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The map label for this gene is mdtD [H]

Identifier: 78067336

GI number: 78067336

Start: 2987625

End: 2989109

Strand: Direct

Name: mdtD [H]

Synonym: Bcep18194_A5867

Alternate gene names: 78067336

Gene position: 2987625-2989109 (Clockwise)

Preceding gene: 78067333

Following gene: 78067337

Centisome position: 80.88

GC content: 67.34

Gene sequence:

>1485_bases
ATGGCTTTCCCTACAATGTCGGCTGTCCCGCGCCACCATCCCGCCCCCATGTTCCAGCGCCCGCCCGCCGCCGCTCCCGG
CGAAAAGAACCTCACCGTGATGCTCTGGCTCGTCGCAACGGGCTTCTTCATGCAGACGCTCGATTCGACGATCGTGAACA
CGGCGCTGCCGTCGATGGCCGCGAGCCTCGGCGAATCGCCGCTGCGCATGCAGTCGGTCGTGATCGCGTACTCGCTGACG
ATGGCGGTGATGATCCCCGTATCGGGCTGGCTCGCCGATACCTTCGGCACGCGGCGCGTGTTCTTCAGCGCGATCCTGGT
GTTCTCGCTCGGCTCGCTGCTGTGCGCCAACGCGCATACGCTGACGCAGCTCGTCGCGTTCCGCGTCGTGCAGGGCGTCG
GCGGCGCGATGCTGCTGCCGGTCGGGCGGCTCGCGGTGCTGCGCACCTTCCCGGCCGAACGCTACCTGCCCGCGCTGTCG
TTCGTCGCGATTCCCGGCCTGATCGGCCCGCTGATCGGGCCGACGCTCGGCGGCTGGCTCGTGAAGATCGCGTCGTGGCA
CTGGATCTTCCTGATCAACGTGCCGGTCGGCGTCGCGGGCTGCATCGCGACCTTCTATTCGATGCCCGATTCGCGCAACC
CGGCCGTCGGCCGTTTCGACCTGAAGGGCTATCTGCTGCTGACGATCGGCATGGTCGCGATCTCGCTGTCGCTCGACGGG
CTCGCCGATCTCGGGATGCAGCACGCGGCCGTGCTCGTGCTGCTGATCCTGAGCCTTGCATGCTTCGTCGCGTACGGGCT
GTATGCGGTGCGCGCGCCGCAACCGATCTTCTCGCTCGAACTGTTCCGGATCCACACGTTCAGCGTCGGGCTGCTCGGCA
ACCTGTTCGCGCGGATCGGCAGCGGCGCGATGCCGTACCTGATCCCGCTGCTGCTGCAGGTGAGCCTCGGCTACTCGGCG
TTCGAGGCCGGGCTGATGATGCTGCCGGTGGCCGCCGCCGGGATGTTCTCGAAGCGGATCATCACGCGCCTGATCACGCG
GCACGGCTACCGCAAGGTGCTGCTCGCGAACACGATCATGGTCGGCGTGATGATGGCGAGCTTCGCGCTGATGCGCGACA
CGGTGCCCGTCTGGGTGAAGGTCGTACATCTCGCGCTGTTCGGCGGCTTCAACTCGATGCAGTTCACCGCGATGAACACG
CTGACGCTGAAGGATCTCGGCACGGGCGGCGCGAGCAGCGGCAACAGCCTGTTCTCGCTCGTGCAGATGCTGTCGATGAG
CCTCGGCGTCACGGTGGCGGGCGCGCTGCTCGCGACGTTCACGGGCATGCTGCGCACCGTGACGCCGAGCAACACGCTGC
CGGCGTTCCATGCGACCTTCATCTGCGTCGGGATCATCACGGCGGCTTCCGCGTGGATCTTCGCGCAGCTCGCGCCCGAG
ATCCGCAGCACCGCGCGCAAGACCGACCCGTCCGAGCGCGCATGA

Upstream 100 bases:

>100_bases
GATGCAGACACTTTTGGCTGAACTGTACTGGTCGTTCGACGGAGACGGGCACCCGTCGGCCCGACTGCGCACCGCCCTTG
CGCCGAACCTGCACGGCGCA

Downstream 100 bases:

>100_bases
CGCGCGGCGCGCGCCGAACCGGGTCGGCGCGCACCATTGCGGTGCGGCTGGGCCCCGCGATGCGCATCTGAAACACCCGC
AATGCCCGCGGCTCGGCCGC

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MAFPTMSAVPRHHPAPMFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMAASLGESPLRMQSVVIAYSLT
MAVMIPVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLTQLVAFRVVQGVGGAMLLPVGRLAVLRTFPAERYLPALS
FVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDG
LADLGMQHAAVLVLLILSLACFVAYGLYAVRAPQPIFSLELFRIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSA
FEAGLMMLPVAAAGMFSKRIITRLITRHGYRKVLLANTIMVGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNT
LTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPE
IRSTARKTDPSERA

Sequences:

>Translated_494_residues
MAFPTMSAVPRHHPAPMFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMAASLGESPLRMQSVVIAYSLT
MAVMIPVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLTQLVAFRVVQGVGGAMLLPVGRLAVLRTFPAERYLPALS
FVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDG
LADLGMQHAAVLVLLILSLACFVAYGLYAVRAPQPIFSLELFRIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSA
FEAGLMMLPVAAAGMFSKRIITRLITRHGYRKVLLANTIMVGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNT
LTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPE
IRSTARKTDPSERA
>Mature_493_residues
AFPTMSAVPRHHPAPMFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMAASLGESPLRMQSVVIAYSLTM
AVMIPVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLTQLVAFRVVQGVGGAMLLPVGRLAVLRTFPAERYLPALSF
VAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDGL
ADLGMQHAAVLVLLILSLACFVAYGLYAVRAPQPIFSLELFRIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAF
EAGLMMLPVAAAGMFSKRIITRLITRHGYRKVLLANTIMVGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTL
TLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEI
RSTARKTDPSERA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=469, Percent_Identity=46.4818763326226, Blast_Score=423, Evalue=1e-119,
Organism=Escherichia coli, GI1788392, Length=448, Percent_Identity=49.7767857142857, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1789042, Length=478, Percent_Identity=27.6150627615063, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1788710, Length=325, Percent_Identity=32.6153846153846, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081983, Length=318, Percent_Identity=31.4465408805031, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1788509, Length=165, Percent_Identity=30.3030303030303, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=353, Percent_Identity=25.2124645892351, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323735, Length=256, Percent_Identity=26.171875, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=125, Percent_Identity=30.4, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52704; Mature: 52572

Theoretical pI: Translated: 10.58; Mature: 10.58

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFPTMSAVPRHHPAPMFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LTQLVAFRVVQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDG
HHHHCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
LADLGMQHAAVLVLLILSLACFVAYGLYAVRAPQPIFSLELFRIHTFSVGLLGNLFARIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEHHHHHHHHHHHHHHHHHHC
SGAMPYLIPLLLQVSLGYSAFEAGLMMLPVAAAGMFSKRIITRLITRHGYRKVLLANTIM
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSL
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEHCCCCCCCCCCHHHHHH
VQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IRSTARKTDPSERA
HHHHHHCCCCCCCC
>Mature Secondary Structure 
AFPTMSAVPRHHPAPMFQRPPAAAPGEKNLTVMLWLVATGFFMQTLDSTIVNTALPSMA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LTQLVAFRVVQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDG
HHHHCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
LADLGMQHAAVLVLLILSLACFVAYGLYAVRAPQPIFSLELFRIHTFSVGLLGNLFARIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEHHHHHHHHHHHHHHHHHHC
SGAMPYLIPLLLQVSLGYSAFEAGLMMLPVAAAGMFSKRIITRLITRHGYRKVLLANTIM
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSL
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEHCCCCCCCCCCHHHHHH
VQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IRSTARKTDPSERA
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA