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The map label for this gene is lutP [H]

Identifier: 78067971

GI number: 78067971

Start: 3674995

End: 3676665

Strand: Reverse

Name: lutP [H]

Synonym: Bcep18194_A6502

Alternate gene names: 78067971

Gene position: 3676665-3674995 (Counterclockwise)

Preceding gene: 78067972

Following gene: 78067969

Centisome position: 99.53

GC content: 67.44

Gene sequence:

>1671_bases
ATGCCAGCTTGGGTCGACTCTGGAGACACGATGAACCCCACCGACGCCCTACCGCCCGGCATCGTCTTCGCACAGCCGTT
GACGCCGGTCGCCAGCTCGCTGTTGCTGTCTTTTCTCGTCGCCGCGATCCCGATCGCGGTCGCGCTGATCGCACTCGGCG
TGCTGCGCCGGCCCGCATGGCAGGCGTCGCTCGCCGGGCTCGTCGCCGGCCTCGCGGTCGCGATCGGCGCATGGGGCATG
CCGGCCGGGCTCGCGTTCAATGCGGTCGGTGCGGGCATGGCGCTCGCGGTCGTGCCGGTGATGTGGATCGTCTTCAACGC
GCTGCTGCTGTACAACATCGCGGTGAAGTCGGGCCGCTTCGACCAGTTCCGGCAGTGGATGCTCGACAACCTGCCCGACG
ACCGGCGCCTCGTGCTGCTCGTCGTCGCGTTTTCGTTCGGCTGCCTGCTCGAAGGGATCTCGGGATTCGGCACGCCGGTC
GCGATCACGAGCGCACTCCTGATCGCGCTCGGTTTCCCCGCGCTCGAAGCGCTCACCTATACGCTGCTGTTCAACACGGC
GCCGGTCGCGTTCGGCGCGCTCGGCGTGCCGATCACCGTGCTCGGCGCGGTCACGTCGCTGCCGCCCGCGACACTCGCGC
AGATGGTCGGCCGACAACTGCCATTTTTCGCGCTGCTGCTGCCGTTCTACGTGGTCGGCGCGTACGGGGGGCTGCGCTCG
ATCTCGAAGTTGTGGCCGGCGCTGCTCGTGTCGGGCGGCAGCTTCGCGATCGCGCAGTTCGTCACGTCGAACTTCCTCGG
CTACCAGCTCACCGACGTGCTGTCGTCGCTCTCGTCGCTGATCGTCACGATCGGCTTCCTACAGGTGTGGAAGCCGCAGC
CCGATCCGCAATACGCGCTCGCGCGCAGCGTGCCGGCAACGGCCGGCGCCGCACGCGCGGGCTTCGGCGGCTGGCTGCCG
TGGCTCGTCGTGTCGGTGGTCGTGATCGTGTGGGTGCACGCGAACATCGCGGCGATCGGCGACGTGAAGATCAAGTGGCC
GGGCCTGCACAACGCTGTGTTCGTGTCGCTGTATCACAAGCCCTATGCGGCGATCTGGGACTTCCAGCCGCTCGGCACGG
GCACCGCGATCCTGGTGTCGGCGATCATCACGGCCGCGCTGACGCGCACCGGCGTCGGCGCGTTCTTCGAATGCGTGGTC
AAGACCTGGCGGCAGACGTGGATCGCGATCGTCACGGTGATGATGATCGTCGGGCTCGCGTACCTGCTGAACTACTCGGG
GATCAGCTACACGCTCGGCACCGGCGTCGCGTCGACGGGCGCGCTGTTCCCGCTGGTGTCCGCGTCGCTCGGCTGGATCG
CCGTGTTCCTGTCCGGCAGCGACACGTCGGGCAATGCGCTGTTCGGCAACCTGCAGGTCGTCGCAGCCCGGCAGCTCGGC
CTGGATCCGGTGTTGATGGCCGCGACCAACTCGTCGGGCGGCGTGATGGGCAAGATGATCTCGCCGCAGAACATCGCGAC
GGGTGTGTCGACGACGGACCTGAAAGGGCAGGAAGGTGTCGTGTTCGCGCGCACGTTCTGGCACAGCGTGATCCTCACGC
TTCTGCTCGGCGTGCTCGTGTTCCTGCAGCAGCACGTACTGACGTGGATGATTCCGGCACTACCGAAGTGA

Upstream 100 bases:

>100_bases
GCGACCGATCGGTTGGCCGTGCGACGTCGTTGCGTGCGCAAGCGCCTGATCTCGGTCGTGACCGCAGGACATCGCCTTGT
ACCGAACCCGGGGCATCCCG

Downstream 100 bases:

>100_bases
TGTGAGCGCAACGACAGAAGGAAGGCACGAGGAAAAACGAGGGAAGGCGCGGGAAAAGCGCCACTGATGTGCGGTACCGG
CGAACGCGCGGCCGTTCAGC

Product: L-lactate transporter

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MPAWVDSGDTMNPTDALPPGIVFAQPLTPVASSLLLSFLVAAIPIAVALIALGVLRRPAWQASLAGLVAGLAVAIGAWGM
PAGLAFNAVGAGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPV
AITSALLIALGFPALEALTYTLLFNTAPVAFGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRS
ISKLWPALLVSGGSFAIAQFVTSNFLGYQLTDVLSSLSSLIVTIGFLQVWKPQPDPQYALARSVPATAGAARAGFGGWLP
WLVVSVVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYHKPYAAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVV
KTWRQTWIAIVTVMMIVGLAYLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLG
LDPVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLVFLQQHVLTWMIPALPK

Sequences:

>Translated_556_residues
MPAWVDSGDTMNPTDALPPGIVFAQPLTPVASSLLLSFLVAAIPIAVALIALGVLRRPAWQASLAGLVAGLAVAIGAWGM
PAGLAFNAVGAGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPV
AITSALLIALGFPALEALTYTLLFNTAPVAFGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRS
ISKLWPALLVSGGSFAIAQFVTSNFLGYQLTDVLSSLSSLIVTIGFLQVWKPQPDPQYALARSVPATAGAARAGFGGWLP
WLVVSVVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYHKPYAAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVV
KTWRQTWIAIVTVMMIVGLAYLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLG
LDPVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLVFLQQHVLTWMIPALPK
>Mature_555_residues
PAWVDSGDTMNPTDALPPGIVFAQPLTPVASSLLLSFLVAAIPIAVALIALGVLRRPAWQASLAGLVAGLAVAIGAWGMP
AGLAFNAVGAGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPVA
ITSALLIALGFPALEALTYTLLFNTAPVAFGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRSI
SKLWPALLVSGGSFAIAQFVTSNFLGYQLTDVLSSLSSLIVTIGFLQVWKPQPDPQYALARSVPATAGAARAGFGGWLPW
LVVSVVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYHKPYAAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVVK
TWRQTWIAIVTVMMIVGLAYLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGL
DPVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLVFLQQHVLTWMIPALPK

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=548, Percent_Identity=39.5985401459854, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI1790031, Length=542, Percent_Identity=39.6678966789668, Blast_Score=321, Evalue=8e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 58374; Mature: 58242

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAWVDSGDTMNPTDALPPGIVFAQPLTPVASSLLLSFLVAAIPIAVALIALGVLRRPAW
CCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QASLAGLVAGLAVAIGAWGMPAGLAFNAVGAGMALAVVPVMWIVFNALLLYNIAVKSGRF
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIALGFPALEALTY
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHH
TLLFNTAPVAFGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRS
HHHHHCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ISKLWPALLVSGGSFAIAQFVTSNFLGYQLTDVLSSLSSLIVTIGFLQVWKPQPDPQYAL
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ARSVPATAGAARAGFGGWLPWLVVSVVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYHK
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCCCCEEEEECCC
PYAAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVVKTWRQTWIAIVTVMMIVGLA
CCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLG
HHHHCCCCEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCEEEECCEEEEHHHCC
LDPVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLV
CCCEEEEEECCCCCCEEECCCCCHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
FLQQHVLTWMIPALPK
HHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PAWVDSGDTMNPTDALPPGIVFAQPLTPVASSLLLSFLVAAIPIAVALIALGVLRRPAW
CCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QASLAGLVAGLAVAIGAWGMPAGLAFNAVGAGMALAVVPVMWIVFNALLLYNIAVKSGRF
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIALGFPALEALTY
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHH
TLLFNTAPVAFGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRS
HHHHHCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ISKLWPALLVSGGSFAIAQFVTSNFLGYQLTDVLSSLSSLIVTIGFLQVWKPQPDPQYAL
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ARSVPATAGAARAGFGGWLPWLVVSVVVIVWVHANIAAIGDVKIKWPGLHNAVFVSLYHK
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCCCCEEEEECCC
PYAAIWDFQPLGTGTAILVSAIITAALTRTGVGAFFECVVKTWRQTWIAIVTVMMIVGLA
CCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLG
HHHHCCCCEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCEEEECCEEEEHHHCC
LDPVLMAATNSSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLV
CCCEEEEEECCCCCCEEECCCCCHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
FLQQHVLTWMIPALPK
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]