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The map label for this gene is ctaB [H]

Identifier: 78067636

GI number: 78067636

Start: 3316996

End: 3317898

Strand: Reverse

Name: ctaB [H]

Synonym: Bcep18194_A6167

Alternate gene names: 78067636

Gene position: 3317898-3316996 (Counterclockwise)

Preceding gene: 78067637

Following gene: 78067635

Centisome position: 89.82

GC content: 65.56

Gene sequence:

>903_bases
ATGCAAAGCACCCTCTCCCAATCGCCCGGTAGCCGGTTTTCGCAATACATGGCGCTGACGAAGCCGCGTGTCACGCAGCT
CGCGGTGTTCTGCGCGGTGATCGGCATGTTCCTCGCGACGCCGGGCATGGTGCCGTGGCACGTGCTGATCGGCGGTACGG
TCGGCATCTGGCTGCTGGCCGGCGCCGCGTTCGCGATCAACTGCCTCGTCGAACAGAAGATCGACGCGATGATGCGTCGC
ACCGCGTGGCGCCCGTCTGCGCGCGGCGAGATCACGACCCCGCAGATCCTGATCTTCTCGGCCGTGCTCGGCAGCGTCGG
CGCATGGACGCTCTATACGTTCACGAACCCGCTGACGATGTGGCTGACGATCGCCACCTTCGTCGGCTATGCGGTGATCT
ACACGCTGCTGCTCAAGCCGATGACGCCGCAGAACATCGTGATCGGCGGCGCATCGGGTGCGATGCCGCCGGCGCTCGGC
TGGGCCGCGGTCACCGGCGCGGTGCCGGGCGACGCGTGGATCCTCGTGCTGATCATTTTCGTGTGGACGCCGCCGCATTT
CTGGGTGCTCGCGCTCTATCGCCGCAAGGATTACGAGAACGCGGGGCTGCCGATGCTGCCCGTCACGCACGGCGAGAAGT
TCACGCGGCTGCACATCCTGCTGTACACGGTGATCCTGTTCGCGGTCACGCTGATGCCGTTCATCTCCGGGATGAGCGGG
GCCGTCTACCTGACGAGCGCGGTGCTGCTCGGCGCGGTGTTCCTCGCGTATGCGTGGAAGATCCATCGCGACTATTCGGA
CGAACTCGCCCGCAAGGCCTTCCGCTACTCGATCGTCTACCTGTCGCTGCTGTTCGCCGCGCTGCTCGTCGATCACTATG
CACGCCCGCTGCTCGGCGTGTAA

Upstream 100 bases:

>100_bases
TGCTGCTGCTCGTCGTCATGTTAAACTTTCGCATCCTTTCAAGCCGCCCCGGCCGTGTCGCGCAGCCTGCGCGCGACGTC
GCCCCGGCGTGACCGCCCCC

Downstream 100 bases:

>100_bases
CCGCACGGTTTGAACGCAATGCTCCACTCACGGTTCGGGCGCCGCGCGCGCCAAGGCTGGATGCTCGCATGCGCATTCAC
GGCAGCACTGCTGCTCGCCG

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLAGAAFAINCLVEQKIDAMMRR
TAWRPSARGEITTPQILIFSAVLGSVGAWTLYTFTNPLTMWLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALG
WAAVTGAVPGDAWILVLIIFVWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTLMPFISGMSG
AVYLTSAVLLGAVFLAYAWKIHRDYSDELARKAFRYSIVYLSLLFAALLVDHYARPLLGV

Sequences:

>Translated_300_residues
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLAGAAFAINCLVEQKIDAMMRR
TAWRPSARGEITTPQILIFSAVLGSVGAWTLYTFTNPLTMWLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALG
WAAVTGAVPGDAWILVLIIFVWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTLMPFISGMSG
AVYLTSAVLLGAVFLAYAWKIHRDYSDELARKAFRYSIVYLSLLFAALLVDHYARPLLGV
>Mature_300_residues
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLAGAAFAINCLVEQKIDAMMRR
TAWRPSARGEITTPQILIFSAVLGSVGAWTLYTFTNPLTMWLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALG
WAAVTGAVPGDAWILVLIIFVWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTLMPFISGMSG
AVYLTSAVLLGAVFLAYAWKIHRDYSDELARKAFRYSIVYLSLLFAALLVDHYARPLLGV

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=35.4166666666667, Blast_Score=98, Evalue=7e-21,
Organism=Escherichia coli, GI1786631, Length=280, Percent_Identity=33.2142857142857, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790473, Length=279, Percent_Identity=25.089605734767, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71998235, Length=286, Percent_Identity=30.7692307692308, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325085, Length=266, Percent_Identity=29.6992481203008, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19921064, Length=292, Percent_Identity=30.8219178082192, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32977; Mature: 32977

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLA
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GAAFAINCLVEQKIDAMMRRTAWRPSARGEITTPQILIFSAVLGSVGAWTLYTFTNPLTM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHH
WLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALGWAAVTGAVPGDAWILVLIIF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
VWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTLMPFISGMSG
HHCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVYLTSAVLLGAVFLAYAWKIHRDYSDELARKAFRYSIVYLSLLFAALLVDHYARPLLGV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLA
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GAAFAINCLVEQKIDAMMRRTAWRPSARGEITTPQILIFSAVLGSVGAWTLYTFTNPLTM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHH
WLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALGWAAVTGAVPGDAWILVLIIF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
VWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTLMPFISGMSG
HHCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVYLTSAVLLGAVFLAYAWKIHRDYSDELARKAFRYSIVYLSLLFAALLVDHYARPLLGV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA