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The map label for this gene is pepA [H]

Identifier: 78188794

GI number: 78188794

Start: 1148836

End: 1150422

Strand: Reverse

Name: pepA [H]

Synonym: Cag_0823

Alternate gene names: 78188794

Gene position: 1150422-1148836 (Counterclockwise)

Preceding gene: 78188795

Following gene: 78188793

Centisome position: 44.73

GC content: 46.94

Gene sequence:

>1587_bases
ATGAAGCGCTGCTGTAACATATCTTTATTAAAAGAGTTAACATTATACTATCCACTGTTTATGAATATTCAGGTTACTGT
TGAAGCGCTTGCAAATGTGCAGGCGGAATTACTTGCACTGCCATGCAGTCGTCAAGAAATAAAAGAGCAGGGTGAAACGC
TGCTTGCCTCTTTTGGGATTGATGCTGCTGTGCTGAGCGATTTTAAAGGTGATGCGGGTGAAATGGTTATGCTTTATGGC
TTAAGTGGTGGTTACGGCGCAAAGCGTGTGGCGCTGCTTGGCATGGGCGATAACGCAAAGCTTGATGATTTTCGTAAAGC
TGCCGTGGCGTTTGCTTCGCGTGCAACCGATTTAAAAGTAGAGAATGCGGCACTTGATGCTTCGCGTTTTGCAGCTTTTG
CAGAGAGTTTAGGTGAGTCGGTAAGCTCGCTTGCTTCCATTGTGGTTGAAAGTGCATTTCGTGGCACCTATCGTTTTAAT
CGCTTAAAGAGTGGTAAAACTGATAAAAAAGCTGATGATGAAGCGGCATCTCAAAAACCAAAAGAGCTTGCAACGTTGCA
GCTTTGCTCAACGGAGGCATCCGCACACGCTGAGCTTGAGCGTGGTGTAGCTGAAGGCGTTGTTCTTGGCTCCTGCCAAC
GTATGGCGCGTGAGTTGGTAAATTTACCCGGTAATTATCTCAACGCAGAGCAGCTTGCAGAAGCAGCCGTTGCATCGGGT
AAACGTGCAGGCTATAGCGTTAAGGTGTTGCATAAAGCAGACATTGAAGCGCTCAGTATGGGTGGTTTACTTGGGGTCAA
TAAAGGGAGCCATAACGCCCCAACCTTCTCAATTCTTGATTACACGCCAAAAGGCGAAGCTCAAGCCGTTATTGCGCTTG
TGGGCAAAGGTGTTACTTTTGATTCAGGTGGCATTTCTATTAAGCCCTCTGAAAATATGGGTGAAATGAAGTCCGATATG
GCTGGTGCCGCTACGGTAATTGCAGCCGTTGAAGCGGCAGCTCGCTTGGAACTTCCATTGCGCATTGTGGGTTTTGTACC
TGCAACCGATAACATGCCCAGCGGCACGGCACAACAACCGGGTGATGTGCTTACTACCATGTCGGGCATTACGGTTGAAG
TTTCTAACACCGATGCTGAAGGACGCTTAATTCTTGCTGATGCACTAACCTATGCGGTAAAAAATTATCAACCTGATGCG
GTTATTGATCTTGCAACATTAACGGGCGCTTGCATTGTAGCGCTTGGCTATTCGGTAGCGGGTTTGTTTAGTAACAACGA
TGCGTTAGCCAACAAACTCTTTACGGCAGGTGAGCGCATGGGTGAAAAAGTGTGGCGTTTACCGCTTTGGGATTTGTATG
ACGAACAAATTAAATCGGATGTTGCTGATGTTAACAACACCGGTGGACGTGGAGCTGGAACAATTACTGCCGCTAAATTC
CTTGAAAAATTTATTGATGGGCACTCACAGTGGGCACATATTGATATTGCAGGTCCATCGTTTGTACCCAAAAGCGGCGG
CAAAGCAAATGGTGGCACCGGTTTTGGAGTGCGTTTGTTAGTAGATGCGTTCAAGCACTGGGCTTAA

Upstream 100 bases:

>100_bases
GGCGGTGGGCATATGAATGCGGCTGGTGCGCTTTTTCCCTATACGCCCGAAAAGGTACAACAAGTGCTTCCGCAAGCTGT
GCGTCGCTTTATAAAAGAGC

Downstream 100 bases:

