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The map label for this gene is guaA

Identifier: 78188567

GI number: 78188567

Start: 691317

End: 692852

Strand: Reverse

Name: guaA

Synonym: Cag_0589

Alternate gene names: 78188567

Gene position: 692852-691317 (Counterclockwise)

Preceding gene: 78188568

Following gene: 78188566

Centisome position: 26.94

GC content: 47.98

Gene sequence:

>1536_bases
ATGCAATCAGTTTTAGTGCTTGATTTTGGTTCACAATACACCCAGCTTATTGCTCGCCGCATTCGCGAACTCAATATTTA
CTCCGAAATTCTTCCCTACAACACTCCAGCCGATACCATTCGCACCCATCAGCCAAAAGCCATTATTCTTTCAGGCGGAC
CAAACAGCGTTTATGACCAAACCGCTTTTATGCCCGATCCCGCTATCTTTTCGCTTGGCATTCCCGTGCTTGGCATTTGT
TATGGCTTGCAAGCAATTGCCAAACACTTTGGCGGCGTAGTTGCAAGTTCCAACAAGCATGAATTTGGACGCTCAAAAAT
TTTGGTGGAACAGCAAGGCGATAATCCCCTCTTTCAAAACATCCCTAACTCTGATGTGTGGATGAGCCATGGCGACAAAG
TGATGCAGCTCCCCGAAGGCTTTCGAGCTACCGCCAGCAGCGACAACTCCGAAATTTGCGCCTTTGAAAGCACAGGAGTT
AATAGCCCCGCTCATATTTACGGCTTACAATTCCACCCCGAAGTTCAGCACACCCTTTACGGCAAAGAGATGCTTGGCAA
CTTTTTGCTCAACATTGCAGCCATTACGCCCGACTGGTCCAGCAAAAGCTTTATAGAGCACCAAATTGAGGAGATTCGCC
GCAAAGCAGGCAACAACACCGTTATTTGCGGCATTAGCGGCGGCGTGGACTCTACGGTTGCCGCCGTGTTAGTTAGCAAA
GCTATTGGCAAGCAACTCCACTGCGTTTTTGTAGATAATGGCTTGTTGCGCAAAAATGAAGCCGAAAAAGTGATGCACTT
CCTCAAACCACTTGGCTTACACATCACCTTAGCCGACTCCTCCGACCTCTTTTTAAAACGCTTAAAAGGCGTTGCCTCAC
CCGAAAAAAAGCGCAAAATTATTGGACGCACCTTTATTCAAGTCTTTGAAGAGCAAATCCATCACGAAAAATTTCTTGTG
CAGGGCACGCTTTACCCCGATGTAATTGAAAGTATAAGCGTTAAAGGACCATCGGAAACCATTAAATCGCACCACAACGT
TGGCGGACTACCCAAACGCATGAAGCTCAAGCTCATTGAGCCACTACGCGAACTTTTTAAGGATGAAGTACGGGCGGTTG
GCAGAGAACTTGGTATTCCTGAAGATATTCTCATGCGCCACCCCTTCCCTGGTCCAGGACTTGCCGTCCGAGTGCTTGGC
TCACTTACGCATGAACGGTTAGAAATACTGCGCGAAGCTGATGAAATTTACATTGAAGAATTACAAGCAAGCGGACTTTA
CAGTAAAGTTTGGCAAGCCTTTGCCGTGCTGCTCCCCGTGCAATCGGTAGGCGTTATGGGCGATAAACGCACCTACGAAA
ACGTGCTTGCCTTGCGTGCTGTGGAATCAAGCGACGGTATGACGGCAGATTGGGCTCCCCTACCGCACGACTTTCTTGCT
CGCGTTTCAAACCGCATTATCAATGAAGTTCGAGGTATTAACCGCGTAGCTTACGACATTTCATCGAAGCCTCCAGCAAC
GATTGAGTGGGAATAG

Upstream 100 bases:

>100_bases
AGTGGAGAAGCCTCACTAACAACTTTTTATAGCGCCACAAACAAGCACGAACGAGCTTGGCGTGGCGCTCCACATTTTCT
AACCCTAACACTCACCTCCT

Downstream 100 bases:

>100_bases
GATGATGGTTGGAAAATATTGGAGGGTAAACGAATATCTATAAAATGCAATAAGACAATGATTCATAGCATTCGACTTGA
TAACCTACTTTCATTTGCAT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MQSVLVLDFGSQYTQLIARRIRELNIYSEILPYNTPADTIRTHQPKAIILSGGPNSVYDQTAFMPDPAIFSLGIPVLGIC
YGLQAIAKHFGGVVASSNKHEFGRSKILVEQQGDNPLFQNIPNSDVWMSHGDKVMQLPEGFRATASSDNSEICAFESTGV
NSPAHIYGLQFHPEVQHTLYGKEMLGNFLLNIAAITPDWSSKSFIEHQIEEIRRKAGNNTVICGISGGVDSTVAAVLVSK
AIGKQLHCVFVDNGLLRKNEAEKVMHFLKPLGLHITLADSSDLFLKRLKGVASPEKKRKIIGRTFIQVFEEQIHHEKFLV
QGTLYPDVIESISVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIPEDILMRHPFPGPGLAVRVLG
SLTHERLEILREADEIYIEELQASGLYSKVWQAFAVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAPLPHDFLA
RVSNRIINEVRGINRVAYDISSKPPATIEWE

Sequences:

>Translated_511_residues
MQSVLVLDFGSQYTQLIARRIRELNIYSEILPYNTPADTIRTHQPKAIILSGGPNSVYDQTAFMPDPAIFSLGIPVLGIC
YGLQAIAKHFGGVVASSNKHEFGRSKILVEQQGDNPLFQNIPNSDVWMSHGDKVMQLPEGFRATASSDNSEICAFESTGV
NSPAHIYGLQFHPEVQHTLYGKEMLGNFLLNIAAITPDWSSKSFIEHQIEEIRRKAGNNTVICGISGGVDSTVAAVLVSK
AIGKQLHCVFVDNGLLRKNEAEKVMHFLKPLGLHITLADSSDLFLKRLKGVASPEKKRKIIGRTFIQVFEEQIHHEKFLV
QGTLYPDVIESISVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIPEDILMRHPFPGPGLAVRVLG
SLTHERLEILREADEIYIEELQASGLYSKVWQAFAVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAPLPHDFLA
RVSNRIINEVRGINRVAYDISSKPPATIEWE
>Mature_511_residues
MQSVLVLDFGSQYTQLIARRIRELNIYSEILPYNTPADTIRTHQPKAIILSGGPNSVYDQTAFMPDPAIFSLGIPVLGIC
YGLQAIAKHFGGVVASSNKHEFGRSKILVEQQGDNPLFQNIPNSDVWMSHGDKVMQLPEGFRATASSDNSEICAFESTGV
NSPAHIYGLQFHPEVQHTLYGKEMLGNFLLNIAAITPDWSSKSFIEHQIEEIRRKAGNNTVICGISGGVDSTVAAVLVSK
AIGKQLHCVFVDNGLLRKNEAEKVMHFLKPLGLHITLADSSDLFLKRLKGVASPEKKRKIIGRTFIQVFEEQIHHEKFLV
QGTLYPDVIESISVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIPEDILMRHPFPGPGLAVRVLG
SLTHERLEILREADEIYIEELQASGLYSKVWQAFAVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAPLPHDFLA
RVSNRIINEVRGINRVAYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=557, Percent_Identity=38.5996409335727, Blast_Score=325, Evalue=5e-89,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=53.639846743295, Blast_Score=544, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=35.304347826087, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=35.304347826087, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=35.304347826087, Blast_Score=293, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6323873, Length=521, Percent_Identity=54.89443378119, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI281365319, Length=549, Percent_Identity=38.7978142076503, Blast_Score=335, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_CHLCH (Q3AT13)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_378905.1
- ProteinModelPortal:   Q3AT13
- SMR:   Q3AT13
- STRING:   Q3AT13
- GeneID:   3747497
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_0589
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- BioCyc:   CCHL340177:CAG_0589-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 56734; Mature: 56734

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 80-80 ACT_SITE 172-172 ACT_SITE 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSVLVLDFGSQYTQLIARRIRELNIYSEILPYNTPADTIRTHQPKAIILSGGPNSVYDQ
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCCC
TAFMPDPAIFSLGIPVLGICYGLQAIAKHFGGVVASSNKHEFGRSKILVEQQGDNPLFQN
CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEEEEECCCCCHHHC
IPNSDVWMSHGDKVMQLPEGFRATASSDNSEICAFESTGVNSPAHIYGLQFHPEVQHTLY
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCHHHHHH
GKEMLGNFLLNIAAITPDWSSKSFIEHQIEEIRRKAGNNTVICGISGGVDSTVAAVLVSK
HHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHH
AIGKQLHCVFVDNGLLRKNEAEKVMHFLKPLGLHITLADSSDLFLKRLKGVASPEKKRKI
HHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCHHHHHH
IGRTFIQVFEEQIHHEKFLVQGTLYPDVIESISVKGPSETIKSHHNVGGLPKRMKLKLIE
HHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHH
PLRELFKDEVRAVGRELGIPEDILMRHPFPGPGLAVRVLGSLTHERLEILREADEIYIEE
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQASGLYSKVWQAFAVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAPLPHDFLA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCHHHHH
RVSNRIINEVRGINRVAYDISSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECCC
>Mature Secondary Structure
MQSVLVLDFGSQYTQLIARRIRELNIYSEILPYNTPADTIRTHQPKAIILSGGPNSVYDQ
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCCC
TAFMPDPAIFSLGIPVLGICYGLQAIAKHFGGVVASSNKHEFGRSKILVEQQGDNPLFQN
CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEEEEECCCCCHHHC
IPNSDVWMSHGDKVMQLPEGFRATASSDNSEICAFESTGVNSPAHIYGLQFHPEVQHTLY
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCHHHHHH
GKEMLGNFLLNIAAITPDWSSKSFIEHQIEEIRRKAGNNTVICGISGGVDSTVAAVLVSK
HHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHH
AIGKQLHCVFVDNGLLRKNEAEKVMHFLKPLGLHITLADSSDLFLKRLKGVASPEKKRKI
HHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCHHHHHH
IGRTFIQVFEEQIHHEKFLVQGTLYPDVIESISVKGPSETIKSHHNVGGLPKRMKLKLIE
HHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHH
PLRELFKDEVRAVGRELGIPEDILMRHPFPGPGLAVRVLGSLTHERLEILREADEIYIEE
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQASGLYSKVWQAFAVLLPVQSVGVMGDKRTYENVLALRAVESSDGMTADWAPLPHDFLA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCHHHHH
RVSNRIINEVRGINRVAYDISSKPPATIEWE
HHHHHHHHHHHHHHHHEEECCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA