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The map label for this gene is arpR [H]

Identifier: 78067410

GI number: 78067410

Start: 3070044

End: 3070685

Strand: Direct

Name: arpR [H]

Synonym: Bcep18194_A5941

Alternate gene names: 78067410

Gene position: 3070044-3070685 (Clockwise)

Preceding gene: 78067406

Following gene: 78067412

Centisome position: 83.11

GC content: 65.26

Gene sequence:

>642_bases
ATGGTCAGACGTACCAAGGAGGAGGCGCTCGAGACGCGCAATCGCATTCTCGACGCCGCCGAGCACGTGTTCTTCGAGAA
GGGCGTGTCGCACACGTCGCTCGCGGACATCGCCCAGCATGCCGGCGTGACGCGCGGCGCGATCTACTGGCATTTCGCGA
ACAAGAGCGAACTGTTCGACGCGATGTTCGACCGCGTGTTTCTGCCGATCGACGAGCTCAAGCGGATGCCGCTCGACGCA
CCGGGCGGCAATCCGCTCGAGAAGATCCGGCAGATCCTGATCTGGTGCCTGCTCGGCGTGCAGCGCGACGCGCAGTTGCG
CCGCGTGTTCAGCATCCTGTTCATGAAGTGCGAGTACGTCGCAGACCTCGAGCCGCTGCTCCAGCGCAACCGCGCGGGGA
TGAGCGAGGCGCTGCACGCGATCGATGCCGATCTCGCGGGGGCCGTGCGGCTCAAGCTGCTGCCCGAGCGGCTCGATACG
TGGCGCGCGACGCTGATGCTGCACACGCTCGTCAGTGGTTTCGTGCGCGACATGCTGATGCTGCCCGACGAGATCGACGC
CGAGCAGCATGCGGAAAAGCTCGTCGACGGCTGCTTCGACATGCTGCGCTACAGTCCGGCGATGCTGAAGGACGGCGACT
GA

Upstream 100 bases:

>100_bases
TTACGGATTGTTACCAACCGCAAGCATAGCCAGTCTATATGACTGCGACGAGGGTTGCAGACCCTATATTCACCTACGAT
CATTCCAATCAGGCCTGCAC

Downstream 100 bases:

>100_bases
CCGCGCGACGCGCGCCCGCCTGCGGTTGCCGTTTCATCGAGCGGCGCGCCAACCTCGCAAACGCACTGCCCGCCCCCTCT
CCCGTCTCCCCGCTGTTTCA

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFDAMFDRVFLPIDELKRMPLDA
PGGNPLEKIRQILIWCLLGVQRDAQLRRVFSILFMKCEYVADLEPLLQRNRAGMSEALHAIDADLAGAVRLKLLPERLDT
WRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDGD

Sequences:

>Translated_213_residues
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFDAMFDRVFLPIDELKRMPLDA
PGGNPLEKIRQILIWCLLGVQRDAQLRRVFSILFMKCEYVADLEPLLQRNRAGMSEALHAIDADLAGAVRLKLLPERLDT
WRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDGD
>Mature_213_residues
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFDAMFDRVFLPIDELKRMPLDA
PGGNPLEKIRQILIWCLLGVQRDAQLRRVFSILFMKCEYVADLEPLLQRNRAGMSEALHAIDADLAGAVRLKLLPERLDT
WRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDGD

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=208, Percent_Identity=37.0192307692308, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789664, Length=205, Percent_Identity=31.7073170731707, Blast_Score=89, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24320; Mature: 24320

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFD
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AMFDRVFLPIDELKRMPLDAPGGNPLEKIRQILIWCLLGVQRDAQLRRVFSILFMKCEYV
HHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ADLEPLLQRNRAGMSEALHAIDADLAGAVRLKLLPERLDTWRATLMLHTLVSGFVRDMLM
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDGD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFD
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
AMFDRVFLPIDELKRMPLDAPGGNPLEKIRQILIWCLLGVQRDAQLRRVFSILFMKCEYV
HHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ADLEPLLQRNRAGMSEALHAIDADLAGAVRLKLLPERLDTWRATLMLHTLVSGFVRDMLM
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDGD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]