>100_bases
ACGAGTGTTGTTTGCCTTATCGAAGTTCTATCTTTGATAGCTCGTTGCATTGTATTTTTGTTCAATTATTTTTTGCTTTA
AAAAAACAACCACACAAATT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MKRCCNISLLKELTLYYPLFMNIQVTVEALANVQAELLALPCSRQEIKEQGETLLASFGIDAAVLSDFKGDAGEMVMLYG
LSGGYGAKRVALLGMGDNAKLDDFRKAAVAFASRATDLKVENAALDASRFAAFAESLGESVSSLASIVVESAFRGTYRFN
RLKSGKTDKKADDEAASQKPKELATLQLCSTEASAHAELERGVAEGVVLGSCQRMARELVNLPGNYLNAEQLAEAAVASG
KRAGYSVKVLHKADIEALSMGGLLGVNKGSHNAPTFSILDYTPKGEAQAVIALVGKGVTFDSGGISIKPSENMGEMKSDM
AGAATVIAAVEAAARLELPLRIVGFVPATDNMPSGTAQQPGDVLTTMSGITVEVSNTDAEGRLILADALTYAVKNYQPDA
VIDLATLTGACIVALGYSVAGLFSNNDALANKLFTAGERMGEKVWRLPLWDLYDEQIKSDVADVNNTGGRGAGTITAAKF
LEKFIDGHSQWAHIDIAGPSFVPKSGGKANGGTGFGVRLLVDAFKHWA

Sequences:

>Translated_528_residues
MKRCCNISLLKELTLYYPLFMNIQVTVEALANVQAELLALPCSRQEIKEQGETLLASFGIDAAVLSDFKGDAGEMVMLYG
LSGGYGAKRVALLGMGDNAKLDDFRKAAVAFASRATDLKVENAALDASRFAAFAESLGESVSSLASIVVESAFRGTYRFN
RLKSGKTDKKADDEAASQKPKELATLQLCSTEASAHAELERGVAEGVVLGSCQRMARELVNLPGNYLNAEQLAEAAVASG
KRAGYSVKVLHKADIEALSMGGLLGVNKGSHNAPTFSILDYTPKGEAQAVIALVGKGVTFDSGGISIKPSENMGEMKSDM
AGAATVIAAVEAAARLELPLRIVGFVPATDNMPSGTAQQPGDVLTTMSGITVEVSNTDAEGRLILADALTYAVKNYQPDA
VIDLATLTGACIVALGYSVAGLFSNNDALANKLFTAGERMGEKVWRLPLWDLYDEQIKSDVADVNNTGGRGAGTITAAKF
LEKFIDGHSQWAHIDIAGPSFVPKSGGKANGGTGFGVRLLVDAFKHWA
>Mature_528_residues
MKRCCNISLLKELTLYYPLFMNIQVTVEALANVQAELLALPCSRQEIKEQGETLLASFGIDAAVLSDFKGDAGEMVMLYG
LSGGYGAKRVALLGMGDNAKLDDFRKAAVAFASRATDLKVENAALDASRFAAFAESLGESVSSLASIVVESAFRGTYRFN
RLKSGKTDKKADDEAASQKPKELATLQLCSTEASAHAELERGVAEGVVLGSCQRMARELVNLPGNYLNAEQLAEAAVASG
KRAGYSVKVLHKADIEALSMGGLLGVNKGSHNAPTFSILDYTPKGEAQAVIALVGKGVTFDSGGISIKPSENMGEMKSDM
AGAATVIAAVEAAARLELPLRIVGFVPATDNMPSGTAQQPGDVLTTMSGITVEVSNTDAEGRLILADALTYAVKNYQPDA
VIDLATLTGACIVALGYSVAGLFSNNDALANKLFTAGERMGEKVWRLPLWDLYDEQIKSDVADVNNTGGRGAGTITAAKF
LEKFIDGHSQWAHIDIAGPSFVPKSGGKANGGTGFGVRLLVDAFKHWA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=443, Percent_Identity=38.1489841986456, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI47155554, Length=316, Percent_Identity=34.8101265822785, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1790710, Length=459, Percent_Identity=38.9978213507625, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI87082123, Length=316, Percent_Identity=41.7721518987342, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17556903, Length=320, Percent_Identity=33.75, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=246, Percent_Identity=30.4878048780488, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355725, Length=285, Percent_Identity=36.8421052631579, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24661038, Length=285, Percent_Identity=37.1929824561403, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI20129969, Length=308, Percent_Identity=33.4415584415584, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24662227, Length=335, Percent_Identity=31.6417910447761, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI161077148, Length=295, Percent_Identity=33.5593220338983, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20130057, Length=295, Percent_Identity=33.5593220338983, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21355645, Length=295, Percent_Identity=32.5423728813559, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24662223, Length=295, Percent_Identity=32.5423728813559, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI20129963, Length=293, Percent_Identity=35.8361774744027, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI19922386, Length=295, Percent_Identity=33.2203389830508, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21357381, Length=319, Percent_Identity=33.5423197492163, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI221379063, Length=318, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379062, Length=318, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24646701, Length=248, Percent_Identity=28.6290322580645, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646703, Length=248, Percent_Identity=28.6290322580645, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358201, Length=248, Percent_Identity=28.6290322580645, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 55590; Mature: 55590

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRCCNISLLKELTLYYPLFMNIQVTVEALANVQAELLALPCSRQEIKEQGETLLASFGI
CCCCCCHHHHHHHHHHHHHHEEHEEHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHCCC
DAAVLSDFKGDAGEMVMLYGLSGGYGAKRVALLGMGDNAKLDDFRKAAVAFASRATDLKV
CHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEE
ENAALDASRFAAFAESLGESVSSLASIVVESAFRGTYRFNRLKSGKTDKKADDEAASQKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCHHHHHCCC
KELATLQLCSTEASAHAELERGVAEGVVLGSCQRMARELVNLPGNYLNAEQLAEAAVASG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
KRAGYSVKVLHKADIEALSMGGLLGVNKGSHNAPTFSILDYTPKGEAQAVIALVGKGVTF
CCCCCEEEEEECCCCHHHHCCCEEECCCCCCCCCEEEEEECCCCCCHHEEEEEEECCCEE
DSGGISIKPSENMGEMKSDMAGAATVIAAVEAAARLELPLRIVGFVPATDNMPSGTAQQP
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCC
GDVLTTMSGITVEVSNTDAEGRLILADALTYAVKNYQPDAVIDLATLTGACIVALGYSVA
CCHHEECCCEEEEEECCCCCCCEEEHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHE
GLFSNNDALANKLFTAGERMGEKVWRLPLWDLYDEQIKSDVADVNNTGGRGAGTITAAKF
EEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LEKFIDGHSQWAHIDIAGPSFVPKSGGKANGGTGFGVRLLVDAFKHWA
HHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRCCNISLLKELTLYYPLFMNIQVTVEALANVQAELLALPCSRQEIKEQGETLLASFGI
CCCCCCHHHHHHHHHHHHHHEEHEEHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHCCC
DAAVLSDFKGDAGEMVMLYGLSGGYGAKRVALLGMGDNAKLDDFRKAAVAFASRATDLKV
CHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEE
ENAALDASRFAAFAESLGESVSSLASIVVESAFRGTYRFNRLKSGKTDKKADDEAASQKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCHHHHHCCC
KELATLQLCSTEASAHAELERGVAEGVVLGSCQRMARELVNLPGNYLNAEQLAEAAVASG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
KRAGYSVKVLHKADIEALSMGGLLGVNKGSHNAPTFSILDYTPKGEAQAVIALVGKGVTF
CCCCCEEEEEECCCCHHHHCCCEEECCCCCCCCCEEEEEECCCCCCHHEEEEEEECCCEE
DSGGISIKPSENMGEMKSDMAGAATVIAAVEAAARLELPLRIVGFVPATDNMPSGTAQQP
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCC
GDVLTTMSGITVEVSNTDAEGRLILADALTYAVKNYQPDAVIDLATLTGACIVALGYSVA
CCHHEECCCEEEEEECCCCCCCEEEHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHE
GLFSNNDALANKLFTAGERMGEKVWRLPLWDLYDEQIKSDVADVNNTGGRGAGTITAAKF
EEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LEKFIDGHSQWAHIDIAGPSFVPKSGGKANGGTGFGVRLLVDAFKHWA
HHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA