Click here to switch to the map view.

The map label for this gene is mco [H]

Identifier: 78067322

GI number: 78067322

Start: 2969600

End: 2971207

Strand: Reverse

Name: mco [H]

Synonym: Bcep18194_A5853

Alternate gene names: 78067322

Gene position: 2971207-2969600 (Counterclockwise)

Preceding gene: 78067324

Following gene: 78067320

Centisome position: 80.43

GC content: 70.34

Gene sequence:

>1608_bases
ATGATACGGAGAACCTTCCTGTCGCGCGCCATCGGTGTCGCGGCCGCGTCGCTGTTCGCGCGCGCCGCGTGGGCGCAGCA
TGCGGGTCACGCTGGCATGGCCGGCATGGACGCGATGGACGACATGCCCGGCATGTCGGGCATGTCAGGGATGGCGGGTC
ATGGGCAGCACGGCAAGTCCGCACCGGCCGCGCTCGCGGCCGCCGACGCGCTGCCGGCCGGCGCGCCGCTTGCGGCGCTG
CGCACGCTCGCGAACGAAAGCCGCGAGCCCGGTACGTTCCGGGCCACGCTGGTGGCACAGCCCGTGGCGCGCCCGATGCT
GCACGGCGCACGGCCGACCACGTTCTGGCAGTTCGGCGCGGGCACGCAGGGCCCCGTCGTCGGTCCGCTGATCGACGTGC
GCGAGGGCGACACGGTCGAGATCAAGTTCGTGAACAAGTTGCCGCAGCCGTCGACGATCCACTGGCACGGCCTGCCCGTG
CCGCCTGACCAGGACGGCAATCCTTCCGATCCCGTCGCGCCCGGCGCGTCGCGCGTGTACCGCTTCACGTTGCCGAAGGG
GAGTGCCGGTACCTACTGGTACCACCCGCATCCGCACATGATGACGGCCGAGCAAGTCTTCCGCGGGCTCGCCGGCCCGT
TCGTCGTGCGCGCCGCGGACGATCCGCTGGCAGGCTGGCCCGAGCGCAACCTGTTCGTGTCGGACCTGAAGCTTGCACGC
GACGGCACGATTGCACCGAACGACATGATGGACTGGATGAATGGCCGCGAGGGCCAGTTCGTGCTGGTCAACGGCGCACG
CCGGCCGCGGATCGACGTCGCGGGCGACGAGCGCTGGCGCGTGTGGAACGCATGCAGCGCGCGCTACCTGCGCATCGCGT
TCGACGACGGCCGCGCGTTCGAGCACGCGGGCACCGACGGCGGGCTGTTCGACGCGCCGCGCCGCGTCACGTCGCTGCTG
ATTGCGCCGGGCGAACGGGCGGAGCTGCTGGTGCGTGCCGGCGATCGCGCGTCGCGCGCCGTGCTGCAGGCGGCCGAATA
CGACCGCCGAAAGATGTCGATGTCGCACGATGACGGACACGGCAGCCTGCCGCCCGATCCGGCGCTGGCCCTGGCTGACG
TCGCATTCGTGCCCGCCGCTGCCCGCGCGCTGCCGGCGACCCTGCGCGCGGTGCCGCCACTGGGCGAACCGGTCGCGCAT
AAGGAAGTCGCGTTCGGCGAAGAGATGGACATGGAGGCGATGATGAAAGGCGCGGCGCACGGCCGTCCGGCGGGCATGCG
CTTCACGATCAACGGCGACACCTACGCGCCGCATCGCGCGACGCTGACGAGCCGCCGGGGCGACGTCGAGCGCTGGACGA
TCCGCAACGGCACCGACATGGATCACCCGTTCCACCTGCACGGCACGCAGTTCCAGGTGACCGAGCGCGCGTCGGGCGCT
TCGCGCACGAGCGAACCGTTCCGCGCATGGCGCGATACGGTGAACGTGCGCAGCGGTGAAACCGTGACGATTCTCGTCAC
GCAAGACATGCCGGGTGAGCGCATGTTTCATTGCCACATTCTCGAACACGAGGATCTCGGCATGATGGGCACGCTGAAGG
TCGTGTAA

Upstream 100 bases:

>100_bases
ACGCGGGCATCAGGATTTGCGTCGCGCATCGGCGCTTCAGCCGGCCGGCGCGGGCATCGCGGCGGCCGCGCGACCCAGCA
TGGATAACGAGGAACGATTG

Downstream 100 bases:

>100_bases
CGAAGTGGCGATTATGTTTCACGCGCCGGATGAGTATTTGATCTGCGCGCGTGACAAGACAATACGTGTTCAATTATCGG
GATTGAACGAAAAGGCCGGC

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MIRRTFLSRAIGVAAASLFARAAWAQHAGHAGMAGMDAMDDMPGMSGMSGMAGHGQHGKSAPAALAAADALPAGAPLAAL
RTLANESREPGTFRATLVAQPVARPMLHGARPTTFWQFGAGTQGPVVGPLIDVREGDTVEIKFVNKLPQPSTIHWHGLPV
PPDQDGNPSDPVAPGASRVYRFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERNLFVSDLKLAR
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVAGDERWRVWNACSARYLRIAFDDGRAFEHAGTDGGLFDAPRRVTSLL
IAPGERAELLVRAGDRASRAVLQAAEYDRRKMSMSHDDGHGSLPPDPALALADVAFVPAAARALPATLRAVPPLGEPVAH
KEVAFGEEMDMEAMMKGAAHGRPAGMRFTINGDTYAPHRATLTSRRGDVERWTIRNGTDMDHPFHLHGTQFQVTERASGA
SRTSEPFRAWRDTVNVRSGETVTILVTQDMPGERMFHCHILEHEDLGMMGTLKVV

Sequences:

>Translated_535_residues
MIRRTFLSRAIGVAAASLFARAAWAQHAGHAGMAGMDAMDDMPGMSGMSGMAGHGQHGKSAPAALAAADALPAGAPLAAL
RTLANESREPGTFRATLVAQPVARPMLHGARPTTFWQFGAGTQGPVVGPLIDVREGDTVEIKFVNKLPQPSTIHWHGLPV
PPDQDGNPSDPVAPGASRVYRFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERNLFVSDLKLAR
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVAGDERWRVWNACSARYLRIAFDDGRAFEHAGTDGGLFDAPRRVTSLL
IAPGERAELLVRAGDRASRAVLQAAEYDRRKMSMSHDDGHGSLPPDPALALADVAFVPAAARALPATLRAVPPLGEPVAH
KEVAFGEEMDMEAMMKGAAHGRPAGMRFTINGDTYAPHRATLTSRRGDVERWTIRNGTDMDHPFHLHGTQFQVTERASGA
SRTSEPFRAWRDTVNVRSGETVTILVTQDMPGERMFHCHILEHEDLGMMGTLKVV
>Mature_535_residues
MIRRTFLSRAIGVAAASLFARAAWAQHAGHAGMAGMDAMDDMPGMSGMSGMAGHGQHGKSAPAALAAADALPAGAPLAAL
RTLANESREPGTFRATLVAQPVARPMLHGARPTTFWQFGAGTQGPVVGPLIDVREGDTVEIKFVNKLPQPSTIHWHGLPV
PPDQDGNPSDPVAPGASRVYRFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERNLFVSDLKLAR
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVAGDERWRVWNACSARYLRIAFDDGRAFEHAGTDGGLFDAPRRVTSLL
IAPGERAELLVRAGDRASRAVLQAAEYDRRKMSMSHDDGHGSLPPDPALALADVAFVPAAARALPATLRAVPPLGEPVAH
KEVAFGEEMDMEAMMKGAAHGRPAGMRFTINGDTYAPHRATLTSRRGDVERWTIRNGTDMDHPFHLHGTQFQVTERASGA
SRTSEPFRAWRDTVNVRSGETVTILVTQDMPGERMFHCHILEHEDLGMMGTLKVV

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=470, Percent_Identity=31.7021276595745, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1789394, Length=443, Percent_Identity=29.7968397291196, Blast_Score=133, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24650186, Length=529, Percent_Identity=23.4404536862004, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 57880; Mature: 57880

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRTFLSRAIGVAAASLFARAAWAQHAGHAGMAGMDAMDDMPGMSGMSGMAGHGQHGKS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
APAALAAADALPAGAPLAALRTLANESREPGTFRATLVAQPVARPMLHGARPTTFWQFGA
CCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEECC
GTQGPVVGPLIDVREGDTVEIKFVNKLPQPSTIHWHGLPVPPDQDGNPSDPVAPGASRVY
CCCCCCCCCEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEE
RFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERNLFVSDLKLAR
EEECCCCCCCCEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHEEECC
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVAGDERWRVWNACSARYLRIAFDDGRAF
CCCCCCHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCEEEECCCCCEEEEEEECCCCEE
EHAGTDGGLFDAPRRVTSLLIAPGERAELLVRAGDRASRAVLQAAEYDRRKMSMSHDDGH
ECCCCCCCCCCCCHHHHEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
GSLPPDPALALADVAFVPAAARALPATLRAVPPLGEPVAHKEVAFGEEMDMEAMMKGAAH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHHHCCCC
GRPAGMRFTINGDTYAPHRATLTSRRGDVERWTIRNGTDMDHPFHLHGTQFQVTERASGA
CCCCCEEEEECCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCEEECCCEEEEECCCCCC
SRTSEPFRAWRDTVNVRSGETVTILVTQDMPGERMFHCHILEHEDLGMMGTLKVV
CCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEC
>Mature Secondary Structure
MIRRTFLSRAIGVAAASLFARAAWAQHAGHAGMAGMDAMDDMPGMSGMSGMAGHGQHGKS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
APAALAAADALPAGAPLAALRTLANESREPGTFRATLVAQPVARPMLHGARPTTFWQFGA
CCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEECC
GTQGPVVGPLIDVREGDTVEIKFVNKLPQPSTIHWHGLPVPPDQDGNPSDPVAPGASRVY
CCCCCCCCCEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEE
RFTLPKGSAGTYWYHPHPHMMTAEQVFRGLAGPFVVRAADDPLAGWPERNLFVSDLKLAR
EEECCCCCCCCEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHEEECC
DGTIAPNDMMDWMNGREGQFVLVNGARRPRIDVAGDERWRVWNACSARYLRIAFDDGRAF
CCCCCCHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCEEEECCCCCEEEEEEECCCCEE
EHAGTDGGLFDAPRRVTSLLIAPGERAELLVRAGDRASRAVLQAAEYDRRKMSMSHDDGH
ECCCCCCCCCCCCHHHHEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCC
GSLPPDPALALADVAFVPAAARALPATLRAVPPLGEPVAHKEVAFGEEMDMEAMMKGAAH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHHHCCCC
GRPAGMRFTINGDTYAPHRATLTSRRGDVERWTIRNGTDMDHPFHLHGTQFQVTERASGA
CCCCCEEEEECCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCEEECCCEEEEECCCCCC
SRTSEPFRAWRDTVNVRSGETVTILVTQDMPGERMFHCHILEHEDLGMMGTLKVV
CCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA