Click here to switch to the map view.

The map label for this gene is hslU

Identifier: 78067911

GI number: 78067911

Start: 3608145

End: 3609488

Strand: Direct

Name: hslU

Synonym: Bcep18194_A6442

Alternate gene names: 78067911

Gene position: 3608145-3609488 (Clockwise)

Preceding gene: 78067910

Following gene: 78067912

Centisome position: 97.67

GC content: 63.47

Gene sequence:

>1344_bases
ATGAGCACCATGACCCCTGCCGAGATCGTCTCGGAACTCGACAAGCACATCATCGGCCAGGCGAAGGCGAAGAAAGCCGT
CGCGGTTGCGCTGCGCAACCGCTGGCGCCGCCAGCAGGTCGCCGACCCGCTGCGCCAGGAAATCACGCCGAAGAACATCC
TGATGATCGGGCCGACGGGTGTCGGCAAGACCGAAATCGCTCGCCGCCTCGCGAAGCTCGCCGACGCGCCGTTCATCAAG
ATCGAAGCGACCAAATTCACCGAAGTCGGCTACGTCGGCCGCGACGTCGACAGCATCGTGCGCGACCTGATCGAGATCTC
GGTCAAGCAGACGCGTGAAACCGAGATGCGCAAGGTGCGCAGCAAGGCGACCGACCAGGCGGAAGACCGCATCCTCGACA
TCCTGCTGCCGCAACCGCGCGCGGTGGGCTTCGGCGGCAACGCCGAACACGCGAACGACGACAACAACGCGACGCGCCAG
ACGTTCCGCAAGCGCCTGCGTGAAGGCCAGCTCGACGACAAGGAAGTCGAGCTCGACATCGAGCAGCCGTCGGCCGGCAT
GGACATCATGGCGCCGCCGGGGATGGAAGAGATGACCGAGCAGATCCGCTCGATGTTCTCGAACCTCGGCAGCGGCAAGA
AGCAGCGCCGCAAGGTGAAGATCAAGGAAGCGCTGAAGCTGCTGACCGACGAGGAAGCGGCGAAGATGCTCAACGACGAG
GAAGTGAAGACGAAGGCCGTGCAGAACGTCGAGCAGAACGGCATCGTGTTCCTCGACGAGATCGACAAGATCACGTCGCG
CAACAACGAAGGCAGCGGCGGCGAAGTGTCGCGCCAGGGCGTGCAGCGCGACCTGCTGCCGCTCGTCGAAGGCACGACGG
TCAACACGAAGTACGGGATGGTGAAGACCGATCACATCCTGTTCATCGCGAGCGGCGCGTTCCACCTCGCGAAGCCGAGC
GACCTGATTCCCGAACTGCAGGGCCGCTTCCCGATCCGCGTCGAACTCGACTCGCTGTCGGTGAACGACTTCGAAGCGAT
CCTCGTCGCGACCGACGCCAGCCTCGTCAAGCAGTACCAGGCGCTGCTCGCGACCGAAGACGTGCAGCTCGAATTCGCCG
ACGACGGCATCCGCCGTCTCGCGGAGATCGCTTATTCGGTCAACGAGAAGACCGAGAACATCGGTGCGCGCCGGCTTTAC
ACGGTGATCGAGAAACTGCTCGAGGAAGTGTCGTTCTCGGCCGGCAACCATGCAGGCGAGCGCGTGACGATCGACGCGAA
GTATGTCGATCGCGCACTCGGCGAAGTGTCGCAGGACGAAGACCTGTCGCGCTACGTGCTGTAA

Upstream 100 bases:

>100_bases
CCGCGCGAGATCGTCGAGAAGTCGCTCGAGATCGCCGGCGACATGTGCATCTATACGAACCACAACCGCATCATCGAAAC
GATCGAGTAAGGACCGCACC

Downstream 100 bases:

>100_bases
CGCGCACGGCGTCGGACGAAAAACGGGCGGCCCCTTCCGGGGTCGCCCGTTTTTTTATAGCCATGCGATGTGGCGCACGC
GCCTGCCGCTGGAACGCGGC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSTMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKATDQAEDRILDILLPQPRAVGFGGNAEHANDDNNATRQ
TFRKRLREGQLDDKEVELDIEQPSAGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
EVKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTVNTKYGMVKTDHILFIASGAFHLAKPS
DLIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQALLATEDVQLEFADDGIRRLAEIAYSVNEKTENIGARRLY
TVIEKLLEEVSFSAGNHAGERVTIDAKYVDRALGEVSQDEDLSRYVL

Sequences:

>Translated_447_residues
MSTMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKATDQAEDRILDILLPQPRAVGFGGNAEHANDDNNATRQ
TFRKRLREGQLDDKEVELDIEQPSAGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
EVKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTVNTKYGMVKTDHILFIASGAFHLAKPS
DLIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQALLATEDVQLEFADDGIRRLAEIAYSVNEKTENIGARRLY
TVIEKLLEEVSFSAGNHAGERVTIDAKYVDRALGEVSQDEDLSRYVL
>Mature_446_residues
STMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKI
EATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRSKATDQAEDRILDILLPQPRAVGFGGNAEHANDDNNATRQT
FRKRLREGQLDDKEVELDIEQPSAGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDEE
VKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTVNTKYGMVKTDHILFIASGAFHLAKPSD
LIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQALLATEDVQLEFADDGIRRLAEIAYSVNEKTENIGARRLYT
VIEKLLEEVSFSAGNHAGERVTIDAKYVDRALGEVSQDEDLSRYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=447, Percent_Identity=64.4295302013423, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1786642, Length=102, Percent_Identity=48.0392156862745, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648289, Length=274, Percent_Identity=30.6569343065693, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648291, Length=274, Percent_Identity=30.6569343065693, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49853; Mature: 49722

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPTG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVR
CCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKATDQAEDRILDILLPQPRAVGFGGNAEHANDDNNATRQTFRKRLREGQLDDKEVELDI
HHHCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
EQPSAGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHH
EVKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTVNTKYGM
HHHHHHHHHHHCCCEEEEECHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCE
VKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQ
EEECEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHH
ALLATEDVQLEFADDGIRRLAEIAYSVNEKTENIGARRLYTVIEKLLEEVSFSAGNHAGE
HHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RVTIDAKYVDRALGEVSQDEDLSRYVL
EEEEEHHHHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
STMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVR
CCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKATDQAEDRILDILLPQPRAVGFGGNAEHANDDNNATRQTFRKRLREGQLDDKEVELDI
HHHCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
EQPSAGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHH
EVKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTVNTKYGM
HHHHHHHHHHHCCCEEEEECHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCE
VKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQ
EEECEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHH
ALLATEDVQLEFADDGIRRLAEIAYSVNEKTENIGARRLYTVIEKLLEEVSFSAGNHAGE
HHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RVTIDAKYVDRALGEVSQDEDLSRYVL
EEEEEHHHHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA