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The map label for this gene is macA [H]

Identifier: 78188841

GI number: 78188841

Start: 1202157

End: 1203377

Strand: Reverse

Name: macA [H]

Synonym: Cag_0871

Alternate gene names: 78188841

Gene position: 1203377-1202157 (Counterclockwise)

Preceding gene: 78188847

Following gene: 78188840

Centisome position: 46.79

GC content: 56.18

Gene sequence:

>1221_bases
ATGAAAGCTATAGAGAAAAAAACCGTGCGCTTGTTGGCGGTTATTGTGCCGTTGTTCCTACTTTTTGCTTTTGTGGCATT
CCGTTCTGGTCCATTAGCGCCTGTGCCTGTAACGGTTACGCGTGTGCAGCAGCAAGCGCTAACGCCAGCGCTGTCGGGCA
TTGGTACGGTTGAGGCGCGTTATGCTTACCGCATTGGTCCCGTAGCCTCTGGACGGGTGCTGCGTTTGTTGGTGGATGTG
GGTGATACGGTGCGGGCAGGGCAGGTGGTGGGCGAAATTGATCCTGTGGATTTGGAGGAGCGCTTGCTTGCTCGCCGTGC
AGCGGTGCTGCGTGCAGAAGCTGTGGTGCGTTCGGCAGCGGCTAAGTTGCACGATGCTGAAGCGCGGCAGCGTTTTGCTG
TTGGGCAGGAGCAGCGTTACACCGAGTTGCTGGCGGTGCGGGCAGCAAGTAGTGAGCAGGTGGAGGCAAAGCGGCAGGAG
GCGGAGGTGGCGCGTGCAACCGCATTGTCGTCGCAAGCGGCGTTAGTGGCGGCGCGTGAGGAGCTTGCGGCGGCAAAGGC
TGATTATCAAGGGTTGGAGGAGCAGCGGCGGAATTTGCTTTTAATTGCGCCTGCCGATGGATTGGTAACCAATCGCTTAG
TGGAGGCTGGTAGCACTGTGGTTGCAGGGCAAAGCGTGCTCGAAATTATTAATCCACAAAGCGTGTGGGTTGCGGCGCGT
TTTGACCAACTGCAAAGTGCAGGCTTGCGTGCGGGTTTGCCTGCTACCGTGCGTCTTCGGTCGCAAGCAGGTGCGCCGTT
AGCTGCCTCAGTTGAACGCATTGAGCCGCTTGCCGATCGCATTACTGAGGAGCTGTTGGCTAAAGTGGTTTTTAATGTGC
TGCCAAATCCTCTCCCTCCAATTGGTGAATTGTGCGAAGTAAGCGTAGGGCTTCCCTCACTGCCGAGAACTCCCGTTGTG
CCAAACGCCAGCGTGCACCGTAGTGAAAGCCATGGGGGTAAACTTGGTGTTTGGGTGGTTGAAGGTTCATCACTACGCTT
TGTGGAAGTGCGCATTGGAGCAACTGACCAAATGGGCAATGTGCAAATTCTTTCGGGGTTGAAGGGTGGCGAGCAAGTGG
TGGTTTATAGCAAAAGTGCGCTGAATGAGGGCAAGCGCATCACTATTGTAAAGCCCACTTCAAAGCAAGGGGCGCAAGGG
GTACAGGGGGGCTTGCAATGA

Upstream 100 bases:

>100_bases
TAACCATTACCCACTAATCCGCAAAATGCTTTTCTTGTACAAAACCAATCGGTTGCTCATTACATTGAAGGCAGCCTTTG
CCAATTAACCACTCCATTAT

Downstream 100 bases:

>100_bases
TTAGTTTAGCAGGTCGCGATATTTTGCATGGATGGGTGCGCTTTATTATGACAGGCTTTGGGCTTGGGCTATTAATTGGC
GTAACGCTCAGTATGGCAGG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MKAIEKKTVRLLAVIVPLFLLFAFVAFRSGPLAPVPVTVTRVQQQALTPALSGIGTVEARYAYRIGPVASGRVLRLLVDV
GDTVRAGQVVGEIDPVDLEERLLARRAAVLRAEAVVRSAAAKLHDAEARQRFAVGQEQRYTELLAVRAASSEQVEAKRQE
AEVARATALSSQAALVAAREELAAAKADYQGLEEQRRNLLLIAPADGLVTNRLVEAGSTVVAGQSVLEIINPQSVWVAAR
FDQLQSAGLRAGLPATVRLRSQAGAPLAASVERIEPLADRITEELLAKVVFNVLPNPLPPIGELCEVSVGLPSLPRTPVV
PNASVHRSESHGGKLGVWVVEGSSLRFVEVRIGATDQMGNVQILSGLKGGEQVVVYSKSALNEGKRITIVKPTSKQGAQG
VQGGLQ

Sequences:

>Translated_406_residues
MKAIEKKTVRLLAVIVPLFLLFAFVAFRSGPLAPVPVTVTRVQQQALTPALSGIGTVEARYAYRIGPVASGRVLRLLVDV
GDTVRAGQVVGEIDPVDLEERLLARRAAVLRAEAVVRSAAAKLHDAEARQRFAVGQEQRYTELLAVRAASSEQVEAKRQE
AEVARATALSSQAALVAAREELAAAKADYQGLEEQRRNLLLIAPADGLVTNRLVEAGSTVVAGQSVLEIINPQSVWVAAR
FDQLQSAGLRAGLPATVRLRSQAGAPLAASVERIEPLADRITEELLAKVVFNVLPNPLPPIGELCEVSVGLPSLPRTPVV
PNASVHRSESHGGKLGVWVVEGSSLRFVEVRIGATDQMGNVQILSGLKGGEQVVVYSKSALNEGKRITIVKPTSKQGAQG
VQGGLQ
>Mature_406_residues
MKAIEKKTVRLLAVIVPLFLLFAFVAFRSGPLAPVPVTVTRVQQQALTPALSGIGTVEARYAYRIGPVASGRVLRLLVDV
GDTVRAGQVVGEIDPVDLEERLLARRAAVLRAEAVVRSAAAKLHDAEARQRFAVGQEQRYTELLAVRAASSEQVEAKRQE
AEVARATALSSQAALVAAREELAAAKADYQGLEEQRRNLLLIAPADGLVTNRLVEAGSTVVAGQSVLEIINPQSVWVAAR
FDQLQSAGLRAGLPATVRLRSQAGAPLAASVERIEPLADRITEELLAKVVFNVLPNPLPPIGELCEVSVGLPSLPRTPVV
PNASVHRSESHGGKLGVWVVEGSSLRFVEVRIGATDQMGNVQILSGLKGGEQVVVYSKSALNEGKRITIVKPTSKQGAQG
VQGGLQ

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=380, Percent_Identity=23.9473684210526, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787013, Length=221, Percent_Identity=29.8642533936652, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43131; Mature: 43131

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIEKKTVRLLAVIVPLFLLFAFVAFRSGPLAPVPVTVTRVQQQALTPALSGIGTVEAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
YAYRIGPVASGRVLRLLVDVGDTVRAGQVVGEIDPVDLEERLLARRAAVLRAEAVVRSAA
EEEEECCCCCCHHHHHEECCCCCHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AKLHDAEARQRFAVGQEQRYTELLAVRAASSEQVEAKRQEAEVARATALSSQAALVAARE
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELAAAKADYQGLEEQRRNLLLIAPADGLVTNRLVEAGSTVVAGQSVLEIINPQSVWVAAR
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEECHHHHHHHCCCCEEEEHH
FDQLQSAGLRAGLPATVRLRSQAGAPLAASVERIEPLADRITEELLAKVVFNVLPNPLPP
HHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGELCEVSVGLPSLPRTPVVPNASVHRSESHGGKLGVWVVEGSSLRFVEVRIGATDQMGN
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEEECCCCCCCC
VQILSGLKGGEQVVVYSKSALNEGKRITIVKPTSKQGAQGVQGGLQ
EEEEECCCCCCEEEEEEHHHHCCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKAIEKKTVRLLAVIVPLFLLFAFVAFRSGPLAPVPVTVTRVQQQALTPALSGIGTVEAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
YAYRIGPVASGRVLRLLVDVGDTVRAGQVVGEIDPVDLEERLLARRAAVLRAEAVVRSAA
EEEEECCCCCCHHHHHEECCCCCHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AKLHDAEARQRFAVGQEQRYTELLAVRAASSEQVEAKRQEAEVARATALSSQAALVAARE
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELAAAKADYQGLEEQRRNLLLIAPADGLVTNRLVEAGSTVVAGQSVLEIINPQSVWVAAR
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEECHHHHHHHCCCCEEEEHH
FDQLQSAGLRAGLPATVRLRSQAGAPLAASVERIEPLADRITEELLAKVVFNVLPNPLPP
HHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGELCEVSVGLPSLPRTPVVPNASVHRSESHGGKLGVWVVEGSSLRFVEVRIGATDQMGN
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEEECCCCCCCC
VQILSGLKGGEQVVVYSKSALNEGKRITIVKPTSKQGAQGVQGGLQ
EEEEECCCCCCEEEEEEHHHHCCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]