIETYSRLLLSQFGAALNEILSQIETNPRLAKRAMARHIVADYYSPEAASAAEEHFDKLF
VHKQAPDNLELLELEATSMPIIDLLTLLGAAPSKSEARRMIQAKSVSIDDEKIEDFNAVIALEGEAKIVRAGKRKFFKIR
SK

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=406, Percent_Identity=25.1231527093596, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1787925, Length=400, Percent_Identity=27.75, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI25145802, Length=305, Percent_Identity=27.8688524590164, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325160, Length=438, Percent_Identity=24.6575342465753, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI20130383, Length=407, Percent_Identity=24.5700245700246, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_CHLCH (Q3ARF2)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379466.1
- ProteinModelPortal:   Q3ARF2
- SMR:   Q3ARF2
- STRING:   Q3ARF2
- GeneID:   3747917
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1161
- eggNOG:   COG0162
- HOGENOM:   HBG288125
- OMA:   YVVQVGK
- ProtClustDB:   PRK05912
- BioCyc:   CCHL340177:CAG_1161-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_02007
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- SMART:   SM00363
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 44767; Mature: 44767

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 235-235

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFPSIQEQLDLITRNTVEIISVDELEQKLVSSQKSGKPLNIKLGADPSRPDLHLGHSVV
CCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHH
LRKLRDFQDLGHHAILIIGNFTAMIGDPSGKSKTRPQLSAEEAAENGRSYFEQAIKILDA
HHHHHHHHHCCCEEEEEEECEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ANTTLCSNADWLGAMTFADVIRLSSHYTVARMLERNDFEQRYRAQEPISIHEFLYPLAQG
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHCC
MDSVHLKNDVELGGTDQKFNLLVGRDLQREYGIAPQVCITMPLLVGTDGKDKMSKSLDNA
CCCEECCCCCCCCCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHC
ISFTDTPNDMYGRALSIPDTLIETYSRLLLSQFGAALNEILSQIETNPRLAKRAMARHIV
EECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ADYYSPEAASAAEEHFDKLFVHKQAPDNLELLELEATSMPIIDLLTLLGAAPSKSEARRM
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHH
IQAKSVSIDDEKIEDFNAVIALEGEAKIVRAGKRKFFKIRSK
HHHHCCCCCHHHHHCCCEEEEECCCHHHHHHCCHHHEEECCC
>Mature Secondary Structure
MNFPSIQEQLDLITRNTVEIISVDELEQKLVSSQKSGKPLNIKLGADPSRPDLHLGHSVV
CCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHH
LRKLRDFQDLGHHAILIIGNFTAMIGDPSGKSKTRPQLSAEEAAENGRSYFEQAIKILDA
HHHHHHHHHCCCEEEEEEECEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ANTTLCSNADWLGAMTFADVIRLSSHYTVARMLERNDFEQRYRAQEPISIHEFLYPLAQG
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHCC
MDSVHLKNDVELGGTDQKFNLLVGRDLQREYGIAPQVCITMPLLVGTDGKDKMSKSLDNA
CCCEECCCCCCCCCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHC
ISFTDTPNDMYGRALSIPDTLIETYSRLLLSQFGAALNEILSQIETNPRLAKRAMARHIV
EECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ADYYSPEAASAAEEHFDKLFVHKQAPDNLELLELEATSMPIIDLLTLLGAAPSKSEARRM
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHH
IQAKSVSIDDEKIEDFNAVIALEGEAKIVRAGKRKFFKIRSK
HHHHCCCCCHHHHHCCCEEEEECCCHHHHHHCCHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA