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The map label for this gene is coaE

Identifier: 78188933

GI number: 78188933

Start: 1303643

End: 1304281

Strand: Reverse

Name: coaE

Synonym: Cag_0965

Alternate gene names: 78188933

Gene position: 1304281-1303643 (Counterclockwise)

Preceding gene: 78188934

Following gene: 78188931

Centisome position: 50.71

GC content: 49.14

Gene sequence:

>639_bases
ATGGAGAGTAAGTTACCACTCCTTGTAGGAGTTACAGGAGGGCTTGGAAGCGGTAAATCTATGGTGTGCCGTTACCTTGC
AAGCATGGGATGTGCCTTGTTTGAAGCCGATGTGGTGGCTAAAGAGTTGCAAGTGCGCGATAGTAAGGTGATTGAGGGAA
TTACAGCGCTTTTTGGCAAAGAGGTCTATTCTTACAATCCAAAGGGAGAGTTGCAGCTTAATAGAAAAGATATTGCGCAA
GTGGTGTTTAGTAATCAAGAAAAGTTGGGCGCATTAAATCGGCTTATTCATCCCCGTGTAGCCGTTGCGTTTCAGCAAGC
GTGCGACAATGCAGCAAGGAGCAATGTGGCAATTCTGGTAAAGGAGGCAGCCATTTTGTTTGAGTCGGGTGCTCATGCAG
GGCTTGATGTGGTGGTGGTGGTGCAAGCGGCAACTGAGCTTCGGGTTGAGCGAGCTGTGCAAAAAGGGCTGGGTACGCGT
GAGGAAATTTTGCGGCGCTTAGCGGTGCAGTGGGCACCCGAAAAGCTTGCGGCGTTAGCTGATGTTGTGATTGATAATAA
TGGCACGCCCGAAGCGCTGTACGAAAAAACCAAGCAGTTATACGAGCAACTTCTTCAGCAAGCAATGTTACGCCGCTAA

Upstream 100 bases:

>100_bases
ATGTCATCGCTGGTGGCCAACTACAGGCGCAATCCTGAGCAGTGGCAAGTGGTGCTGGAGCAAGTGCGTGGCAATTTGCG
CAATAAAGCAAGGGAGGCAA

Downstream 100 bases:

>100_bases
GTGTTGTGTCAACAGCCCATCCTTTCCATTTACGCCTTTGCTTGTAACGCTTTATTTTTGCGATTAACGTGGGCTGAAAT
TAAAATGCTTGCTTCGTAGA

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MESKLPLLVGVTGGLGSGKSMVCRYLASMGCALFEADVVAKELQVRDSKVIEGITALFGKEVYSYNPKGELQLNRKDIAQ
VVFSNQEKLGALNRLIHPRVAVAFQQACDNAARSNVAILVKEAAILFESGAHAGLDVVVVVQAATELRVERAVQKGLGTR
EEILRRLAVQWAPEKLAALADVVIDNNGTPEALYEKTKQLYEQLLQQAMLRR

Sequences:

>Translated_212_residues
MESKLPLLVGVTGGLGSGKSMVCRYLASMGCALFEADVVAKELQVRDSKVIEGITALFGKEVYSYNPKGELQLNRKDIAQ
VVFSNQEKLGALNRLIHPRVAVAFQQACDNAARSNVAILVKEAAILFESGAHAGLDVVVVVQAATELRVERAVQKGLGTR
EEILRRLAVQWAPEKLAALADVVIDNNGTPEALYEKTKQLYEQLLQQAMLRR
>Mature_212_residues
MESKLPLLVGVTGGLGSGKSMVCRYLASMGCALFEADVVAKELQVRDSKVIEGITALFGKEVYSYNPKGELQLNRKDIAQ
VVFSNQEKLGALNRLIHPRVAVAFQQACDNAARSNVAILVKEAAILFESGAHAGLDVVVVVQAATELRVERAVQKGLGTR
EEILRRLAVQWAPEKLAALADVVIDNNGTPEALYEKTKQLYEQLLQQAMLRR

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=183, Percent_Identity=26.2295081967213, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI191252795, Length=183, Percent_Identity=26.2295081967213, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786292, Length=201, Percent_Identity=31.8407960199005, Blast_Score=97, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17554944, Length=198, Percent_Identity=30.8080808080808, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320402, Length=210, Percent_Identity=29.0476190476191, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644728, Length=197, Percent_Identity=27.4111675126904, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24658602, Length=205, Percent_Identity=24.390243902439, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_CHLCH (Q3ARZ7)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379271.1
- ProteinModelPortal:   Q3ARZ7
- SMR:   Q3ARZ7
- STRING:   Q3ARZ7
- GeneID:   3746540
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_0965
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   RIIEEQY
- ProtClustDB:   PRK14731
- BioCyc:   CCHL340177:CAG_0965-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 23131; Mature: 23131

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKLPLLVGVTGGLGSGKSMVCRYLASMGCALFEADVVAKELQVRDSKVIEGITALFGK
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVYSYNPKGELQLNRKDIAQVVFSNQEKLGALNRLIHPRVAVAFQQACDNAARSNVAILV
HHHCCCCCCCEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KEAAILFESGAHAGLDVVVVVQAATELRVERAVQKGLGTREEILRRLAVQWAPEKLAALA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
DVVIDNNGTPEALYEKTKQLYEQLLQQAMLRR
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MESKLPLLVGVTGGLGSGKSMVCRYLASMGCALFEADVVAKELQVRDSKVIEGITALFGK
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVYSYNPKGELQLNRKDIAQVVFSNQEKLGALNRLIHPRVAVAFQQACDNAARSNVAILV
HHHCCCCCCCEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KEAAILFESGAHAGLDVVVVVQAATELRVERAVQKGLGTREEILRRLAVQWAPEKLAALA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
DVVIDNNGTPEALYEKTKQLYEQLLQQAMLRR
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA