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The map label for this gene is yeaE [H]

Identifier: 78067332

GI number: 78067332

Start: 2983510

End: 2984355

Strand: Reverse

Name: yeaE [H]

Synonym: Bcep18194_A5863

Alternate gene names: 78067332

Gene position: 2984355-2983510 (Counterclockwise)

Preceding gene: 78067334

Following gene: 78067325

Centisome position: 80.79

GC content: 69.74

Gene sequence:

>846_bases
ATGACAGACACGATCGCCACGGTCGTCCTGCCGGACGGCGAGACGATTCCGAAGCTTGGCCTGGGCACGTGGGAAATGGG
CGAACGGCCGGCCCGGCGCGCAGACGAGATCGCCGCGCTGCGCGAAGGCATCGCGCTCGGGATGACGCTGGTCGATACGG
CCGAGATGTACGGCGACGGCGCGACCGAGGAGCTGGTCGGCGAGGCGCTCGCGGGCCTGCGCGACGACGTGTTCCTCGTC
AGCAAGGTCTATCCGCACCACGCGAGCCGGCGCGGCGTCGTCGCCGCATGCGATGCGAGCCTCAAGCGCTTGCGGACCGA
TCGCCTCGACCTGTACTTGCTGCACTGGCGTGGCTCGGTGCCGCTCGAGGAGACGATCGAAGGCTTCGAAGCGCTGCAGC
GCGCGGGCAAGATTCGTCGCTGGGGCGTCAGCAACTTCGATACGGCCGACATGGCCGAGCTCGTCGATGAAGCCGGTGGC
GGCGCGTGCGCGACCAACCAGGTCCTCTACAACATCGCGCGGCGCGGCCCGGAGTTCGACCTGCTGCCGTGGCTTGCCGA
GCACCGGATGCCGGCGATGGCGTACAGCCCGGTCGATCACGGGCGGCTGCCGAAGCGCTCGCCGCTCGACGAGATCGCGC
GGCAGCGCGGGGTGTCGGTGATGCGCGTCGCGCTCGCGTGGGTGCTCGCGCAGCCGGGGGTTTTCGCGATCCCGAAGGCG
TCGCGGCTCGAACACGTGCGCGACAACCGCGCCGCGCTCGATTTCGTGTTCAGCGATGACGAGCGCGCGCAGCTTGACGC
GTACTTCCGTCCGCCACGCAGCAAGCGCGCGCTCGAGATGCTCTGA

Upstream 100 bases:

>100_bases
GCCGTGCAATAGGTGAATTGCGCGCCGATTGACTACACTGATGCGTCGTATTTCATGGCTGGGCCGCGATGCGCGGCCAC
GAATCCGCAACGAGGAACGC

Downstream 100 bases:

>100_bases
CGACACCCGGCCGGGCAACGCAGCGGGTCAGTGGTTGGCTCCGGACGATCCGCCGTTGCCGTGACCGCCGCCATTGCCGT
TCCCGGTGCCATGGCCGTTG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTDTIATVVLPDGETIPKLGLGTWEMGERPARRADEIAALREGIALGMTLVDTAEMYGDGATEELVGEALAGLRDDVFLV
SKVYPHHASRRGVVAACDASLKRLRTDRLDLYLLHWRGSVPLEETIEGFEALQRAGKIRRWGVSNFDTADMAELVDEAGG
GACATNQVLYNIARRGPEFDLLPWLAEHRMPAMAYSPVDHGRLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKA
SRLEHVRDNRAALDFVFSDDERAQLDAYFRPPRSKRALEML

Sequences:

>Translated_281_residues
MTDTIATVVLPDGETIPKLGLGTWEMGERPARRADEIAALREGIALGMTLVDTAEMYGDGATEELVGEALAGLRDDVFLV
SKVYPHHASRRGVVAACDASLKRLRTDRLDLYLLHWRGSVPLEETIEGFEALQRAGKIRRWGVSNFDTADMAELVDEAGG
GACATNQVLYNIARRGPEFDLLPWLAEHRMPAMAYSPVDHGRLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKA
SRLEHVRDNRAALDFVFSDDERAQLDAYFRPPRSKRALEML
>Mature_280_residues
TDTIATVVLPDGETIPKLGLGTWEMGERPARRADEIAALREGIALGMTLVDTAEMYGDGATEELVGEALAGLRDDVFLVS
KVYPHHASRRGVVAACDASLKRLRTDRLDLYLLHWRGSVPLEETIEGFEALQRAGKIRRWGVSNFDTADMAELVDEAGGG
ACATNQVLYNIARRGPEFDLLPWLAEHRMPAMAYSPVDHGRLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKAS
RLEHVRDNRAALDFVFSDDERAQLDAYFRPPRSKRALEML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24497577, Length=306, Percent_Identity=27.4509803921569, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI5174391, Length=306, Percent_Identity=27.4509803921569, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI223468663, Length=314, Percent_Identity=27.3885350318471, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310109922, Length=294, Percent_Identity=27.2108843537415, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI45446745, Length=314, Percent_Identity=27.0700636942675, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4503285, Length=314, Percent_Identity=27.0700636942675, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI5453543, Length=314, Percent_Identity=27.0700636942675, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310109920, Length=314, Percent_Identity=27.0700636942675, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI24497585, Length=302, Percent_Identity=27.1523178807947, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI24497583, Length=307, Percent_Identity=26.0586319218241, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI223718702, Length=210, Percent_Identity=30, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788081, Length=272, Percent_Identity=54.0441176470588, Blast_Score=297, Evalue=4e-82,
Organism=Escherichia coli, GI87081735, Length=297, Percent_Identity=28.2828282828283, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082198, Length=269, Percent_Identity=28.6245353159851, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=25.8823529411765, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788070, Length=303, Percent_Identity=28.0528052805281, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787674, Length=283, Percent_Identity=28.2685512367491, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1789199, Length=325, Percent_Identity=28.9230769230769, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI48994888, Length=267, Percent_Identity=30.7116104868914, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789375, Length=312, Percent_Identity=27.5641025641026, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17552492, Length=271, Percent_Identity=26.5682656826568, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17566692, Length=313, Percent_Identity=26.1980830670927, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17561298, Length=297, Percent_Identity=28.6195286195286, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71998625, Length=278, Percent_Identity=28.7769784172662, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17564128, Length=306, Percent_Identity=28.4313725490196, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550248, Length=302, Percent_Identity=23.1788079470199, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538386, Length=283, Percent_Identity=28.9752650176678, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17537077, Length=304, Percent_Identity=25.9868421052632, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561300, Length=267, Percent_Identity=26.9662921348315, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537075, Length=307, Percent_Identity=26.0586319218241, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324694, Length=297, Percent_Identity=28.956228956229, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320576, Length=316, Percent_Identity=27.2151898734177, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325169, Length=291, Percent_Identity=23.3676975945017, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=26.6903914590747, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553081, Length=302, Percent_Identity=26.8211920529801, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24657054, Length=303, Percent_Identity=25.0825082508251, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644950, Length=305, Percent_Identity=25.5737704918033, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20129731, Length=308, Percent_Identity=26.9480519480519, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24662789, Length=297, Percent_Identity=25.5892255892256, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281366140, Length=263, Percent_Identity=26.2357414448669, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 31131; Mature: 31000

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTIATVVLPDGETIPKLGLGTWEMGERPARRADEIAALREGIALGMTLVDTAEMYGDG
CCCCEEEEEECCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATEELVGEALAGLRDDVFLVSKVYPHHASRRGVVAACDASLKRLRTDRLDLYLLHWRGSV
CHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHCCCEEEEEEECCCC
PLEETIEGFEALQRAGKIRRWGVSNFDTADMAELVDEAGGGACATNQVLYNIARRGPEFD
CHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
LLPWLAEHRMPAMAYSPVDHGRLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKA
HHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEECCCH
SRLEHVRDNRAALDFVFSDDERAQLDAYFRPPRSKRALEML
HHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
TDTIATVVLPDGETIPKLGLGTWEMGERPARRADEIAALREGIALGMTLVDTAEMYGDG
CCCEEEEEECCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATEELVGEALAGLRDDVFLVSKVYPHHASRRGVVAACDASLKRLRTDRLDLYLLHWRGSV
CHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHCCCEEEEEEECCCC
PLEETIEGFEALQRAGKIRRWGVSNFDTADMAELVDEAGGGACATNQVLYNIARRGPEFD
CHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
LLPWLAEHRMPAMAYSPVDHGRLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKA
HHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEECCCH
SRLEHVRDNRAALDFVFSDDERAQLDAYFRPPRSKRALEML
HHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]