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The map label for this gene is ada [H]

Identifier: 78067976

GI number: 78067976

Start: 3679660

End: 3680619

Strand: Reverse

Name: ada [H]

Synonym: Bcep18194_A6507

Alternate gene names: 78067976

Gene position: 3680619-3679660 (Counterclockwise)

Preceding gene: 78067977

Following gene: 78067974

Centisome position: 99.63

GC content: 71.15

Gene sequence:

>960_bases
TTGAGCATCGCAAAAACAACGATTACGTCCATCGTGAACGGCGGCCAGGTGCCGCCGTCCGCGCAAATGGAGCTGCGCTT
CAATGCGCCTTACGACTGGGCGCGCGTGCTGCGCTTCTTCAGCGGGCGCGCGATTCCGGGCGTCGAGCAGGTGGCGGACG
GCGTGTATCGACGCATCGTCGACCTGCACGGCGACGCCGGCCGGCTCACGGTCGCGAAACATCCGCGCAAGCATTGCCTG
GTCGCGACGGTCGAAGGCGCGGTCGCGCGTCATGTCGATGACGCGTTCGCCGCGCGTGTCGCGACGATGTTCGACCTCGG
CGCCGATCCGGCCGCCATCGGCAGCGGGCTCGCGCGCGATCCGTGGTTCGCGCCGCTCGTCGAGGCCGCGCCGGGGCTGC
GCGTGCCGGGCGCATGGTCGGGGTTCGAACTGGCCGTGCGCGCGATCGTCGGCCAGCAGGTGAGCGTGAAGGCCGCGACG
ACGATCGTCGGCCGGCTCGTCGAGCGGGCCGGAGAGCGAGTGGTTCATGAAGACGACGGCGCGCCTGCGTGGCGCTTTCC
GACGCCCGATGCGCTGGCCGCCTGTGACCTCGACAAGATCGGGATGCCCGGCAAGCGGGTGGCGGCACTGACGGGCGTGG
CGCGCGCGGTGGCGGCCGGCGACGTGCCGGTCGATCGCGAGCACGCCGATCTCGCGACGCTGCGCAGTGCGTGGCTCGAT
CTGCCCGGCATCGGCCCGTGGACCGTCGAATACATCGCGATGCGCGCATGGCGCGATCCGGACGCATGGCCGGCCTCCGA
TCTCGTGCTGATGCAGTCGATTACCGCGCGCGATCCCACGCTCGACCGGCTCGCGACCCAGAAGCACCGCACTGAGGGCT
GGCGGCCGTGGCGCGCGTATGCGGCGCTGCATTTGTGGAATGAAGTGGCCGACCGGGCGGGCGGTGCGCGCGGCGGGTGA

Upstream 100 bases:

>100_bases
GGTATCGTTGGGGCGTGCGCCGCAAGGCGACGCTGCTCGCGTCCGAGGCGCGGCATGTGAACGACGATCAGACCGAATCC
GTTGCGGAGGGCAGTGCAGT

Downstream 100 bases:

>100_bases
GGGCGACGGGTGACTGCTGAGGCTCGTGGCCGGGTGCGACCACACCAGGCCGCGATGCATCCTGCTGCGCAGGTCGCGCC
GACATGTGCAGCCTAACGGC

Product: DNA-3-methyladenine glycosylase II

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSIAKTTITSIVNGGQVPPSAQMELRFNAPYDWARVLRFFSGRAIPGVEQVADGVYRRIVDLHGDAGRLTVAKHPRKHCL
VATVEGAVARHVDDAFAARVATMFDLGADPAAIGSGLARDPWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAAT
TIVGRLVERAGERVVHEDDGAPAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDREHADLATLRSAWLD
LPGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSITARDPTLDRLATQKHRTEGWRPWRAYAALHLWNEVADRAGGARGG

Sequences:

>Translated_319_residues
MSIAKTTITSIVNGGQVPPSAQMELRFNAPYDWARVLRFFSGRAIPGVEQVADGVYRRIVDLHGDAGRLTVAKHPRKHCL
VATVEGAVARHVDDAFAARVATMFDLGADPAAIGSGLARDPWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAAT
TIVGRLVERAGERVVHEDDGAPAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDREHADLATLRSAWLD
LPGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSITARDPTLDRLATQKHRTEGWRPWRAYAALHLWNEVADRAGGARGG
>Mature_318_residues
SIAKTTITSIVNGGQVPPSAQMELRFNAPYDWARVLRFFSGRAIPGVEQVADGVYRRIVDLHGDAGRLTVAKHPRKHCLV
ATVEGAVARHVDDAFAARVATMFDLGADPAAIGSGLARDPWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAATT
IVGRLVERAGERVVHEDDGAPAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDREHADLATLRSAWLDL
PGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSITARDPTLDRLATQKHRTEGWRPWRAYAALHLWNEVADRAGGARGG

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=293, Percent_Identity=36.518771331058, Blast_Score=153, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 34288; Mature: 34157

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAKTTITSIVNGGQVPPSAQMELRFNAPYDWARVLRFFSGRAIPGVEQVADGVYRRIV
CCCHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DLHGDAGRLTVAKHPRKHCLVATVEGAVARHVDDAFAARVATMFDLGADPAAIGSGLARD
HHCCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
PWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAATTIVGRLVERAGERVVHEDDG
CCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCC
APAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDREHADLATLRSAWLD
CCCCCCCCCHHHHHCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
LPGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSITARDPTLDRLATQKHRTEGWRPWRAY
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
AALHLWNEVADRAGGARGG
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SIAKTTITSIVNGGQVPPSAQMELRFNAPYDWARVLRFFSGRAIPGVEQVADGVYRRIV
CCHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DLHGDAGRLTVAKHPRKHCLVATVEGAVARHVDDAFAARVATMFDLGADPAAIGSGLARD
HHCCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
PWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAATTIVGRLVERAGERVVHEDDG
CCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCC
APAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDREHADLATLRSAWLD
CCCCCCCCCHHHHHCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
LPGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSITARDPTLDRLATQKHRTEGWRPWRAY
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
AALHLWNEVADRAGGARGG
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]