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The map label for this gene is pyrC

Identifier: 78188868

GI number: 78188868

Start: 1231394

End: 1232722

Strand: Reverse

Name: pyrC

Synonym: Cag_0898

Alternate gene names: 78188868

Gene position: 1232722-1231394 (Counterclockwise)

Preceding gene: 78188874

Following gene: 78188867

Centisome position: 47.93

GC content: 50.49

Gene sequence:

>1329_bases
ATGAACTATATTTTTCAAAACGCCCACCTACTTAATCCCCTTGAAAAACTTGATGCCGTTGGCACCCTCACCGTTACAAG
CGATGGCACTATTGCCGCCGTAACGCTTGGCAACGAAGCCCCTCCCATTACCGCTGACGACCAGCTTATTAATTGTGAAG
GAAAGATGATTGTGCCGGGGCTTTTTGATATGCACTGCCATTTTCGTGAACCGGGGCAGGAGTACAAGGAGACGCTTGAG
AGCGGGGCAGAAGCCGCTTTAGCGGGTGGCTTTACCGGTGTGGCGCTTATGCCCAACACACGCCCCGTCATTGATAGCCC
ACTTGGCGTTGCCTACATTCGCCACCACAGCACCACGCTTCCCGTTGATTTGGAGGTTATTGGCGCCATGACGGTAGAAA
GCAAAGGCGAACATCTTGCACCGTATGGCAAGTTTAGCTCTTACGGCGTTACCGCAATTTCGGATGATGGTGCCGCAATT
CAAAGCAGCCAAATGATGCGCTTAGCGCTGGAGTATGCTTCAAATTTTGATTTACTCATTATTCAGCATTGCGAAGATCG
CTCGCTGAGTGCAGGCGGCGTTATGAACGAAGGGCTGTACTCAACACGGTTGGGCTTAAAGGGGATTCCCGAAGTAGCCG
AAGCCATCACACTTGGGCGCGACCTCATGCTGTTGCGTTACCTTGAAGAGCACAAATTACACACGCCACTGCGTCGCCCA
CGCTACCACGTTGCCCACATAAGCACCCGTCAAGCAATTGAGTTGGTGCGCCAAGCAAAAATGGAAGGGTTGCAAGTAAC
CTGCGAAATTACCCCTCACCACTTCACTTTGTGCGATCAAGAGCTTTTTGAAGCCGAACGCAAAGGCAATTTTATTATGA
AACCGCCGCTTGCCTCACAAGCCACGCGCGAGCACCTGCTTGCTGCCCTTGCTGATGGCACCATTGATGCCATTGCCACC
GACCACGCTCCACACGCTCTGCACGAAAAAGAGTGCCCACCCGACCAAGCCTCATTTGGCATTATTGGGCTTGAAACCTC
GCTTGCGCTTACCATTACAGAGTTAGTACAAAAAGAGGTTATTTCAATGGCACGCGCTATTGAGTTACTCTCGGTTAATC
CACGCGCTATTATGCGGCTCAAACCAATTCGCTTTGCAGCAGGTGAAGCTGCCAACTTCACCATTATTGATCCCAATGCA
GAATGGGTTGTAACGGCTGAACATATTCGCTCAAAATCATCCAACACACCATTTATTGGACGCACCCTTCGCGGTAAATC
GTTAGGAACATTCCATAAAGGTGCATTGCGTATGACGGTTGAGGAATAA

Upstream 100 bases:

>100_bases
AAAAAATTCGGTTTTTCCTGAAAAAGGGAAGATGGCTGAATTGTCGTATCTTTAGAGATTCTATGCGGCAGCATTCTATC
AACCAACTCTGTTTTGTGCC

Downstream 100 bases:

>100_bases
ATCACATCTAAGCCCCCAAAGCATTTCTTTTCGATGCTCTTTGGTTATCAAGAGGCTTTTTACTACATTTGCGTTTATTT
TTCCGAGTGGTTACCATACC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MNYIFQNAHLLNPLEKLDAVGTLTVTSDGTIAAVTLGNEAPPITADDQLINCEGKMIVPGLFDMHCHFREPGQEYKETLE
SGAEAALAGGFTGVALMPNTRPVIDSPLGVAYIRHHSTTLPVDLEVIGAMTVESKGEHLAPYGKFSSYGVTAISDDGAAI
QSSQMMRLALEYASNFDLLIIQHCEDRSLSAGGVMNEGLYSTRLGLKGIPEVAEAITLGRDLMLLRYLEEHKLHTPLRRP
RYHVAHISTRQAIELVRQAKMEGLQVTCEITPHHFTLCDQELFEAERKGNFIMKPPLASQATREHLLAALADGTIDAIAT
DHAPHALHEKECPPDQASFGIIGLETSLALTITELVQKEVISMARAIELLSVNPRAIMRLKPIRFAAGEAANFTIIDPNA
EWVVTAEHIRSKSSNTPFIGRTLRGKSLGTFHKGALRMTVEE

Sequences:

>Translated_442_residues
MNYIFQNAHLLNPLEKLDAVGTLTVTSDGTIAAVTLGNEAPPITADDQLINCEGKMIVPGLFDMHCHFREPGQEYKETLE
SGAEAALAGGFTGVALMPNTRPVIDSPLGVAYIRHHSTTLPVDLEVIGAMTVESKGEHLAPYGKFSSYGVTAISDDGAAI
QSSQMMRLALEYASNFDLLIIQHCEDRSLSAGGVMNEGLYSTRLGLKGIPEVAEAITLGRDLMLLRYLEEHKLHTPLRRP
RYHVAHISTRQAIELVRQAKMEGLQVTCEITPHHFTLCDQELFEAERKGNFIMKPPLASQATREHLLAALADGTIDAIAT
DHAPHALHEKECPPDQASFGIIGLETSLALTITELVQKEVISMARAIELLSVNPRAIMRLKPIRFAAGEAANFTIIDPNA
EWVVTAEHIRSKSSNTPFIGRTLRGKSLGTFHKGALRMTVEE
>Mature_442_residues
MNYIFQNAHLLNPLEKLDAVGTLTVTSDGTIAAVTLGNEAPPITADDQLINCEGKMIVPGLFDMHCHFREPGQEYKETLE
SGAEAALAGGFTGVALMPNTRPVIDSPLGVAYIRHHSTTLPVDLEVIGAMTVESKGEHLAPYGKFSSYGVTAISDDGAAI
QSSQMMRLALEYASNFDLLIIQHCEDRSLSAGGVMNEGLYSTRLGLKGIPEVAEAITLGRDLMLLRYLEEHKLHTPLRRP
RYHVAHISTRQAIELVRQAKMEGLQVTCEITPHHFTLCDQELFEAERKGNFIMKPPLASQATREHLLAALADGTIDAIAT
DHAPHALHEKECPPDQASFGIIGLETSLALTITELVQKEVISMARAIELLSVNPRAIMRLKPIRFAAGEAANFTIIDPNA
EWVVTAEHIRSKSSNTPFIGRTLRGKSLGTFHKGALRMTVEE

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=400, Percent_Identity=29, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1786722, Length=430, Percent_Identity=25.8139534883721, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082175, Length=203, Percent_Identity=25.615763546798, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=375, Percent_Identity=29.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24642586, Length=421, Percent_Identity=28.7410926365796, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48266; Mature: 48266

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYIFQNAHLLNPLEKLDAVGTLTVTSDGTIAAVTLGNEAPPITADDQLINCEGKMIVPG
CCEEECCCHHCCHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEEECCCCEECCC
LFDMHCHFREPGQEYKETLESGAEAALAGGFTGVALMPNTRPVIDSPLGVAYIRHHSTTL
CEECCCCCCCCCHHHHHHHHCCCCEECCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCC
PVDLEVIGAMTVESKGEHLAPYGKFSSYGVTAISDDGAAIQSSQMMRLALEYASNFDLLI
CEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEE
IQHCEDRSLSAGGVMNEGLYSTRLGLKGIPEVAEAITLGRDLMLLRYLEEHKLHTPLRRP
EEECCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCC
RYHVAHISTRQAIELVRQAKMEGLQVTCEITPHHFTLCDQELFEAERKGNFIMKPPLASQ
CEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCHHHHHHHHCCCEEECCCCCHH
ATREHLLAALADGTIDAIATDHAPHALHEKECPPDQASFGIIGLETSLALTITELVQKEV
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
ISMARAIELLSVNPRAIMRLKPIRFAAGEAANFTIIDPNAEWVVTAEHIRSKSSNTPFIG
HHHHHHHHHHCCCCHHEEEECCEEEECCCCCEEEEECCCCCEEEEHHHHHCCCCCCCEEE
RTLRGKSLGTFHKGALRMTVEE
EECCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MNYIFQNAHLLNPLEKLDAVGTLTVTSDGTIAAVTLGNEAPPITADDQLINCEGKMIVPG
CCEEECCCHHCCHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEEECCCCEECCC
LFDMHCHFREPGQEYKETLESGAEAALAGGFTGVALMPNTRPVIDSPLGVAYIRHHSTTL
CEECCCCCCCCCHHHHHHHHCCCCEECCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCC
PVDLEVIGAMTVESKGEHLAPYGKFSSYGVTAISDDGAAIQSSQMMRLALEYASNFDLLI
CEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEE
IQHCEDRSLSAGGVMNEGLYSTRLGLKGIPEVAEAITLGRDLMLLRYLEEHKLHTPLRRP
EEECCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCC
RYHVAHISTRQAIELVRQAKMEGLQVTCEITPHHFTLCDQELFEAERKGNFIMKPPLASQ
CEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCHHHHHHHHCCCEEECCCCCHH
ATREHLLAALADGTIDAIATDHAPHALHEKECPPDQASFGIIGLETSLALTITELVQKEV
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
ISMARAIELLSVNPRAIMRLKPIRFAAGEAANFTIIDPNAEWVVTAEHIRSKSSNTPFIG
HHHHHHHHHHCCCCHHEEEECCEEEECCCCCEEEEECCCCCEEEEHHHHHCCCCCCCEEE
RTLRGKSLGTFHKGALRMTVEE
EECCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]