Click here to switch to the map view.

The map label for this gene is strD [H]

Identifier: 78067509

GI number: 78067509

Start: 3178866

End: 3179585

Strand: Direct

Name: strD [H]

Synonym: Bcep18194_A6040

Alternate gene names: 78067509

Gene position: 3178866-3179585 (Clockwise)

Preceding gene: 78067508

Following gene: 78067511

Centisome position: 86.05

GC content: 72.36

Gene sequence:

>720_bases
ATGAGCACCACCCTGACCACGGCGATGATCTTCGCCGCCGGGCGCGGCGAACGGATGCGCCCGCTCACCGACACCCGCCC
GAAGCCGCTGCTCGAAGCGGGCGGCAAGCCGCTGATCGTGTGGCAGATCGAAGCGCTCGCCCGCGCGGGCATCGAGACGA
TCGTGATCAACCACGCGTGGCTCGGCGAGCAGATCGAGGCTGCGCTCGGCGACGGCTCGCGCTGGGGCGTGCGGCTCGTG
TATTCGGCCGAGGGCGAGGCACTGGAAACCGCGGGCGGCATCGCACAGGCGTTGCCGCTGCTCGAGCACGACGGGCAGCC
GGCCGTGTTCGCGGCGGTCAGCGGCGACGTGTACTGCGCGTTCGACTACCGGTCGCTCGCACCGCGCGCCGCCCGGATGG
CCGCGCTCGACGCACCGGCGATGCACCTCGTGATGGTGCCGAACCCGCCGTTCCACCCGGCCGGCGACTTCGCGCTCGGC
GACGACGGCCGCCTTGCGCTCGACGGCGCCGCGCGCTTCACGTTCGGCAACATCGGCCTGTACGACACGCGGATGTTCCG
CGATCTCGCGCCCGGCACGCGGCGCGCGCTGACGCCGTACTATCGCGCGGCGATCGAGGCCGGCCGCGCGAGCGGCGAAC
TGTATGAAGGAATCTGGGAGAACGTCGGCACGCCCGCGCAGCTCGGCGAGCTGGATGCGCGGCTGCGCGCCGTGAAGTGA

Upstream 100 bases:

>100_bases
GTGCCGTTCGCGAAGCTGCTCGACGAGCTCGAGGGCAGCGCGCCGGCCGACGTGGGCTACACCTTCTGATCGCTCCGACT
CTCCTGACACCCGGCCGAAC

Downstream 100 bases:

>100_bases
CCGGCTGACGGGTCGTCGGGCCGATCGATCAGACGGCTGGTGAGCTGACGGGCGGGTTGGCCGGCAAACCGGCCGGGTCG
GCCTGGCTGATCAATAGGTT

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSTTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAWLGEQIEAALGDGSRWGVRLV
YSAEGEALETAGGIAQALPLLEHDGQPAVFAAVSGDVYCAFDYRSLAPRAARMAALDAPAMHLVMVPNPPFHPAGDFALG
DDGRLALDGAARFTFGNIGLYDTRMFRDLAPGTRRALTPYYRAAIEAGRASGELYEGIWENVGTPAQLGELDARLRAVK

Sequences:

>Translated_239_residues
MSTTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAWLGEQIEAALGDGSRWGVRLV
YSAEGEALETAGGIAQALPLLEHDGQPAVFAAVSGDVYCAFDYRSLAPRAARMAALDAPAMHLVMVPNPPFHPAGDFALG
DDGRLALDGAARFTFGNIGLYDTRMFRDLAPGTRRALTPYYRAAIEAGRASGELYEGIWENVGTPAQLGELDARLRAVK
>Mature_238_residues
STTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAWLGEQIEAALGDGSRWGVRLVY
SAEGEALETAGGIAQALPLLEHDGQPAVFAAVSGDVYCAFDYRSLAPRAARMAALDAPAMHLVMVPNPPFHPAGDFALGD
DGRLALDGAARFTFGNIGLYDTRMFRDLAPGTRRALTPYYRAAIEAGRASGELYEGIWENVGTPAQLGELDARLRAVK

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=121, Percent_Identity=35.5371900826446, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI11761619, Length=121, Percent_Identity=35.5371900826446, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=121, Percent_Identity=41.3223140495868, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320148, Length=120, Percent_Identity=40, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355443, Length=123, Percent_Identity=38.2113821138211, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24644084, Length=123, Percent_Identity=38.2113821138211, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25589; Mature: 25457

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAW
CCCHHEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEEEEHHHHHCCCEEEEEECCC
LGEQIEAALGDGSRWGVRLVYSAEGEALETAGGIAQALPLLEHDGQPAVFAAVSGDVYCA
CCHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHHCCCCCEEEEEECCCEEEE
FDYRSLAPRAARMAALDAPAMHLVMVPNPPFHPAGDFALGDDGRLALDGAARFTFGNIGL
ECCHHHCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEECCCCCEEECCCEEEEECCCCC
YDTRMFRDLAPGTRRALTPYYRAAIEAGRASGELYEGIWENVGTPAQLGELDARLRAVK
HHHHHHHHCCCCCHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHEECC
>Mature Secondary Structure 
STTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAW
CCHHEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEEEEHHHHHCCCEEEEEECCC
LGEQIEAALGDGSRWGVRLVYSAEGEALETAGGIAQALPLLEHDGQPAVFAAVSGDVYCA
CCHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHHCCCCCEEEEEECCCEEEE
FDYRSLAPRAARMAALDAPAMHLVMVPNPPFHPAGDFALGDDGRLALDGAARFTFGNIGL
ECCHHHCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEECCCCCEEECCCEEEEECCCCC
YDTRMFRDLAPGTRRALTPYYRAAIEAGRASGELYEGIWENVGTPAQLGELDARLRAVK
HHHHHHHHCCCCCHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]